• International Journal of Aeronautical and Space Sciences
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• 제2권1호
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• pp.1-11
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• 2001

The time implicit point SGS scheme is applied to compute hypersonic viscous flows in thermochemical nonequilibrium. The performance of the point SGS scheme is then compared with those of the line SGS and the LU-SGS schemes. Comparison of convergence histories with the effect of multiple forward and backward sweeps are made for the flow over a 2D cylinder experimentally studied by Hornung and the flow over a hemisphere at conditions corresponding to the peak heating condition during the reentry flight of an SSTO vehicle. Results indicate that the point SGS scheme with multiple sweeps is as robust and efficient as the line SGS scheme. For the point SGS and the LU-SGS scheme, the rate of improvement in convergence is largest with two sweep cycles. However, for the line SGS scheme, it is found that more than one sweep cycle deteriorates the convergence rate.

• 무역상무연구
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• 제44권
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• pp.239-255
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• 2009

The purpose of this article is to examine the Utilization of Umbrella Clauses in Investor-State Contract Disputes. To accomplish the purpose, this article analyzes the ICSID case of SGS v. Pakistan and SGS v. Philippines. Umbrella clauses have become a regular feature of international investment agreements and have been included to provide additional protection to investors by covering the contractual obligations in investment agreements between host countries and foreign investors. In particular, two recent ICSID decisions, SGS v. Pakistan and SGS v. Philippines, have brought to the forefront the question of whether the umbrella clause applies to obligations arising under otherwise independent investment contracts between the investor and the host State. In focusing on the SGS decisions, this article will give some useful guidelines to Government and Academia under currently prevailing environment of the Free Trade Agreement("FTA") in Korea.

• Molecules and Cells
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• 제43권10호
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• pp.848-855
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• 2020

Cells assemble stress granules (SGs) to protect their RNAs from exposure to harmful chemical reactions induced by environmental stress. These SGs release RNAs, which resume translation once the stress is relieved. During stem cell differentiation, gene expression is altered to allow cells to adopt various functional and morphological features necessary to differentiate. This process induces stress within a cell, and cells that cannot overcome this stress die. Here, we investigated the role of SGs in the progression of stem cell differentiation. SGs aggregated during the neuronal differentiation of human bone marrow-mesenchymal stem cells, and not in cell lines that could not undergo differentiation. SGs were observed between one and three hours post-induction; RNA translation was restrained at the same time. Immediately after disassembly of SGs, the expression of the neuronal marker neurofilament-M (NF-M) gradually increased. Assembled SGs that persisted in cells were exposed to salubrinal, which inhibited the dephosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2α), and in eIF2α/S51D mutant cells. When eIF2α/S51A mutant cells differentiated, SGs were not assembled. In all experiments, the disruption of SGs was accompanied by delayed NF-M expression and the number of neuronally differentiated cells was decreased. Decreased differentiation was accompanied by decreased cell viability, indicating the necessity of SGs for preventing cell death during neuronal differentiation. Collectively, these results demonstrate the essential role of SGs during the neuronal differentiation of stem cells.

• International Journal of Aeronautical and Space Sciences
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• 제16권2호
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• pp.254-263
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• 2015

In this study, numerical simulations are carried out to investigate the dynamic SGS model effects in a Kerosene-LOx coaxial swirl injector under high pressure conditions. The turbulent model is based on large-eddy simulation (LES) with real-fluid transport and thermodynamics. To assess the effect of the dynamic subgrid-scale (SGS) model, the dynamic SGS model is compared with that of the algebraic SGS model. In a swirl injector under supercritical pressure, the characteristics of temporal pressure fluctuation and power spectral density (PSD) present comparable discrepancies dependant on the SGS models, which affect the mixing characteristics. Mixing efficiency and the probability density (PDF) function are conducted for a statistical description of the turbulent flow fields according to the SGS models. The back-scattering of turbulent kinetic energy is estimated in terms of the film thickness of the swirl injector.

