• 제목/요약/키워드: S1PC

검색결과 2,012건 처리시간 0.028초

총명탕(聰明湯)과 목근피총명탕(木槿皮聰明湯)이 CT105로 유도된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향 (Effects of ChongMyung-Tang and MokguenpiChongMyung-Tang Extract on the Alzheimer's Disease Model Induced by CT105)

  • 정인철;이상룡
    • 동의생리병리학회지
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    • 제20권2호
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    • pp.394-403
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    • 2006
  • This research investigated the effect of the CMT and MCMT on Alzheimer's disease. The effects of the CMT and MCMT extract on expression of proinflammatory cytokine($IL-1{\beta}$, IL-6, $TNF-{\alpha}$) in the THP-1 cell; amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT105; the AChE activity and the APP production of PC-12 cell lysate treated with CT105 were investigated. The CMT and MCMT extract suppressed overexpression of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ in the THP-1 cell treated by LPS; the expression of APP, AChE mRNA in PC-12 cells treated with CT105; the AChE activity and the production of APP in PC-12 cell lysate treated with CT105 significantly. This study suggest that CMT and MCMT may be effective for the prevention and treatment of Alzheimer's disease.

Usefulness of four commonly used neuropathic pain screening questionnaires in patients with chronic low back pain: a cross-sectional study

  • Gudala, Kapil;Ghai, Babita;Bansal, Dipika
    • The Korean Journal of Pain
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    • 제30권1호
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    • pp.51-58
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    • 2017
  • Background: Recently symptoms-based screening questionnaires have gained attention for screening for a neuropathic pain component (NePC) in various chronic pain conditions. The present study assessed the usefulness of four commonly used NePC screening questionnaires including the Self-completed douleur neuropathique 4 (S-DN4), the ID Pain, the painDETECT questionnaire (PDQ), and the Self-completed Leeds Assessment of neuropathic Symptoms and Signs (S-LANSS) questionnaire in patients with chronic low back pain (CLBP) to assess the presence of NePC. Methods: This is a single-center cross-sectional study where patients with CLBP, with or without leg pain, were included. Participants were initially screened for NePC presence by a physician according to the regular practice, and later assessed using screening questionnaires. The diagnostic accuracy of these questionnaires was compared assuming the physician-made diagnosis as the gold standard. Results: A total of 215 patients with CLBP of which 164 (76.3%, 95% CI, 70.2-81.5) had a NePC were included. S-DN4, ID Pain, and PDQ have an area under the curve (AUC) > 0.8 indicating excellent discrimination. However, S-LANSS has an AUC of 0.69 (0.62-0.75), indicating low discrimination. S-DN4 has a significantly higher AUC as compared to ID Pain (d(AUC) = 0.063, P < 0.01) and S-LANSS (d(AUC) = 0.197, P < 0.01). But the AUC of S-DN4 does not significantly differ from that of PDQ (d(AUC) = 0.013, P = 0.62). Conclusions: S-DN4, ID Pain, and PDQ, but not S-LANSS, have good discriminant validity to screen for NePCs in patients with CLBP. Despite using all the tests, 20-30% of patients with an NePC were missed. Thus, these questionnaires can only be used as an initial clue in screening for NePCs, but do not replace clinical judgment.

Effect of Family Size and Genetic Correlation between Purebred and Crossbred Halfsisters on Response in Crossbred and Purebred Chickens under Modified Reciprocal Recurrent Selection

  • Singh, Neelam;Singh, Raj Pal;Sangwan, Sandeep;Malik, Baljeet Singh
    • Asian-Australasian Journal of Animal Sciences
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    • 제18권1호
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    • pp.8-12
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    • 2005
  • Response in a modified reciprocal recurrent selection scheme for egg production was evaluated considering variable family sizes and genetic correlation between purebred and crossbred half sisters. The criteria of selection of purebred breeders included pullet's own performance, purebred full and half sisters and crossbred half sister's performance. Heritability of egg production of crossbreds (aggregate genotype) and purebred's was assumed to be 0.2 and genetic correlation between purebred and crossbred half sisters ($r_{pc}$) as 0.1, 0.2, 0.3, 0.4, 0.5, 1.0, -0.1, -0.2, -0.3, -0.4, -0.5 and -1.0. Number of dams per sire to produce purebred and crossbred progenies assumed to be 5, 6, 7, 8, while number of purebred female progeny ($N_p$) and crossbred progeny ($N_c$) per dam were considered to be 3, 4, 5 and 6 in each case. Considering phenotypic variance as unity, selection indices were constructed for different combinations of dams and progeny for each value of $r_{pc}$. Following selection index theory, response in crossbred and purebred for egg production was computed. Results indicated that response in crossbreds depended mainly on crossbred family size and also on magnitude of$r_{pc}$ irrespective of its direction, and response was greater with large crossbred family size than the purebred families. Correlated response in purebreds depends both on magnitude and direction of $r_{pc}$ and was expected to be greater with large purebred family size only. Inclusion of purebred information increased the accuracy of selection for crossbred response for higher magnitude of$r_{pc}$ irrespective of its direction. Present results indicate that desirable response in both crossbred and purebred performance is a function of $r_{pc}$ and family sizes. The ratio of crossbred and purebred family sizes can be optimized depending on the objective of improving the performance of crossbreds and/or of purebreds.

