• 동의생리병리학회지
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• 제25권2호
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• pp.242-245
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• 2011

Socheongryong-tang has been used for the treatment of inflammatory allergic diseases such as allergic rhinitis and bronchial asthma in Asian countries. This study was conducted to investigate the safety of Socheongryong-tang in rats. The safety of this tang on acute toxicity was evaluated by single dose toxicity study. Rats were orally administrated in a single dose of 0 and 2000 mg/kg (limited dose) Socheongryong-tang. There were 7 rats in each groups. All animals were sacrificed after 14 days of treatment. After single administration, mortality, clinlcal signs, body weight changes and gross pathological findings were observed for 14 days. Three parameters were tested: organ weight measurement, clinical chemistry, and hematology. In this study with rats, Socheongryong-tang treatment did not show any acute toxicity. No mortality was noted for 14 days of treatment. There were no adverse effects on clinical signs, body weight, organ eight and gross pathological findings at all treatment groups. The clinical chemistry parameters attesting to liver and kidney functions as well as the hematological parameters were within the normal ranges. From single dose toxicity study with rats, it is considered that $LD_{50}$ of Socheongryong-tang is over 2000 mg/kg in oral administration. This finding of the safety on single dose toxicity study of Socheongryong-tang are expected to strengthen the position of Socheongryong-tang as nontoxic medicine.

• 한국정밀공학회지
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• 제33권5호
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• pp.333-339
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• 2016

In this paper, a fundamental experiment regarding the formation of porous 3D structures for personal safety products using 3D PPP (Porous Polymer Printing) was introduced for the first time. The filament was manufactured by mixing PP (Polypropylene) and CBA (Chemical Blowing Agent) with polymer extruder, and the diameter of the filament was approximately 1.75mm. The proposed 3D PPP method, combined with the conventional FDM (Fused Deposition Modeling) procedure, was influenced by process parameters, such as the nozzle temperature, printing speed and CBA density. In order to verify the best processing conditions, the depositing parameters were experimentally investigated for the porous polymer structure. These results provide parameters under which to form a multiple of 3D porous polymer structures, as well as various other 3D structures, and help to improve the mechanical shock absorption for personal safety products.

• 한국수자원학회논문집
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• 제56권spc1호
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• pp.1007-1014
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• 2023

천수방정식 기반 흐름해석모형은 하천 및 수로에서의 흐름을 수평 2차원적으로 수치모의하는데 활용되며 매개변수인 와점성계수와 조도계수에 큰 영향을 받는다. 따라서 적절한 매개변수의 선택은 흐름특성을 정확하게 모사하기 위해 매우 중요하다. 본 연구에서는 2차원 흐름해석에 적용되는 매개변수의 최적조합을 찾기 위한 자동화 알고리즘을 개발하고 적용하였다. 기존연구에서 2차원 흐름해석모형을 적용하는 경우 매개변수의 선정에 있어 경험적인 방법을 사용하여 최적의 매개변수를 찾는데 어려움이 있었다. 따라서 본 연구에서는 실험결과를 활용하여 다양한 매개변수의 조합에 따른 오차를 추적하고, 매개변수의 최적조합을 결정할 수 있는 알고리즘을 Python 언어를 이용하여 개발하고 적용하였다. 자동화 알고리즘은 121(11×11)개의 매개변수 조합에 따른 2차원 흐름해석결과 중 유속모의결과의 오차값을 비교하여 가장 정확한 조합을 손쉽게 결정하도록 구성되었다. 오차가 가장 작은 매개변수의 최적조합을 자동화 알고리즘의 적용을 통해 신속하고 간단하게 결정할 수 있다는 측면에서 높은 활용가치가 있을 것으로 기대된다.

• Nuclear Engineering and Technology
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• 제51권7호
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• pp.1715-1720
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• 2019

Jozef Stefan Institute (JSI), TRIGA Mark II reactor employs the homogeneous mixture of uranium and zirconium hydride fuel type. Since its upgrade, a series of fresh fuel steady state experimental benchmarks have been conducted. The benchmark results have provided data for testing computational neutronics codes which are important for reactor design and safety analysis. In this work, we investigated the JSI TRIGA Mark II reactor neutronics characteristics: the effective multiplication factor and two safety parameters, namely the control rod worth and the fuel temperature reactivity coefficient using SuperMC. The modeling and real-time cross section generation methods of SuperMC were evaluated in the investigation. The calculation analysis indicated the following: the effective multiplication factor was influenced by the different cross section data libraries; the control rod worth evaluation was better with Monte Carlo codes; the experimental fuel temperature reactivity coefficient was smaller than calculated results due to change in water temperature. All the results were in good agreement with the experimental values. Hence, SuperMC could be used for the designing and benchmarking of other TRIGA Mark II reactors.

• 대한교통학회지
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• 제14권2호
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• pp.223-237
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• 1996

Based on the traffic and accident data collected on a 4.2km (2.6mile) section of Interstate highway 35W in Minneapolis the relationship between traffic operation variables and safety measures is investigated. An aggregate specification that could be integrated into an urban freeway safety prediction methodology is proposed as a multiple regression model. The specification includes lane occupancy and volume data, which are the control parameters commonly used because they can be measured in real time. The primary variables that appear to affect the safety of urban freeway are : vehicle-miles of travel, entrance ramp volumes and the dynamic effect of queue building. The potential benefits of freeway traffic control strategies on freeway safety are also investigated via a simulation study. It was concluded that improvement of urban freeway safety is achievable by traffic control strategies which homogenize traffic conditions areound critical occupancy values.

