• Structural Engineering and Mechanics
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• 제69권3호
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• pp.347-359
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• 2019

This paper aims to evaluate the behavior of Dorim-Goh bridge in Seoul, Korea, under static and dynamic loads effects by ambient trucks. The prestressed concrete (PSC) girders and reinforcement concrete (RC) slab of the bridge are evaluated and assessed. A short period monitoring system is designed which comprises displacement, strain and accelerometer sensors to measure the bridge performance under static and dynamic trucks loads. The statistical analysis is used to assess the static behavior of the bridge and the wavelet analysis and probabilistic using Weibull distribution are used to evaluate the frequency and reliability of the dynamic behavior of the bridge. The results show that the bridge is safe under static and dynamic loading cases. In the static evaluation, the measured neutral axis position of the girders is deviated within 5% from its theoretical position. The dynamic amplification factor of the bridge girder and slab are lower than the design value of that factor. The Weibull shape parameters are decreased, it which means that the bridge performance decreases under dynamic loads effect. The bridge girder and slab's frequencies are higher than the design values and constant under different truck speeds.

• Nuclear Engineering and Technology
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• 제53권11호
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• pp.3665-3674
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• 2021

One of the important parts of the in-core fuel management is loading pattern optimization (LPO). The loading pattern optimization as a reasonable design of the in-core fuel management can improve both economic and safe aspects of the nuclear reactor. This work proposes the hybrid of fuzzy logic controller with harmony search algorithm (HS) for loading pattern optimization in a pressurized water reactor. The music improvisation process to find a pleasing harmony is inspiring the harmony search algorithm. In this work, the adjustment of the harmony search algorithm parameters such as the bandwidth and the pitch adjustment rate are increasing performance of the proposed algorithm which is done through a fuzzy logic controller. Hence, membership functions and fuzzy rules are designed to improve the performance of the HS algorithm and achieve optimal results. The objective of the method is finding an optimum core arrangement according to safety and economic aspects such as reduction of power peaking factor (PPF) and increase of effective multiplication factor (Keff). The proposed approach effectiveness has been tried in two cases, Michalewicz's bivariate function problem and NEACRP LWR core. The results show that by using fuzzy harmony search algorithm the value of the fitness function is improved by 15.35%. Finally, with regard to the new solutions proposed in this research it could be used as a trustworthy method for other optimization issues of engineering field.

• 한국컴퓨터정보학회논문지
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• 제24권10호
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• pp.41-48
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• 2019

2018년 Cui 등은 생체 정보를 사용하는 three-factor 원격 사용자 인증 프로토콜을 제안하였다. Cui 등은 자신들의 인증 프로토콜이 도청 공격, 스마트카드 분실 공격, 특별히 DoS(denial-of-service) 공격에 안전하다고 주장하였다. 또한 그들은 패스워드 추측 공격, 가장 공격, 그리고 익명성 공격 등에 안전하다고 주장하였다. 그러나 본 논문에서는 Cui 등의 인증 프로토콜을 분석하고, 이 인증 프로토콜이 재생 공격, 내부자 공격, 스마트카드 분실 공격, 그리고 사용자 가장 공격 등에 취약함을 보인다. 게다가 우리는 Cui 등의 인증 프로토콜의 설계 오류도 함께 제시한다.

• Journal of Microbiology and Biotechnology
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• 제30권12호
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• pp.1810-1818
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• 2020

Inhibitor K562 (IK) protein was first isolated from the culture medium of K562 cells, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK) protein showed potential as a therapeutic agent for inflammation-related diseases. In this study, we designed a novel putative anti-inflammatory peptide derived from tIK protein based on homology modeling of the human interleukin-10 (hIL-10) structure, and investigated whether the peptide exerted inhibitory effects against pro-inflammatory cytokines such as IL-17 and tumor necrosis factor-α (TNF-α). The peptide contains key residues involved in binding hIL-10 to the IL-10 receptor, and exerted strong inhibitory effects on IL-17 (43.8%) and TNF-α (50.7%). In addition, we used circular dichroism spectroscopy to confirm that the peptide is usually present in a random coil configuration in aqueous solution. In terms of toxicity, the peptide was found to be biologically safe. The mechanisms by which the short peptide derived from human tIK protein exerts inhibitory effects against IL-17 and TNF-α should be explored further. We also evaluated the feasibility of using this novel peptide in skincare products.

• International Journal of Internet, Broadcasting and Communication
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• 제13권3호
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• pp.84-91
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• 2021

The purpose of this study is to investigate the structural relationship between resort selection attributes, emotional responses, and empirical values of scuba diving participants. The general population who enjoys scuba diving in Korea was selected as the population. Using the convenience sampling method, 553 of the 600 questionnaire samples were extracted as the final valid sample. For data processing, frequency analysis, exploratory factor analysis, and Cronbach's α test were performed using SPSS 23, and confirmatory factor analysis and structural equation model analysis were performed with AMOS 18. The results are as follows: First, among the sub-factors of selection attributes, equipment, facility environment, and diving point showed a positive effect on emotional response, but staff service did not have any significant effect. Second, the emotional response positively affected by the selection attribute showed a positive effect on all factors of service excellence, consumer utility, fun value, and aesthetic value of empirical value. Therefore, scuba diving resort managers must recognize the importance of equipment, facility environment, and diving point among these selection attributes of customers. And to satisfy the customer needs the resort must accurately identify the needs for diving equipment, facility environment and diving point. Various methods for this should be explored through the needs of the identified customers, and efforts should be made to provide safe equipment, comfortable facilities, and various diving points.