PC-Cluster 구축 및 활용 (Needs for PC-Cluster and its Applicable Fields)

  • 이상문;양우진;신순철
    • 한국전산유체공학회:학술대회논문집
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    • 한국전산유체공학회 2002년도 춘계 학술대회논문집
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    • pp.1-1
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    • 2002
  • This abstract contains information of PC-Cluster systems that Samsung Advanced Institute of Technology (SAIT) have developed and researched since 1998. This paper introduce not only the reasons that why SAIT has been interested and focused in such system, but also where to SAIT has applied. There are many other applicable areas but this paper emphasis only in the fields of high performance computing and storage system. With the result of SAIT's PC-Cluster research, we hope we can create many new applicable areas with collaborations.

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PC카메라와 일반광학현미경을 이용한 빵효모 배양액의 효모세포 자동계수 (Automatic Counting of Yeast Cells in Baker's Yeast Culture Using PC Camera and Conventional Light Microscope)

  • 이형춘
    • KSBB Journal
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    • 제26권1호
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    • pp.87-91
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    • 2011
  • Automatic counting of yeast cells in baker's yeast culture was tried using a conventional light microscope equipped with a pc camera. Relatively good binary image was obtained by using white LED as microscope light source, but uneven brightness distribution in original image hindered counting accuracy. A block binarization method using local thresholds proportional to local brightnesses was used to get improved binary images. The brightnesses of the blocks were expressed as the value component in HSV color model. Good quality binary images were obtained by binarization on $8{\times}6$ blocks of original images and connected-component labelling of the binarized images produced reliable counting results in the concentration range $1.4{\times}10^5/mL{\sim}1.4{\times}10^7\;cells/mL$.

발전용 연료전지 PCS 기술 및 개발 동향

  • 최세완
    • 전력전자학회지
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    • 제15권1호
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    • pp.36-42
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    • 2010
  • 발전용 연료전지로서 가장 유망한 MCFC와 SOFC는 현재 국내에서도 활발히 상용화가 진행되고 있다. 300kW급의 스택을 이용하여 작게는 수MW급 분산전원으로부터 수십 또는 수백 MW급의 대규모 발전플랜트를 구축하는데 있어서 PCS는 전체가격의 10~25%를 차지하는 상용화에 매우 중요한 핵심 장치이다. 본고에서는 발전용 연료전지 PCS의 국내외 기술개발 동향을 소개하고 저전압 출력의 PCS 기술 및 PCS의 대규모화에 요구되는 차세대 기술과 기술적인 이슈를 소개하고자 한다.

항산화 식물의 페놀성화합물에 의한 PC12 세포보호 효과연구 (Phenolic Compounds from Antioxidant Plant Materials and their Protective Effect on PC12 cells)

  • 유소현;김건희
    • 한국식생활문화학회지
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    • 제33권1호
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    • pp.86-94
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    • 2018
  • This study was designed to evaluate the antioxidant activities and protective effects on PC12 cells of the extract of Epimedium koreanum and its main constituents icariin and icariside I. After screening the seven identified flavonoid glycosides from E. koreanum through DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, E. koreanum, Icariin and Icariside I exhibited significant effect on radical scavenging activity. E. koreanum, icariin and icariside I were examined using DPPH, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (ferric reducing ability power) assay. In all antioxidant assays, E. koreanum, icariin and icariside I showed high radical scavenging activities in a dose-dependent manner. Protective effects against $H_2O_2-induced$ PC12 cells were assessed with MTT assay. The results indicated that cell viability and protection on PC12 cells of icariside I and icariin increased dose dependently. These study results suggest that E. koreanum, icariin and icariside showed high antioxidant capacities and cell protective effects. Icariside I, one of the metabolites of icariin, may be a new and effective flavonoid compound as a functional component.

