• 제목/요약/키워드: STC2

검색결과 111건 처리시간 0.026초

Stanniocalcin 2 enhances mesenchymal stem cell survival by suppressing oxidative stress

  • Kim, Pyung-Hwan;Na, Sang-Su;Lee, Bomnaerin;Kim, Joo-Hyun;Cho, Je-Yoel
    • BMB Reports
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    • 제48권12호
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    • pp.702-707
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    • 2015
  • To overcome the disadvantages of stem cell-based cell therapy like low cell survival at the disease site, we used stanniocalcin 2 (STC2), a family of secreted glycoprotein hormones that function to inhibit apoptosis and oxidative damage and to induce proliferation. STC2 gene was transfected into two kinds of stem cells to prolong cell survival and protect the cells from the damage by oxidative stress. The stem cells expressing STC2 exhibited increased cell viability and improved cell survival as well as elevated expression of the pluripotency and self-renewal markers (Oct4 and Nanog) under sub-lethal oxidative conditions. Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways. Taken together, the STC2 can be used to enhance cell survival and maintain long-term stemness in therapeutic use of stem cells.

Expert형 제어기법에 의한 자기동조 제어기에 관한 연구 (A Study on the STC Utilizing Expert Control Technique)

  • 최창현;이창훈;임은빈;우광방
    • 대한전기학회논문지
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    • 제38권8호
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    • pp.617-628
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    • 1989
  • In systematic tuning of digital STC parameters, systems with time-varying parameters and systems with time-varying delays are studied individually because of many preconditions and difficulties. In order to eliminate all these difficulties effectively, the expert control technique is required to enhance STC control functions. In this paper, an expert controller, a STC utilizing expert control technique, for process control is designed. The expert controller is composed of an unstability indicator for detecting plant unstability, an expert back-up controller and an expert STC which are switched each other by the unstability indication, and expert system with knowledge base and inference engine. This expert controller is able to perform control functions successfuly for the following` 1) a system which has unknown and time-varying delay time, 2) a time-varying system which has unknown parameters, and 3) a system with minimun and non-minimum phase. The robust control function is demonstrated by computer simulations.

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고속라우터에 대한 고찰(I)-STC104의 레이블링 알고리즘 (Study on High Speed Routers(I)-Labeling Algorithms for STC104)

  • 이효종
    • 정보처리학회논문지A
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    • 제8A권2호
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    • pp.147-156
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    • 2001
  • A high performance routing switch is an essential device to either the high performance parallel processing or communication networks that handle multimedia transfer systems such as VOD. The high performance routing chip called STC104 is a typical example in the technical aspect which has 32 bidirectional links of 100Mbps transfer sped. It has exploited new technologies, such as wormhole routing, interval labeling, and adaptive routing method. The high speed router has been applied into some parallel processing system as a single chip. However, its performance over the various interconnection networks with multiple routing chips has not been studied. In this paper, the strucrtures and characteristics of the STC104 have been investigated in order to evaluate the high speed router. Various topology of the STC104, such as meshes, torus, and N-cube are defined and constructed. Algorithms of packet transmission have been proposed based on the interval labeling and the group adaptive routing method implemented in the interconnected network. Multicast algorithms, which are often requited to the processor networks and broadcasting systems, modified from U-mesh and U-torus algorithms have also been proposed overcoming the problems of point-to-point communication.

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상심자의 모노아민산화효소 저해활성 (The Inhibitory Activity on Monoamine Oxidase of the Fruit of Morus alba)

  • 황금희;송임
    • 생약학회지
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    • 제34권2호통권133호
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    • pp.185-189
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    • 2003
  • We examined the inhibitory activities against monoamine oxidase (MAO) of Morus alba in vitro and in vivo methods. Methanolic extract of M. alba showed significantly inhibitory activities on MAO-A and MAO-B that were prepared from rat brain and liver in vitro. The inhibitory activities were measured by serotonin and benzylamine as substrates, respectively. MAO-A and MAO-B activities were potently inhibited by ethylacetate extracts of M. alba in vitro tests. Those activities in vivo tests have different tendency each other. MAO-A activity was increased by the oral administration of methanolic extract of M. Alba, while, MAO-B activity was decreased. Consequently, we can suggest that M. alba may have the effects on the inhibitory activities against MAO both in vitro and in vivo.

