• Journal of Food Hygiene and Safety
• /
• v.29 no.4
• /
• pp.356-362
• /
• 2014

Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in $Fc{\varepsilon}RI$-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogen-activated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgE-mediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.

• Nuclear Engineering and Technology
• /
• v.53 no.3
• /
• pp.825-832
• /
• 2021

A simulation-based approach is proposed to study the protective actions taken by residents during nuclear emergencies using cognitive findings. Human perception-based behaviors are not heavily incorporated in the evacuation study for nuclear emergencies despite their known importance. This study proposes a generic framework of perception-based behavior simulation, in accordance with the ecological concept of affordance theory and a formal representation of affordance-based finite state automata. Based on the generic framework, a simulation model is developed to allow an evacuee to perceive available actions and execute one of them according to Newton's laws of motion. The case of a shadow evacuation under nuclear emergency is utilized to demonstrate the applicability of the proposed framework. The illustrated planning algorithm enables residents to compute not only prior knowledge of the environmental map, but also the perception of dynamic surroundings, using widely observed heuristics. The simulation results show that the temporal and spatial dynamics of the evacuation behaviors can be analyzed based on individual perception of circumstances, while utilizing the findings in cognitive science under unavoidable data restriction of nuclear emergencies. The perception-based analysis of the proposed framework is expected to enhance nuclear safety technology by complementing macroscopic analyses for advanced protective measures.

• Journal of Animal Science and Technology
• /
• v.62 no.6
• /
• pp.864-874
• /
• 2020

Lactic acid bacteria are well-known probiotics, conferring several health benefits. In this study, we isolated lactobacilli from human breast milk and identified Lactobacillus reuteri LM1071 (RR-LM1071) using 16S rDNA sequencing. We tested the hemolytic activity, biogenic amine production, and antibiotic susceptibility of this strain to assess its safety. RR-LM1071 was found to be negative for hemolytic activity and biogenic amine production, as well as was measured in susceptible level for antibiotics in the minimal inhibitory concentration (MIC) test. The adhesive properties of RR-LM1071 were higher than those of LGG in HT-29 cells, and showed a greater hydrophobicity than LGG in hexadecane solvent. Under inflammatory conditions, RR-LM1071 suppressed the mRNA expression of IL-6, TNF-α, and IL-4 produced in IL-1β-induced HT-29 cells. Our results suggest that RR-LM1071 is a safe and valuable probiotic that can be used for the treatment of inflammatory bowel disease.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.46 no.6
• /
• pp.1128-1141
• /
• 2022

Due to increased interest in safety in sports, leisure, industries, and daily life; the demand for products that protect the head is increasing. As a preparatory study for the development of head protection for head injury prevention, this study analyzed patents and utility models related to head protection products such as industrial safety helmets, vehicle helmets, and sports protection gear. For this study, 368 patents and utility models for head protection products searched through WipsOn were selected and analyzed by application year, function, application, protection area, main material, and subject. From the analytic results of this study, the quantitative and qualitative flow and characteristics of developing technology related to head protection products were identified. Through the trend of current technology, it provided data to seek the development direction in the future. The significance of this study is to secure objective data to establish a road map for creating new Intellectual Property for head protection products.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.19 no.1
• /
• pp.127-136
• /
• 2024

Because the hazardous working environments and high labor intensity of the root industry can potentially impact the health of workers, current regulations have focused on measuring and controlling environmental factors, on a semi-annual basis. However, there is a lack of quantitative criteria addressing workers' health conditions other than the physical work environment. This gap makes it challenging to prevent occupational diseases resulting from continuous exposure to harmful substances below regulatory thresholds. Therefore, this paper proposes a machine learning-based method for determining the peak level of risk in root industry work environments and enables real-time safety assessment in workplaces utilizing this approach.

• Journal of Auto-vehicle Safety Association
• /
• v.16 no.2
• /
• pp.20-26
• /
• 2024

The delivery using drones has been attracting attention because it can innovatively reduce the delivery time from the time of order to completion of delivery compared to the current delivery system, and there have been pilot projects conducted for safe drone delivery. However, the current drone delivery system has the disadvantage of limiting the operational efficiency offered by fully autonomous delivery drones in that drones mainly deliver goods to pre-set landing sites or delivery bases, and the final delivery is still made by humans. In this paper, to overcome these limitations, we propose obstacle detection and landing site selection algorithm based on a vision sensor that enables safe drone landing at the delivery location of the product orderer, and experimentally prove the possibility of station-to-door delivery. The proposed algorithm forms a 3D map of point cloud based on simultaneous localization and mapping (SLAM) technology and presents a grid segmentation technique, allowing drones to stably find a landing site even in places without prior information. We aims to verify the performance of the proposed algorithm through streaming data received from the drone.

