• 제목/요약/키워드: SIS

검색결과 390건 처리시간 0.022초

다수로해석 방법론에 의한 국산핵연료 노심 열적 여유도 평가 (Evaluation of the Thermal Margin in a KOFA-Loaded Core by a Multichannel Analysis Methodology)

  • D. H. Hwang;Y. J. Yoo;Park, J. R.;Kim, Y. J.
    • Nuclear Engineering and Technology
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    • 제27권4호
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    • pp.518-531
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    • 1995
  • 단일수로 해석 모형을 다수로 해석 모형으로 대체할 경우 얻을 수 있는 열적 여유도 향상에 대한 연구를 수행하였다. 이를 위하여 17$\times$17 국산핵 연료 장전 노심에 적용할 수 있는 새로운 임계열속 상관식을 개발하였으며, 여기에 사용된 부수로 국부 조건은 다수로 해석 코드인 TORC로 계산하였다. 그리고, 고온부구로 DNBR 분석을 위하여 전 노심에 대한 단일단계 해석 모형을 개발하였다. 분석 결과 다수로 해석 모형인 TORC/KRB-1 체제를 사용할 경우 단일수로 해석 모형인 PUMA/ERB-2 체제에 비하여 약 5% 이상의 열적 여유도를 회복할 수 있는 것으로 나타났다. 이러한 열적 여유도의 증가는 두 코드간의 고온부수로 국부조건 예측 성능 차이와 임계열속 상관식의 특성 차이에서 기인한 것이다.

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보두산(寶豆散) 메탄올 추출물의 항염증 효과 (Anti-inflammatory Effect of Bodusan)

  • 김판준;윤현정;허숙경;김경애;김동완;김재은;박선동
    • 대한본초학회지
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    • 제24권2호
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    • pp.49-56
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    • 2009
  • Objectives : Inflammation is important event in the development of vascular diseases including hypertension, atherosclerosis, and restenosis. Bodusan (BDS) was a traditional Korean herbal medicine and widely used in treatment of gastrointestinal complaint and stomach ulcer. The aim of this study was to determine whether BDS and its components inhibit production of nitrite, PGE2 and proinflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Methods : Cytotoxic activity of BDS and its components on RAW 264.7 cells was using 5-(3caroboxymcrophages. eth-oxyphenyj)-2H-tetra-zolium inner salt (MTS) assay. The nitric oxide (NO) production was measured by Griess reagent system. And proinflammatory cytokines were measured by ELISA kit. The levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were detected by western blot. Results : Our results indicated that BDS and its components significantly inhibited the LPS-induced NO and PGE2 production. Moreover. BDS and its components inhibited iNOS and COX-2 expression accompanied by an attenuation of TNF-${\alpha}$, IL-11${\beta}$, IL-6 and MCP-1 formation in macrophages. Conclusions: These results indicate that BDS and its components have potential as an anti-inflammatory agent.

Assessment of INSPYRE-extended fuel performance codes against the SUPERFACT-1 fast reactor irradiation experiment

  • L. Luzzi;T. Barani;B. Boer;A. Del Nevo;M. Lainet;S. Lemehov;A. Magni;V. Marelle;B. Michel;D. Pizzocri;A. Schubert;P. Van Uffelen;M. Bertolus
    • Nuclear Engineering and Technology
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    • 제55권3호
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    • pp.884-894
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    • 2023
  • Design and safety assessment of fuel pins for application in innovative Generation IV fast reactors calls for a dedicated nuclear fuel modelling and for the extension of the fuel performance code capabilities to the envisaged materials and irradiation conditions. In the INSPYRE Project, comprehensive and physics-based models for the thermal-mechanical properties of U-Pu mixed-oxide (MOX) fuels and for fission gas behaviour were developed and implemented in the European fuel performance codes GERMINAL, MACROS and TRANSURANUS. As a follow-up to the assessment of the reference code versions ("pre-INSPYRE", NET 53 (2021) 3367-3378), this work presents the integral validation and benchmark of the code versions extended in INSPYRE ("post-INSPYRE") against two pins from the SUPERFACT-1 fast reactor irradiation experiment. The post-INSPYRE simulation results are compared to the available integral and local data from post-irradiation examinations, and benchmarked on the evolution during irradiation of quantities of engineering interest (e.g., fuel central temperature, fission gas release). The comparison with the pre-INSPYRE results is reported to evaluate the impact of the novel models on the predicted pin performance. The outcome represents a step forward towards the description of fuel behaviour in fast reactor irradiation conditions, and allows the identification of the main remaining gaps.

