• Journal of Ginseng Research
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• v.46 no.2
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• pp.206-213
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• 2022

Ginsenoside Rb2 is an active protopanaxadiol-type saponin, widely existing in the stem and leave of ginseng. Rb2 has recently been the focus of studies for pharmaceutical properties. This paper provides an overview of the preclinical and clinical pharmacokinetics for Rb2, which exhibit poor absorption, rapid tissue distribution and slow excretion through urine. Pharmacological studies indicate a beneficial role of Rb2 in the prevention and treatment of diabetes, obesity, tumor, photoaging, virus infection and cardiovascular problems. The underlying mechanism is involved in an inhibition of oxidative stress, ROS generation, inflammation and apoptosis via regulation of various cellular signaling pathways and molecules, including AKT/SHP, MAPK, EGFR/SOX2, TGF-β1/Smad, SIRT1, GPR120/AMPK/HO-1 and NF-κB. This work would provide a new insight into the understanding and application of Rb2. However, its therapeutic effects have not been clinically evaluated. Further studies should be aimed at the clinical treatment of Rb2.

• Journal of Life Science
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• v.21 no.1
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• pp.141-145
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• 2011

Actinomycin D is a natural antibiotic that is used in anti-cancer chemotherapy and is known as a transcription inhibitor. Interestingly, actinomycin D induces phosphorylation of signal transducers and activators of transcription 3 (STAT3) in renal cancer Caki cells. In this study, we examined the molecular mechanism of actinomycin D-induced STAT3 phosphorylation. Treatment with actinomycin D induced phosphorylation of STAT3 (Tyr705) in a dose- and time-dependent manner. However, actinomycin D did not induce phosphorylation of STAT3 (Ser727), STAT1 (Tyr701) and STAT1 (Ser727). Moreover, actinomycin D-induced STAT3 phosphorylation was caused by decreased protein and mRNA levels of SOCS3, but not by JAK2 and SHP-1. In addition, other transcription inhibitor (5,6-dichloro-1-b-D-ribofuranosyl benzimidazole; DRB) also induced phosphorylation of STAT3 (Tyr705). Taken together, the present study demonstrates that transcriptional inhibitors (actinomycin D and DRB) induce phosphorylation of STAT3 (Tyr705) in Caki cells by down-regulation of SOCS3.

• BMB Reports
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• v.47 no.10
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• pp.581-586
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• 2014

Epidermal growth factor (EGF) is known to play key roles in skin regeneration and wound-healing. Here, we demonstrate that Pep2-YAC, a tripeptide covering residues 29-31 in the B loop of EGF, promotes the proliferation of HaCaT keratinocytes with activity comparable to EGF. The treatment of HaCaT cells with Pep2-YAC induced phosphorylation, internalization, and degradation of EGFR and organization of signaling complexes, which consist of Grb2, Gab1, SHP2, and PI3K. In addition, it stimulated the phosphorylation of ERK1/2 at Thr 202/Tyr 204 and of Akt1 at Ser 473 and the nuclear translocation of EGFR, STAT3, c-Jun, and c-Fos. These results suggest that Pep2-YAC may be useful as a therapeutic agent for skin regeneration and wound-healing as an EGFR agonist.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.11 no.8
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• pp.1392-1398
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• 2000

In this paper, Sub Harmonic Ring Mixer using Anti-Parallel Diode Pair is studied. Conventional mixers mix LO signal with RF signal and, obtain IF signal from the difference between LO and RF. Sub harmonic ring mixers using APDP mix RF signal with the second harmonic of LO signal, LO frequency needed for conventional receiver is reduced by 1/2.The produced mixer showed 12 dB conversion loss, and 1 dB compression point of IF signal, in respect to RF signal, was found at the 0 dBm RF signal. Isolation LO/IF and LO/RF is 24.6 dB and 22.5 dB respectively. Isolation RF/LO and LO/RF is 32.6 dB and 22.5 dB respectively.

• Proceedings of the KOSOMBE Conference
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• v.1991 no.11
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• pp.57-60
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• 1991

A new approach to texture classification for ultrasound liver diagnosis using run difference matrix was developed. The run difference matrix consists of the gray level difference along with distance. From this run difference matrix, we defined several parameters such as LDE, LDEL, NUF, SMO, SMG, SHP etc. and three vectors namely DOD, DGD and DAD. Each parameter value calculated in fatty cirrhotic, chronic hepatitic and normal liver mage was plotted in two dimensional plane. We compared our results with run length method. There are several advantages of run difference matrix method over the run lengths. 1) It is more sensitive to small difference of gray level distribution. 2) The parameters provide more statistically significant value. Images were classified with the extracted parameters to each diseases using neural networks. In preliminary clinical exprements, this approach showed satisfying results.