• 한국동물생명공학회지
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• 제37권2호
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• pp.113-120
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• 2022

Sperm cryopreservation is a fundamental process for the long-term conservation of livestock genetic resources. Yet, the packaging method has been shown, among other factors, to affect the frozen-thawed (FT) sperm quality. This study aimed to develop a new mini-straw for sperm cryopreservation. In addition, the kinematic patterns, viability, acrosome integrity, and mitochondrial membrane potential (MMP) of boar spermatozoa frozen in the developed 0.25 mL straw, 0.25 mL (minitube, Germany), or 0.5 mL (IMV technologies, France) straws were assessed. Post-thaw kinematic parameters were not different (experiment 1: total motility (33.89%, 32.42%), progressive motility (19.13%, 19.09%), curvilinear velocity (42.32, 42.86), and average path velocity (33.40, 33.62) for minitube and the developed straws, respectively. Further, the viability (38.56%, 34.03%), acrosome integrity (53.38%, 48.88%), MMP (42.32%, 36.71%) of spermatozoa frozen using both straw were not differ statistically (p > 0.05). In experiment two, the quality parameters for semen frozen in the developed straw were compared with the 0.5 mL IMV straw. The total motility (41.26%, 39.1%), progressive motility (24.62%, 23.25%), curvilinear velocity (46.44, 48.25), and average path velocity (37.98, 39.12), respectively, for IMV and the developed straw, did not differ statistically. Additionally, there was no significant difference in the viability (39.60%, 33.17%), acrosome integrity (46.23%, 43.23%), and MMP (39.66, 32.51) for IMV and the developed straw, respectively. These results validate the safety and efficiency of the developed straw and highlight its great potential for clinical application. Moreover, both 0.25 mL and 0.5 mL straws fit the present protocol for cryopreservation of boar spermatozoa.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.92-96
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• 2015

Due to unique characteristics of small construction companies, safety management is comprised of complex problems (e.g., resources constraints, a lack of formalized management structures, low level of management safety commitment etc.). In order to understand causal interdependencies between safety factors at different system levels (regulation, organization, technical and individual), this paper aims to develop a system dynamics (SD) model of safety management in small construction companies. The purpose of the SD model is to better understand why small construction companies have low level of safety performance. A causal loop diagram (CLD) was developed based on literature, with an attempt to map causal relationships between variables. The CLD was then converted into stock and flow diagram for simulation. Various tests were conducted to build confidence in the model's ability to represent the reality. A number of policies were analyzed by changing the value of parameters. The value of a system dynamics approach to safety management in small construction companies is its ability to address joint effects of multiple safety risk factors on safety performance with a systems thinking perspective. By taking into account feedback loops and non-linear relationships, such a system dynamics model provides insights into the complex causes of relatively poor safety performance of small construction companies and improvement strategies.

• 생물정신의학
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• 제3권1호
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• pp.102-108
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• 1996

본 연구는 한국인의 우울증 환자에서 moclobemide가 효과적이며 안전하게 사용될 수 있음을 입증하였으며, 투약 방법으로 초기 권장량인 1일 300mg을 2회 분복시키는 방법이 추천될 수 있음을 확인하였다.

• Journal of Construction Engineering and Project Management
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• 제5권4호
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• pp.1-6
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• 2015

Due to unique characteristics of small construction companies, safety management is comprised of complex problems. This paper aims to better understand the complexity and dynamics of safety management in small construction companies. A system dynamics (SD) model was built in order to capture the causal interdependencies between factors at different system levels (regulation, organization, technical and individual) and their effects on safety outcomes. Various tests were conducted to build confidence in the model's usefulness to understand safety problems facing small companies from a system dynamics view. A number of policies were analyzed by changing the value of parameters. The value of a system dynamics approach to safety management in small construction companies is its ability to address joint effects of multiple safety risk factors on safety performance with a systems thinking perspective. By taking into account feedback loops and non-linear relationships, such a system dynamics model provides insights into the complex causes of relatively poor safety performance of small construction companies and improvement strategies.

• Safety and Health at Work
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• 제9권1호
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• pp.30-41
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• 2018

Background: The purpose of the work is to develop a system that allows processing of information for analysis and industrial risk management, to monitor the level of industrial safety and to perform necessary measures aimed at the prevention of accidents, casualties, and development of professional diseases for effective management of industrial safety at hazardous industrial sites. Methods: Risk assessment of accidents and incidents is based on expert evaluations. Based on the lists of criteria parameters and their possible values, provided by the experts, a unified information and analytical database is compiled, which is included in the final interrogation questionnaires. Risk assessment of industrial injuries and occupational diseases is based on statistical methods. Results: The result of the research is the creation of Guidelines for risk management on hazardous industrial sites of the Republic of Kazakhstan. The Guidelines determine the directions and methods of complex assessment of the state of industrial safety and labor protection and they could be applied as methodological basis at the development of preventive measures for emergencies, casualties, and incidents at hazardous industrial sites. Conclusion: Implementation of the information-analytical system of risk level assessment allows to analyze the state of risk of a possible accident at industrial sites, make valid management decisions aimed at the prevention of emergencies, and monitor the effectiveness of accident prevention measures.