• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.36 no.5
• /
• pp.791-803
• /
• 2016

Recently, frequency of extreme rainfall events in South Korea has been substantially increased due to the enhanced climate variability. Korea is prone to flooding due to being surrounded by mountains, along with high rainfall intensity during a short period. In the past three decades, an increase in the frequency of heavy rainfall events has been observed due to enhanced climate variability and climate change. This study aimed to analyze extreme rainfalls informed by their frequency of occurrences using a long-term rainfall data. In this respect, we developed a Poisson-Generalized Pareto Distribution (Poisson-GPD) based rainfall frequency method which allows us to simultaneously explore changes in the amount and exceedance probability of the extreme rainfall events defined by different thresholds. Additionally, this study utilized a Bayesian approach to better estimate both parameters and their uncertainties. We also investigated the synoptic patterns associated with the extreme events considered in this study. The results showed that the Poisson-GPD based design rainfalls were rather larger than those of based on the Gumbel distribution. It seems that the Poisson-GPD model offers a more reasonable explanation in the context of flood safety issue, by explicitly considering the changes in the frequency. Also, this study confirmed that low and high pressure system in the East China Sea and the central North Pacific, respectively, plays crucial roles in the development of the extreme rainfall in South Korea.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.32 no.4 s.59
• /
• pp.209-217
• /
• 2006

Emulsion is a dispersion system among liquids which are not miscible together. There are numerous cosmetic raw materials which have different physicochemical properties. Therefore, emulsion technology is very useful in cosmetics. With the development of emulsifier, several emulsification technologies have been developed. Since HLB method by Griffin in 1950's, PIT method, gel method, and D-phase methods, etc, have been developed. Recently, the application of natural emulsifier and polymeric emulsifier increases in cosmetics in order to achieve enhanced safety and biocompatibility. Besides nano-emulsion, multiple-emulsion, liquid crystal emulsion, and Pickering emulsion have been developed and applied as means of differentiating appearance and texture of products and achieving enhanced delivery of active ingredients. Meanwhile, the application studies of nano-dispersed structural system such as liposome or cubosome are on progress. Liposome is a bi- or multi-lamella layer dispersion system composed of amhiphilic molecules - phospholipids which are main components of plasma membrane. Cubosome also is a nano-sized dispersion system composed of a specific molecule like glyceryl monoloeate derived from natural products. And it has a cubic bicontinuous structure in water due to its unique molecular structure. Incorporating compounds (active materials) into such nano-particles can increase biocompatibility and delivery efficiency of target compounds. Manufacturing process and application of cosmetic emulsions and nano-particles are briefly introduced in this paper.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.11 no.2
• /
• pp.293-300
• /
• 2007

As the development of the various IP-based services, it is expected that Internet telephony service will gradually replace the traditional PSTN-based telephony service. But there are many issues resolved to spread the Internet telephony service. One of them is to support the emergency services in the Internet telephony. In the case of USA, it has been regulated that 911 services should be supported in the Internet telephony services using VoIP on the similar performance level to PSTN 911 service. According to the regulation, basic VoIP 911 calls should be routed to the general access line of LEA without the location information or the callback number, but the enhanced VoIP 911 calls with the location information and callback number should be routed on the dedicated 911 network and destined to the local 911 distribution center such as PSAP. But, in the current VoIP-based Internet telephony network, the emergency call service has not been handled as one of the special services as well at has a worse performance in comparison to it on PSTN. Moreover, the service has a critical problem that it can not be destined to the nearest PSAP because of the insufficient information about the location information and the call back number. In this paper, we suggest the SIP-based emergency call service mechanism in order to resolve the problems above mentioned. This suggested mechanism is implemented to show its effectiveness and efficiency.

