• Macromolecular Research
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• 제17권2호
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• pp.99-103
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• 2009

We evaluated the efficacy of pH-sensitive micelles, formed by methoxy poly(ethylene glycol)-b-poly($\beta$)-amino ester) (PEG-PAE), as carriers for paclitaxel (PIX), a drug currently used to treat various cancers. PTX was successful encapsulated by a film hydration method. Micelles encapsulated more than 70% of the PTX and the size of the PTX-encapsulated micelles (PTX-PM) was less than 150 nm. In vitro experiments indicated that the micelles were unstable below pH 6.5. After encapsulation of PTX within the micelles, dynamic light scattering (DLS) studies indicated that low pH had a similar demicellization effect. An in vitro release study indicated that PTX was slowly released at pH 7.4 (normal body conditions) but rapidly released under weakly acidic conditions (pH 6.0). We demonstrated the safety of micelles from in vitro cytotoxicity tests on HeLa cells and the in vivo anti-tumor activity of PTX-PM in B16F 10 tumor-bearing mice. We concluded that these pH-sensitive micelles have potential as carriers for anti-cancer drugs.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.809-810
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• 2016

본 논문에서는 주행 중 운전자가 브레이크 페달을 조작할 경우, 차량 후미의 브레이크등과 연계되어 점등됨과 동시에 차량의 감속 정도에 따라 점등되는 영역이 단계적으로 점멸되며 표시되는 속도 감응형 차량용 브레이크등 시스템을 구현하여 실험적으로 확인하였다. 뒤따르는 후방 차량이 선행차량의 감속상태를 더욱 쉽고 빠르게 인지시킴으로써 선행 차량의 급정거에 따른 추돌 사고를 예방할 수 있으며, 후방 차량의 신속한 대응을 이끌어낼 수 있다. 또한 초음파 센서를 이용하여 차간 거리가 일정 거리 이상으로 가까워지는 경우, 부져와 함께 비상등이 켜지며 후방 차량의 운전자에게 상황을 전달한다.

• 한국환경보건학회지
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• 제44권2호
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• pp.124-132
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• 2018

Objectives: All enterprises intending to install and operate hazardous chemical handling facilities should prepare an off-site risk assessment (ORA) report that evaluates the impact of potential chemical accidents on the surrounding environment and population. This study was conducted to introduce the process of development and the functioning of the Korea Off-site Risk Assessment support tool (KORA) developed by the National Institute of Chemical Safety and to suggest manners to increase its utilization. Additionally, this article provided an overview of KORA. Methods: In order to identify problems with and refinements for KORA, the required items for each phase of KORA were derived by analyzing the Chemical Control Act and related administrative regulations. Results: The functions of KORA made receptor-considered assessment of chemical accidents possible, but several limitations were found in particular phases, such as the analysis of impact range, consideration of sensitive receptors, and assessment of environmental receptors. Conclusion: In this study, we suggested manners to increase the utilization of KORA. It is anticipated that the further research suggested in the study could contribute to the stabilization of the KORA system.

• 한국가스학회지
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• 제23권6호
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• pp.67-73
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• 2019

수소는 차량에 충전 시 급격한 온도변화와 압력상승으로 인해 정확한 충전량의 측정이 어렵다. 수소 인프라 구축을 위하여 상거래 시 민감한 문제가 될 수 있는 충전량 정밀 측정 기술은 중요하다. 본 연구에서는 수소 충전기의 계량 관리를 위한 연구의 일환으로 국내 수소 충전소의 계량정확성 평가를 실시하였다. 실험을 위하여 표준유량계법을 적용한 장비를 제작하고 실제 수소자동차의 충전 환경에서 유량을 측정하였다. 그 결과 평균적으로 10% 내외의 오차가 발생하였으며, 1대 충전 당 수소 손실량은 최대 60g까지 나타나는 것으로 확인되었다.

• 한국식품과학회지
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• 제45권5호
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• pp.531-536
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• 2013

Prometryn은 트리아진계 제초제로 일년생 쌍자엽 식물체와 같은 일년생 잡초 제거에 탁월한 효과가 있으나 일부 토양에 약효가 여러 달 지속될 경우 수중계에 스며들어 축적과 이동, 생물학적 농축(biomagnification)등의 심각한 환경문제를 비롯한 수질오염, 야생동물 및 국민건강에 심각한 문제를 일으킬 수 있는 잔류물질이다. 최근 국내에서 중국산 바지락 및 그 가공품에서 prometryn의 검출이 보고된 바 있어 이에 대한 지속적인 모니터링이 필요하기 때문에 바지락 중의 prometryn 분석법 개발이 필요한 실정이다. 본 연구에서는 수산물 중 바지락을 시료로 사용하였다. 시료를 아세토니트릴로 추출하고 농축한 다음 20% 아세톤 함유 헥산을 첨가하여 용해하였다. 이 용액을 florisil 카트리지로 정제한 후 농축하여 GC-MS로 분석하였다. 기기분석은 SIM 모드로 m/z 241 이온에 대하여 정량하였고, LOQ는 0.04 mg/kg으로 계산되었으며, LOQ, $2{\times}LOQ$ 농도에서의 회수율 및 분석오차가 각각 84.0-98.0%, 3.1-7.1%로 분석되어 Codex 가이드라인 규정에 만족하였다.

