Journal of Physiology & Pathology in Korean Medicine
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v.30
no.2
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pp.109-115
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2016
Hataedock is a Korean medical treatment that administers herbal extracts orally to newborn infants. This method is used for alleviating harmful heat and excreting fetal wastes by meconium. The purpose of this study was to evaluate anti-inflammatory effect of Hataedock method with Douchi on 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD). The 3-week-old NC/Nga mice were divided into 3 groups: the control group (Ctrl), the AD-induced group (AE), and the Hataedock-treated group (GT). Only the GT group was treated with Hataedock at the 3rd week. After 28 days from Hataedock treatment, we induced AD-like dermatitis to the AE and GT group by DNFB. The effects of Hataedock were evaluated by immunohistochemical method. In the epithelium, PKC-positive reaction of the GT group was decreased by 57%. In the dermal papillae, IL-4-positive reaction was decreased by 34%. In the dermis, the distribution of degranulated mast cells was decreased and substance P-positive reaction was decreased by 49%. In the skin tissue, edema was decreased and MMP-9-positive reaction was decreased by 71%. Tissue damage such as epithelial cell hyperplasia, infiltration of granulocyte and lymphocyte, and capillary distribution were also decreased. The Hataedock method with Douchi maintained skin barrier and inhibited skin-damaging factors via regulating Th2 differentiation. In conclusion, Hataedock has a potential for preventative treatment of AD. Further studies are necessary to investigate the immune-regulating mechanism and verify the safety and efficacy of the Hataedock method.
The current traffic accident reduction procedure in economic feasibility study does not consider the characteristics of road and V/C ratio. For solving this problem, this paper suggests methods to be able to evaluate safety of each road in construction and improvement through developing accident Prediction model in reflecting V/C ratio Per road types and traffic characters. In this paper as primary process, model is made by tke object of urban roads. Most of all, factor effecting on accident relying on road types is selected. At this point, selecting criteria chooses data obtained from road planning procedure, traffic volume, existence or non-existence of median barrier, and the number of crossing point, of connecting road. and of traffic signals. As a result of analyzing between each factor and accident. all appear to have relatives at a significant level of statistics. In this research, models are classified as 4-categorized classes according to roads and V/C ratio and each of models draws accident predicting model through Poisson regression along with verifying real situation data. The results of verifying models come out relatively satisfactory estimation against real traffic data. In this paper, traffic accident prediction is possible caused by road's physical characters by developing accident predicting model per road types resulted in V/C ratio and this result is inferred to be used on predicting accident cost when road construction and improvement are performed. Because data using this paper are limited in only province of Jeollabuk-Do, this paper has a limitation of revealing standards of all regions (nation).
Journal of the Computational Structural Engineering Institute of Korea
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v.19
no.1
s.71
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pp.93-103
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2006
It is absolutely essential that safety assessment of the containment buildings during service life because containment buildings are last barrier to protect radioactive substance due to the accidents. Therefore, this study describes an enhanced degenerated shell finite element(FE) which has been developed for nonlinear FE analysis of reinforced concrete(RC) containment buildings with elasto-plastic material model. For the purpose of the material nonlinear analysis, Drucker-Prager failure criteria is adapted in compression region and material parameters which determine the shape of the failure envelop are derived from biaxial stress tests. Reissner-Mindlin(RM) assumptions are adopted to develop the degenerated shell FE so that transverse shear deformation effects is considered. However, it is found that there are serious defects such as locking phenomena in RM degenerated shell FE since the stiffness matrix has been overestimated in some situations. Therefore, shell formulation is provided in this paper with emphasis on the terms related to the stiffness matrix based on assumed strain method. Finally, the performance of the present shell element to analysis RC containment buildings is tested and demonstrated with several numerical examples. From the numerical tests, the present results show a good agreement with experimental data or other numerical results.
