• The Korean Journal of Physiology and Pharmacology
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• 제20권1호
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• pp.63-67
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• 2016

Severe graft-versus-host disease (GVHD) is an often lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT). The safety of clinical-grade mesenchymal stem cells (MSCs) has been validated, but mixed results have been obtained due to heterogeneity of the MSCs. In this phase I study, the safety of bone marrow-derived homogeneous clonal MSCs (cMSCs) isolated by a new subfractionation culturing method was evaluated. cMSCs were produced in a GMP facility and intravenously administered to patients who had refractory GVHD to standard treatment resulting after allogeneic HSCT for hematologic malignancies. After administration of a single dose ($1{\times}10^6cells/kg$), 11 patients were evaluated for cMSC treatment safety and efficacy. During the trial, nine patients had 85 total adverse events and the rate of serious adverse events was 27.3% (3/11 patients). The only one adverse drug reaction related to cMSC administration was grade 2 myalgia in one patient. Treatment response was observed in four patients: one with acute GVHD (partial response) and three with chronic GVHD. The other chronic patients maintained stable disease during the observation period. This study demonstrates single cMSC infusion to have an acceptable safety profile and promising efficacy, suggesting that we can proceed with the next stage of the clinical trial.

• 한국정보시스템학회지:정보시스템연구
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• 제9권1호
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• pp.61-86
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• 2000

CALS(Commerce At Light Speed) which originated in the early 1980's in the military sector is now an integral component in our global strategy to further heighten competitiveness. Through integration and streamlining of production, distribution, technical information and management, CALS will certainly lead the world out of these economically challenging times and into new global prosperity. However, not much effort have been focused on the development and diffusion issues of component technologies such as ERP/SCM(Enterprise Resourses Planning/supply Chain Management), PDM(Product Data Management), and BPR(Business Process Reengineering) related with the CALS in electronic industry. Therefore, the purpose of this study is to analyze the advancing status and to present suggestions for the development of the CALS in electronic industry. In order to achieve the purpose, the case study has been conducted using the questionaries on the end-users and the interviews on the managers in the CALS area. The case study cover 57 users of the CALS for the three outstanding electronics(L, S, and D Electronics) in Korea. The questionaries include five success measures and eleven diffusion factors for the component technologies such as ERP/SCM, PDM, and BPR. In summary, the CALS will serve as the bases for exciting corporated innovations and the common business framework which facilitates the realization of Virtual Enterprise and Electronic Commerce in the 21st century.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제37권
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• pp.40.1-40.7
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• 2015

Surgical procedures for parotidectomy had been developed to gain adequate approach, prevent morbidity of nerve, and give esthetic satisfaction. We performed two cases of parotidectomy through facelift incision. One case was reconstructed with superficial musculoaponeurotic system (SMAS) flap and sternocleidomastoid (SCM) muscle rotated flap at the parotid bed. In second case, same procedures were performed, but collagen membrane was additionally implanted for prevention of Frey's syndrome. After surgery, two cases showed esthetic results without neck scar and hollow defect on parotid bed area.

• 한국산업정보학회논문지
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• 제10권4호
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• pp.78-89
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• 2005

급격하게 변화하는 기업환경에 능동적으로 대체하는 기업만이 생존한다는 것은 역사적인 교훈이다. 21세기 디지털 경제시대에 있어서 e-비즈니스는 기업이 직면한 새로운 과제들중의 하나이다. 이에 따라 국내외 유수의 기업들은 정보기술 기반의 e-비즈니스 체제 구축에 많은 노력을 기울이고 있으며, 삼성SDI는 e-비즈니스를 기반으로 경영혁신 전략을 성공적으로 추진한 대표적인 사례이다. 삼성SDI가 e-비즈니스 체제 구축에 성공한 핵심적인 요인은 최고경영자의 확고한 디지털 경영의지, 경영혁신을 완성하는 도구로써 변화관리와 지식경영활동의 성공적인 수행, 그리고 임직원의 경영혁신 역량을 향상시키기 위한 다양한 교육훈련 프로그램을 들 수 있다. 삼성SDI의 경영혁신 노력은 프로세스 효율성과 고객 만족도의 향상으로 나타났고 이는 곧 탁월한 재무적 성과로 이어졌다.

