• 한국정보통신학회논문지
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• 제17권7호
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• pp.1740-1746
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• 2013

보완대체 의사소통도구는 구어(口語)로 자신의 의사를 표현할 수 없는 장애인의 의사소통을 보조하는 상호작용 시스템으로 전통적으로는 그림이나 글자로 된 의사 소통판을 활용하여 왔다. 최근에는 스마트폰 기기 등의 높은 휴대성을 가진 기기를 이용한 의사소통도구의 연구가 활발하게 이루어지고 있다. 또한 최근 상황인식 컴퓨팅의 개념이 출현하면서 모바일 디바이스는 사용자에서 즉시적이며 위치기반서비스를 제공하는 주요도구가 되고 있다. 본 논문에서는 스마트 기기의 다양한 멀티미디어 기능을 이용한 장애인을 위한 맞춤형 보완대체 의사소통도구 제안한다. 맞춤형 의사소통도구를 위해서 가변적인 레이아웃과 장애정도에 따른 AAC 항목의 선택이 가능하게 하였으며 시간정보, 위치정보, 그리고 클릭 수 등의 상황인식 기능을 적용하였다.

• 한국약용작물학회지
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• 제21권6호
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• pp.466-473
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• 2013

This study investigates the effect of supercritical fluid extract (CMPB803-C) of Lithospermum erythrorhizon, shikonin and acetylshikonin isolated from Lithospermum erythrorhizon on IL-$1{\beta}$-induced chondrocytes and monosodium iodoacetate (MIA)-induced osteoarthritis in rat. Shikonin ($50{\mu}m$) and acetylshikonin ($3{\mu}M$) treatment reduced significantly the mRNA expression and enzyme activity of matrix metalloproteinase (MMP)-1, -3 and -13 in IL-$1{\beta}$-induced SW1353 chondrosarcoma cells. The chondro-protective effects of CMPB803-C and acetylshikonin were than analyzed in a rat OA model using a single intra-articular injection of MIA (1mg) in the right knee joint. CMPB803-C (200mg/kg) or acetylshikonin (5mg/kg) was orally administered daily for two weeks starting after 1 week of MIA injection. In the histological observation, CMPB803-C and acetylshikonin clearly improved OA lesions being comparable to or better that control group. Our results demonstrated that CMPB803-C and acetylshikonin as active compound of Lithospermum erythrorhizon have a strong chondro-protective effect in OA rats, which likely attributes to its anti-inflammatory activity and inhibition of MMPs production.

• 디지털융복합연구
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• 제12권3호
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• pp.211-218
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• 2014

최근 풍력에너지는 풍력터빈의 지능화뿐만 아니라 풍력 발전량 예측 부분에서 컴퓨팅과의 결합이 확대되고 있다. 풍력 발전은 기상상태에 따라 출력변동이 심하고 출력 예측이 어려워 효율적인 전력 생산을 위해서 신재생에너지를 전력계통에 안정적으로 연계할 수 있는 기술이 필요하다. 본 논문에서는 분산형 전원의 예측정보를 향상시켜 예측한 발전량과 실제 발전량의 차이를 최소화하기 위한 분산형 전원전력의 단기예측 모델을 설계한다. 제안된 모델은 단기 예측을 위해서 물리모델과 통계모델을 결합하였으며, 물리모델에서 생산된 격자별 예측값 중 예측 지점내 예측지점의 값을 추출하고, 물리 모델 예측값에 통계모델을 적용하여 발전량 산정을 위한 최종 기상 예측값을 생성한다. 또한, 제안 모델에서는 실시간 기상청 관측자료와 실시간 중기 예측 자료를 입력 자료로 사용하여 단기 예측모델을 수행한다.