연잎 건분이 고지방식이를 먹인 흰쥐의 지질 농도에 미치는 영향 (Effects of Lotus (Nelumbo Nucifera Gaertner) Leaf Powder on Lipid Concentrations in Rats Fed High Fat Diet Rats)

  • 신미경;한성희
    • 한국식생활문화학회지
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    • 제21권2호
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    • pp.202-208
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    • 2006
  • The effects of Lotus (Nelumbo nucifera Gaertner) leaf dry powder on serum lipid concentrations were evaluated in rats. Forty-eight male Sprague-Dawley rats were divided into six groups and fed high fat diets for sis weeks. Experimental groups were following diets; Control group (CON), 40 % animal and plant high fat group (AHF and PHF) control with 2% Lotus leaf dry powder group (CLDP), animal and plant high fat diets with 2% Lotus leaf powder group (AHFLDP, PHFLDP). Tissue weights of liver, heart, kidney, spleen and lung of AHF group exposed rats were decreased by PHFLDP groups. The concentrations of serum triglyceride in rats fed the CLDP and PHFLDP group were lower than those in other groups. The concentrations of total cholesterol in CLDP and PHFLDP group the were lower than those in AHF groups. The concentrations of HDL-cholesterol in serum of the CLDP and PHFLDP groups were significantly higher than those of other groups. The levels of LDL-cholesterol in serum of the CLDP and PHFLDP groups were tended to be lower than those of other groups. GPT and GOT were decreased in CLDP and PHFLDP groups and than in the AHF group. LDHase was lower in CLDP and PHFLDP groups than in the AHF group. These results suggest that 2% Lotus leaf dry powder groups may reduce elevated levels of serum lipid concentrations in rats fed high fat.

소방수 공급설비에 대한 공통원인고장을 고려한 확률론적 신뢰도 분석 (Reliability Analysis on Firewater Supply Facilities based on the Probability Theory with Considering Common Cause Failures)

  • 고재선;김효
    • 한국화재소방학회논문지
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    • 제17권4호
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    • pp.76-85
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    • 2003
  • 본 논문에서는 공통원인고장의 이론적 고찰로서 정의와 그 원인, 분석방법을 기술하고 대표적인 소방설비의 하나인 소방펌프에 대해 공통원인고장을 고려한 신뢰도분석에 적용함으로써 공통원인고장의 중요성과 그 한계성을 규명하고자 한다. 공통원인고장을 고려한 소방수 공급설비에 대한 신뢰도분석 결과 알 수 있듯이 펌프의 운전고장이 계통실패의 가장 큰 요인으로 나타났으며 특히 두 펌프의 공통원인고장이 지배적이다. 다시 말하면 공통원인고장을 고려하지 않을 경우에 계통신뢰도를 실제보다 2배 이상 초과하여 평가할 수 있다는 것이다. 이로서 계통 신뢰도분석에서 공통원인고장의 중요성을 인식할 수 있으며 분석결과는 공통원인고장의 변수인자의 값에 크게 의존하는 것을 알 수 있다. 그리고 소방수 공급설비설계에 계통설계 시 다중성을 반영하면 신뢰도가 증가하는 것은 사실이나 공통원인고장 요인 때문에 다중기기 설치대수에 비례하는 정도의 신뢰도 향상을 얻지 못할 수도 있다. 또한 공통원인고장의 한계성으로는 분석모델의 차이로 인한 차이는 미미한 수준이었으나 각각 다른 데이터 원을 사용했을 경우 그 결과는 큰 차이를 나타내었다. 따라서 공통원인고장 분석에 사용되는 모델보다는 이용 가능한 경험데이터의 품질이 그 분석결과의 신뢰성에 큰 영향을 미친다는 것을 알 수 있었다. 결과적으로 다중기기의 공통원인고장을 방지하기 위한 기본적이고 공학적인 방안으로는 설계시 요구되는 적정 신뢰도를 유지하는 것이므로 적어도 소방펌프에 요구되는 신뢰도수준으로 설계되어야 한다. 즉 SIS(Safety Instrumented system)에 요구되는 신뢰도수준인 안전건전성수준(SIL; Safety integrity level)에 적합한가의 유무를 PFD를 활용하여 정량적으로 파악하는 것이다. 공통원인고장을 고려한 소방수 공급설비에 대한 신뢰도분석 결과 계통작동요구시 실패확률(PFD: Probability of failure on demand), 즉 계통 이용 불능도는 3.80E-3이므로 규정목표인 SIL5의 범주 안에 들어있지 않아 안전건전성수준으로 설계되어 있지 않다고 판단되며, 만일 공통원인고장을 고려하지 않았을 경우인 계통 이용불능도 또한 1.82E-3으로 계산되는데, 이 또한 SIL5의 범주 안에 들어있지 않으므로 단전건전성수준으로 설계되어 있지 않다고 판단된다.