• Journal of Microbiology and Biotechnology
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• 제32권6호
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• pp.783-791
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• 2022

Gamma-aminobutyric acid (GABA) improves various physiological illnesses, including diabetes, hypertension, depression, memory lapse, and insomnia in humans. Therefore, interest in the commercial production of GABA is steadily increasing. Lactic acid bacteria (LAB) have widely been reported as a GABA producer and are safe for human consumption. In this study, GABA-producing LAB were preliminarily identified and quantified via GABase assay. The acid and bile tolerance of the L. plantarum FBT215 strain were evaluated. The one-factor-at-a-time (OFAT) strategy was applied to determine the optimal conditions for GABA production using HPLC. Response surface methodology (RSM) with Box-Behnken design was used to predict the optimum GABA production. The strain FBT215 was shown to be acid and bile tolerant. The optimization of GABA production via the OFAT strategy resulted in an average GABA concentration of 1688.65 ± 14.29 ㎍/ml, while it was 1812.16 ± 23.16 ㎍/ml when RSM was applied. In conclusion, this study provides the optimum culture conditions for GABA production by the strain FBT215 and indicates that L. plantarum FBT215 is potentially promising for commercial functional probiotics with health claims.

• 생물정신의학
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• 제30권1호
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• pp.1-6
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• 2023

Many psychiatric disorders are associated with brain functional dysfunctions and neuronal degeneration. According to the research so far, enhanced brain plasticity reduces neurodegeneration and recovers neuronal damage. Brain-derived neurotrophic factor (BDNF) is one of the most extensively studied neurotrophins in the mammalian brain that plays major roles in neuronal survival, development, growth, and maintenance of neurons in brain circuits related to emotion and cognitive function. Also, BDNF plays an important role in brain plasticity, influencing dendritic spines in the hippocampus neurogenesis. Changes in neurogenesis and dendritic density can improve psychiatric symptoms and cognitive functions. BDNF has potent effects on brain plasticity through biochemical mechanisms, cellular signal pathways, and epigenetic changes. There are pharmacological and non-pharmacological interventions to increase the expression of BDNF and enhance brain plasticity. Non-pharmacological interventions such as physical exercise, nutritional change, environmental enrichment, and neuromodulation have biological mechanisms that increase the expression of BDNF and brain plasticity. Non-pharmacological interventions are cost-effective and safe ways to improve psychiatric symptoms.

• 드라이브 ㆍ 컨트롤
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• 제19권1호
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• pp.34-42
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• 2022

Hydrostatic transmission (HST) comprises rotary parts, shafts, valve plate, swashplate, and servo pistons. Ensuring structural stability of each part of an HST has a significant impact on product safety. In this study, the structural stability of HST in agricultural machinery and industrial vehicles was analyzed using ANSYS software. For conservative evaluation, high-pressure conditions (35.5 MPa and 2 MPa pilot pressure) were applied as load conditions. The number of grids used in the calculations ranged from 0.4 to 0.8 million depending on modeling requirements. Structural analysis was performed for essential parts and safety factor was analyzed. All major parts of HST had a safety factor of ≥ 1.5. Thus, they were judged to be structurally safe. This study provides important information for designing an HST system.

• Journal of Microbiology and Biotechnology
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• 제33권8호
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• pp.1039-1049
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• 2023

Atopic dermatitis (AD) is a chronic inflammatory disease caused by immune dysregulation. Meanwhile, the supernatant of lactic acid bacteria (SL) was recently reported to have anti-inflammatory effects. In addition, HaCaT keratinocytes stimulated by tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) are widely used for studying AD-like responses. In this study, we evaluated the anti-inflammatory effects of SL from lactic acid bacteria (LAB) on TNF-α/IFN-γ-induced HaCaT keratinocytes, and then we investigated the strains' probiotic properties. SL was noncytotoxic and regulated chemokines (macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC)) and cytokines (interleukin (IL)-4, IL-5, IL-25, and IL-33) in TNF-α/IFN-γ-induced HaCaT keratinocytes. SL from Lacticaseibacillus rhamnosus MG4644, Lacticaseibacillus paracasei MG4693, and Lactococcus lactis MG5474 decreased the phosphorylation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK). Furthermore, the safety of the three strains was demonstrated via hemolysis, bile salt hydrolase (BSH) activity, and toxicity tests, and the stability was confirmed under simulated gastrointestinal conditions. Therefore, L. rhamnosus MG4644, L. paracasei MG4693, and Lc. lactis MG5474 have potential applications in functional food as they are stable and safe for intestinal epithelial cells and could improve atopic inflammation.

• 무역학회지
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• 제46권4호
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• pp.149-166
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• 2021

This paper aims to reduce the frequency of dangerous goods storage accidents in China. Advocating the managers of warehousing and logistics enterprises to pay attention to the operation process of dangerous goods warehousing business. Improving the safe storage and management capabilities of dangerous goods warehouses. This article first collects official data on dangerous goods storage accidents in China and conducts a general statistical analysis of the accidents. Based on the results of accident statistics and related literature research on dangerous goods storage management, establish a dangerous goods storage safety management factor system, use the analytic hierarchy process, establish a factor importance questionnaire and implement data collection. Through statistics, this paper finds that the storage accidents of dangerous goods in China in the past ten years mainly occurred in the inbound phase of dangerous goods and the storage phase of dangerous goods warehouses. Through the results of the analytic hierarchy process, it is found that the professionalism of the dangerous goods storage practitioners, the compliance of the practitioners with safety regulations, and the awareness of operational safety are the most important.