• Journal of Microbiology and Biotechnology
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• 제22권12호
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• pp.1621-1628
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• 2012

The agar-degrading bacterium GNUM-1 was isolated from the brown algal species Sargassum serratifolium, which was obtained from the West Sea of Korea, by using the selective artificial seawater agar plate. The cells were Gram-negative, $0.5-0.6{\mu}m$ wide and $2.0-2.5{\mu}m$ long curved rods with a single polar flagellum, forming nonpigmented, circular, smooth colonies. Cells grew at $20^{\circ}C-37^{\circ}C$, between pH 5.0 and 9.0, and at 1-10% (w/v) NaCl. The DNA G+C content of the GNUM-1 strain was 45.5 mol%. The 16S rRNA sequence of the GNUM-1 was very similar to those of Alteromonas stellipolaris LMG 21861 (99.86% sequence homology) and Alteromonas addita $R10SW13^T$(99.64% sequence homology), which led us to assign it to the genus Alteromonas. It showed positive activities for agarase, amylase, gelatinase, alkaline phosphatase, esterase (C8), lipase (C14), leucine arylamidase, valine arylamidase, ${\alpha}$-chymotrypsin, acid phosphatase, naphthol-AS-BI-phosphohydrolase, ${\alpha}$-galactosidase, ${\beta}$-galactosidase, ${\beta}$-glucosidase, catalase, and urease. It can utilize citrate, malic acid, and trisodium citrate. The major fatty acids were summed feature 3 (21.5%, comprising $C_{16:1}{\omega}7c/iso-C_{15:0}$ 2-OH) and C16:0 (15.04%). On the basis of the variations in many biochemical characteristics, GNUM-1 was considered as unique and thus was named Alteromonas sp. GNUM-1. It produced the highest agarase activity in modified ASW medium containing 0.4% sucrose, but lower activity in rich media despite superior growth, implying that agarase production is tightly regulated and repressed in a rich nutrient condition. The 30 kDa protein with agarase activity was identified by zymography, and this report serves as the very first account of such a protein in the genus Alteromonas.

• 자원환경지질
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• 제21권3호
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• pp.223-234
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• 1988

A large number of gold and/or silver-bearing quartz veins occur in or near Mesozoic granite batholith elongated in a NE-SW direction within the Chungcheong Province. Precambrian schists and gneisses, and Jurassic and Cretaceous granitic rocks serve as hosts for gold and/or silver deposits. On the basis of Ag/Au total production and ore grade ratio, 15 mines may be divided into three major groups: gold-dominant deposits, gold-silver deposits, and silver-dominant deposits. The chemical composition of electrum from skarn deposit (Geodo mine), alaskite-type deposit (Geumjeong mine) and 15 vein deposits was summarized. It was found that the Au content of electrum for vein deposits ranging from 5.2 to 86.5 is lower than that for skarn and alaskite deposits. Among 15 vein deposits, the composition of electrum associated with pyrrhotite is relatively high and has a narrow range of 40.8 to 86.5 atomic % Au, but the Au content of electrum with pyrite is in range of 5.2 to 82.8 atomic %, and is clearly lower than that with pyrrhotite. The grouping of ages for these mines indicates that gold and/or silver mineralizations occurred during two periods in the Mesozoic. Daebo igneous activities are restricted to gold mineralization in the range of 158 to 133 Ma, whereas Bulgugsa igneous activities are related to gold and/or silver mineralization ranging from 108 to 71 Ma. Generally speaking, Jurassic gold-dominant veins have many common characteristics; notably prominent association with pegmatites, simply massive vein morphology, high fineness in the ore concentrates, rarity of silver minerals, and a distinctively simple mineralogy, including sphalerite, galena, chalcopyrite, pyrrhotite and/or pyrite. Although individual deposits exhibit widely differing diversity, Cretaceous gold-silver and silver-dominant veins are characterized by features such as complex vein, low to medium fineness in the ore concentrates and abundance of silver minerals including Ag sulfosalts, Ag sulfides, Ag tellurides and native silver.

