• 제목/요약/키워드: S-locus

검색결과 759건 처리시간 0.033초

진폐환자의 우울에 영향을 미치는 요인 (The Factors Affecting the Depression in Pneumoconiosis Patients)

  • 박주현;임현우;채정미;조현주;정혜선;조선진;이원철
    • 한국직업건강간호학회지
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    • 제16권1호
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    • pp.28-36
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    • 2007
  • Objectives: The objective of this study was to analyze factors affecting depression in pneumoconiosis patients. Methods: The subjects were 200 pneumoconiosis patients hospitalized in Pneumoconiosis Hospitals in An-san and Tae-beck. Collected 114 surveys were used in this study among 200 surveys since 86 surveys offered insufficient data. SAS for Windows 8.01 was used to analyse the data Results: Percentage of normal and mild depression is 2.6%, Percentage of moderate depression is 14.9%, Percentage of severe depression is 79.8%. In order to analyze the factors affecting depression rate, the factors with p-values less than 0.1, such as age, education, religion, work department, hospitalized period, physical pain existence, daily living ability, family supports and internal locus of control, were selected as independent factors and analyzed using a stepwise multiple regression. As results, the factor that affected the rate of depression were of the age, education, ADL(Activities of Daily Living), the internal locus of control, family support. Conclusion: It is necessary to develop health program which can improve the patient's ADL(Activities of Daily Living), enforce internal locus of control to minimize the depression rate in pneumoconiosis patients.

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누에를 이용한 환경 변이원 검색계 재선 (Improvement of a Screening System for Environmental Mutagens by Means of a Specific Locus Mutation of the Silkworm, Bombyx mori)

  • 윤형주;김삼은;김종길;최지영
    • 한국응용곤충학회지
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    • 제45권3호
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    • pp.283-291
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    • 2006
  • 누에의 가시 돌연변이 형질을 이용한 환경변이원 검색계 수립을 위하여 MMC, EMS, PCB에 대한 누에알 변이원 검색계의 감수성을 조사한 결과, 난모세포계는 MMC, 정세포계는 EMS에 대하여 특정적으로 높은 감수성을 보였고, PCB와 dioxin에 대해서도 양성반응을 얻을 수 있었다. 수나방의 사정횟수에 따른 정세포의 변이원 감수성 변화를 시험한 결과, 1교와 3교 때 사정된 정자 간에는 큰 차이가 없었다. 변이원 감수성은 높으나, 산란성, 우화율 등 검색계로서 주요형질이 극히 불량한 선3호는 C5, Nl2, 한삼면과의 교잡으로 주요형질이 개선되고 높은 변이원 감수성을 유지하였다.

SRD5A2 Gene Polymorphisms and the Risk of Benign Prostatic Hyperplasia but not Prostate Cancer

  • Choubey, Vimal Kumar;Sankhwar, Satya Narayan;Carlus, S. Justin;Singh, Anand Narayan;Dalela, Divakar;Thangaraj, Kumarasamy;Rajender, Singh
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권3호
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    • pp.1033-1036
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    • 2015
  • Background: Testosterone, a primary androgen in males, is converted into its most active form, dihydrotestosterone (DHT), by $5{\alpha}$-reductase type 2 (encoded by the SRD5A2 gene) in the prostate. DHT is necessary for prostatic growth and has five times higher binding affinity than testosterone for androgen receptors. We hypothesized that polymorphic variations in the SRD5A2 gene may affect the risk of benign prostatic hyperplasia and prostate cancer. Materials and Methods: We analyzed SRD5A2 gene polymorphisms in 217 BPH patients, 192 PCa cases, and 171 controls. Genotyping was undertaken using direct DNA sequencing. Genotype data were compared between cases and controls using a Chi square statistical tool. Results: We found that the A49T locus was monomorphic with 'AA' genotype in all subjects. At V89L locus, the presence of 'VV' showed a marginally significant correlation with increased BPH risk (p=0.047). At the $(TA)_n$ locus, longer TA repeats were found to be protective against BPH (p=0.003). However, neither of these polymoprhisms correlated with the risk of PCa. Conclusions: We conclude that A49T is monomorphic in the study population, VV marginally correlates with BPH risk, and longer $(TA)_n$ repeats are protective against BPH. None of these polymorphisms affect the risk of PCa.

