• International Journal of Aeronautical and Space Sciences
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• v.2 no.1
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• pp.1-11
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• 2001

The time implicit point SGS scheme is applied to compute hypersonic viscous flows in thermochemical nonequilibrium. The performance of the point SGS scheme is then compared with those of the line SGS and the LU-SGS schemes. Comparison of convergence histories with the effect of multiple forward and backward sweeps are made for the flow over a 2D cylinder experimentally studied by Hornung and the flow over a hemisphere at conditions corresponding to the peak heating condition during the reentry flight of an SSTO vehicle. Results indicate that the point SGS scheme with multiple sweeps is as robust and efficient as the line SGS scheme. For the point SGS and the LU-SGS scheme, the rate of improvement in convergence is largest with two sweep cycles. However, for the line SGS scheme, it is found that more than one sweep cycle deteriorates the convergence rate.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.44
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• pp.239-255
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• 2009

The purpose of this article is to examine the Utilization of Umbrella Clauses in Investor-State Contract Disputes. To accomplish the purpose, this article analyzes the ICSID case of SGS v. Pakistan and SGS v. Philippines. Umbrella clauses have become a regular feature of international investment agreements and have been included to provide additional protection to investors by covering the contractual obligations in investment agreements between host countries and foreign investors. In particular, two recent ICSID decisions, SGS v. Pakistan and SGS v. Philippines, have brought to the forefront the question of whether the umbrella clause applies to obligations arising under otherwise independent investment contracts between the investor and the host State. In focusing on the SGS decisions, this article will give some useful guidelines to Government and Academia under currently prevailing environment of the Free Trade Agreement("FTA") in Korea.

• Molecules and Cells
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• v.43 no.10
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• pp.848-855
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• 2020

Cells assemble stress granules (SGs) to protect their RNAs from exposure to harmful chemical reactions induced by environmental stress. These SGs release RNAs, which resume translation once the stress is relieved. During stem cell differentiation, gene expression is altered to allow cells to adopt various functional and morphological features necessary to differentiate. This process induces stress within a cell, and cells that cannot overcome this stress die. Here, we investigated the role of SGs in the progression of stem cell differentiation. SGs aggregated during the neuronal differentiation of human bone marrow-mesenchymal stem cells, and not in cell lines that could not undergo differentiation. SGs were observed between one and three hours post-induction; RNA translation was restrained at the same time. Immediately after disassembly of SGs, the expression of the neuronal marker neurofilament-M (NF-M) gradually increased. Assembled SGs that persisted in cells were exposed to salubrinal, which inhibited the dephosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2α), and in eIF2α/S51D mutant cells. When eIF2α/S51A mutant cells differentiated, SGs were not assembled. In all experiments, the disruption of SGs was accompanied by delayed NF-M expression and the number of neuronally differentiated cells was decreased. Decreased differentiation was accompanied by decreased cell viability, indicating the necessity of SGs for preventing cell death during neuronal differentiation. Collectively, these results demonstrate the essential role of SGs during the neuronal differentiation of stem cells.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.254-263
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• 2015

In this study, numerical simulations are carried out to investigate the dynamic SGS model effects in a Kerosene-LOx coaxial swirl injector under high pressure conditions. The turbulent model is based on large-eddy simulation (LES) with real-fluid transport and thermodynamics. To assess the effect of the dynamic subgrid-scale (SGS) model, the dynamic SGS model is compared with that of the algebraic SGS model. In a swirl injector under supercritical pressure, the characteristics of temporal pressure fluctuation and power spectral density (PSD) present comparable discrepancies dependant on the SGS models, which affect the mixing characteristics. Mixing efficiency and the probability density (PDF) function are conducted for a statistical description of the turbulent flow fields according to the SGS models. The back-scattering of turbulent kinetic energy is estimated in terms of the film thickness of the swirl injector.

• Journal of the Korean Institute of Telematics and Electronics
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• v.21 no.1
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• pp.1-6
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• 1984

Calculation of the launch-condition dependent near field pattern, modal power distribution and far field pattern of the SGS mode scrambler by ray optical approch fits well with the experiment. These results were applied to explain how to establish the stable mode launching into the grated index multimode fiber under test by the SGS mode scrambler. The effective use of the 5G5 mode scrambler is found to restrict the launching NA as well as possible. This was also confirmed by experiment.

• Journal of Energy Engineering
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• v.21 no.3
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• pp.228-236
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• 2012

Large eddy simulation (LES) is increasingly used as a tool for studying the dynamics of turbulence in combustion chamber flows due to the promise of wider generality and more accurate results compared to Reynolds averaged Navier-Stokes(RANS) models. This study presents the appropriate subgrid-scale(SGS) model in LES for predicting the turbulent flow field in the internal combustion engine. The study of the effects of model and numerical parameters such as discretization scheme, initial condition, time step and SGS model was performed. The results of LES using the SGS model were found to be in the good agreement with experimental data.

• Journal of Korea Water Resources Association
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• v.43 no.11
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• pp.933-944
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• 2010

This study compares the CEM and SGS methods which are geostatistical stochastic simulation methods for assessing the uncertainty by spatial variability in the estimation of the spatial distribution of probability rainfall. In the stochastic simulations using CEM and SGS, two methods show almost similar results for the reproduction of spatial correlation structure, the statistics (standard deviation, coefficient of variation, interquartile range, and range) of realizations as uncertainty measures, and the uncertainty distribution of basin mean rainfall. However, the CEM is superior to SGS in aspect of simulation efficiency.

• 한국전산유체공학회:학술대회논문집
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• 2004.10a
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• pp.73-77
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• 2004

In the present study, an efficient and robust implicit operator for the LU-SGS method is proposed. Numerical experiments for supersonic flow are performed to demonstrate the performance of the proposed method.

• Journal of information and communication convergence engineering
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• v.1 no.1
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• pp.44-47
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• 2003

The split ground structure for microstrip structure can be used to protect analog/RF signal from SSN interference of digital circuits on PCB with common ground. However, the split ground structure gives rise to undesired emissions that may interfere with nearby circuitry due to the ground discontinuity. In this paper, we have proposed the modified structure, Dumbbell shaped SGS and the method to reduce the radiation by adding the lumped resistor on the proposed Dumbbell shaped SGS.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.1-14
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• 2005

This study was performed to evaluate antithrombotic activities of Saegeumsan (瑞金散, SGS) which has effects of activating blood, removing thrombus. This study is designed to measure the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. We standardized the time when the experimental animals were incapable of functioning the hind legs more than 20 minutes or maintained trembling. Being classified one group of eight mice, each of them was divided into Normal, Control, and SGS. The normal group supplied a saline solution and the control group brought the dextran extravasated blood after an hour of administering the saline solution. Also, SGS was dissolved in $2m{\ell}$ saline solution and then we dosed it to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood in the same way as the Control group. The results were obtained as follows, SGS significantly inhibited platelet aggregation induced by ADP and epinephrine when analyzed by the Sigmoid $E_{max}$ model in WinNonlin. $EC_{50}$ values of SGS were 4.61 mg/ml and 12.41 mg/ml for ADP and epinephrine respectively. SGS showed fibrinolytic activity insignificantly as compared with the control group. SGS increased blood flow rate significantly as compared with the control group in vitro. SGS inhibited pulmonary embolism induced by collagen and epinephrine(inhibitive rate is 37.5 %). SGS increased number of platelet and fibrinogen amount significantly, and shortened PT and APTT as compared with the control group in thrombus model induced by dextran. According to, SGS is effective antithrombotic activity from experimental result.