• 한국정보통신학회논문지
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• 제20권11호
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• pp.2125-2130
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• 2016

본 논문에서는 모바일 증강현실기술 기반을 활용한 3D전래동화 콘텐츠에 관한 연구이다. 지식기반사회의 핵심콘텐츠 산업으로 주목받고 있는 시공간을 연결하는 SW기술 증강현실(Augmented Reality) 기술을 활용하여 흥미로운 전래동화를 한국어, 중국어, 영어로 자막언어선택으로 외국어학습에 적용한다. 이를 위해 상호작용 AR게임(놀이)으로 재구성하였다. 전래동화는 3D 콘텐츠 제작을 위해 6~8개의 scene으로 분량을 구성하고, 각색하여 번역하였다. 더빙은 모국어로 사용하는 원어민 성우를 통해 표준발음을 사용하여 더빙하였고, 효과음은 장면에 어울리도록 별도 제작하여 편집하였다. 시나리오를 구성하고, 3D 모델구성, 인터렉션 구성, 사운드 이펙트를 구성하고 콘텐츠 메타데이터를 작성한 후, Unity 3D 게임엔진을 실행하여 프로젝트를 생성하고, 스크립터로 기술한다. 재미있고 유익한 전래동화를 ICT기술을 접목한 융복한 콘텐츠로 경험하면서, 첨단기술기반 교육을 수용하며, 생활주변에서 소프트웨어를 인식할 수 있는 기회를 가지게 한다.

• 산업경영시스템학회지
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• 제42권3호
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• pp.25-38
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• 2019

This study is to develop a diagnostic model for the effective introduction of smart factories in the manufacturing industry, to diagnose SMEs that have difficulties in building their own smart factory compared to large enterprise, to identify the current level and to present directions for implementation. IT, AT, and OT experts diagnosed 18 SMEs using the "Smart Factory Capacity Diagnosis Tool" developed for smart factory level assessment of companies. They analyzed the results and assessed the level by smart factory diagnosis categories. Companies' smart factory diagnostic mean score is 322 out of 1000 points, between 1 level (check) and 2 level (monitoring). According to diagnosis category, Factory Field Basic, R&D, Production/Logistics/Quality Control, Supply Chain Management and Reference Information Standardization are high but Strategy, Facility Automation, Equipment Control, Data/Information System and Effect Analysis are low. There was little difference in smart factory level depending on whether IT system was built or not. Also, Companies with large sales amount were not necessarily advantageous to smart factories. This study will help SMEs who are interested in smart factory. In order to build smart factory, it is necessary to analyze the market trends, SW/ICT and establish a smart factory strategy suitable for the company considering the characteristics of industry and business environment.

• ALGAE
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• 제38권1호
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• pp.81-92
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• 2023

Obesity-induced inflammation is crucial in the pathogenesis of insulin resistance and type 2 diabetes. In this study, we investigated the effects of the Gracilaria chorda (GC) on lipid accumulation and obesity-induced inflammatory changes or glucose homeostasis in cell models (3T3-L1 adipocytes and RAW 264.7 macrophages). Samples of GC were extracted using solvents (water, methanol, and ethanol) and subcritical water (SW) at different temperatures (90, 150, and 210℃). The total phenolic content of GCSW extract at 210℃ (GCSW210) showed the highest content compared to others, and GCSW210 highly inhibited lipid accumulation and significantly reduced gene expressions of peroxisome proliferator-activated receptor-γ, CCAAT/enhancer-binding protein-α, sterol regulatory element-binding protein-1c, and fatty acid synthase in 3T3-L1 adipocytes. In addition, GCSW210 effectively downregulated the pro-inflammatory cytokine regulator pathways in RAW 264.7 macrophages, including mitogen-activated protein kinase, signal transducers and activators of transcription and nuclear factor-κB. In co-culture of 3T3-L1 adipocytes and RAW 264.7 macrophages, GCSW210 significantly reduced nitric oxide production and interleukin-6 levels, and improved glucose uptake with dose-dependent manner. These findings suggest that GCSW210 improves glucose metabolism by attenuating obesity-induced inflammation in adipocytes, which may be used as a possible treatment option for managing obesity and associated metabolic disorders.