• Journal of rehabilitation welfare engineering & assistive technology
• /
• v.7 no.2
• /
• pp.125-132
• /
• 2013

This research is focused on improvement of satisfaction of the assistive products, which is used by long term care elderly people. We investigated 1,200 long-term cared elderly and this survey was conducted by care-giver. The average satisfaction of the assistive products are in convenience 3.43, in function and effectiveness 3.33, in safety and secure 3.29 and in adequacy cost compared to effectiveness 2.69. Total average satisfaction of utilization is 3.19. Satisfaction with the use of assistive products in using motivation does not show a statistically significant difference, but in selection factors is a difference to be statistically significant. In conclusion, expert-consulting should be enhanced for the improvement of satisfaction and the provision of assistive products should be expanded in long-term care insuance schemes. Also, the rational index and evaluation method of the satisfaction of the assistive products should be developed through continuous studies.

• BMB Reports
• /
• v.28 no.1
• /
• pp.57-61
• /
• 1995

The expression of a recombinant human lactoferrin is reported in mouse HC11 mammary epithelial cells. Expression of human lactoferrin (hLF) was achieved by placing its cDNA under the control of the bovine ${\beta}$-casein gene. To improve the hLF expression level in a cell culture system, two artificial introns were also introduced to construct expression vectors. One intron was a hybrid-splice signal consisting of bovine ${\beta}$-casein intron 1 and rabbit ${\beta}$-globin intron II. The other intron was a DNA fragment spanning intron 8 of the bovine ${\beta}$-casein gene. The hybrid intron moderately elevated hLF expression, whereas intron 8 alone did not express any detectable amount of hLF as judged by Northem and Western blot analyses. When the two introns were used together they contributed to a synergistic elevation of hLF expression. These data indicate that artificial introns on both sides of the hLF cDNA were necessary to increase expression of cDNA.

• Biomolecules & Therapeutics
• /
• v.21 no.1
• /
• pp.42-48
• /
• 2013

Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated. In the current study, we investigated the question of whether nystatin was able to induce expression of macrophage inflammatory protein-1 (MIP-1). THP-1 cells rarely express MIP-$1{\alpha}$ and MIP-$1{\beta}$, however, upon exposure to nystatin, significantly elevated expression of MIP-$1{\alpha}$ and MIP-$1{\beta}$ was observed in a dose-dependent fashion at the messenger and protein levels. Cellular factors activated by nystatin as well as involved in nystatin-induced expression of MIP-1 proteins were identified in order to understand the molecular mechanisms of action of the anti-fungal agent. Treatment with nystatin resulted in enhanced phosphorylation of Akt, ERK, p38 MAPK, and JNK. Abrogation or significant attenuation of nystatin-induced expression of MIP-$1{\alpha}$ and MIP-$1{\beta}$ was observed by treatment with Akt inhibitor IV, LY294002, and SP6001250. Inhibition of ERK or p38MAPK using U0126 and SB202190 did not lead to attenuation of MIP-1 expression. In addition, inhibitors of protein kinase C, such as GF109203X and Ro-318220, also attenuated expression of MIP-1. These results indicate that nystatin is able to activate multiple cellular kinases and, among them, Akt and JNK play primary roles in nystatin-induced expression of MIP-1 proteins.

• Fire Science and Engineering
• /
• v.23 no.5
• /
• pp.125-132
• /
• 2009

In this study we could contribute to the development of a precise checking tool with which the reliability of the automatic fire detection systems was enhanced and the safety of the people was ensured. In the same way as the domestic technical standard, the portable smoke sensitivity tester, which was developed in this work, could be used to check the capability of the smoke detectors installed in the field. Its heater inside was warmed up to $400^{\circ}C$ in 40 seconds and the paper as a smoke source was burned to produce smoke for the test. With the Photoelectric smoke detector it was possible to measure and control the smoke concentration in a range from 0%/m to 25%/m. With the adjustment of rpm of the fan, it was possible to keep a constant wind velocity in a range from 20cm/sec to 40cm/sec.