Journal of the Computational Structural Engineering Institute of Korea
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v.28
no.5
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pp.535-542
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2015
A reactor containment acts as a final barrier to prevent leakage of radioactive material due to the possible reactor accidents into external environment. Because of the functional importance of the containment building, the SIT(Structural Integrity Test) for containments shall be performed to evaluate the structural acceptability and demonstrate the quality of construction. In this paper, numerical analyses are presented, which simulate the results obtained from the SIT for a prestressed concrete(PSC) structure. A sophisticate structural analysis model is developed to simulate the structural behavior during the SIT properly based on various preliminary analysis results considering contact condition among structural elements. From the comparison of the analysis and test results based on the acceptance criteria of ASME CC-6000, it can be concluded that the construction quality of the containment has been well maintained and the acceptable performance of new design features has been verified.
Journal of the Computational Structural Engineering Institute of Korea
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v.28
no.5
/
pp.523-533
/
2015
A reactor containment acts as a final barrier to prevent leakage of radioactive material due to the possible reactor accidents into external environment. Because of the functional importance of the containment building, the SIT(Structural Integrity Test) for containments shall be performed to evaluate the structural acceptability and demonstrate the quality of construction. An initial numerical analysis was performed to simulate the results obtained from the SIT for a prestressed concrete(PSC) structure. But the analysis results by the initial model expected smaller displacements than the measured ones by 30% at some locations. Accordingly, the research and development to improve the initial model to corelate the measured results of the SIT more properly have been performed. In this paper, the effects of the loss of concrete due to duct for tendons and the contact of duct and tendons in un-bonded tendon system are mainly evaluated based on the preliminary analysis results. In addition, the importances of the proper definition of mesh connectivity among structural elements of concrete, liner plates, rebars and tendons are discussed.
During maintenance or construction works in or at the tracks of railways, high risks for passengers and railway staff, especially for the workers on the construction site exist. The high risks result out of the movement of rail vehicles, like trains or construction vehicles, which must be faced by using any available technical and operational technologies for securing them against the environment. Therefore, it is necessary to evaluate the level of protection continuously and to identify new and innovative methods and technologies for the protection of the gang (construction worker, machines and material). Especially on construction sites at line sections with two or more parallel tracks but also with single tracks, there are still a lot of incidents and accidents mostly with seriously injured persons or fatalities. These were mainly gang members that breach the railway-loading gage. By using proper warning or protection systems, the avoidance of such accidents must be achieved. The latest developments. in gang protection systems concern on the one hand fixed barriers in the middle between the construction site and the operated track and on the other hand construction vehicles equipped with automatic warning systems. The disadvantage of such protection methods is that the gang can be warned against an approaching train but a monitoring of the gang members cannot be performed. Only one part of a potential dangerous situation will be detected. If the gang members will overhear the acoustic warning signal of the security staff and the workers will not leave the danger zone in the track, the driver of the approaching train had no chance to react to the dangerous situation. An accident is often inevitable. While the detection of acoustic warning signals by the gang members working on a construction site is very difficult, the acoustical planning of an automatic warning system has to be designed for an acoustic short range level of one meter besides the construction vehicle. The decision about the use of today's technical warning system (fixed systems, automatic warning systems, etc.) must be geared to the technical feasibility and the level of safety which is needed. Criteria for decision guidance to block a track should be developed by danger estimation and economical variables. To realize the actual jurisdiction and to minimize the hazards of railway operations by the use of construction vehicles near the tracks further developments are needed. This means, that the warning systems have to be enhanced to systems for protection, which monitor the realization of the warning signal as a precondition for giving a movement authority to a train. This method can protect against accidents caused by predictable wrongdoing. The actual state of the art technique of using a collective warning combined with additional security staff is no longer acceptable. Therefore, the Institute of Transportation System of the German Aerospace Center in Braunschweig (Germany) will develop a gang warning and protection system based upon imaging methods, with optical sensors such as video in visible and invisible ranges, radar, laser, and other. The advantage of such a system based on the possibility to monitor both the gang itself and the railway-loading gauge either of the parallel track or of the same track still in use. By monitoring both situations, the system will be able to generate a warning message for the approaching train, that there are obstacles in the track, so that the train can be stopped to prevent an accident. And also the gang workers will be warned, while they breach their area.
