• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1033-1036
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• 2015

Background: Testosterone, a primary androgen in males, is converted into its most active form, dihydrotestosterone (DHT), by $5{\alpha}$-reductase type 2 (encoded by the SRD5A2 gene) in the prostate. DHT is necessary for prostatic growth and has five times higher binding affinity than testosterone for androgen receptors. We hypothesized that polymorphic variations in the SRD5A2 gene may affect the risk of benign prostatic hyperplasia and prostate cancer. Materials and Methods: We analyzed SRD5A2 gene polymorphisms in 217 BPH patients, 192 PCa cases, and 171 controls. Genotyping was undertaken using direct DNA sequencing. Genotype data were compared between cases and controls using a Chi square statistical tool. Results: We found that the A49T locus was monomorphic with 'AA' genotype in all subjects. At V89L locus, the presence of 'VV' showed a marginally significant correlation with increased BPH risk (p=0.047). At the $(TA)_n$ locus, longer TA repeats were found to be protective against BPH (p=0.003). However, neither of these polymoprhisms correlated with the risk of PCa. Conclusions: We conclude that A49T is monomorphic in the study population, VV marginally correlates with BPH risk, and longer $(TA)_n$ repeats are protective against BPH. None of these polymorphisms affect the risk of PCa.

• 방송공학회논문지
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• 제24권5호
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• pp.849-858
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• 2019

최근 컴퓨터 그래픽 기술과 영상 처리 기술의 발달로 현실의 공간 및 물체 정보를 3차원 데이터로 표현하는 포인트 클라우드 기술에 관한 관심이 증대되고 있다. 특히, 포인트 클라우드 기술은 공간 정보를 정밀하게 제공할 수 있어 AR (Augmented Reality)/VR (Virtual Reality), 자율 주행 자동차 분야 등 높은 관심을 받고 있다. 그러나 기존의 2차원 영상보다 많은 데이터가 필요로 되는 3차원 포인트 클라우드 콘텐츠를 사용자에게 서비스하기 위해서는 다양한 기술 개발이 요구된다. 이러한 문제점을 해결하기 위해 국제 표준화 기구인 MPEG (Moving Picture Experts Group)에서는 효율적인 압축 및 전송 방안에 대해 논의를 진행 중이다. 본 논문에서는 기존의 MPEG-DASH (Dynamic Adaptive Streaming over HTTP)-SRD (Spatial Relationship Description) 기술의 확장을 통해 3차원 포인트 클라우드 콘텐츠의 영역 분할 전송 방안을 제안하고, 네트워크 상황뿐 아니라 사용자의 요구에 따라 선택적으로 품질 파라미터를 결정할 수 있도록 MPEG-DASH 표준에서 정의한 시그널링 메시지에 품질 파라미터를 추가로 정의한다. 또한, ROUTE (Real time Object delivery Over Unidirectional Transport)/DASH 기반 이종망 환경의 검증플랫폼을 설계하고, 결과를 통해 제안한 기술의 타당성을 확인한다.

• 한국산학기술학회논문지
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• 제18권5호
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• pp.467-474
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• 2017

본 연구의 목적은 만성 뇌졸중 환자 8자 모양 경로 보행 검사(Figure-of-Eight Walk Test, F8WT)의 측정자간 절대적 신뢰도와 타당도를 알아보고자 하였다. 만성 뇌졸중 환자 36명을 대상으로 하였으며 F8WT 소요 시간의 측정자간 신뢰도는 급간내상관계수(Intra Class Coefficient, $ICC_{2,1}$)를 구하였고, 절대적 신뢰도는 측정의 표준 오차값(Standard Error Measurment, SEM)과 최저 실제 차이(Small Real Difference, SRD)를 구하였다. F8WT 소요시간의 타당도는 뇌졸중 자세 평가 척도(Postural Assessment Scale for Stroke, PASS)와 체간 장애 척도(Trunk Impairment Scale, TIS)간의 스피어만 상관 계수(Spearman Correlation Coefficient)를 구하였다. 연구 결과 F8WT 소요 시간의 측정자간 신뢰도 ICC=0.95(0.91~0.97)로 매우 높았고, SEM과 SRD는 각각 1.02점, 2.82점으로 수용할 만 하였다. F8WT 소요 시간은 PASS(r=-0.82), TIS(r=-0.85)와 유의한 상관관계가 있는 것으로 나타났으며, 뇌졸중 환자의 특이성 장애인 자세 및 체간 조절과 유의한 관련성이 있는 것으로 확인되었다. 따라서 F8WT는 만성 뇌졸중 환자의 보행 능력을 평가하는데 유용한 평가 도구로 사용될 수 있을 것이다.

