Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of ChongMyung-Tang and MokguenpiChongMyung-Tang Extract on the Alzheimer's Disease Model Induced by CT105

총명탕(聰明湯)과 목근피총명탕(木槿皮聰明湯)이 CT105로 유도된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향

  • Jung, In-Chul (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University) ;
  • Lee, Sang-Ryong (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2006.04.25
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Abstract

This research investigated the effect of the CMT and MCMT on Alzheimer's disease. The effects of the CMT and MCMT extract on expression of proinflammatory cytokine($IL-1{\beta}$, IL-6, $TNF-{\alpha}$) in the THP-1 cell; amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT105; the AChE activity and the APP production of PC-12 cell lysate treated with CT105 were investigated. The CMT and MCMT extract suppressed overexpression of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ in the THP-1 cell treated by LPS; the expression of APP, AChE mRNA in PC-12 cells treated with CT105; the AChE activity and the production of APP in PC-12 cell lysate treated with CT105 significantly. This study suggest that CMT and MCMT may be effective for the prevention and treatment of Alzheimer's disease.

Keywords

References

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