• 대한전자공학회논문지
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• 제21권1호
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• pp.1-6
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• 1984

기하광학적 해석방법으로 입사조건에 따른 SCS(step-graded-step) 모드 스크램블러의 near field pattern, 모달 파우어 분포 및 far field pattern을 계산하고, 실험결과와 일치함을 보였다. 이로부터 SGS 모드 스크램블러에 의해 피측정 graded index 광섬유에서 stable mode launching이 이루어짐을 설명하였다. 또한 SGS 모드 스크램블러의 효과적 사용 방법으로는 입사 NA를 적게하는 것이 좋다는 것을 알았으며, 실험으로 확인하였다.

• 에너지공학
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• 제21권3호
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• pp.228-236
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• 2012

큰 에디 모사(LES)는 복잡한 연소실 유동에서 RANS 모델과 비교해 난류 유동장에 대해 모델의 보편성과 더 정확한 결과를 제공하기 때문에 점차적으로 사용이 증대되고 있다. 내연 기관의 연소실 내 난류 유동장 해석을 큰 에디 모사를 사용하여 수행하였다. 이산화 방식, 초기 조건, 시간 간격과 SGS 모델과 같은 모델과 수치 인자에 따른 영향을 평가하였다. SGS 모델을 사용한 LES 모사는 실험치와 유사한 결과를 보여주었다.

• 한국수자원학회논문집
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• 제43권11호
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• pp.933-944
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• 2010

본 논문에서는 확률강우량에 대한 공간분포 추정에 있어서 공간변동성에 따른 불확실성을 평가하기 위하여 지구통계 학적 추계모의기법인 CEM과 SGS 기법을 비교하였다. CEM과 SGS를 이용한 추계모의에 있어서 공간상관구조의 재생성, 확률강우량에 대한 불확실성 평가측도로서 실현치에 대한 통계치(표준편차, 변동계수, 사분위수 범위 및 범위)의 공간분포, 유역평균강우량의 불확실성 분포의 경우 두 기법이 대체로 비슷한 결과를 보이는 것으로 분석되었다. 그러나 모의 효율성 측면에서는 CEM이 SGS에 비해 우수한 결과를 나타내는 것으로 분석되었다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2004년도 추계 학술대회논문집
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• pp.73-77
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• 2004

In the present study, an efficient and robust implicit operator for the LU-SGS method is proposed. Numerical experiments for supersonic flow are performed to demonstrate the performance of the proposed method.

• Journal of information and communication convergence engineering
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• 제1권1호
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• pp.44-47
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• 2003

The split ground structure for microstrip structure can be used to protect analog/RF signal from SSN interference of digital circuits on PCB with common ground. However, the split ground structure gives rise to undesired emissions that may interfere with nearby circuitry due to the ground discontinuity. In this paper, we have proposed the modified structure, Dumbbell shaped SGS and the method to reduce the radiation by adding the lumped resistor on the proposed Dumbbell shaped SGS.

• 대한한방부인과학회지
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• 제18권1호
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• pp.1-14
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• 2005

This study was performed to evaluate antithrombotic activities of Saegeumsan (瑞金散, SGS) which has effects of activating blood, removing thrombus. This study is designed to measure the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. We standardized the time when the experimental animals were incapable of functioning the hind legs more than 20 minutes or maintained trembling. Being classified one group of eight mice, each of them was divided into Normal, Control, and SGS. The normal group supplied a saline solution and the control group brought the dextran extravasated blood after an hour of administering the saline solution. Also, SGS was dissolved in $2m{\ell}$ saline solution and then we dosed it to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood in the same way as the Control group. The results were obtained as follows, SGS significantly inhibited platelet aggregation induced by ADP and epinephrine when analyzed by the Sigmoid $E_{max}$ model in WinNonlin. $EC_{50}$ values of SGS were 4.61 mg/ml and 12.41 mg/ml for ADP and epinephrine respectively. SGS showed fibrinolytic activity insignificantly as compared with the control group. SGS increased blood flow rate significantly as compared with the control group in vitro. SGS inhibited pulmonary embolism induced by collagen and epinephrine(inhibitive rate is 37.5 %). SGS increased number of platelet and fibrinogen amount significantly, and shortened PT and APTT as compared with the control group in thrombus model induced by dextran. According to, SGS is effective antithrombotic activity from experimental result.