• Title/Summary/Keyword: S-locus

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A Case of Single-step Mutations at Two Short Tandem Repeat loci (D13S317 and DXS10148) among Three Generations of a Korean Family

  • Byeong Ju Youn;Kyungmyung Lee;Cho Hee Kim
    • Biomedical Science Letters
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    • v.28 no.4
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    • pp.327-333
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    • 2022
  • The DNA profiling of short tandem repeat (STR) markers is a powerful tool for forensic identification and forensic paternity testing. However, STR loci are susceptible to mutation that cause mismatches between parents and children when paternity is tested. Herein, we examined paternity disputes with 23 autosomal STR loci using two commercial human identification kits and revealed successive mismatches at the D13S317 locus across three generations of a Korean family. Additionally, we investigated 12 X-chromosomal STRs and discovered an inconsistency at the DXS10148 locus between the father and daughter of the same Korean family. Furthermore, we confirmed STR genotypes at the D13S317 and DXS10148 loci of the family using sequencing analysis. Consequently, we identified a successive single-step mutation at the D13S317 locus and one single-step mutation at the DXS10148 locus in three generations of the Korean family. Therefore, this case study may be useful for interpreting and understanding forensic paternity tests.

Relationships among Children's Perceived Social Support, Locus of Control, and Self-Esteem (아동이 지각한 사회적 지지 및 귀인 성향과 아동의 자아존중감의 관계)

  • Kim, Yun Hee;Park, Kyung Ja
    • Korean Journal of Child Studies
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    • v.22 no.2
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    • pp.49-64
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    • 2001
  • This study explored the relationship of children's perceived social support and locus of control to their self-esteem. Subjects were 190 5th grade children. Instruments were the revised Coopersmith Self-Esteem Inventory (1967), Dubow and Ullman's Social Support Appraisal Scale (1989), and Crandall's Intellectual Achievement Responsibility (1965). Data were analysed by t-tests and Pearson's correlations. Children with high perceived social support had higher self-esteem than children with low perceived social support. Children who attributed their success to internal factors had high self-esteem; children who attributed their success to external factors had low self-esteem. Successful children who attributed their success to external factors had low self-esteem, regardless of their social support level. Children who attributed their success to their abilities or hard work had high self-esteem only if they received high social support.

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The Effect of Learner's Locus of Control and Types of Learning Control on Academic Achievement in CAl (CAI 에서 학습자의 통제 소재와 학습 주도권이 학업 성취도에 미치는 영향)

  • Baek, Mi-Sook;Lee, Sung-Keun
    • The Journal of Korean Association of Computer Education
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    • v.4 no.1
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    • pp.65-76
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    • 2001
  • The purposes of this study are to test the learning effects of CAI in relation to the learner's locus of control and to test the interactive effects between learner's locus of control and types of learning control. In order to achieve the above purpose, a test was administered to investigate learner's locus of control to 160 First grades of J middle school located in Yosu. On the basis of the test results, the subjects who belonged to the extreme of both pole were divided into the internal and external control groups. Both groups were randomly assigned to teacher-control and learner-control types in CAI. After class, post-test on learning achievement was administered and ANOVA was employed to analyze the data. The research findings are as follows. First, as a result of learning through CAI, the learning scores of internals were shown higher than that of the external group. Second, learner-control group showed higher learning scores than teacher-control group. Third, there was not found a significant interactive effect between learner's locus of control and types of learning control of CAI.