• 한국안전학회지
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• 제27권5호
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• pp.9-15
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• 2012

The ignition characteristics in a confined axisymmetric coflow $CH_4$ jet were investigated numerically with the Fire Dynamics Simulator(FDS). The $CH_4$ fuel stream was diluted with main combustion product gases, such as $O_2$, $N_2$, CO, $CO_2$, and $H_2O$, and the mixed fuel stream was heated up to the sufficient temperature where a supplying fuel stream can be ignited. For the calculation of chemical reaction in the simulation, a 2-step global finite chemistry model was considered. Boundary condition for confined wall was optimized by investigating the effects of wall temperature on the ignition characteristics of fuel stream. In addition, the effects of composition of diluents in the fuel stream and fuel stream temperature on the ignition of fuel steam were investigated. The ignition characteristics of $CH_4$ stream with diluents were very sensitive to the wall temperature, composition of diluents in the fuel stream and fuel stream temperature.

• 한국패류학회지
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• 제30권3호
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• pp.177-187
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• 2014

Mussels have been commonly used in bioassay for quality assessments of environment. Moreover, several standard protocols for the developmental bioassay of bivalves have been proposed. In this study, the EC50 of polycyclic aromatic hydrocarbons (PAHs) was determined using mussel, Mytilus galloprovincialis embryonic developmental bioassay. To determine the sensitivity of M. galloprovincialis, their fertilized eggs were exposed to five PAHs (2-metylnaphthalene, fluorene, dibenzothiophene, phenanthrene, pyrene). The EC50 of 2-metylnaphthalene, fluorene, dibenzothiophene, phenanthrene, and pyrene were 232, 273, 67.9, 43.2, and $33.1{\mu}g/L$, respectively. The overall sensitivity of M. galloprovincialis in the present developmental bioassay was similar to or more sensitive than that of other marine organisms commonly used in aquatic bioassays. The results of this study could be provide with fundamental data of setting standard for protection of marine life and or can use prediction the aquatic toxicity of PAHs.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2005년도 춘계 학술대회논문집
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• pp.109-113
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• 2005

Recently, the weight of train is decreased by using the light material for improvement in energy efficiency. And the length of whole train is more increased for mass transportation of passengers and cargo. However, decrease of the weight and increase of the length of train can cause the train to be overturned or derailed by strong crosswind. In case of Korean Tilting Train eXpress (TTX), the situation can be more severe. TTX will be developed for a quasi-high speed train at 200km/h speed rate and operated on the existing tracks. Moreover, the weight of TTX will be much less than that of conventional train. It is supposed that TTX will be very sensitive to crosswind. In this paper, numerical analysis is used to investigate aerodynamic characteristics around TTX and obtain the induced lateral force by crosswind. After calculating derailment coefficient and overturning coefficient using numerical results, the crosswind safety of TTX is judged. This paper will be good data for judging crosswind safety of TTX.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• 제1권1호
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• pp.83-89
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• 2020

Methods for detecting the presence of genetically modified (GM) crops are evolving to comply with legislation and to enhance monitoring by biotechnology companies and regulators. In order to cover a broad range of detection methods for a new GM crop, conventional multiplex PCR methods are required. Based on the genetic information on three GM alfalfa varieties (J101, J163, and KK179), which were recently approved in South Korea, we developed a fast, reliable, and highly specific multiplex polymerase chain reaction (PCR) method with basic PCR equipment and inexpensive reagents. To validate and verify the newly developed multiplex PCR method, we applied a limit of detection assay and random reference material analysis. We also monitored the unintentional environmental release of GM alfalfa in South Korea by performing the multiplex PCR analysis with 91 feral alfalfa specimens collected from 2000 to 2018. Our methodology is a sensitive, simple, quick, and inexpensive tool for detecting and identifying three GM alfalfa varieties.

• 한국안전학회지
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• 제26권6호
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• pp.26-30
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• 2011

Experimental investigations were performed to examine the effects of different electrostatic discharge ignition energies on LPG/air mixture explosions in an explosion chamber. The chamber consisted of 500 mm in length, with a $100{\times}100mm^2$ cross section. Three different ignition energies were used: 0.30 mJ, 46 mJ and 98 mJ. Flame propagations were recorded by a high speed video camera. The results of flame speed and pressure obtained from the different ignition energies were discussed. It was found that as the energy increased, different flame initiations occurred. This caused the time interval in both the flame and pressure developments. It was also found that the flame speed and the pressure were less sensitive to both 0.30 mJ and 46 mJ, except for the ignition energy of 98 mJ.