만성환아의 가족에 관한 국내 연구논문 분석 (An Analysis of Nursing Research on the Family with chronfcally ill children in Borea)

  • 정연;이군자;백승남;조결자
    • Child Health Nursing Research
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    • 제2권1호
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    • pp.69-92
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    • 1996
  • The purpose of study was : 1) to analyze the trend of research on the family with chronically ill children in Korea, 2) to suggest direction for future study on the family with chronically ill children, and contributing to the use of intervention in family nursing practice. Research studies on the family with chronically ill children were selected from the Korean Nusre, the Korean Nurses' Academic Society Journal, and from dissertations, which were conducted between 1975 and 1995. The total numbers of the studies were 35. These studies were analyzed for 1)time of publication or presentation, 2)research design, 3)characteristics of subjects, 4) type of chronic disease, 5)main concepts, 6)measurement tool, 7) the sis for a degree or nondegree, 8) result of correlational studies. The findings of the analysis were as follows : 1) The numbers of studies on the family with chronically ill children have increas rapidly the early 1990's. In research design, the numbers of survey research studies were the highest. Especially, the most frequently research design was the correlational survey. There were 19 correlational studies(25.7%) during the early 1990's. 2) The subjects in 16 studies(45.7%) were mother of chronically ill children and, in 8 studies (22.9% ) were their parents. 3) In most types of chronic diseases, there were 14 hematooncologic disease(32.6%) and 14 hadicapped children (32.6% ). 4) Frequently used research concepts were stress, degree of coping or way of coping, social support, parents' support, family functioning, intensity of family and family adaptation. 5) Acceding to the results of correlational studies, the more family stress was higher the more degree of coping, family functioning, intensity of family and degree of family adaption was lower. The more degree of social support was higher the more stress was lower and degree of coping, family functioning and intensity of family was higher. The more family functioning was higher the more intensity of family and family adaptation was higher. 6) 24 researches on the family with chronically ill children were done for a thesis for a degree and 11 were nondegree research studies. The following suggestions are made based on the above findings : 1) The pattern of these studies related to the family with chronically ill children in domain of Nursing need to be compared with trend in other domains. 2) More replicated research on the family with chronically ill children is needed to develop family nursing intervention and prove the effect of that and more qualitative research on the family with chronically ill children is needed to comprehensive indepth the family with chronically ill children. 3) Further research on the family with chronically ill children is needed to verify subjects and type of chronic disease, develop applicable measurement tools in Korea and identify relation between other concepts. 4) Family nursing researchers should make an effort to apply research result in various clinical settings and community settings, and try to carry out not only team research with clinical nurse but also other multidisciplinary researcher related to the family.

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Regulation of c-Fos and c-Jun Gene Expression by Lipopolysaccharide and Cytokines in Primary Cultured Astrocytes: Effect of PKA and PKC Pathways

