• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.31-39
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• 2014

Objectives: This study was performed to analyze the toxicity and to find the lethal dose of the test substance Water-soluble Carthami-flos pharmacopuncture (WCF) when used as a single intravenous-dose in 6-week-old, male and female Sprague-Dawley rats. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices. 20 female and 20 male Spague-Dawley rats were divided into 4 groups of 5 female and 5 male animals per group. The rats in the three experimental groups received single intravenous injections with 0.125-mL, 0.25-mL and 0.5-mL/animal doses of WCF, Groups 2, 3, and 4, respectively, and the control group, Group 1, received a single intravenous injection with a 0.5-mL dose of normal saline. Clinical signs were observed and body weight measurements were carried out for 14 days following the injections. At the end of the observation period, hematology, clinical chemistry, histopathological tests and necropsy were performed on the injected parts. Results: No deaths occurred in any of the groups. Also, no significant changes in body weight, hematological parameters or clinical chemistry test results between the control group and the experimental groups were observed. Visual inspection after necropsy showed no abnormalities. Histopathological tests on the injected parts showed no significant differences, except for Group 1 females; however, the result was spontaneous generation and had no toxicological meaning because it was not dose-dependent. Therefore, this study showed that WCF had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusion: As a result of single intravenous-dose tests of the test substance WCF in 4 groups of rats, the lethal dose for both males and females exceeded 0.5 mL/animal. Therefore, WCF is a relatively safe pharmacopuncture that can be used for treatment, but further studies should be performed.

• Korean Journal of Plant Resources
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• v.12 no.2
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• pp.145-151
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• 1999

This study was conducted to know the influence of transplanting dates on yield and chemical component of colored rice varieties at Taejon area in middle part in Korea. The late transplanting led to late heading in which the latest transplanting on June 18 headed on August 9 in Heugiinjubyeo and on August 24 in Heugnambyeo, respectively, which in the safe latest heading date at Taejon area. The highest yield was attained by middle of June transplanting in Heugjinjubyeo, while that for the Heugnambyeo was transplanting from end of May to beginning of June. The relative optical density(ROD) of the pigment measured at 530 nm was higher in Heugjinjubyeo than that of Heugnambyeo. The late transplanting increased the ROD in Heugnambyeo, while later than May 28 decreased the ROD in Heugjinjubyeo. There was a varietal difference in cation contents such as K, Ca, Mg and Fe. The Contents of the former three was not influenced by different transplanting dates, while the Fe content was increased by early transplanting.

• Journal of Convergence for Information Technology
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• v.10 no.7
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• pp.20-32
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• 2020

This study is to develop and provide a personal information protection framework that enables IoT service providers to safely and systematically operate personal information of IoT service subjects in the overall process of providing IoT devices and services. To this end, a framework for personal information framework was derived through literature survey, and FGI with experts, it was divided into three stages, each of three stages: IoT service provision process and IoT personal information processing process. The study conducted an e-mail survey of related experts using AHP techniques to determine the importance of the components of the selected personal information protection framework. As a result, in the IoT service provision process, the IoT product and service design and development stage (0.5413) is the most important, and in the IoT personal information processing process, personal information protection in the collection and retention of personal information (0.5098) is the most important. Therefore, based on this research, as the IoT service is spreading, it is expected that a safe personal information protection framework will be realized by preventing security threats and personal information infringement accidents.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.3
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• pp.298-306
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• 2014

The railway signalling system for safe train operation regulates the train speed to ensure the safety distance between consecutive trains by using wayside facilities such as track circuits and interlocking systems. In addition, this signalling system controls the trackside equipment such as a railway point along the train line. This ground-equipment-based train control systems require high CAPEX and OPEX. To deal with these problems, the train control system using the on-board controller has been recently proposed and its related technologies have been widely studied. The on-board-controller-based train control system is that the on-board controller can directly control the trackside equipment on the train line. In addition, if this system is used, the wayside facilities can be simplified, and as a result, the efficient and cost-effective train control system can be realized. To this end, we have developed the prototypes of the on-board controller and wayside object control units which control the point and crossing gate and performed the integrated operation simulation in a testbed. In this paper, before the field test of the on-board-controller-based train control system, we perform the preliminary field trial including the installation test, wireless access test, interface test with other on-board devices, and normal operation test.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.3D
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• pp.363-373
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• 2011

With rapid economic development, general demand and interest in surroundings that consist of our lives have grown gradually. In addition, as there has been increased social interest in creating landscape of roads, which considers all important factors from the user's view including accessibility, safety, and psychological stability, efforts to improve quality of roads are required. Therefore it is needed to establish standards on safe and comfort road design based on sensibility satisfaction of road users rather than based on standardized road design guidance from the engineering perspective. To this end, research was carried out to analyze sensibility satisfaction of users about road landscape focused on elements of road cross section in a city. It identified relation between sensibility satisfaction and the elements by using principal and cluster analysis, and the multiple regression models. It also found that user's satisfaction about roads and a road landscape is high with road width (3~5 meters), clear zone (2.2~3.9 meters), road central garden (1.05~1.9 meters), shoulder (0.55~1.43 meters), median (0.65~1.625 meters), the number of travel lanes (2~5), height of trees at the central garden (6.4~15 meters) and height of buildings surrounding roads (18~44 meters or 6~15 floors).

• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.6
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• pp.567-571
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• 2008

Purpose: The purpose was to assess the usefulness of midazolam in patients undergoing minor oral surgery under conscious sedation. Materials and methods: Bispectral index was examined in 20 patients receiving oral minor surgery with conscious sedation supplemented with local anesthesia. All patients included were ASA I and had no contraindications to the study medications. The patients were escorted to the day surgery operation room where, before the commencement of the sedation and surgical procedures, routine monitoring was applied, including the noninvasive monitoring of arterial blood pressure, arterial oxygen saturation, and 3-lead electrocardiogram (Electrocardiogram). Bispectral index electrodes were applied on the frontotemporal region after cleansing the skin with alcohol. Bispectral index was calculated with the Electrocardiogram monitor (A-2000; Aspect Co.). Midazolam was then titrated (initially 3mg wait 2min and 2mg). Vital sign and Bispectral index checked every 5 minute until the end of the procedure. The results were then compared. Results: The Bispectral index index values throughout the sedation study period alter many level. The index was dropped at 5 minutes after administration, but raised at injection and odontomy procedure. During the operation, mean Bispectral index index was higher than conscious sedation index range($60{\sim}80$). The amnesic effect was shown 17 cases out of 20 cases(85%). Conclusion: Conscious sedation technique using midazolma is a safe and effective method of controlling behavior in oral and maxillofacial surgery.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.19 no.2
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• pp.89-103
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• 2020

As we face an aging society, the demand for personal mobility for disabled and aged people is increasing. In fact, as of 2017, the number of electric wheelchair in the country continues to increase to 90,000. However, people with disabilities and seniors are more likely to have accidents while driving, because their judgment and coordination are inferior to normal people. One of the causes of the accident is the interference of personal vehicle steering control due to unbalanced road surface conditions. In this paper, we introduce a encoder type semantic segmentation algorithm that can recognize road conditions at high speed to prevent such accidents. To this end, more than 1,500 training data and 150 test data including road surface damage were newly secured. With the data, we proposed a deep neural network composed of encoder stages, unlike the Auto-encoding type consisting of encoder and decoder stages. Compared to the conventional method, this deep neural network has a 4.45% increase in mean accuracy, a 59.2% decrease in parameters, and an 11.9% increase in computation speed. It is expected that safe personal transportation will be come soon by utilizing such high speed algorithm.

• Journal of Pharmacopuncture
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• v.16 no.4
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• pp.22-29
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• 2013

Objectives: This study was performed to analyze the toxicity of the test substance, anti-inflammatory pharmacopuncture (AIP), when used as a single intramuscular-dose in 6-week-old, male and female Sprague-Dawley rats and to find the lethal dose. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices. Twenty (20) female and 20 male Spague-Dawley rats were divided into 4 groups of five 5 female and 5 male animals per group. The rats in the three experimental groups received single intramuscular injections with 0.1-$m{\ell}$, 0.5-$m{\ell}$ and 1.0-$m{\ell}$/animal doses of AIP, Groups 2, 3, and 4, respectively, and the control group, Group 1, received a single intramuscular injection with a 1.0-$m{\ell}$ dose of normal saline. Clinical signs were observed and body weight measurements were carried out for 14 days following the injections. At the end of the observation period, hematology, clinical chemistry, histopathological tests and necropsy were performed on the injected parts. Results: No deaths occurred in any of the groups. Also, histopathological tests showed that AIP had no effect on the injected parts in terms of clinical signs, body weight, hematology, clinical chemistry, and necropsy. Conclusions: As a result of single intramuscular-dose tests of the test substance AIP in 4 groups of rats, the lethal dose for both males and females exceeded $1.0m{\ell}$/animal. Therefore, AIP is a relatively safe pharmacopuncture that can be used for treatment, but further studies should be performed.

• Geotechnical Engineering
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• v.5 no.1
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• pp.7-18
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• 1989

In pile load tests on end bearing piles, generally, it is not possible to continue loading to the ultimate load. Thus, the concept of yield load has been introduced for determining design loads Iron the pile load test records. The conventional rules to determine the yield load were not available for evaluation on pile load test records obtained in 6 fields nearby westers 8r Southern Coasts in Korea. A new rule 9.as presented to determine easily the yield load, based on investigations on the pile load test records. The yield load of piles is determined at the infiection point on semi-logarithmic coordinates (P-logS), in which load is plotted in normal scale and settlement is plotted in logarithmic scale. This method may not only save much costs and times but also present safe luorking circumstances for pile load tests in field. It was found that the yield load represented the elastic limit of the pile load-settlement behalf.iota. The ultimate load, which is given at 25.4mm settlement on pile head, was 1.5 times of the yield load. The allowable long-term and short-term load capacities were, respectively, 50% and 75% of the yield load. The safety factors to get the allowable pile capacity were obtained as 2.0~4.0 for the equations to predict the static pile capacity.

• Korean Chemical Engineering Research
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• v.54 no.2
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• pp.200-205
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• 2016

A drug transport carrier could be used for safe send of drugs to the affected region in a human body. The chitosan is adequate for the drug delivery carrier because of adaptable to living body. The gold, a metallic nanoparticles, tends to form a nano complex at rapidly when it combined with chitosan because of its negative charge. having energy from the other, outer gold nano-complex make heat due to its property to release the contained drugs to the target area. Silver could be also formed an useful biocompatible nano-composites with chitosan which should be used as an useful drug transfer carrier because its special ability to protect microbial contamination. Being one of the oxidized nano metals, $Fe_3O_4$ is nontoxic and has been used for its magnetic characteristics. In this study, the control of catalyst, reducing agent, and solvent amount. The chitosan-$Fe_3O_4$-gold & silver nanoshell have been changed to form about 100 nm size by ionic bond between the amine group, an end group of chitosan, and the metal. It was observed the change in order to seek for its optimum reaction condition as a drug transfer carrier.