• Steel and Composite Structures
• /
• v.52 no.4
• /
• pp.435-450
• /
• 2024

The geometry change of railway tracks significantly influences the safety and ride comfort of high-speed trains. This paper presents an analytical method to map the thermal deformations of a long-span arch bridge to the geometry of CRTS Type I double-block ballastless tracks for high-speed railways. A mechanical model of the bridge-track coupled system was developed to derive analytical formulae of the deformations of the track. The analytical formulae explicitly consider the mechanical properties of the bridge-track coupled system and the temperature profile. A three-dimensional finite element model was established to evaluate the predictions obtained from the analytical formulae. The results show that the analytical formulae provide accurate predictions of the track deformations caused by the thermal deformations of bridges. This research will promote the design, evaluation, and operation of high-speed railway bridges for improved safety and ride comfort in engineering practices.

• Nuclear Engineering and Technology
• /
• v.56 no.8
• /
• pp.3425-3434
• /
• 2024

The main features of the loading pattern optimization (LPO) problem, such as high-dimensionality, multi-modality, and non-linearity, make it difficult to achieve a truly optimal configuration. In recent years, metaheuristic methods have been successfully used to solve this problem. In this research, a discrete golden eagle optimization (DGEO) algorithm has been developed to solve the LPO problem in the first cycle of VVER-1000 reactor core. To evaluate the proposed algorithm, a linear multi-purpose fitness function has been used to improve the safety parameters of the reactor core by obtaining a flatter power distribution during the first cycle, and also to enhance the economic parameters by increasing the cycle length and reducing the cost of fuel recycling. For this purpose, a FORTRAN program has been written to map the DGEO algorithm for the LPO problem using the PMAX and PARCS core calculation code to compute the fitness function in each iteration. To speed up the calculations, parallel computing has been applied in the written program. The results demonstrated that the loading pattern, which is suggested by the DGEO algorithm, enhances all the safety and economic parameters in the fitness function. Thus, the DGEO algorithm is highly reliable for the LPO problems in the VVER 1000 reactor core.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.8
• /
• pp.355-360
• /
• 2017

Recently, with the development of autonomous vehicle technology, the importance of precise road maps is increasing. A precise road map is a digital map with lane information, regulations, safety information, and various road facilities. Conventional precise road maps have been tested and developed based on the mobile mapping system (MMS). But they have not been activated due to high introduction costs. However, in the case of unmanned aerial vehicles (UAVs), the application field is continuously increasing. This study tries to extract information through classification of high-resolution UAV images for autonomous driving. Autonomous vehicle test roads were selected as study sites, and high-resolution orthoimages were produced using UAVs. In addition, the utilization of high-resolution orthoimages has been proposed by effectively extracting data for precise road map construction, such as road lines, guards, and machines through image classification. If additional experimentation and verification are performed, the field of UAV image use will be expanded, providing the data to automobile manufacturers and related public and private organizations, and venture companies will contribute to the development of domestic autonomous vehicle technology.

• Journal of the Korean earth science society
• /
• v.37 no.1
• /
• pp.52-61
• /
• 2016

The purpose of the study was to create a probabilistic seismic hazard map using the input data that reflected the seismo-tectonic characteristics of the Korean Peninsula by applying USGS program (Harmsen (2008). The program was partly modified for the purpose of this study. The uncertainty of input parameters given by specialists was reflected in calculating the seismic hazard values by logic tree method. The general pattern of PGA was quite sensitive and similar to the shape of areal source. The probabilistic seismic hazard map showed the contour distribution of peak acceleration (%g) with 10% probability of exceedance in 5, 10, 20, 50, 100, 250, and 500 years. The result showed that the peak ground acceleration (PGA) values of the northern peninsula were almost half values of the southern peninsula except Hwanghae province. The general trend of the hazard map extended in the direction of NW-SE from Whanghae province to south-eastern regions of the peninsula. The values in northern part of Kangwon province were relatively lower than other areas in the southern peninsula. The maps produced through this study are considered valuable in regulating the seismic safety of the major facilities in the Korean Peninsula.