Browse > Article

Effects of ChongMyung-Tang and MokguenpiChongMyung-Tang Extract on the Alzheimer's Disease Model Induced by CT105  

Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Lee, Sang-Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 394-403 More about this Journal
Abstract
This research investigated the effect of the CMT and MCMT on Alzheimer's disease. The effects of the CMT and MCMT extract on expression of proinflammatory cytokine($IL-1{\beta}$, IL-6, $TNF-{\alpha}$) in the THP-1 cell; amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT105; the AChE activity and the APP production of PC-12 cell lysate treated with CT105 were investigated. The CMT and MCMT extract suppressed overexpression of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ in the THP-1 cell treated by LPS; the expression of APP, AChE mRNA in PC-12 cells treated with CT105; the AChE activity and the production of APP in PC-12 cell lysate treated with CT105 significantly. This study suggest that CMT and MCMT may be effective for the prevention and treatment of Alzheimer's disease.
Keywords
ChongMyung-Tang(CMT); MokguenpiChongMyung-Tang(MCMT); Dementia; Alzheimer's disease; CT105; cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 張介賓. 張氏景岳全書. 서울, 翰成社, pp 610-611, 1978
2 陳士澤. 國譯石室秘錄. 서울, 書苑堂, p 102, 1984
3 채종걸, 정인철, 이상룡. 山査肉이 CT-105로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響. 동의신경정신과학회지 13(1):79-115, 2002
4 Skehan, P., Storeng, R., Scudiero, D., Monk, A., McMahon, J., Visca, D., Warren, J.T., Kennedy, S., Boyd, M.R. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst, 82(13):1107-1112, 1990   DOI
5 金宇哲 외. 統計學槪論. 서울, 英志文化社, pp 177-179, 1990
6 서무규. 성인병.노인병학. 서울, 高麗醫學, pp 225-267, 1986
7 Kontush, A. Amyloid-beta ; an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease. Free Radic Biol Med, 31(9):1120-1131, 2001   DOI   ScienceOn
8 Racchi, M., Johnston, J.A., Flood, F.M., Cowburn, R.F., Govoni, S. Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein(APP) gene. Biochem J, 338, 777-782, 1999   DOI   ScienceOn
9 Lee, S.C., Liu, W., Dickson, D.W., Brosnan, C.F., Berman, J.W. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. The Journal of Immunology, 150(7):2659-2667, 1993
10 Selmaj, K., Shafit-Zagardo, B., Aquino, D.A., Farooq, M., Raine, C.S., Norton, W.T., Brosnan, C.F. Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. J Neurochem, 57(3):823-830, 1991   DOI
11 Stephen, L.Y., Loyd, H.B., June, K.A., Joyce, M.A., Michael, D.D., Paula, B.E., Anthony, M.P., Piorkowski, Kurt, R.B. Amyloid ${\beta}$ and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem, 74(3):1017-1025, 2000   DOI   ScienceOn
12 Yan, S.D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., Migheli, A., Nawroth, P., Stern, D., Schmidt, A.M. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature, 382(6593):685-691, 1996   DOI   ScienceOn
13 許浚. 東醫寶鑑. 서울, 大星文化社, pp 55-56 , 1996
14 康秉秀 외. 本草學. 서울, 永林社, p 649, 650, 1991
15 Li, W.Y., Butler, J.P., Hale, J.E., McClure, D.B., Little, S.P., Czilli, D.L., Simmons, L.K. Suppression of an amyloid beta peptide-mediated calcium channel response by a secreted beta-amyloid precursor protein. Neuroscience, 95(1):1-4, 2000   DOI   ScienceOn
16 Mattson, M.P., Guo, Z.H., Geiger, J.D. Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism. J Neurochem, 73(2):532-537, 1999   DOI   ScienceOn
17 洪元植. 精校黃帝內經靈樞. 서울, 東洋醫學硏究院, p 68, 342, 1985
18 Stephen, L.Y., Loyd, H.B., June, K.A., Joyce, M.A., Michael, D.D., Paula, B.E., Anthony, M.P., Piorkowski, Kurt, R.B. Amyloid ${\beta}$ and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem, 74(3):1017-1025, 2000   DOI   ScienceOn
19 Stephen, L.Y., Loyd, H.B., June, K.A., Joyce, M.A., Michael, D.D., Paula, B.E., Anthony, M.P., Piorkowski, Kurt, R.B. Amyloid ${\beta}$ and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia. J Neurochem, 74(3):1017-1025, 2000   DOI   ScienceOn
20 朱震亨. 金櫃鉤玄. 서울, 鼎談出版社, pp 306-307, 1992
21 홍대성, 김종우, 황의완. 麝香蘇合元이 情緖反應性과 Alzheimer's disease 모델 白鼠의 學習에 미치는 影響. 동의신경정신과학회지 10(1):17-38, 1999
22 陳 輝 외. 實用中醫腦病學. 北京, 學苑出版社, pp.242-251, 784-791, 1993