• 한국항행학회논문지
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• 제10권1호
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• pp.13-19
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• 2006

본 논문에서는 FCC의 방사 스펙트럼 제한 규정에 따라 5 GHz-WLAN 주파수 대역을 억제한 DS-UWB 가우시안 임펄스 생성기를 제안하고, 이를 실험적으로 구현하였다. 단극 구형파를 가우시안 임펄스로 변환하기 위해 SRD를 이용한 첫 번째 임펄스 생성기와 반도체 레이저의 이득 스위칭을 이용한 두 번째 임펄스 생성기로 구성된 2단 구조의 임펄스 생성기를 사용하였다. 출력된 가우시안 임펄스의 폭은 약 180 psec로 매우 짧다. 또한 WLAN 주파수 대역을 제거하기 위해 4단 링 공진기 구조의 고차 미분 가우시안 필터를 설계 및 제작하여 최종적으로 WLAN 신호 대역은 약 25 dB의 억제 효과를 갖는 DS-UWB 신호의 발생기를 실험적으로 구현하였다.

• 대한본초학회지
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• 제36권3호
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• pp.39-46
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• 2021

Objectives : Mangifera indica leaves are well known for having a variety of benefits, including anti-inflammatory, anti-tumor, diabetic retinopathy and diabetic vasculosis. However, the effects of Mangifera indica leaves on hair loss inhibition have not been studied. In this study, we investigated to find out the activity of Mangifera indica leaves on hair loss. Methods : 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid(ABTS) analysis was performed to confirm the antioxidant efficacy of the water extract of Mangifera indica leaves (WEML). To examine the effect of WEML on cell viability in dermal papillar (DP) cells, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetra Zolium (MTS) analysis was performed. The changes in the mRNA expression level of the hair loss and hair growth-related genes in dermal papilla cells by WEML treatment were confirmed by quantitative RT-PCR. Results : In dermal papilla (DP) cells, ABTS analysis and MTS analysis of WEML showed antioxidant efficacy and low cytotoxicity. As a result of gene expression analysis through Quantitative RT-PCR, no changes in hair growth-related genes BMP6 and CTNNB1 was confirmed. but inhibitory activity of WEML on hair loss-related genes EGR1, SGK, DKK1, SRD5A1 and SRD5A2 was confirmed. Conclusion : We confirmed that WEML has excellent antioxidant efficacy and a inhibitory activity of hair loss-related genes including 5α-reductase genes. These results suggest that Mangifera indica leaves have a potential activity as a hair loss treatment for hair loss and hair growth. Biochemical or molecular biological research on hair loss is needed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1255-1262
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• 2014

Background: The aim of the study was to investigate any associations between benign prostate hyperplasia (BPH) and single nucleotide polymorphisms (SNPs) in the VDR gene (FokI, BsmI, ApaI and Taq${\alpha}$I loci) and the CYP17 gene (MspA1I locus), as well as TA repeat polymorphism in SRD5A2 gene among Lebanese men. Materials and Methods: DNA extracted from blood of 68 subjects with confirmed BPH and 79 age-matched controls was subjected to PCR/PCR-restriction fragment length polymorphism analysis. The odds ra=tio (OR) of having a genotype and the relative risk (RR) of developing BPH for having the genotype were calculated and the alleles were designated risk-bearing or protective. Results: Our data indicated that the A and B alleles of the VDR ApaI and BsmI SNPs were highly associated with increased risk of BPH (p=0.0168 and 0.0002, respectively). Moreover, 63% of the controls compared to 43% of the subjects with BPH were homozygous for none of the risk-bearing alleles (p=0.0123) whereas 60% of the controls and 28% of the subjects with BPH were homozygous for two or more protective alleles (p<0.0001). Conclusions: For the first time, our study demonstrated that ApaI and BsmI of the VDR gene are associated with risk of BPH among Lebanese men. Our study also indicated that overall polymorphism profile of all the genes involved in prostate physiology could be a better predictor of BPH risk.

