• Interdisciplinary Bio Central
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• 제4권1호
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• pp.1.1-1.7
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• 2012

Background: The F-box proteins represent one of the largest families of proteins in eukaryotes. Apart from being a component of the ubiquitin (Ub)/26 S proteasome pathways, their regulatory roles in other cellular and developmental pathways have also been reported. One interesting feature of the genes encoding the proteins of this particular family is their variable selection patterns across different lineages. This resulted in the presence of lineage specific F-box proteins across different species. Findings: In this study, 48 non-redundant F-box proteins in E. siliculosus have been identified by a homology based approach and classified into three classes based on their variable C-terminal domains. A greater number of the F-box proteins have domains similar to the ones identified in other species. On the other hand, when the proteins having unknown or no C-terminal domain (as predicted by InterProScan) were analyzed, it was found that some of them have the polyglutamine repeats. To gain evolutionary insights on the genes encoding the F-box proteins, their selection patterns were analyzed and a strong positive selection was observed which indicated the adaptation potential of the members of this family. Moreover, four lineage specific F-box genes were found in E. siliculosus with no identified homolog in any other species. Conclusions: This study describes a genome wide in silico analysis of the F-box proteins in E. siliculosus which sheds light on their evolutionary patterns. The results presented in this study provide a strong foundation to select candidate sequences for future functional analysis.

• Journal of Digital Convergence
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• 제15권11호
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• pp.199-207
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• 2017

The business environment changing very fast with technology advance and convergence makes the role of R&D become more and more important to firms' success. By analyzing the 683 firm-level data of small and medium venture firms with the ordinary least squares regression, this study sheds new light on the following four points. First, small and medium venture firms' exterior R&D collaboration network heterogeneity positively impacts their import substitution from technology development. Second, the existence of the corporate R&D center moderates the positive impact of small and venture firms' exterior R&D collaboration network heterogeneity on their import substitution from technology development. Third, small and venture firms' exterior R&D information network heterogeneity positively impacts their import substitution from technology development. Fourth, The existence of the corporate R&D center moderates the positive influence of small and venture firms' exterior R&D information network heterogeneity on their import substitution from technology development.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제17권6호
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• pp.663-669
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• 2016

This study explores the effect of tagging in Social Network Services, especially Facebook, which has become popular as a marketing platform. In Facebook, users generally make recommendations using 'Like', 'Share', or 'Tag'. 'Tag' is different from 'Like' or 'Share' in that it can be used to deliver certain messages directly to specific people based on their interests or characteristics. Tagging can be categorized into rewarded tagging and non-rewarded tagging. As a result of our exploratory research, we found that non-rewarded tagging by certain users can indicate that the people, who are tagged, are interested in the contents of the users and share the same interest as them. Also, tagging indicates that these users want to share these services, such as restaurants and tours, with their friends who are tagged in the contents. Therefore, this study sheds light on the importance of the tagging function, as well as 'Like' and 'Share'.

• The Mathematical Education
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• 제56권3호
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• pp.341-363
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• 2017

This case study contributes to the efforts on identifying the essential features of responsive teaching practice where students' mathematical thinking is central in instructional interactions. We firstly conceptualize responsive teaching as a type of teachers' instructional decisions based on noticing literature, and agree on the claim which teachers' responsive decisions should be accounted in classroom interactional contexts where teacher, students and content are actively interacting with each other. Building on this responsive teaching model, we analyze classroom observation data of a 7th grade teacher who implemented a lesson package specifically designed to respond to students' mathematical thinking, called Formative Assessment Lessons. Our findings suggest the characteristics of responsive teaching practice and identify the relationship between noticing and responsive teaching as: (a) noticing on students' current status of mathematical thinking by eliciting and anticipating, (b) noticing on students' potential conceptual development with follow-up questions, and (c) noticing for all students' conceptual development by orchestrating productive discussions. This study sheds light on the actual teachable moments in the practice of mathematics teachers and explains what, when and how to support teachers to improve their classroom practice focusing on supporting all students' mathematical conceptual development.

• Archives of design research
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• 제16권4호
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• pp.323-334
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• 2003

This study examines the multi-functionality of the cultural facilities and explores the architectural characteristics of cultural facilities in city environment. For this purpose, 1 examine the major cultural facilities in USA and Singapore. Recently, the inter-cultural communication methods have been diversified and the cultural facilities need to be designed to effectively accommodate the public's interests in these activities. It is also necessary to reexamine cultural facilities' functions in terms of how the multi-functionality facilities reflect the surrounding environment. This study also sheds a new light on the meaning of the relationships between cultural activity, and the cultural facility design. For this, I primarily look at the various design categories of cultural buildings and their main functions. Finally, I demonstrate how both cultural activity and cultural facility design elements are embodied in the city environment.

