Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Brain-Derived Neurotrophic Factor and Brain Plasticity: Non-Pharmacological Intervention

뇌유래신경영양인자와 뇌 신경가소성: 비약물적 개입

  • Nak-Young Kim (Department of Psychiatry, Keyo Hospital) ;
  • Hyun Kook Lim (Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 김낙영 (계요병원 정신건강의학과) ;
  • 임현국 (가톨릭대학교 여의도성모병원 정신건강의학과)
  • Received : 2022.09.27
  • Accepted : 2022.10.24
  • Published : 2023.04.30
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Abstract

Many psychiatric disorders are associated with brain functional dysfunctions and neuronal degeneration. According to the research so far, enhanced brain plasticity reduces neurodegeneration and recovers neuronal damage. Brain-derived neurotrophic factor (BDNF) is one of the most extensively studied neurotrophins in the mammalian brain that plays major roles in neuronal survival, development, growth, and maintenance of neurons in brain circuits related to emotion and cognitive function. Also, BDNF plays an important role in brain plasticity, influencing dendritic spines in the hippocampus neurogenesis. Changes in neurogenesis and dendritic density can improve psychiatric symptoms and cognitive functions. BDNF has potent effects on brain plasticity through biochemical mechanisms, cellular signal pathways, and epigenetic changes. There are pharmacological and non-pharmacological interventions to increase the expression of BDNF and enhance brain plasticity. Non-pharmacological interventions such as physical exercise, nutritional change, environmental enrichment, and neuromodulation have biological mechanisms that increase the expression of BDNF and brain plasticity. Non-pharmacological interventions are cost-effective and safe ways to improve psychiatric symptoms.

Keywords

References

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