• 대한물리의학회지
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• 제5권4호
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• pp.655-666
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• 2010

Purpose : The examine the reliability and validity of the modified Emory Functional Ambulation Profile(mEFAP) for assessing gait function in chronic stroke patients. Methods : A total of 45 stroke patients, who had a stroke more than 6 months, participated in the study. Reliability was determined by Intra-class Correlation Coefficient($ICC_{3,1}$), including Bland and Altman method (Standard Error of Measurement: SEM, Small Real Differences: SRD). Validity was examined by correlating results to the gait ability(mEFAP, Modified Motor Assessment Scale-Gait(MMAS-G), Scandinavian Stroke Scale-Gait(SSS-G), Functional Ambulation Category(FAC), 10m Waking Test(10m WT)), and Fugl Meyer-Lower/Extremity(FM-L/E), Berg Balance Scale(BBS). Results : Inter-rater reliability for the total mEFAP was High($ICC_{2,1}$=.998), and absolute reliability were excellent (SEM: 1.75, SRD: 4.85). Subjects without assistance factor performed better on all tests than did subjects who had stroke. There were significant correlations between the mEFAP and MMAS-G, SSS-G, FAC(r=-.66~-.79), 10 m WT(r=-.86), and FM-L/E, BBS(r=-.72~-.78), indicating good validity. Increased times on the mEFAP correlated with poor performance on the gait ability, motor function of lower extremity, BBS and slow gait speeds on the 10 m WT in stroke patients. Conclusion : The mEFAP can be administered easily and comprehensively. It is a reliable gait assessment tool for patients with stroke and correlated with known of function, the mEFAP may be a clinically useful measure of ambulation.

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 2003년도 제12차 추계학술대회
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• pp.19-19
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• 2003

• 한국한의학연구원논문집
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• 제2권1호
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• pp.514-550
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• 1996

There are many theory in acupuncture mechanism, so we must know the detail contents. and then we can use the acupuncture as we know. the follow article will be helpful in this part. 1. Spinal cord are role in intermediate part in somatosensorypathway also in acupuncture stumulating tract 2. Acute pain pathway started in laminae I, V of gray colmn, next are the spinothalamic tract(trigeminal spinothalamic tract in above neck part) and then go to the specific thalamic nucleus. but chronic pain in laminae II, III, VI, VII, next are spinoreticular tract(trigeminal spinoreticular tract in the neck part) and finally to the nonspecific thalamic nucleus. 3. Thalamus is very important area in somatosensory stimuation including acupuncture stumulating sensory also as a pain control center. but except this, there are Hypothalamus, Limbic system Cerebral cortex and Cerebellum as intermediator. as we Know hypothalamus is related to the emotional analgesic system with a limbic system. 4. A ${\delta$ fiber has relationship in Acute, sharp and initial pain, contrary this C fiber is related with Chronic, dull and last pain. 5. In Acupuncture mechanism of pain analgesia, there are two theory, one is gate control theory as large fiber another is stimuation produced analgesia as small diameter fier. 6. In DNIC, the stimulation sources are mechanical, thermal, heating, pain and acupuncture stimulation etc. we call these as a Heterotopic Noxious Stimulation. 7. In DNIC, SRD(Subnucleus reticularis dorsalis)is core nucleus in pain imtermediated analgesic mechanism. 8. Takeshige insisted nonacupuncture point dependent analgesic mechanism and acupuncture point dependent analgesic mechanism. and protested that Stimulation acupuncture piing evoke blocking nomacupuncture point analgesic pathway.

• 대한전자공학회논문지SD
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• 제48권1호
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• pp.14-21
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• 2011

본 논문에서는 LTE-Advanced, Software defined radio(SRD)등 4G 이동통신 핵심기술에 응용 가능한 10b 500MS/s $0.13{\mu}m$ CMOS A/D 변환기(ADC)를 제안한다. 제안하는 AD는 저전력 특성을 만족하기 위해 특별한 보정기법을 포함하지 않는 단일 채널 형태로 설계되었으며, 500MS/s의 고속 변환속도를 만족하기 위해 폴딩 신호처리 기법을 사용하였다. 또한 하위 7b ADC의 높은 folding rate(FR)을 극복하기 위해 cascaded 형태의 폴딩 인터폴레이팅 기법을 적용하였으며, 폴딩 버스에서 발생하는 기생 커패시턴스에 의한 주파수 제한 및 전압이득 감소를 최소화하기 위해 folded cascode 출력단을 갖는 폴딩 증폭기를 설계하였다. 제안하는 ADC는 $0.13{\mu}m$ lP6M CMOS 공정으로 설계되었으며 유효면적은 $1.5mm^2$이다. 시제품 ADC의 INL, DNL은 10b 해상도에서 각각 2.95LSB, 1.24LSB 수준으로 측정되었으며, 입력주파수 9.27MHz, 500MHz의 변환속도에서 SNDR은 54.8dB, SFDR은 63.4dBc의 특성을 보인다. 1.2V(1.5V)의 전원전압에서 주변회로를 포함한 전체 ADC의 전력소모는 150mW ($300{\mu}W/MS/s$)이다.