• Journal of Microbiology and Biotechnology
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• 제33권11호
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• pp.1484-1494
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• 2023

NUC1 (Nutraceutical compound 1) is an ethanol extract composed of a formulation based on medicinal herbs traditionally used for the treatment of arthritis in Korea and China. This study investigated the therapeutic effects of NUC1 on osteoarthritis (OA). The protective effect of NUC1 on OA was tested in a rabbit model of collagenase-induced arthritis (CIA) for 4 weeks. Results were compared among four groups (n = 9 per group): the normal group (untreated), the CIA group (vehicle control), the NUC1 group (CIA rabbits treated with 200 mg/kg NUC1), and the JOINS group (positive control, CIA rabbits treated with 200 mg/kg JOINS tablet). NUC1 significantly inhibited NO production (p < 0.05 at 125 ㎍/ml, p < 0.01 at 250 ㎍/ml, and p < 0.001 at 500 ㎍/ml) and iNOS expression in macrophages, in a concentration-dependent manner. NUC1 also inhibited the release and protein expression of MMP-1, 3, and 13, in TNF-α-induced chondrosarcoma cells in a concentration-dependent manner. In vivo, the MMP-1 and MMP-3 levels in synovial fluids were significantly (p < 0.05) lower in NUC1 group (77.50 ± 20.56 and 22.50 ± 7.39 pg/ml, respectively) than in the CIA group (148.33 ± 68.58 and 77.50 ± 20.46 pg/ml, respectively). Also, in histopathological, NUC1 ameliorated articular cartilage damage in OA by increasing the abundance of chondrocytes and proteoglycan in the articular cartilage. Thus, NUC1 showed promise as a potential therapeutic agent, and it can be generalized to a broader study population in different OA animal models.

• 한국초지조사료학회지
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• 제4권3호
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• pp.187-193
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• 1984

Meadow fescue품종(品種)을 공시(供試)하여 엽면적(葉面積)의 수직적분포(垂直的分布)와 건물수량(乾物收量)과의 관계(關係)를 검토(檢討)하였다. 1. 엽면적(葉面積)의 수직적분포(垂直的分布)로서 품종(品種)을 분류(分類)한 결과(結果), 최대엽면적(最大葉面積)이 하층부(下層部)에 분포(分布)되어 상층부(上層部)로 갈수록 엽량(葉量)이 적어지는 품종(品種)(M), 중간층(中間層)에 최대엽면적(最大葉面積)이 분포(分布)되어 상(上) 하층부(下層部)로 갈수록 엽량(葉量)이 감소(減少)되는 품종(品種)(Leto First, Bundy), 최대엽면적(最大葉面積)이 중간층(中間層)에 분포(分布)되어 있으나 상층부(上層部)에 엽량(葉量)이 대부분(大部分)이 집중분포(集中分布)된 품종(品種)(Tammisto) 및 하층부(下層部)에서 최대엽면적(最大葉面積)을 나타내나 전층(全層)에 엽량(葉量)이 비교적(比較的) 균등(均等)히 분포(分布)된 품종(品種)(Trader)의 4 가지 형(型)으로 분류(分類)되었다. 2. 유효엽면적지수는 건물수량(乾物收量), 엽면적지수(葉面積指數), 경중(莖重) 및 경면적지수(莖面積指數)와 유의(有意)한 정상관(正相關)을 나타 내었다. 3. 출수경(出穗莖)이 많은 품종(品種)의 유효엽면적은 상층부(上層部)에 분포(分布)되었으나 영양경(榮養莖)이 많은 품종(品種)은 유효엽면적지수의 비율(比率)이 높았다. 4. 최대엽면적(最大葉面積)을 나타내는 층(層) 이상(以上)에 분포(分布)된 엽면적(葉面積)과 엽면적중(葉面積重)의 관계(關係)는 M과 Trader가 유의(有意)한 부(負)의 상관(相關)이 인정(認定)되었으나 그 외의 품종(品種)에서는 유의(有意)한 상관(相關)이 인정(認定)되지 않았다.