23 김영욱 외. 聰明湯이 健忘誘導白鼠의 學習과 記憶에 미치는 영향. 韓方再活醫學科學會誌 8(2):464-479, 1998
24 Hunot, S., Dugas, N., Faucheux, B., Hartmann, A., Tardieu, M., Debre, P., Agid, Y., Dugas, B., Hirsch, E.C. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J Neurosci, 19(9):3440-3447, 1999   DOI
25 楊思澎 외. 中醫臨床大全, 北京, 北京科學技術出版社, pp 224- 230, 1991
26 Kasa, P., Papp, H., Torok, I. Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Neuroscience, 101(1):89-100, 2000   DOI   ScienceOn
27 李尙仁 외. 漢藥臨床應用. 서울, 成輔社, pp 151-153, 308-313, 419-420, 426-428, 1990
28 정인철, 이상룡. 導痰益氣活血湯이 Alzheimer's Disease 病態 모델의 生化學的 變化 및 記憶에 미치는 影響. 동의생리병리학회지 15(2):260-276, 2001
29 Kim, H.S., Park, C.H., Cha, S.H., Lee, J.H., Lee, S., Kim, Y., Rah, J.C., Jeong, S.J., Suh, Y.H. Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. FASEB J, 14(11):1508-1517, 2000   DOI   ScienceOn
30 Sramek, J.J., Frackiewicz, E.J., Cutler, N.R. Review of the acetylcholinesterase inhibitor galanthamine. Expert Opin Investig Drugs, 9(10):2393-2402, 2000   DOI   ScienceOn
31 洪元植. 精校黃帝內經素問. 서울, 東洋醫學硏究院, pp 217, 218, 229, 1985
32 黃大東 외. 實用中醫內科學. 上海, 上海科學技術出版社, pp 378-381, 1989
33 Breakefield, X.O., Geller, A.I. Gene transfer into the nervous system. Mol Neurobiol, 1(4):339-371, 1987   DOI   ScienceOn
34 金知赫, 黃義完. 東醫精神醫學. 서울, 現代醫學書籍社, pp 256- 271, 327-330, 1992
35 孫思邈. 備急千金要方. 서울, 杏林出版社, pp 129-135, 534, 545, 550, 1982
36 錢鏡湖. 辨證奇問全書. 台北, 甘地出版社, pp 222-225, 233-235, 1990
37 Fukuyama, R., Izumoto, T., Fushiki, S. The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia. Eur Neurol, 46(1):35-38, 2001   DOI   ScienceOn
38 McGeer, E.G., McGeer, P.L. The importance of inflammatory mechanisms in Alzheimer disease. Exp Gerontol, 33(5):371-378, 1998   DOI   ScienceOn
39 趙 佶. 聖濟總錄. 北京, 人民衛生出版社, pp 822-825, 1987
40 우종인 외. 한국의 한 농촌 지역에 거주하는 老人에서의 치매의 유병율. 신경정신의학 36(1):92-101, 1997
41 Linert, W., Bridge, M.H., Huber, M., Bjugstad, K.B., Grossman, S., Arendash, G.W. In vitro and in vivo studies investigating possible antioxidant actions of nicotine ; relevance to Parkinson's and Alzheimer's diseases. Biochim Biophys Acta, 1454(2):143-152, 1999   DOI
42 李定均. 精神醫學. 서울, 一潮閣, pp 87-88, 465-467, 514-518, 600, 1995
43 Trabace, L., Cassano, T., Steardo, L., Pietra, C., Villetti, G., Kendrick, K.M., Cuomo, V. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease. J Pharmacol Exp Ther, 294(1):187-194, 2000
44 Zor, T., Selinger, Z. Linearization of the Bradford protein assay increases its sensitivity ; theoretical and experimental studies. Anal Biochem, 236(2):302-308, 1996   DOI   ScienceOn
45 Bryan-Sisneros, A.A., Fraser, S.P., Suh, Y.H., Djamgoz, M.B. Toxic effect of the beta-amyloid precursor protein C-terminus fragment and $Na^+/Ca^{2+}$ gradients. Neuroreport, 11(15):3357-3360, 2000   DOI   ScienceOn
46 김명진, 이상룡. 醒心地黃湯이 老化白鼠의 血液 變化 및 血淸과 腦組織의 抗酸化活性에 미치는 影響. 동의신경정신과학회지 10(2):71-84, 1999
47 Ho, P.I., Collins, S.C., Dhitavat, S., Ortiz, D., Ashline, D., Rogers, E., Shea, T.B. Homocysteine potentiates beta-amyloid neurotoxicity ; role of oxidative stress. J Neurochem, 78(2):249-253, 2001   DOI   ScienceOn
48 Zhao, W., Bing-sheng, L., Alkon, D.L., Barker, J.L., Chang, Y.H., Wu, M., Rubinow, D.R. TNF-alpha induced over-expression of GFAP is associated with MAPKs. Neuroreport, 11(2):409-412, 2000   DOI   ScienceOn
49 최병만. 木槿皮가 CT-105로 유도된 Alzheimer's Disease 병태 모델에 미치는 영향. 大田大學校大學院, 2003
50 채종걸, 이상용. 拱淸丸이 老化 白鼠의 血液變化 및 血淸과 腦組織의 抗酸化物活性에 미치는 影響. 동의신경정신과학회지 9(2):71-86, 1998
51 Wu, D.C., Xiao, X.Q., Ng, A.K., Chen, P.M., Chung, W., Lee, N.T., Carlier, P.R., Pang, Y.P., Yu, A.C., Han, Y.F. Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor. Neurosci Lett, 288(2):95-98, 2000   DOI   ScienceOn
52 Downen, M., Amaral, T.D., Hua, L.L., Zhao, M.L., Lee, S.C. Neuronal death in cytokine-activated primary human brain cell culture ; role of tumor necrosis factor-alpha. Glia, 28(2):114-127, 1999   DOI   ScienceOn
53 Reznik-Wolf, H., Machado, J., Haroutunian, V., DeMarco, L., Walter, G.F., Goldman, B., Davidson, M., Johnston, J.A., Lannfelt, L., Dani, S.U., Friedman, E. Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains. J Neurogenet, 12(1):55-65, 1998   DOI   ScienceOn