Replication origins oriGNAI3 and oriB of the mammalian AMPD2 locus nested in a region of straight DNA flanked by intrinsically bent DNA sites

  • Balani, Valerio Americo;De Lima Neto, Quirino Alves;Takeda, Karen Izumi;Gimenes, Fabricia;Fiorini, Adriana;Debatisse, Michelle;Fernandez, Maria Aparecida
    • BMB Reports
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    • 제43권11호
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    • pp.744-749
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    • 2010
  • The aim of this work was to determine whether intrinsically bent DNA sites are present at, or close to, the mammalian replication origins oriGNAI3 and oriB in the Chinese hamster AMPD2 locus. Using an electrophoretic mobility shift assay and in silico analysis, we located four intrinsically bent DNA sites (b1 to b4) in a fragment that contains the oriGNAI3 and one site (b5) proximal to oriB. The helical parameters show that each bent DNA site is curved in a left-handed superhelical writhe. A 2D projection of 3D fragment trajectories revealed that oriGNAI3 is located in a relatively straight segment flanked by bent sites b1 and b2, which map in previously identified Scaffold/Matrix Attachment Region. Sites b3 and b4 are located approximately 2 kb downstream and force the fragment into a strong closed loop structure. The b5 site is also located in an S/MAR that is found just downstream of oriB.

귀인상담과 능력별 예습과제의 활용을 통한 귀인성향의 변화가 수학학습 능력에 미치는 효과 (Scholastic Improvement in Mathematics Learning resulting from Changes in Attribution through Structural Preparations by Counseling and Assignment Projects suitable for an individuals′ ability)

  • 오후진;구완규
    • 한국학교수학회논문집
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    • 제2권1호
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    • pp.15-30
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    • 1999
  • For the purpose of turning learners' locus of control into internal-controllable variables, counseling materials were developed, and attribution counseling was given. The counseling effects were practically confirmed by way of teaching and evaluation in the actual classes, and furthermore the efforts to provide learners with successful experiences in learning were repeatedly made. As a result, the conclusions are as follows: 1. The procedure of Individual counseling for learning attribution based on individual standard grades and data of the variable order of merit apparently shows learners that if learners are to try their best in learning, they will surely go far in terms of learning in the near future. 2. The procedure of Individual counseling for teaming attribution based on achievement distribution in individual behavior-oriented fields suggests to learners that how to learn is as important as how much effort they make. Surely enough, learners are required to make more effective and efficient efforts, considering their own learning abilities. 3. With the above 1, 2 procedures involved, learners have attributed locus of causality in achievement to their internal-controllable causes. 4. With preparatory assignments according to learner's abilities provided, even slower learners came to be assured that their constant efforts could give rise to success in learning achievement. 5. Above all, it was confirmed that the learners' struggling attitude might well have a significant correlation with achievement success. The learners who are willing to attribute locus of causality in achievement to their internal-controllable causes or strenuous efforts and intrinsic motivation tend to be convinced that they can address themselves to whatever faces them, so they can set up specific learning goals fit for their abilities. Accordingly, they will bit by bit acquire successful experiences (often called 'Aha' experiences) and in turn, feeling the senses of self-efficacy and self-esteem enough to push their efforts even further, they can grow to form a positive self-concept. With one successful experience after another fed back into learners, they are gradually motivated to bring the oncoming achievement expectation to a higher level. To conclude, it is necessary that instruction leading to internal-controllable attribution should be provided, inducing learners to recognize success and failure in learning achievement as a result of their strenuous efforts.

