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The Inhibitory Activity on Monoamine Oxidase of the Fruit of Morus alba  

Hwang, keum-Hee (STC NARA Co. STC Life Science Center)
Song, Im (STC NARA Co. STC Life Science Center)
Publication Information
Korean Journal of Pharmacognosy / v.34, no.2, 2003 , pp. 185-189 More about this Journal
Abstract
We examined the inhibitory activities against monoamine oxidase (MAO) of Morus alba in vitro and in vivo methods. Methanolic extract of M. alba showed significantly inhibitory activities on MAO-A and MAO-B that were prepared from rat brain and liver in vitro. The inhibitory activities were measured by serotonin and benzylamine as substrates, respectively. MAO-A and MAO-B activities were potently inhibited by ethylacetate extracts of M. alba in vitro tests. Those activities in vivo tests have different tendency each other. MAO-A activity was increased by the oral administration of methanolic extract of M. Alba, while, MAO-B activity was decreased. Consequently, we can suggest that M. alba may have the effects on the inhibitory activities against MAO both in vitro and in vivo.
Keywords
Monoamine oxidase (MAO); Serotonin (5-HT); Morus alba;
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