Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
권호 표지
DOI QR코드

DOI QR Code

Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children

  • Cheon, Bo Ram (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shin, Jeong Eun (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Yun Ji (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, Jae Won (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Deok Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jung, Hye Lim (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Moon Soo (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, Jung Yeon (Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2014.07.09
  • Accepted : 2014.09.25
  • Published : 2015.03.10
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. Methods: We enrolled 91 children with AD and 32 control subjects without history or symptoms of allergic diseases. Blood was drawn to evaluate complete blood cell count, total eosinophil count (TEC), and total IgE, specific IgE to common allergens, 25(OH)D, and IL-31 levels. Serum 25(OH)D and IL-31 levels were measured using high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. The scoring atopic dermatitis (SCORAD) index was used to evaluate the severity of AD. Results: The mean 25(OH)D level was significantly lower in the AD group than in the control group; 25(OH)D decreased greatly in the moderate and severe AD groups compared with the mild AD group. Children with atopic sensitization showed significantly lower 25(OH)D levels than nonatopic children. However, serum IL-31 levels were not related to AD group, SCORAD index, or 25(OH)D levels. The SCORAD index was inversely correlated with serum 25(OH)D level and positively correlated with TECs and total IgE levels. Children with moderate and severe AD had significantly higher TECs than children with mild AD. Conclusion: Vitamin D is related to the severity of AD independently of IL-31.

Keywords

References

  1. Zeppa L, Bellini V, Lisi P. Atopic dermatitis in adults. Dermatitis 2011;22:40-6.
  2. Spergel JM. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am 2010;30:269-80. https://doi.org/10.1016/j.iac.2010.06.003
  3. Boguniewicz M, Leung DY. Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev 2011;242: 233-46. https://doi.org/10.1111/j.1600-065X.2011.01027.x
  4. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005;97: 93-101. https://doi.org/10.1016/j.jsbmb.2005.06.002
  5. Hewison M. Vitamin D and innate and adaptive immunity. Vitam Horm 2011;86:23-62. https://doi.org/10.1016/B978-0-12-386960-9.00002-2
  6. Oren E, Banerji A, Camargo CA Jr. Vitamin D and atopic disorders in an obese population screened for vitamin D deficiency. J Allergy Clin Immunol 2008;121:533-4. https://doi.org/10.1016/j.jaci.2007.11.005
  7. Peroni DG, Piacentini GL, Cametti E, Chinellato I, Boner AL. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol 2011;164: 1078-82. https://doi.org/10.1111/j.1365-2133.2010.10147.x
  8. Solvoll K, Soyland E, Sandstad B, Drevon CA. Dietary habits among patients with atopic dermatitis. Eur J Clin Nutr 2000;54:93-7. https://doi.org/10.1038/sj.ejcn.1600901
  9. Sidbury R, Sullivan AF, Thadhani RI, Camargo CA Jr. Randomized controlled trial of vitamin D supplementation for winter-related atopic dermatitis in Boston: a pilot study. Br J Dermatol 2008; 159:245-7. https://doi.org/10.1111/j.1365-2133.2008.08601.x
  10. Amestejani M, Salehi BS, Vasigh M, Sobhkhiz A, Karami M, Alinia H, et al. Vitamin D supplementation in the treatment of atopic dermatitis: a clinical trial study. J Drugs Dermatol 2012;11:327-30.
  11. Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 2008;62:68-77. https://doi.org/10.1038/sj.ejcn.1602680
  12. Back O, Blomquist HK, Hernell O, Stenberg B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol 2009;89:28-32. https://doi.org/10.2340/00015555-0541
  13. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 2004;5:752-60.
  14. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006;117:411-7. https://doi.org/10.1016/j.jaci.2005.10.033
  15. Nobbe S, Dziunycz P, Muhleisen B, Bilsborough J, Dillon SR, French LE, et al. IL-31 expreBion by inflammatory cells is preferentially elevated in atopic dermatitis. Acta Derm Venereol 2012; 92:24-8. https://doi.org/10.2340/00015555-1191
  16. Raap U, WeiBmantel S, Gehring M, Eisenberg AM, Kapp A, Folster-Holst R. IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis. Pediatr Allergy Immunol 2012;23:285-8. https://doi.org/10.1111/j.1399-3038.2011.01241.x
  17. Kanda N, Hau CS, Tada Y, Sato S, Watanabe S. Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis: relationship between IL-31 and oncostatin M. Allergy 2012;67:804-12. https://doi.org/10.1111/j.1398-9995.2012.02824.x
  18. Hanifin JM. Atopic dermatitis. J Am Acad Dermatol 1982;6:1-13. https://doi.org/10.1016/S0190-9622(82)70001-5
  19. Miyake Y, Sasaki S, Tanaka K, Hirota Y. Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J 2010;35:1228-34. https://doi.org/10.1183/09031936.00100609
  20. Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, et al. 25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. J Invest Dermatol 2004;122:984-92. https://doi.org/10.1111/j.0022-202X.2004.22424.x
  21. Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D, et al. Injury enhances TLR2 function and antimicrobial peptide expreBion through a vitamin D-dependent mechanism. J Clin Invest 2007;117:803-11. https://doi.org/10.1172/JCI30142
  22. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol 2012;188:2127-35. https://doi.org/10.4049/jimmunol.1102412
  23. McGrath JA, Uitto J. The filaggrin story: novel insights into skin-barrier function and disease. Trends Mol Med 2008;14:20-7. https://doi.org/10.1016/j.molmed.2007.10.006
  24. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002;347:1151-60. https://doi.org/10.1056/NEJMoa021481
  25. Zhang JZ, Maruyama K, Ono I, Kaneko F. Production and secretion of platelet-derived growth factor AB by cultured human keratinocytes: regulatory effects of phorbol 12-myristate 13-acetate, etretinate, 1,25-dihydroxyvitamin D3, and several cytokines. J Dermatol 1995;22:305-9. https://doi.org/10.1111/j.1346-8138.1995.tb03393.x
  26. Zhang JZ, Maruyama K, Ono I, Iwatsuki K, Kaneko F. Regulatory effects of 1,25-dihydroxyvitamin D3 and a novel vitamin D3 analogue MC903 on secretion of interleukin-1 alpha (IL-1 alpha) and IL-8 by normal human keratinocytes and a human squamous cell carcinoma cell line (HSC-1). J Dermatol Sci 1994;7:24-31. https://doi.org/10.1016/0923-1811(94)90018-3
  27. Komine M, Watabe Y, Shimaoka S, Sato F, Kake K, Nishina H, et al. The action of a novel vitamin D3 analogue, OCT, on immunomodulatory function of keratinocytes and lymphocytes. Arch Dermatol Res 1999;291:500-6. https://doi.org/10.1007/s004030050444
  28. Fukuoka M, Ogino Y, Sato H, Ohta T, Komoriya K, Nishioka K, et al. RANTES expreBion in psoriatic skin, and regulation of RANTES and IL-8 production in cultured epidermal keratinocytes by active vitamin D3 (tacalcitol). Br J Dermatol 1998;138:63-70. https://doi.org/10.1046/j.1365-2133.1998.02027.x
  29. Akan A, Azkur D, Ginis T, Toyran M, Kaya A, Vezir E, et al. Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations. Pediatr Dermatol 2013;30:359-63. https://doi.org/10.1111/pde.12058
  30. Hartmann B, Heine G, Babina M, Steinmeyer A, Zugel U, Radbruch A, et al. Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response. Allergy 2011;66:540-8. https://doi.org/10.1111/j.1398-9995.2010.02513.x
  31. Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 2001;167:4974-80. https://doi.org/10.4049/jimmunol.167.9.4974
  32. Staeva-Vieira TP, Freedman LP. 1,25-dihydroxyvitamin D3 inhibits IFN-gamma and IL-4 levels during in vitro polarization of primary murine CD4+ T cells. J Immunol 2002;168:1181-9. https://doi.org/10.4049/jimmunol.168.3.1181
  33. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM. IL-31 Serum Protein and TiBue mRNA Levels in Patients with Atopic Dermatitis. Ann Dermatol 2011;23:468-73. https://doi.org/10.5021/ad.2011.23.4.468
  34. Bonanno A, Gangemi S, La Grutta S, Malizia V, Riccobono L, Colombo P, et al. 25-Hydroxyvitamin D, IL-31, and IL-33 in children with allergic disease of the airways. Mediators Inflamm 2014;2014:520241.
  35. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20:1807-20. https://doi.org/10.1007/s00198-009-0954-6