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Factors Influencing Health Promoting Behavior in Patients with Multiple Myeloma (다발성골수종 환자의 건강증진행위에 영향을 미치는 요인)

  • Choi, Geon-Hui;Kang, Hee-Young
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.18 no.2
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    • pp.217-225
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    • 2011
  • Purpose: The purpose of this study was to analyzing the relationship between perceived health status, health locus of control, self-esteem, self-efficacy and HPB in patients with multiple myeloma to identify factors influencing health promoting behavior (HPB). Methods: One hundred patients were recruited into the study. The data were collected by personal interviews using questionnaires. Descriptive statistics, Pearson's correlation coefficients and stepwise multiple regression analysis were used with SPSS program to were analyze the data. Results: There were significant relationships between self-esteem (r=.787, p<.001), self-efficacy (r=.681, p<.001), internal health locus of control (r=.557, p<.001), powerful others health locus of control (r=.517, p<.001), chance health locus of control (r=-.251, p=.012), perceived health status (r=.532, p<.001) and HPB. Significant factors in explaining HPB were self-esteem, powerful others health locus of control, self-efficacy and perceived health status and together they accounted for 71% of variance. Conclusion: The study findings indicate that self-esteem, powerful others health locus of control, self-efficacy, and perceived health status were important factors in explaining HPB in patients with multiple myeloma. As self-esteem was an important variable in HPB, health promotion program designed for this population should focus on self-esteem and these other factors to enhance effective health promotion behavior.

The Relationships among Health Locus of Control and Resilience, Social Support and Health Promoting Behavior in Patients with Newly Diagnosed Coronary Artery Diseases (관상동맥질환자의 건강통제위, 회복력, 사회적 지지와 건강증진행위 간의 관계)

  • Shin, Nayeon;Kang, Younhee
    • Korean Journal of Adult Nursing
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    • v.27 no.3
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    • pp.294-303
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    • 2015
  • Purpose: The purpose of this study was to determine the relationships among health locus of control, resilience, social support, and health promoting behavior in patients with coronary artery diseases. Methods: This study utilized a descriptive correlational design using a survey method. The subjects were 165 coronary artery disease patients at the cardiology out-patient clinic of the C university hospital. Data were collected through Health Locus of Control Scale, Resilience Scale, ENRICHD Social Support Instrument, Health Promoting Lifestyle Profile scale. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and hierarchial regression. Results: There were significant positive bivariate correlations of health promoting behavior with internal health locus of control, doctors health locus of control, resilience and social support respectively, and correlation between resilience and social support. Among predictors, internal health locus of control (${\beta}$=.28), social support (${\beta}$=.28) and resilience (${\beta}$=.25) had statistically significant influences on health promoting behavior. Conclusion: These results proposed that internal health locus of control, social support and resilience have important influences on health promoting behavior. Nursing interventions to enhance internal health locus of control, resilience and social support might be essential for patients with coronary artery disease in order to promote their health behaviors.

Awareness and Performance on Standard Precautions of Hospital-acquired Infection Control in Nursing Students: The Mediating Effect of Internal Health Locus of Control (간호 대학생의 의료관련감염 관리에 대한 표준주의 인지도와 표준주의 수행도: 내적 건강통제위의 매개효과)

  • Yang, Sun-Yi;Lim, Hyo-Nam
    • The Journal of Korean Academic Society of Nursing Education
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    • v.23 no.4
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    • pp.378-388
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    • 2017
  • Purpose: The aim of this study was to identify the status of performance on standard precautions among nursing students and to examine the mediating effects of internal health locus of control on the relationship between awareness and performance on standard precautions of hospital-acquired infection control. Methods: The participants in this study were 134 nursing students. The measurements included a standard precautions awareness and performance scale, and a multidimensional health locus of control scale. Data were analyzed using independent t-test, one-way ANOVA, $Scheff{\acute{e}}$ test, Pearson correlation coefficient, and simple and multiple regression techniques. Mediation analysis was performed by the Baron and Kenny's method and Sobel test. Results: The mean score of standard awareness, standard performance, and internal health locus of control about standard precaution were $174.30{\pm}9.08$; $169.48{\pm}12.04$; and $20.43{\pm}2.82$; respectively. There was a positive correlation between standard awareness and performance (r=.414, p<.001). Also, standard awareness was significantly correlated with internal health locus of control (r=.413, p=.014). Internal health locus of control showed partial mediating effects in the relationship between awareness and performance. Conclusion: The results indicate a need to improve the internal health locus of control of nursing students. Therefore, an internal health locus of control improvement program should improve performance on standard precautions for patients and themselves.

