• The Journal of Korean Medicine
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• v.37 no.4
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• pp.22-29
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• 2016

Objectives: We developed a Korean translation of this questionnaire by sequential forward-and-backward translation. The purpose of this study is to validate the Korean version of the POEM, the "POEM-K" by Korean patients with atopic dermatitis (AD). Methods: A single-center prospective study was conducted with 50 participants diagnosed with AD. The POEM was translated to Korean version by an expert panel. Scoring Atopic Dermatitis (SCORAD) and Short Form 36 Health Survey (SF-36) were used as external comparators. Results: Twenty men and thirty women between the ages of 18 and 63 participated in the study. The test-retest reliability of the total POEM-K was estimated using the intra-class correlation coefficient (ICC) that showed a strong agreement (ICC = 0.72). By using Pearson correlation coefficients, we compared the POEM-K to SCORAD and yielded a concurrent validity that showed a significant result. The responsiveness of the POEM-K was represented by the effect size (ES) of 1.41 and statistically significant (p = 0.004). Conclusions: The Korean version of the POEM is a reliable, valid, and responsive disease-specific questionnaire for assessing the symptoms and quality of life of Korean patients with AD.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.2
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• pp.40-55
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• 2014

Objectives This study investigated the effect of camping style Hospitalization program for atopic dermatitis children patients. Methods 6 patients were admitted for camping style hospitalization program. The program includes acupuncture, herbal medicine, examination, education, psychotherapy, dressing, exercise. The patients were analyzed by Severity Scoring Atopic Dermatitis (SCORAD) index and measured skin pH value (pH). Also, patients evaluated themselves by writing an atopic dermatitis diary which consists of diet, emotion, severity of pruritus, and sleep loss. Checked questionnaires which consists of atopic dermatitis, self treatment methods and each program satisfaction. Results After 7 days of hospitalization program, the patient's SCORAD index scores were decreased and most of the patient's symptoms were improved. Conclusions The hospitalization program could be helpful for atopic dermatitis children patients.

• Journal of Sasang Constitutional Medicine
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• v.25 no.2
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• pp.115-123
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• 2013

Objectives The purpose of this case study is to report that a Soeumin patient diagnosed as adult atopic dermatitis was treated with Sipyimigwanjung-tang and then his symptoms improved. Methods We diagnosed the patient as Soeumin Greater Yin Pattern based on his nature & emotion, physical characteristics, symptoms. So we treated him with Sipyimigwanjung-tang and used Visual Analogue Scale(VAS), SCORAD(Scoring of Atopic Dermatitis) index and pictures of the affected part for the assessment. Results & Conclusions After treatment, his SCORAD index results significantly decreased from 76.3 to 41.8, VAS of itching decreased from 10 to 4 and the patient's subjective symptom and general condition considerably improved. This case study describe the effectiveness of Sipyimigwanjung-tang on Soeumin adult atopic dermatitis symptoms.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.167-175
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• 2019

Objetives : The purpose of this study is to report the effect of Oryeong-san on adult whole-body atopic dermatitis. Methods : We treated a 21-year-old male patient who have adult whole-body atopic dermatitis by Korean medicine. This treatment was enforced from 2019.5.25 to 2019.6.29. And we have confirmed the improvement of itching, rashes and oozing. We recorded photos that includes change of symptoms. Results : After the treatments was done, the grade of VAS and SCORAD was decreased. The VAS grade was decreased from grade 8 to grade 2. The SCORAD score was decreased from 72.1 to 52.1. And itching, rashes, oozing were clearly decreased. Conclusions : Oryeong-san has effect on decreasing itching, rashes and oozing. Also, sleeping time reduced due to itchness was normalized. Thus, It is able that Oryeong-san works on skin desease like atopic dermatitis.

• Journal of Convergence Korean Medicine
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• v.2 no.1
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• pp.35-55
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• 2021

Objectives: To investigate the characteristics of topical agents including natural products using for atopic dermatitis treatment via a review on the cases and clinical trials. Methods: Through a search on Pubmed, EMBASE, Cochrane library, DBPIA, NDSL, and OASIS, we selected papers that applied natural products externally for atopic dermatitis and analyzed them. Results: Finally, Seventeen papers were selected. As the primary outcome, changes in the SCORAD and EASI, were the most used. The most frequent type of external formulation was cream. In terms of the frequency of use, it was used at least twice a day in all studies. When evaluated based on SCORAD, EASI, SH and TEWL, the improvement effect on atopic dermatitis was highest when the ointment formulation and the moisturizer formulation were used. A few side effects of topical agents including natural products were observed, but most were mild symptoms and no serious side effects occurred. Conclusion: This study is meaningful in that it has drawn a significant trend for studies that have been published in the last 5 years that contain a single intervention for topical agents including natural products, and that it presents the direction and evidence for the application of external therapy to increase the therapeutic effect of atopic dermatitis.