  • Suh Hong-Won;Choi Seong-Soo;Lee Jin-Koo;Lee Han-Kyu;Han Eun-Jung;Lee Jongho
    • Archives of Pharmacal Research
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    • 제27권4호
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    • pp.396-401
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    • 2004
  • The effects of lipopolysaccharide (LPS) and several cytokines or the c-fos and c-jun mRNA expression were examined in primary cultured astrocytes. Either LPS (500 ng/mL) or inter-feron-$\gamma$ (IFN-$\gamma$ 5 ng/mL) alone increased the level of c-fos mRNA (1 h). However, tumor necro-sis factor-$\alpha$ (TNF-$\alpha$; 10 ng/mL) or interleukin-4 (IL-1$\beta$: 5 ng/mL) alone showed no significant induction of the level of c-fos mRNA. TNF-$\alpha$ showed a potentiating effect in the regulation of LPS-induced c-fos mRNA expression, whereas LPS showed an inhibitory action against IFN-Y-induced c-fos mRNA expression. LPS, but not TNF-$\alpha$, IL-1$\beta$ and IFN-$\gamma$, increased the level of c-jun mRNA (1 h). TNF-$\alpha$ and IFN-$\gamma$ showed an inhibitory action against LPS-induced c-jun mRNA expression. Both phorbol 12-myristate 13-acetate (PMA; 2.5 mM) and forskolin (FSK, 5 mM) increased the c-fos and c-jun mRNA expressions. In addition, the level of c-fos mRNA was expressed in an antagonistic manner when LPS was combined with PMA. When LPS was co-treated with either PMA or FSK, it showed an additive interaction for the induction of c-jun mRNA expression. Our results suggest that LPS and cytokines may be actively involved in the regulation of c-fos and c-jun mRNA expressions in primary cultured astrocytes. Moreover, both the PKA and PKC pathways may regulate the LPS-induced c-fos and c-jun mRNA expressions in different ways.

항만하역관할의 원인분석 및 예방대책에 관하여 (On the Countermeasure for Preventing the Accident of Cargo Handling in Port)

  • 박용욱;이철영
    • 한국항해학회지
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    • 제17권3호
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    • pp.57-68
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    • 1993
  • The economy of Korea has grown up significantly in its scale. It has, therefore, become imperative to develop countermeasures to prevent work related injuries and occupational illnesses resultining from haza-rdous working conditions and handling harmful substances. A lot of cargo handling accident in port have occurred due to the characteristics of poor working environment, diversity of working place and method, fluctuation of the amount of cargo and handling of heavy, long, harmful and dangerous cargo, etc. According to '91 industrial accident analysis carried out by the ministry of labour, the number of the stevedores injured by cargo handling accident in port were 1, 432 persons (the death accident : 22 per-sons), the amount of industrial accident compensation in port was 6.7 billion won (the amount of economic loss : 33.6 billion won), and the injury occurance rate of the stevedoring industry was higher than that of the whole industry. This paper, therefore, aims to the actual status of the stevedoring industry and to extract the main cau-ses of the accidents related to cargo handling in port through factor analysis using the data of the accide-nts in the whole habour from 1990 to 1992, and to suggest the countermeasures to prevent such accident. The main causes of the accident and countermeasures are found to be as follows through the factor analy-sis : Factor1, factor2, and factor3 related to a defect of human being and management, a defect of state and environment, and an insufficiency of education and law are extracted. The short-term countermeasures to prevent these accidents are 1) to consolidate the safety and health organization in the working spot, 2) to secure a safe condition in working spot before dock work, 3) to strengthen a dock worker's safety educa-tion. The long-term countermeasures are 1) to promote a decasualisation of dock workers, 2) to modernize the cargo working methods through constructing exclusive pier and introducing exclusive cargo handling equipment, 3) to establish a exclusive dock accident prevention organization and the dock workers law. Factor 4, factor5, factor6, and factor7 related to an unfitness, a deficiency of technical knowledge, a nonfu-lfilment of safety measures, and a bad arrangement are extracted. The countermeasures to prevent these accidents are 1) to perform a complete safety inspection of cargo handling equipments and tools and to carry out the dock work according to a working plan, 2) to publish and supply technical safety books, safety instruction book, safety check list, etc., 3) to strengthen the safety patrol at the working spot in habour and to activate a safety fund, 4) to maintain always a clean workshop with the safety consciousness in which the good arragement of the working spot is considered to be the beginning of safety.