• Journal of the Korean Institute of Rural Architecture
• /
• v.12 no.4
• /
• pp.21-28
• /
• 2010

As the issues such as safety, hygiene, convenience of school facility from the perspective of living environment for students and teachers arise as an important task in recent, there is increasing concern for resting convenience facility in school. In recent, the government is planning to change middle high school into the departmental classroom system. The departmental classroom system refers to the school operation system in which the classroom is structured as a subject-specialized classroom and the students move to the classroom according to their class schedules. This departmental classroom system is advantageous in that each subject can be equipped with professional facilities or preparations; the usage rate of the classroom can be enhanced; the common study space or living space can be used substantially; the school can plan and operate its own specialized space. On the contrary, it has the weaknesses that there is need to prepare the home base for the guidance of the class or student guidance; there is need for the facilities including personal lockers. Thus, the departmental classroom system requires the space expansion for home base or the resting convenience space for students and thus has to provide various spaces. Under this background, it is also important to check and plan the resting space for the schools. Therefore, this study is aimed to examine and analyze the arrangement location and space Layout of the resting convenience space among school facilities to propose the architectural data for future resting/convenience spaces for the schools.

• Journal of the Korean Electrochemical Society
• /
• v.22 no.4
• /
• pp.172-176
• /
• 2019

The first commercialized cathode material, $LiCoO_2$, suffers from disadvantages such as high cost and toxicity and also possesses safety problems. The nickel-rich $LiNi_{0.9}Mn_{0.1}O_2$ cathode material, used as an alternative to $LiCoO_2$, has highly reversible capacity and high energy density. So, the nickel-rich $LiNi_{0.9}Mn_{0.1}O_2$ cathode material is widely used as an alternative to $LiCoO_2$ due to its highly reversible capacity and high energy density. However, $LiNi_{0.9}Mn_{0.1}O_2$ has several disadvantages as well, such as poor cycle performance and poor thermal instability. To address these problems, we synthesized a new material, $LiNi_{0.5}Mn_{0.5}O_2$, as a shell on the surface of a core to suppress the surface degradation. The new material showed high structural and thermal stabilities and could also maintain a high capacity. The capacity retention of the core-shell cathode (87.7%) was better than that of the core cathode (76.9%) after 50 cycles. Analysis using differential scanning calorimetry revealed that the heat generation in the core-shell cathode ($65.9Jg^{-1}$) was lower than that in the core cathode ($559.7Jg^{-1}$).

• Journal of dental hygiene science
• /
• v.19 no.2
• /
• pp.107-112
• /
• 2019

Background: Good oral health is important for systemic body health and quality of life. Spray oral cleansers are increasingly preferred because of their convenience of carrying and the ease of oral hygiene management. In addition, many kinds of oral cleanser products containing various ingredients with antibacterial, washing, and moisturizing effects are being manufactured. However, concerns about the safety and side effects of oral sprays are increasing, and there is very little information regarding the use and care of oral sprays is available to consumers. This study aimed to investigate the effects of oral spray on oral bacteria and tissue to elucidate the factors that need to be considered when using oral sprays. Methods: The effects of oral spray on the growth of dental plaque bacteria was assessed using disk diffusion assays. Cytotoxicity and morphological changes in oral epithelial cells were observed by microscopy. The effects of oral spray on dental plaque growth were also confirmed on specimens from permanent incisors of bovines by Coomassie staining. Results: The pH of spray products, such as Perioe Dental Cooling, Cool Sense, and Dentrix, were 3.65, 3.61, and 6.15, respectively. All tested spray products showed strong toxicity to dental plaque bacteria and oral epithelial cells. Compared with those on the control, dental plaque bacteria deposits on the enamel surface increased following the use of oral spray. Conclusion: Three types of oral spray, namely Perioe Dental Cooling, Cool Sense, and Dentrix, strongly inhibited the growth of dental plaque bacteria and oral epithelial cells. The oral spray ingredient enhanced dental plaque growth on the enamel surface. Users should be informed of precautions when using oral sprays and the need for oral hygiene after its use.