Cited by

  1. Relationship between serum interleukin-31/25-hydroxyvitamin D levels and the severity of atopic dermatitis in children vol.3, pp.6, 2015, https://doi.org/10.4168/aard.2015.3.6.396
  2. Biomarkers for Atopic Dermatitis in Children vol.29, pp.4, 2015, https://doi.org/10.1089/ped.2016.0703
  3. Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis vol.8, pp.12, 2016, https://doi.org/10.3390/nu8120789
  4. Prevalence of Vitamin D Deficiency and Insufficiency in Korean Children and Adolescents and Associated Factors vol.6, pp.2, 2015, https://doi.org/10.3343/lmo.2016.6.2.70
  5. Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis vol.12, pp.8, 2015, https://doi.org/10.1586/1744666x.2016.1171143
  6. TSLP, IL‐31, IL‐33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis vol.30, pp.11, 2016, https://doi.org/10.1111/jdv.13679
  7. The relationship between severity of disease and vitamin D levels in children with atopic dermatitis vol.34, pp.3, 2015, https://doi.org/10.5114/pdia.2017.66054
  8. Suboptimal vitamin D status in Korean adolescents: a nationwide study on its prevalence, risk factors including cotinine-verified smoking status and association with atopic dermatitis and asthma vol.7, pp.7, 2017, https://doi.org/10.1136/bmjopen-2017-016409
  9. Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis vol.7, pp.4, 2015, https://doi.org/10.5826/dpc.0704a07
  10. Relationship of serum vitamin D and interleukin-31 levels to allergic or nonallergic rhinitis in children vol.6, pp.1, 2018, https://doi.org/10.4168/aard.2018.6.1.41
  11. Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis: A Randomized Controlled Trial vol.23, pp.1, 2015, https://doi.org/10.1177/1203475418805744
  12. Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children vol.11, pp.8, 2019, https://doi.org/10.3390/nu11081854
  13. Study on Vitamin D Status and Related Factors in Middle School Students in Gyeongnam vol.29, pp.5, 2019, https://doi.org/10.17495/easdl.2019.10.29.5.345
  14. Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients vol.10, pp.1, 2015, https://doi.org/10.1038/s41598-020-77968-1
  15. 비타민 D의 기능성: 아토피피부염의 조절에 미치는 영향 연구 vol.53, pp.2, 2021, https://doi.org/10.9721/kjfst.2021.53.2.139
  16. Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study vol.20, pp.3, 2015, https://doi.org/10.15690/vsp.v20i3/2273