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수정 연쇄 말콥체인을 이용한 2차원 공간의 추계론적 예측기법의 개발 (A Development of Generalized Coupled Markov Chain Model for Stochastic Prediction on Two-Dimensional Space)

  • 박은규
    • 한국지하수토양환경학회지:지하수토양환경
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    • 제10권5호
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    • pp.52-60
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    • 2005
  • 본 연구에서는 기존 연쇄 말콥체인(Coupled Markov Chain, CMC) 확률식의 연산 경직성을 개선하기 위하여 일반화 된 2차원 연쇄 말콥체인(Generalized Coupled Markov Chain, GCMC) 확률식이 개발되었다. 또한 개발된 확률식에 근거하여 평면상에서 무작위적으로 분포하는 참조정보를 효율적으로 활용하는 연산 알고리듬이 개발되었다. 개발된 모델은 대안적 지구통계 기법으로의 새로운 기능성을 제시한다. 본 연구를 통해 새롭게 개발된 GCMC 확률식은 기존 CMC 확률식에 비해 보다 유연한 참조 정보 활용 가능성을 가지며 특수한 경우로 기존 CMC 확률식이 유도되었다. 또한 순차적 연산의 인위적 오류 발생 기능성 및 실제 야외 데이터의 낮은 빈도를 고려하여 무작위로 추출된 위치에서 각 범위를 이용한 연산 알고리듬이 제안되었다. 개발된 모델은 가상의 2차원 토양도에 적용되었으며 기존 지구통계 기법인 SIS에 비하여 손색이 없는 새로운 지구통계 기법으로 토양 및 지질을 포함한 다양한 예측에 이용 될 수 있는 가능성을 보였다. 낮은 빈도로 샘플링 된 지시자에 대해서는 기존 지구통계 기법과 마찬가지로 저평가되는 현상을 보였으며 이를 보완하기 위하여 다양한 소스의 데이터 융합 등을 바탕으로 한 계속적인 연구가 요구된다.

자궁경부 상피세포위축과 골다공증의 상관관계 분석 (Analysis of the Correlation between atrophy of exocervical epithelial cell and osteoporosis)

  • 이대일;남하경;이미화;곽민정;이현정;이수배;홍광선
    • 한국건강관리협회지
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    • 제4권1호
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    • pp.75-84
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    • 2006
  • Background : Osteoporosis and atrophic cell pattern in Pap smear are frequent findings In postmenopausal women due to loss of ovarian function, The present study attempted to find out possible correlation between morphologic characteristics of Pap smear and osteoporosis. Material & methods: The subjects were 825 women(age from 35 to 80) who had undergone Pap smear and bone mineral density(BMD) at The Korea Association of Health Promotion, Seoul Branch, from March 8 to May 10, 2005. Pap smears from 825 women were reviewed and classified either mature cell pattern or atrophic cell pattern by their cytologic patterns, BMD were measured using LUNAR DPX MdIQ(Minster, Ohio, USA). BMD value of lumbar spine(Ll, L2,L3 and L4) were measured from 825 women and BMD value of proximal region off emur(neck NK, Wards triangle WT, and trochanter TR) were measured from 818 women and their bone status were classified as normal( T-sore:>-1.0), osteopenia (T-score: -l~<-2,5) and osteoporosis(T-score: ≤ -2.5). And age distribution of Pap smear, average T-value andfrequency ofsteoporo-sis of each region of the bone, percentage of osteoporosis of each boneregion by age group and changing pattern of percentage of osteopenia and osteoporosis in certain postmenopausal period were compared between mature and atrophic cell pattern. Results: Pap smears revealed total mature cell pattern 53,9%(445/825) and total atrophic cell pattern 46.1%(380/825), Percentage of mature cell pattern decreased from 98.2%(168/171)under 44 age group to 13,3%(17/128) over 65 age group and mature cell pattern increased from 1.8%(3/171) under 44 age group to 86.7%(111/128) oyer 65 age group. Mean T-value of each region of lumbar spine and femur of mature cell pattern were lower than that of atrophic cell pattern about -1,5. And osteoporosis has noted in atrophic cell pattern showing odds ratio Ll 13.9, L2 15.3, L3 12.0, L4 10,4, UK 6.7, WT 10.9 and TR 4.1.Atrophic cell pattern started to increase after 45 years of age and osteoporosis of a trophic cell pattern started after 55 years of age. During 50 to 64 years of age period, L3, L4 and WT revealed parallel increased of osteopenia and osteoporosis and Ll, L2 revealed decreased of osteopenia and increased of osteoporosis. nia Conclusion: Above findings suggest that atrophic cell pattern of Pap smear precedes osteoporosis about 10 years and one of predictor of osteoporosis.

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