• Herbal Formula Science
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• v.31 no.2
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• pp.125-132
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• 2023

Objective : The objective of this study is to report a case of atopic dermatitis (AD) treated with Hoeyeok-tang. Methods : We retrospectively reviewed the course of herbal medicine treatment in a 20-year-old male patient with a topic dermatitis. Changes in main symptoms were confirmed based on the gross findings and assessed using SCORing Atopic Dermatitis(SCORAD) Index. Accompanying symptoms and side effects that can be referred to for diagnosis were analyzed By referring to the clinical records. Results : According to the Shanghanlun provision, the patient's AD was diagnosed with Terminal-yin Gwakran 389^th provision. The patient was treated with Hoeyeok-tang for 90 days. The severity of pruritus decreased, and SCORAD Index was decreased from 44.6 to 8.4. VAS for eye fatigue and nausea was decreased from 10 to 5, also. No particular side effects occurred to the patient while taking the Hoeyeok-tang. Conclusions : The result suggests the clinical applicability of 389^th provision of Shanghanlun.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.1
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• pp.36-49
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• 2013

Objectives The goal of this review is to investigate clinical and experimental studies on external application treatment for atopic dermatitis in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Methods Electronic researches were performed with KTKP, OASIS, National Assembly Library, Korean Medicine Database, KISS, DBpia, and KISTI. Results and Conclusions In Twenty six studies, the numbers of clinical and experimental studies are respectively 10 (38.46%) and 16 (61.54%). The numbers of studies that used herbal complex were 20 (76.92%), and out of that, 6 studies had used a single herbal medicine (23.08%). The external application with oriental medicine for the atopic dermatitis used with Phellodendri Cortex (7), Sophorae Radix (6), Scutellariae Radix (6), Lonicerae Flos (5), Coptidis Rhizoma (5) and so on. Among the clinical studies, the 5 studies were double-blind and randomized-controlled study (50%). The numbers of studies that used Hanifin and Rajka Diagnostic Criteria (1980) were 6 (60%), and that used the Diagnostic Criteria in Korean Atopic Dermatitis (2005) were 4 (40%). Among the clinical studies, categories to evaluate of atopic dermatitis are respectively SCORAD Index (80%), Total IgE (80%), Eosinophil count (70%) and so on. All of the clinical studies (100%) showed a statistically significant decline in atopic dermatitis according to the SCORAD Index, Modified SCORAD Index, the Clinic index score. Among the experimental studies, the numbers of studies that used NC/Nga mice were 9 (56.25%), and out of that 5 studies used BALB/c mice (31.25%). Most of the studies (68.75%) used DNCB as allergy inducing materials. The scales for evaluation of atopic dermatitis were Clinical skin severity score, Histopathologic examination, Immunohematologic examination, safety test and so on. In 12 cases (75%) of experimental studies, the IgE level of experimental group showed a statistically significant decline after using external application. In 8 study cases (50%), Clinical skin severity score of experimental group showed a statistically significant decline after using external application.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.3
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• pp.122-137
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• 2010

Objective : Atopic dermatitis (AD) in children may profoundly affect the quality of life (QOL), and also cause financial burden, to the families of those suffering from this ailment. The aim of our study was to examine the quality of life and the financial burden of atopic dermatitis in children and their families to evaluate this relationship with the degree of AD. Methods : 37 infant and child atopic dermatitis patients were included and evaluated using the SCORing of Atopic Dermatitis (SCORAD) Index and Eczema Area and Severity Index (EASI). Patients and carers were asked to fill in the questionnaires about their quality of life and financial costs during the past year. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation was used for statistical analysis. Results : 1. The mean score of Children's Dermatology Life Quality Index (CDLQI) was $10.52{\pm}4.82$, Infants' Dermatologic Quality of Life (IDQOL) was $8.21{\pm}3.95$. 2. The mean score of Family Dermatology Life Quality Index (FDLQI) was $13.30{\pm}5.72$, Dermatitis Family Impact (DFI) was $12.5{\pm}4.98$. 3. By analyzing the questionnaire, the monthly average cost was determined to be 730,800 won for each patient : the direct cost was 283,500 won, and the indirect cost was 447,300 won. 4. By analyzing the correlation between the severity of AD and QOL, subjective SCORAD were significantly and positively correlated with QOL(IDQOL, FDLQI, DFI, CDLQI). 5. By analyzing the correlation between the severity of AD and any economic impact, EASI were significantly and positively correlated with the direct cost. Conclusion : The above results show that the QOL of the patients and carers is significantly related to their disease severity. Atopic dermatitis patients pay an average of 730,800 won a month, and the economic impact on the patients is significantly related to their disease severity. The CDLQI, IDQOL, FDLQI and DFImay potentially be of value to help in the appropriate management of AD and can be used as an added measurement in clinical trials involving AD management.

• Clinical and Experimental Pediatrics
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• v.58 no.3
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• pp.96-101
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• 2015

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.