The Mediating Effect of Internal Locus of Control in the Relationship between Family and Friend Support and Acculturative Stress of North Korean Adolescent Refugees (북한이탈청소년이 경험하는 가족 및 친구지지와 문화적응 스트레스의 관계에서 내적 통제성의 매개효과)

  • Jeong, Jae Kyeong;Kang, Min Ju
    • Human Ecology Research
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    • v.57 no.4
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    • pp.485-498
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    • 2019
  • This study examined the mediating effect of internal locus of control in the relationship between family and friend support and acculturative stress of North Korean adolescent refugees. Participants consisted of 101 North Korean adolescent refugees (40 males and 61 females) aged 13 to 24, who live in Seoul, Gyeonggi Province, and Busan. SPSS 25.0 and Mplus 5.12 were used to analyze data. Descriptive statistics and Pearson's correlation coefficients were calculated and structural equation modeling (SEM) examined the mediating effect. The results of this study are as follows. First, a higher level of family support and friend support were associated with a higher level of internal locus of control. A higher level of internal locus of control was associated with a lower level of acculturative stress among North Korean adolescent refugees. Second, the level of internal locus of control mediated the relationship between friend support and acculturative stress. This study is meaningful in that it examines the specific paths affecting acculturative stress of North Korean adolescent by examining family and friend support, which are environmental factors, and internal locus of control, which is internal factor of individuals. The study results suggest that improving friend support as well as increasing the level of internal locus of control for North Korean adolescent refugees can be an effective way to prevent or intervene acculturative stress.

Effects of Nursing Intervention of Mutual Goal Setting on Gastrectomy Patients According to Health Locus of Control (위절제술환자의 건강통제위에 따른 상호목표설정 간호중재의 효과)

  • Jang Eun-Hee
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.5 no.1
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    • pp.107-124
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    • 1998
  • Based on King's goal attainment theory, this research deals with applying nursing intervention of mutual goal settings to gastrectomy patients. It tests the effects of nursing intervention, according to the patients' health locus of control, suggested as external boundary criteria for the theory by employing a quasi-experimental design which consists of a pretest-posttest non-equivalent control and experimental groups. The subjects of this research were 62 gastrectomy patients hospitalized at Y medical center and the experimental and control groups consisted of 31 subjects. The experimental group received nursing intervention at the mutual goal setting of 5 times from the day before the surgery to the 5th day after the surgery, while the control group received only routine nursing care. Recovery indicators of both groups were measured and compared. Measurement variables included patients' characteristics, health locus of control, forced vital capacity, forced expiratory volume in one second, peak expiratory flow, bowel movement recovery, mobility recovery, level of pain, patients' stress and patients' satisfaction. Data were analyzed using SPSS statistical package and the hypotheses were tested by ANOVA and ANCOVA. Results of the analyses are summarized as follows : 1) Internal health locus of control had higher effects of the nursing intervention of mutual goal setting than external health locus of control on pulmonary ventilatory functions of forced vital capacity, forced expiratory volume in one second, and peak expiratory flow. 2) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the bowel movement recovery between the internal and external health locus of control. 3) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the mobility recovery between the internal and external health locus of control. 4) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of pain between the internal and external health locus of control. 5) There was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of stress between the internal and external health locus of control. 6) There was a statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of satisfaction with provision of nursing information between the internal and external health locus of control, and there was no statistically significant difference in the effects of nursing intervention of mutual goal setting on the level of satisfaction with outcome of nursing between the internal and external locus of control. On the basis of the research results, the following are recommended : 1) Repeated research on responses to health locus of control is necessary. 2) Not only the effectiveness of nursing intervention in acute recovery periods, but also the long term effects are to be investigated. 3) The development of instruments is needed to accurately measure mutual goal setting regarding postoperative deep breath, coughing, early ambulation, etc. so that the relationship among the postoperative recovery indicators may be explored. 4) It is required that an instrument be developed to measure perception which facilitates goal attainment in the interactive setting between patients and nurses.