Reliability and validity of pelvic mobility measurement using a cushion sensor in healthy adults

  • Jung, Seung-Hwa;Kim, Su-Kyeong;Lee, Ji-Hyun;Choi, Soo-Ih;Park, Dae-Sung
    • Physical Therapy Rehabilitation Science
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    • 제9권2호
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    • pp.74-81
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    • 2020
  • Objective: To prevent low back pain, an objective evaluation tool to evaluate pelvic mobility and exercise to improve the flexibility of the lumbar region is needed. The purpose of this study was to compare the results of pelvic mobility measurements using the Wii Balance Board (WBB) and Sensbalance Therapy Cushion (STC), evaluate the usefulness of the STC as a tool for measuring pelvic mobility. Design: Cross-sectional study. Methods: Fifty healthy subjects participated in this study. The subjects performed pelvic mobility range, proprioception, reaction time and reach of the arm using the STC. The pelvic movement parameter was measured two times to determine the intra-rater reliability. To measure the correlation between lumbar muscle tension and pelvic mobility, Myovision was used to measure tension of L4, L5 level erector spinae muscle. Correlations between measured variables were checked to determine the validity of the pelvic mobility assessment tool. Results: STC showed high test-retest reliability in pelvic tilt measurement and reaching task [intraclass correlation coefficients (3,1)=0.804-0.915]. The relationship between WBB and STC showed a significant positive correlation with the pelvic tilt and reaching task (p<0.05). Posterior tilt and erector spinae activation (Lt. L5) showed a significant negative correlation (p<0.05). Left, right tilt and erector spinae activation (L5) showed a significant negative correlation (p<0.05). Conclusions: This study confirmed the advantages of the STC and found efficiency as an objective measuring device of pelvic mobility.

보조 사이리스터의 턴-오프 회로를 간소화한 HVDC 사이리스터 밸브 시험용 합성시험회로 (A Synthetic Test Circuit for HVDC Thyristor Valve Test with Simplified Turn-Off Circuit of Auxiliary Thyristor)

  • 정재헌;구법진;조한제;노의철;한병문;정용호;백승택
    • 전력전자학회논문지
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    • 제19권5호
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    • pp.475-480
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    • 2014
  • This study proposes a new synthetic test circuit (STC) for HVDC thyristor valve tests. The conventional STC with a 2-phase chopper requires a 3-phase transformer, a 3-phase diode rectifier, and an IGBT to facilitate the off state of an auxiliary thyristor. In the proposed STC, these three components are replaced with one diode and one resistor, which result in the simplified implementation of the hardware of the STC. Simulation and experimental results demonstrate the validity of the proposed scheme.

힌지재료의 찰과마멸부식에 미치는 부식환경의 영향( I ) (Effect of Corrosion Environment on the Fretting Wear Corrosion of a Hinge Material( I ))