• Korean Institute of Interior Design Journal
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• 제15권5호
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• pp.95-103
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• 2006

Ron Arad, the master of contemporary design in the U.K., is one of representative leaders of this age who has left distinguished achievements in the history of contemporary design through innovative design. Analyzing and understanding the Deconstructive design concept and the deconstructive characteristics of interior space of Ron Arad will contribute to finding directions for today's design and laying the ground for explaining the development pattern of design in the 21st century. After analyzing the deconstructive characteristics of each selected space, One Off and Ron Arad Associates have shown a deconstructive design trend of a creative formula by using methods that shed conventional processes and material while a space composition and form of new concept was attempted in the resting space of the New Tel Aviv Opera House, offering not only the establishment of a new circulation system, but also diverse experiences of space to visitors. Likewise, a temporal experience and communication between the user and the space was attempted in Belgo Noord and Belgo Central by partially applying a narrative space composition that sheds existing design concepts. At the Millennium House, they have produced an interior space for future house developed by breaking off from existing typical design development work and material through computer operation, and made various forms of space and atmosphere possible by attempting variable elements and the use of ultramodern material. Y's fashion shop has granted variability to the form and volume of space according to time by presenting display elements that have shed existing form and function. Hotel Puerta America as well, with a curved structure that has broken off with existing forms and maximized space variability through structures that have utilized ultramodern materials and instruments. Through this study, it has been verified that Ron Arad has been unraveling connections between interior space and its user, its requirements, and the original unique principles of space by applying deconstructive design concepts, and that through the mediation of these spaces, he is attempting indirect communication with the user. Eventually, he is taking part in the harmony and development of all elements of space connected with human beings by applying deconstructive design concepts.

• Journal of Korean Library and Information Science Society
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• 제48권3호
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• pp.207-232
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• 2017

Recent efforts to systematically transfer older materials from local library collections to preserve in a cooperative preservation facility, such as regional main library, are being made in each region. The study, in this regard, sheds light the regional preservation program, as it identifies status of preservation in local libraries and analyze the opinions of librarians in order to illustrate the planning process of regional preservation program. Based on the data about preservation status of public library in Busan metro area, the study focused on the strategies to operate a cooperative preservation program for public libraries. Specifically, 1) it investigates the preservation status of public library in Busan area and the librarians' opinion on a cooperative preservation facility in Busan library. 2) It adds a proposal composed with a materials transfer strategy and a space management program.

• Journal of Korean Society of Transportation
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• 제20권3호
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• pp.83-92
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• 2002

Freight mode choice models are essential to the analysis of many areas of transport research. However, observations of actual market choices have only been made in a limited number of situations. Therefore, stated preference(SP) techniques have emerged as an alternative source of actual market choices to be used for estimating freight mode choice models. Considerable confidence exists about SP data, but little consideration has been given to the potential for estimation bias. This paper has been motivated by the theoretical side of estimating SP discrete choice models, focusing on a case study of freight mode choice. Recently developed simulation methods are used to construct inherent random heterogeneity legit models, which consider individual heterogeneity, its inheritance to the next choices and overcome the independence from irrelevant alternatives (IIA) property. This Paper contributes to the development of models dealing with heterogeneity and its inheritance, and sheds light on the heterogeneity of freight transport.

• Wind and Structures
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• 제26권4호
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• pp.215-229
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• 2018

The appearance of a rivulet at the upper surface of a stay cable is responsible for rain-wind-induced vibration (RWIV) of cables of cable-stayed bridges. However, the formation mechanism of the upper rivulet and its aerodynamic effects on the stay cable has not been fully understood. Large eddy simulation (LES) method is used to investigate flow around and aerodynamics of a circular cylinder with an upper rivulet at a Reynolds number of 140,000. Results show that the mean lift coefficients of the circular cylinder experience three distinct stages, zero-lift stage, positive-lift stage and negative-lift stage as the rivulet located at various positions. Both pressure-induced and friction-induced aerodynamic forces on the upper rivulet are helpful for its appearance on the upside of the stay cable. The friction-induced aerodynamic forces, which have not been considered in the previous theoretical models, may not be neglected in modeling the RWIV. In positive-lift stage, the shear layer separated from the upper rivulet can reattach on the surface of the cylinder and form separation bubbles, which result in a high non-zero mean lift of the cylinder and potentially induces the occurrence of RWIV. The separation bubbles are intrinsically unsteady flow phenomena. A serial of small eddies first appears in the laminar shear layer separated from the upper rivulet, which then coalesces and reattaches on the side surface of the cylinder and eventually sheds into the wake.

• Asian-Australasian Journal of Animal Sciences
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• 제14권6호
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• pp.850-854
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• 2001

Feed intake, egg weight, rate of lay and shell quality characteristics were measured in an Australian tinted egg laying strain from 31-42 weeks of age, housed at $30^{\circ}C$ and provided drinking water at 5, 10, 17 and $30^{\circ}C$. In a second experiment a European brown egg laying strain (59-66 weeks of age) housed at $30^{\circ}C$ were provided drinking water at 5, 10, 15 and $30^{\circ}C$. Brown egg layers given cool drinking water (5, 10 and $15^{\circ}C$) consumed more (p<0.05) feed and produced significantly (p<0.05) thicker and heavier shells than hens given drinking water at ambient temperature ($30^{\circ}C$). However the tinted egg layers given chilled drinking water only consumed more (p<0.05) feed and produced thicker (p<0.05) and heavier (p<0.05) shells when consuming drinking water at $5^{\circ}C$. As the tinted egg layers acclimatised to the environmental temperature there was a decline in the influence of cool drinking water on feed intake and shell quality. For brown egg layers, however, cool drinking water resulted in an improvement (p<0.05) in feed intake and shell quality over the entire period birds were provided cool water. These studies suggest that there is potential for using cool drinking water to improve feed intake and shell quality of hens housed under hot conditions. The combination of high ambient temperature and high drinking water temperature, a common occurrence in Australian layer sheds, should be avoided.