• 한국멀티미디어학회논문지
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• 제20권12호
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• pp.1928-1939
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• 2017

Fog computing is another paradigm of the cloud computing, which extends the ubiquitous services to applications on many connected devices in the IoT (Internet of Things). In general, if we access a lot of IoT devices with existing cloud, we waste a huge amount of bandwidth and work efficiency becomes low. So we apply the paradigm called fog between IoT devices and cloud. The network architecture based on cloud and fog computing discloses the security and privacy issues according to mixed paradigm. There are so many security issues in many aspects. Moreover many IoT devices are connected at fog and they generate much data, therefore light and efficient security mechanism is needed. For example, with inappropriate encryption or authentication algorithm, it causes a huge bandwidth loss. In this paper, we consider issues related with data encryption and authentication mechanism in the network architecture for cloud and fog-based M2M (Machine to Machine) IoT services. This includes trusted encryption and authentication algorithm, and key generation method. The contribution of this paper is to provide efficient security mechanisms for the proposed service architecture. We implemented the envisaged conceptual security check mechanisms and verified their performance.

• 대한안전경영과학회지
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• 제17권1호
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• pp.149-168
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• 2015

It is expected that the temperature in Pyeongyang will be similar to that ($16.6^{\circ}C$) in Seogwipo in the late 21st century, and most of South Korea will enter the subtropical climate due to climate change. Change in the precipitation pattern like the range of fluctuation caused by climate change will lead to expanded uncertainty in securing reliable water supply, along with a serious impact on demands for living and industrial water due to change in the volume and period of river outflow. As industrial water for production activities is estimated based on the contract quantity, it is difficult to apply rationalization of water usage and incentives in water recycling. Therefore many companies are making efforts in complying with the effluent standard while spending few resources on such rationalization and recycling. This study researched water risk management over 115 Korean companies by 28 questions in 4 categories. Through the research, this study aims to understand water risk management levels and seek response plans.

• 한국정밀공학회지
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• 제11권1호
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• pp.44-53
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• 1994

We experimented on cutting characteristics-cutting force, behavior of cutting temprature, surface foughness, behavior of chips-under low tempdeature, which generated by liquid nitrogen (77K). The workpieces were freezed to -195 .deg. C and liquid nitrogen was also sprinkled on cutting area in order to increase the efficiency of machining in low temperature. The workpiece was became to -195 .deg. C in 5 minutes, and cutting temperature in CC was lower about 170 .deg. C than NC. The cutting force trended to increase slighty in cooled cutting, but chip thickness was decreased, shear angle was however increased. The form of chips was in good conditions of long or short tubular chips in CC. In CC surface roughness of workpiece was better than NC. In NC surface hardness of chips trended to increase according to increasing of cutting speed, but in CC it trended to decrease. The power spectrum of vertical cutting force trended to increase according to increasing of feed, and in CC it was higher than NC.

• 사상체질의학회지
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• 제19권1호
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• pp.90-97
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• 2007

1. Objectives and Methods This study was done to investigate the relationships of Sound parameters between Liver Heat Symptom and Esophagus Symptom of Taeumin using PSSC(Phonetic System of Sasang Constitution) in a sentence. Experimental Participants were 20 Korean adult males including, each 10 Liver Heat Symptom and Esophagus Symptom of Taeumin. 2. Results In Pitch segment, APQ segment and Shimmer segment, there were no significant differences between Liver Heat Symptom and Esophagus Symptom of Taeumin. In Octave segment, there were significant differences in Octave 1, Octave 3, Octave 4, Octave 6 of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. In Energy segment, FreQ Domain Total Sum / cnt(0), 0k-2k Total Sum,0k-2k sum dev., 2k-4k Total Sum, 2k-4k sum dev., A# Tot E, B__TOT_E, C__TOT_E, C# Tot E, D__TOT_E, A sum dev., A# sum dev., B sum dev., C sum dev., C# sum dev., Dsum dev., D# sum dev., E sum dev., F sum dev., F# sum dev., G sum dev., G# sum dev. of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. In Voice Recording time segment, Total Voice Recording Time, Voice Recording Time, Divide By Time3, Divide By Energy10, Total Unit, Max Unit Position, U_0 TO 3 of Liver Heat Symptom of Taeumin were significantly high compared with Esophagus Symptom of Taeumin. 3. Conclusion From above result, there is the postbility of efficiency quide constitutional sx. of Taeumin by Voice characteristics. More Soeumin, Soyangin and Taeyangin Symptoms are needed to determine Sasang Constitution using PSSC and to make PSSC effective.