  • 곽남인;임우조;이종락
    • 한국가스학회지
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    • 제4권1호
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    • pp.26-32
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    • 2000
  • 본 연구에서는 힌지재인 SM20C, YBsC3 및 STC4H재에 대하여 공기 및 여러 가지 부식환경중에서 이종금속간의 찰과마멸부식실험을 실시하여, 이종금속간의 찰과마멸부식특성에 미치는 환경조건의 영향을 연구하였으며, 주요 결론은 다음과 같다. 1) 이동측 금속인 SM20C의 찰과마멸부식에 미치는 지하수의 영향은 STC4H에서 더 민감하고 YBsC3에서는 둔화된다. 2) STC4H의 찰과마멸부식에 미치는 지하수의 영향은 작지만, $0.5\%\;H_2SO_4$$0.5\%HNO_3$ 용액중에서 더 크게 된다. 3) 이동측 SM20C의 찰과마멸부식은 $3.5\%\;NaCl$, $0.5\%\;H_2SO_4$$0.5\%\;HNO_3$ 용액중에서보다 지하수중에서 가장 작게 나타났다. 4) 시간이 경과함에 따라 찰과마멸부식에 미치는 영향은 $0.5\%\;HNO_3$ 용액중에서는 증가하지 $0.5\%\;H_2SO_4$ 용액중에서는 둔화된다.

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Characterization of intrinsic molecular structure spectral profiles of feedstocks and co-products from canola bio-oil processing: impacted by source origin

  • Alessandra M.R.C.B., de Oliveira;Peiqiang, Yu
    • Animal Bioscience
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    • 제36권2호
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    • pp.256-263
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    • 2023
  • Objective: Feed molecular structures can affect its availability to gastrointestinal enzymes which impact its digestibility and absorption. The molecular spectroscopy-attenuated total reflectance Fourier transform infrared vibrational spectroscopy (ATR-FTIR) is an advanced technique that measures the absorbance of chemical functional groups on the infrared region so that we can identify and quantify molecules and functional groups in a feed. The program aimed to reveal the association of intrinsic molecular structure with nutrient supply to animals from canola feedstocks and co-products from bio-oil processing. The objective of this study was to characterize special intrinsic carbohydrate and protein-related molecular structure spectral profiles of feedstock and co-products (meal and pellets) from bio-oil processing from two source origins: Canada (CA) and China (CH). Methods: The samples of feedstock and co-products were obtained from five different companies in each country arranged by the Canola Council of Canada (CCC). The molecular structure spectral features were analyzed using advanced vibrational molecular spectroscopy-ATR-FTIR. The spectral features that accessed included: i) protein-related spectral features (Amide I, Amide II, α-helix, β-sheet, and their spectral intensity ratios), ii) carbohydrate-related spectral features (TC1, TC2, TC3, TC4, CEC, STC1, STC2, STC3, STC4, TC, and their spectral intensity ratios). Results: The results showed that significant differences were observed on all vibrationally spectral features related to total carbohydrates, structural carbohydrates, and cellulosic compounds (p<0.05), except spectral features of TC2 and STC1 (p>0.05) of co-products, where CH meals presented higher peaks of these structures than CA. Similarly, it was for the carbohydrate-related molecular structure of canola seeds where the difference between CA and CH occurred except for STC3 height, CEC and STC areas (p>0.05). The protein-related molecular structures were similar for the canola seeds from both countries. However, CH meals presented higher peaks of amide I, α-helix, and β-sheet heights, α-helix:β-sheet ratio, total amide and amide I areas (p<0.05). Conclusion: The principal component analysis was able to explain over 90% of the variabilities in the carbohydrate and protein structures although it was not able to separate the samples from the two countries, indicating feedstock and coproducts interrelationship between CH and CA.

TMS320C6201을 이용한 2.4 kbps STC 음성 부호화기의 실시간 구현 (Implementation of 2.4 kbps STC Speech Codec on the TMS320C6201)

  • 유승형;이승원;배건성
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2002년도 하계종합학술대회 논문집(4)
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    • pp.167-170
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    • 2002
  • In this paper, we implement a 2.4 kbps STC speech codec using the TMS320C6201 DSP The main job for this work is twofold: one is to convert floating-point operation in the codec into fixed-point operation while maintaining the high resolution, and the other is to optimize the program to make it run in real time with memory size as small as possible. The implemented decoder uses 54.8 kbyte of program memory, 29.7 kbyte of data ROM and 55.2 kbyte of data RAM, respectively. It also uses about 45% of maximum computation capacity of TMS320C6201.

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