PC 구성물질에 관한 LCA 사례연구 (A LCA Case Study on Basic Materials of PC)

  • 이성호
    • 산업경영시스템학회지
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    • 제28권3호
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    • pp.10-17
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    • 2005
  • In this paper, the life cycle assessment(LCA) methodology is applied to Personal Computer's basic materials in order to analyze the impact to the environment. LCA data collection is carried out taking into account on main materials of PC's parts and component. And the impact assessment is the environmental burden on three factor into air emission(CO2, SOx, NOx), five factor into water emission(BOD, COD, SS, N, P), and three factor on transported substance(cl, NH4, SO4). According to the result, the environmental burden of PC's basic materials was proved to be used total energy 6,285Mj and emitted CO2 259.8kg, SOx 3,571g, NOx 330g, COD 1,328g, P 246g, N 2,434g. And this paper was presented the problems of its disposition-incinerating, landfill, and recycling.

The Flower Morphological Characteristics of Salix caprea×Salix gracilistyla

  • Seo, Han-Na;Chae, Seung-Beom;Lim, Hyo-In;Cho, Wonwoo;Lee, Wi-Young
    • Journal of Forest and Environmental Science
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    • 제37권1호
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    • pp.35-43
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    • 2021
  • The interspecific hybrid of Salix caprea and Salix gracilistyla has never been identified or studied in Korea. Accordingly, this study investigated the flower morphological characteristics of the interspecific hybrid between S. caprea and S. gracilistyla and compared the interspecific hybrid with S. caprea and S. gracilistyla, respectively. The female flowers were investigated for 12 characteristics and the male flowers were investigated for nine. For the female flowers, those of the hybrids were larger than those of S. caprea and S. gracilistyla in terms of catkin length (CL), bract length (BL), and bract width (BW). The hybrids are intermediates between S. caprea and S. gracilistyla in terms of ovary length, width, and stipitate length as well as gland length (GL). For the male flowers, those of the hybrids were bigger than those of S. caprea and S. gracilistyla in terms of CL, BL, and BW. The hybrids are intermediates between S. caprea and S. gracilistyla in terms of catkin width and stamen length (SL). A principal component analysis (PCA) of the female data showed that the first principal component (PC) explained 57.5% of the total variation. The first PC highly correlated the ovary stipitate and pistil style lengths. The analysis was divided into three groups of S. caprea, S. gracilistyla, and the hybrid by the first PC. The results of a PCA of the male data showed that the first PC explained 35.7% of the total variation. The first PC highly correlated with the adelphous SL and was divided into three groups of S. caprea, S. gracilistyla, and the hybrid. The results of the discriminant analysis showed that S. caprea, S. gracilistyla, and the hybrid were distinguishable by flower morphological characteristics. Therefore, the hybrid was distinctly separated from S. caprea and S. gracilistyla by flower characteristics.

Zinc phthalocyanine(ZnPc)화합물의 이용한 유기용제 센서 (Solvent Sensing Properties of Thin Films Based on Zinc phthalocyanine (ZnPc) Compounds)

  • 김동현;강영구;김정훈;노상철;김현주
    • 한국가스학회지
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    • 제9권4호
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    • pp.26-29
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    • 2005
  • 본 연구에서는 Metallophthalocyanine Macrocyclic Compounds인 Zinc phthalocyanine(ZnPc)를 이용하여 박막 films를 만들어 solvent sensor의 특성에 대한 연구을 수행하였다. 측정에 사용한 유기용제의 종류는 Acetic acid, Ethyl alcohol, Methyl alcohol, Ammonia 및 1,1,1-trichloroethane이였으며, solvent sensing 특성으로는 전기저항 변화를 측정 분석하였다. 또한 Zinc phthalocyanines과 $N,N'-diphenyl-N,N'-bis(1-naphthyl)-1,\;1-biphenyl-4,4'-diamine\;and/or\; Poly[2-methoxy-5-(2'-ethylhexyloxy)-1,4-phenylene-vinylene]$를 blend하여 spin-coating, evaporation박막을 만들어 유기용제 농도에 따라서 전기 저항 변화를 측정 분석하였다.

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