• 한국건설관리학회논문집
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• 제23권2호
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• pp.3-15
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• 2022

본 연구에서는 모듈러 공법 기반 강교 건설공사에 대해 공급사슬 관리를 위한 시뮬레이션 모형을 개발한다. 이를 위해, 우선 강교 건설에 대한 공장 제작/현장 시공 체계 자료를 수집한 후, 이를 바탕으로 공급사슬, 개체, 자원, 공정 등을 정의하였다. 이후, Arena 소프트웨어를 이용하여 데이터, 플로차트, 애니메이션 모듈을 작성함으로써 강교 공급사슬 시뮬레이션 모형을 개발하였다. 마지막으로, 개발된 모형의 논리성 검증과 유효성 확인을 위한 애니메이션 검증, 극한 조건 검증, 평균값 확인, 리틀의 법칙 확인, 사례 실적값 확인 등의 방법론을 이용하여 모형의 타당성을 검토하였다. 검토 결과, 개발된 시뮬레이션 모형은 논리적 오류 없이 강교 공급사슬의 공정과 특성을 적합하게 표현하며, 분석 대상 공급사슬에 대한 정확한 성능평가척도 예측치를 제공하였다. 향후, 본 연구에서 개발된 시뮬레이션 모형은 강교 공급사슬 체계를 최적으로 운영하기 위한 관리기법을 개발함에 있어 성능 평가 플랫폼으로서의 역할을 충실히 수행할 수 있을 것이다.

• Korean Journal of Acupuncture
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• 제19권1호
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• pp.15-23
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• 2002

This study was carried to identify the component of Large Intestine Meridian Muscle in human, dividing into outer, middle, and inner part. Brachium and antebrachium were opened widely to demonstrate muscles, nerve, blood vessels and the others, displaying the inner structure of Large Intestine Meridian Muscle. We obtained the results as follows; 1. Meridian Muscle is composed of the muscle, nerve and blood vessels. 2. In human anatomy, it is present the difference between a term of nerve or blood vessels which control the muscle of Meridian Muscle and those which pass near by Meridian Muscle. 3. The inner composition of meridian muscle in human arm is as follows. 1) Muscle; extensor digitorum tendon(LI-1), lumbrical tendon(LI-2), 1st dosal interosseous muscle(LI-3), 1st dosal interosseous muscle and adductor pollicis muscle(LI-4), extensor pollicis longus tendon and extensor pollicis brevis tendon(LI-5), adductor pollicis longus muscle and extensor carpi radialis brevis tendon(LI-6), extensor digitorum muscle and extensor carpi radialis brevis mucsle and abductor pollicis longus muscle(LI-7), extensor carpi radialis brevis muscle and pronator teres muscle(LI-8), extensor carpi radialis brevis muscle and supinator muscle(LI-9), extensor carpi radialis longus muscle and extensor carpi radialis brevis muscle and supinator muscle(LI-10), brachioradialis muscle(LI-11), triceps brachii muscle and brachioradialis muscle(LI-12), brachioradialis muscle and brachialis muscle(LI-13), deltoid muscle(LI-14, LI-15), trapezius muscle and supraspinous muscle(LI-16), platysma muscle and sternocleidomastoid muscle and scalenous muscle(LI-17, LI-18), orbicularis oris superior muscle(LI-19, LI-20) 2) Nerve; superficial branch of radial nerve and branch of median nerve(LI-1, LI-2, LI-3), superficial branch of radial nerve and branch of median nerve and branch of ulna nerve(LI-4), superficial branch of radial nerve(LI-5), branch of radial nerve(LI-6), posterior antebrachial cutaneous nerve and branch of radial nerve(LI-7), posterior antebrachial cutaneous nerve(LI-8), posterior antebrachial cutaneous nerve and radial nerve(LI-9, LI-12), lateral antebrachial cutaneous nerve and deep branch of radial nerve(LI-10), radial nerve(LI-11), lateral antebrachial cutaneous nerve and branch of radial nerve(LI-13), superior lateral cutaneous nerve and axillary nerve(LI-14), 1st thoracic nerve and suprascapular nerve and axillary nerve(LI-15), dosal rami of C4 and 1st thoracic nerve and suprascapular nerve(LI-16), transverse cervical nerve and supraclavicular nerve and phrenic nerve(LI-17), transverse cervical nerve and 2nd, 3rd cervical nerve and accessory nerve(LI-18), infraorbital nerve(LI-19), facial nerve and infraorbital nerve(LI-20). 3) Blood vessels; proper palmar digital artery(LI-1, LI-2), dorsal metacarpal artery and common palmar digital artery(LI-3), dorsal metacarpal artery and common palmar digital artery and branch of deep palmar aterial arch(LI-4), radial artery(LI-5), branch of posterior interosseous artery(LI-6, LI-7), radial recurrent artery(LI-11), cephalic vein and radial collateral artery(LI-13), cephalic vein and posterior circumflex humeral artery(LI-14), thoracoacromial artery and suprascapular artery and posterior circumflex humeral artery and anterior circumflex humeral artery(LI-15), transverse cervical artery and suprascapular artery(LI-16), transverse cervical artery(LI-17), SCM branch of external carotid artery(LI-18), facial artery(LI-19, LI-20)