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A study on the relationship of family support and personality with quality of life in the Patients receiving radiotherapy for cervix cancer (방사선 치료를 받는 자궁경부암 환자의 가족지지와 성격이 삶의 질에 미치는 영향)

  • Noh, Young-Hee
    • The Journal of Korean Society for Radiation Therapy
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    • v.8 no.1
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    • pp.149-159
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    • 1996
  • This descriptive correlational study was undertaken in order to investigate the relationship of family support and personality with quality of life in patients receiving radiotherapy for cervix cancer and to provide basic data to help them improve a better quality of life. The subjects for this study Were 80 out-patients undergoing a radiation therapy at C university hospital in K-city, from April, 1992 to October, 1994. The data were obtained using a convenience sampling technique. The tools used for this study were Ro's quality of life scale, Kang's family support scale and Wallston & others health locus of control scale. The collected data were analyzed by the SAS program using percentage, mean, standard deviation, pearson's correlation coefficients. The result were as follows : 1. The total average score of the quality of life of the subjects was 138.95(minimum score 121-maximum score 164), item mean score(range 1-5) was 2.95. The total average score of the family support of the subjects was 32.55 (minimum score 16-maximum score 47), item mean score(range 1-5) was 2.95 The total average score of the health locus of control of the subjects was 37.00 (minimum score 24-maximum score 49), item mean score (range 1-6) was 3.36. 2 The results of the analysis of the relationship between the quality of life scale and the health locus of control were as follows : the total average score in the quality of life of internal locus of control scale was 136.97, the total average score in the quality of life of external locus of control scale was 144.90. 3. There was a significant positive correlation between the health locus of control and the quality of life(r = 0.2927, p<0.01). The result of the analysis of the relationship between the each factor in the quality of life and health locus of control were as follows : There were significant differences between the health locus of control and emotional state factor(r=0.1514, p<0.01), economic life factor(r=0.2560, p<0.05), self-esteem factor(r=0.2289, p<0.05), physical state and function factor(r=0.1455, p<0.05), relationship with neighbors factor(r=0.0754, p<0.05), relationship with family factor (r=0.3324, p<0.01). 4. There was a significant positive correlation between the family support and the quality of life(r=0.459, p<0.001). The result of the analysis of the relationship between the each factor in the quality of life and family support were as follows : there were significant differences between family support and emotional state factor (r=0.3891, p<0.01), self-esteem factor(r=0.2661, p<0.05), relationship with family factor (r=0.4353, p<0.001).

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Analysis of the DNA Fingerprints from the Teeth -Using Chelex$^\textregistered$ 100 as a Medium of Simple Extraction of DNA from the Teeth- (치아에서의 DNA 유전자지문 분석 -Chelex$^\textregistered$ 100을 매개체로 한 DNA추출-)

  • Chang-Lyuk Yoon
    • Journal of Oral Medicine and Pain
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    • v.20 no.2
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    • pp.515-528
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    • 1995
  • The human genomic deoxyribonucleic acid(DNA) was extracted from the pulp, dentin of 22 teeth by clelex, phenol methods. Samples of the tooth-derived DNA were amplified by polymerase chain reaction(PCR), electrophosed for sex determination by detection of X-Y homologus amelogenin gene and D1S80 locus detection The following results have been achieved. 1. Chelex and phenol method are effective to sex determination in the pulp and dentin 2. Chelex method is not suitable for detection of D1S80 locus. 3. Concentration and purity of DNA for teeth using chelex method is lower than using phenol method. From the above investigation, chelex method is simple, rapid for sex determination, but it is not suitable for detection of VNTRs.

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