• ETRI Journal
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• v.33 no.5
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• pp.818-821
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• 2011

A D-band subharmonically-pumped resistive mixer has been designed, processed, and experimentally tested. The circuit is based on a $180^{\circ}$ power divider structure consisting of a Lange coupler followed by a ${\lambda}$/4 transmission line (at local oscillator (LO) frequency). This monolithic microwave integrated circuit (MMIC) has been realized in coplanar waveguide technology by using an InAlAs/InGaAs-based metamorphic high electron mobility transistor process with 100-nm gate length. The MMIC achieves a measured conversion loss between 12.5 dB and 16 dB in the radio frequency bandwidth from 120 GHz to 150 GHz with 4-dBm LO drive and an intermediate frequency of 100 MHz. The input 1-dB compression point and IIP3 were simulated to be 2 dBm and 13 dBm, respectively.

• Journal of the Korea Institute of Military Science and Technology
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• v.9 no.2 s.25
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• pp.42-52
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• 2006

Tube erosion can be defined as a phenomenon for an increment of bore diameter, a declination of accuracy and utility of tube by firing. This study introduces the characteristics of tube life for the 155 mm K9 SHP Using a tube history book with bore measurement data and firing data of standard charge, this study analyzed the EFC vs Tube life and EFC with heat transfer effect formula as a consideration of continuous firing vs tube life. The results were compared with Firing Table(FT 155-K9-1) after the analysis. Also, this study suggests that CN98 tube can be rifled as 1000 EFC through the severe condition with continuous firing.

• Membrane Journal
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• v.32 no.6
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• pp.427-441
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• 2022

Polymer electrolyte membrane (PEM) serving as a separator that can prevent the permeation of unreacted fuels as well as an electrolyte that selectively transports protons from the anode to the cathode has been considered a key component of polymer electrolyte membrane fuel cell (PEMFC). The perfluorinated sulfonic acid-based PEMs, represented by Nafion®, have been commercialized in PEMFC systems due to their high proton conductivity and chemical stability. Nevertheless, these PEMs have several inherent drawbacks including high manufacturing costs by the complex synthetic processes and environmental problems caused by producing the toxic gases. Although numerous studies are underway to address these drawbacks including the development of sulfonated hydrocarbon polymer-based PEMs (SHP-PEMs), which can easily control the polymer structures, further improvement of PEM performances and durability is necessary for practical PEMFC applications. Therefore, this study focused on the various strategies for the development of SHP-PEMs with outstanding performance and durability by 1) introducing cross-linked structures, 2) incorporating organic/inorganic composites, and 3) fabricating reinforced-composite membranes using porous substrates.

• Korean Journal of Agricultural and Forest Meteorology
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• v.17 no.3
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• pp.261-269
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• 2015

The purpose of this research is to identify the significance of climate factors related to the significance of change of dry matter yield (DMY) of whole crop maize (WCM) by year through the exploratory data analysis. The data (124 varieties; n=993 in 7 provinces) was prepared after deletion and modification of the insufficient and repetitive data from the results (124 varieties; n=1027 in 7 provinces) of import adaptation experiment done by National Agricultural Cooperation Federation. WCM was classified into early-maturity (25 varieties, n=200), mid-maturity (40 varieties, n=409), late-maturity (27 varieties, n=234) and others (32 varieties, n=150) based on relative maturity and days to silking. For determining climate factors, 6 weather variables were generated using weather data. For detecting DMY and climate factors, SPSS21.0 was used for operating descriptive statistics and Shapiro-Wilk test. Mean DMY by year was classified into upper and lower groups, and a statistically significant difference in DMY was found between two groups (p<0.05). To find the reasons of significant difference between two groups, after statistics analysis of the climate variables, it was found that Seeding-Harvesting Accumulated Growing Degree Days (SHAGDD), Seeding-Harvesting Precipitation (SHP) and Seeding-Harvesting Hour of sunshine (SHH) were significantly different between two groups (p<0.05), whereas Seeding-Harvesting number of Days with Precipitation (SHDP) had no significant effects on DMY (p>0.05). These results indicate that the SHAGDD, SHP and SHH are related to DMY of WCM, but the comparison of R2 among three variables (SHAGDD, SHP and SHH) couldn't be obtained which is needed to be done by regression analysis as well as the prediction model of DMY in the future study.

• Spatial Information Research
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• v.12 no.2
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• pp.151-163
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• 2004

This study aims to develop a standard protocol by which users can exchange data information efficiently between KOSDIC and GIS. The ultimate goal from this study is to propose a data exchange format using KOSIC. The background of this study is that GIS industry sector is vigorously developing linked to spatial information construction such as UIS, LIS, EIS, AM/FM through supporting by regional government institution. According to do, the format of data transformation becomes major issue. GIS data can easily transfer to CAD version but when CAD data convert to GIS format (DWG->DXF->SHP) cannot get high success rate due to errors and problems. In addition, CAD data feature is made from oriental structure which is made of point and line faeture so that GIS system is impossible to data transformation. In the reason, the biggest problem is discordance of symbolization in integration and standard of data format. By investigation the usability of this study, conclusion are drawn efficient alternative plan in data transformation. Though this wort we will be able to provide a better transformation of data conversion between CAD format and GIS format. Accordingly, it is of important to enrich the integrated construction information infrastructure, which accommodates ever-changing constructions environment.