Environmental DNA (eDNA) is a genetic material derived from organisms in various environments (water, soil, and air). eDNA has many advantages, such as high sensitivity, short investigation time, investigation safety, and accurate species identification. For this reason, it is used in various fields, such as biological monitoring and searching for harmful and endangered organisms. To collect eDNA from a freshwater ecosystem, it is necessary to consider the target organism and gene and a wide variety of items, such as on-site filtration and eDNA preservation methods. In particular, the method of collecting eDNA from the environment is directly related to the eDNA concentration, and when collecting eDNA using an appropriate collection method, accurate (good quality) analysis results can be obtained. In addition, in preserving and extracting eDNA collected from the freshwater ecosystem, when an accurate method is used, the concentration of eDNA distributed in the field can be accurately analyzed. Therefore, for researchers at the initial stage of eDNA research, the eDNA technology poses a difficult barrier to overcome. Thus, basic knowledge of eDNA surveys is necessary. In this study, we introduced sampling of eDNA and transport of sampled eDNA in aquatic ecosystems and extraction methods for eDNA in the laboratory. In addition, we introduced simpler and more efficient eDNA collection tools. On this basis, we hope that the eDNA technique could be more widely used to study aquatic ecosystems and help researchers who are starting to use the eDNA technique.
The Journal of The Korea Institute of Intelligent Transport Systems
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v.18
no.2
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pp.12-28
/
2019
Road geometry is one of the many factors that cause crashes, but the effect on traffic accident depends on weather conditions even under the same road geometry. This study identifies the variables affecting the crash severity by matching the highway accident data and weather data for 14 years from 2001 to 2014. A hierarchical ordered Logit model is used to reflect the effects of road geometry and weather condition interactions on crash severity, as well as the correlation between individual crashes in a region. Among the hierarchical models, we apply a random intercept model including interaction variables between road geometry and weather condition and a random coefficient model including regional weather characteristics as upper-level variables. As a result, it is confirmed that the effects of toll, ramp, downhill slope of 3% or more, and concrete barrier on the crash severity vary depending on weather conditions. It also shows that the combined effects of road geometry and weather conditions may not be linear depending on rainfall or snowfall levels. Finally, we suggest safety improvement measures based on the results of this study, which are expected to reduce the severity of traffic accidents in the future.
The purpose of this study is to provide the useful reference to establish the system improvement plan that activates the counseling service quality for the disabled parents peer counselors. The qualitative case study method of Yin (2009) has been used to understand and reflect to the system for the experience of field counseling of the peer counselors for the disabled parents. 10 parents peer counselors for the disabled were proportionately sampled and interviewed about their experiences through a FGI and two individual interviews. The result of the study derived from total 87 abstract concepts and 17 categories and personal motivations for participating and changes from the experience are as follows: the effects of counseling are "mutual sympathy toward the same disability," "Identity transformation from nobody to somebody who gives hope," and "another social insurance and social safety network that parents disability make." The barrier facts for the parents peer counseling activation are: "problem of securing the position of the counseling site" and difficulty in finding the client due to lack of awareness and publicity. "The study suggests four programs to upgrade the parents peer counseling: (1) To secure the position of the counseling site, (2) To reestablish the status as a professional counselor. (3) The need of pokicy supplement and support from the government, (4) The expectancy of creating jobs through the conversion of full-time workers.
The purpose of this study is to derive an equation to verify the accuracy of the dose rate for each component calculated at the measurement point outside the maze door when designing the maze door of 6 MV X-ray beam. Based on the component-specific dose rate calculation formula for the measurement point outside the maze door described in NCRP Report 151 and IAEA Safety Report Series 47, the dose rate calculation formula for each component when applying the values of the drawing-based parameters and the dose rate calculation formula for each component when applying the values of conservative parameters are derived. From the two dose rate calculation formulas for each component, the dose rate verification formula for each component at the measurement point outside the maze door was derived. The resulting dose rate verification formula for each component at the measurement point outside the maze door can be compared and analyzed whether the dose rate for each component at the measurement point outside the maze door calculated by the designer falls within the range of the dose rate obtained from the derived dose rate verification formula for each component. This verification formula is considered to be practically useful in verifying the accuracy of the dose rate for each component calculated by the designer.
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