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성별에 따른 일부 대학생의 건강증진 행위 관련요인 (Related Factors in Health Promotion Behavior by Gender among College Students)

  • 정영해;서남숙;문소현
    • 한국학교ㆍ지역보건교육학회지
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    • 제12권2호
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    • pp.29-42
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    • 2011
  • Objectives: This is an explanatory correlational study to assess the level of and the relationship of the related factors of health promotion behavior by gender among college students. Methods: Subjects were 950 of the freshmen of the year 2010 at a university in a city adjacent to a metropolis, in S. Korea. Data were collected from the freshmen who understood the purpose of the study and agreed to participate during a freshmen core course using a structured questionnaire. Related factors include active- and passive-self efficacy, internal health locus of control, and social support. Related factors were compared between male and female using t-test and the relationship between the related factors and the health promotion behavior was analyzed separately for each sex, by multiple regression analysis using SPSS 12.0. Results: There were differences in the related factors of BMI between male and female students. They were alcohol behavior and perceived health status among female students while smoking status, alcohol behavior, perceived health status, and BMI among male students. Result from the multiple regression analysis revealed difference in the related factors and in the magnitude of the relationship evaluated by the standardized beta coefficients. Significant factors, listed by the magnitude of beta coefficients, among female were social support, active self efficacy, passive self efficacy, internal health locus of control, and alcohol behavior. Significant factors among male students were social support, active self efficacy, smoking, internal health locus of control, passive self efficacy, and perceived health status. Conclusions: There are gender difference in health promotion behavior and the related factors. The results suggest that the gender differences need to be considered when planning health promotion programs in college. Further research is necessary in order to draw consensus on roles of the related factors of health promotion behavior.

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Development of a High-Resolution Multi-Locus Microsatellite Typing Method for Colletotrichum gloeosporioides

  • Mehta, Nikita;Hagen, Ferry;Aamir, Sadaf;Singh, Sanjay K.;Baghela, Abhishek
    • Mycobiology
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    • 제45권4호
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    • pp.401-408
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    • 2017
  • Colletotrichum gloeosporioides is an economically important fungal pathogen causing substantial yield losses indifferent host plants. To understand the genetic diversity and molecular epidemiology of this fungus, we have developed a novel, high-resolution multi-locus microsatellite typing (MLMT) method. Bioinformatic analysis of C. gloeosporioides unannotated genome sequence yielded eight potential microsatellite loci, of which five, CG1 $(GT)_n$, CG2 $(GT1)_n$, CG3 $(TC)_n$, CG4 $(CT)_n$, and CG5 $(CT1)_n$ were selected for further study based on their universal amplification potential, reproducibility, and repeat number polymorphism. The selected microsatellites were used to analyze 31 strains of C. gloeosporioides isolated from 20 different host plants from India. All microsatellite loci were found to be polymorphic, and the approximate fragment sizes of microsatellite loci CG1, CG2, CG3, CG4, and CG5 were in ranges of 213-241, 197-227, 231-265, 209-275, and 132-188, respectively. Among the 31 isolates, 55 different genotypes were identified. The Simpson's index of diversity (D) values for the individual locus ranged from 0.79 to 0.92, with the D value of all combined five microsatellite loci being 0.99. Microsatellite data analysis revealed that isolates from Ocimum sanctum, Capsicum annuum (chili pepper), and Mangifera indica (mango) formed distinct clusters, therefore exhibited some level of correlation between certain genotypes and host. The developed MLMT method would be a powerful tool for studying the genetic diversity and any possible genotype-host correlation in C. gloeosporioides.

한국인 중년여성과 한국계 미국인 중년여성의 건강통제위, 우울, 안녕감 및 건강증진 생활양식의 비교 연구 (Comparison of Health Locus of Control, Depression, Wellbeing, and Health Promoting Lifestyle Profile II in Middle Aged Korean and Korean-American Women)

  • 이은희;소애영;이경숙
    • 여성건강간호학회지
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    • 제16권2호
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    • pp.157-165
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    • 2010
  • Purpose: The purpose of this study was to identify differences in Health Locus of Control (HLOC), depression, wellbeing, and Health Promoting Lifestyle Profile II (HPLP) between middle aged Korean and Korean-American women. Methods: Data from 80 Korean-American women living in Los Angeles, USA and 82 Korean women living in W-city, Korea, were collected using a self administered questionnaire including items on HLOC, HPLP, a Wellbeing Index and Major Depression Inventory. Results: There were statistically significant differences between the middle aged Koreans and Korean-Americans on mean age, education, religion, and current health insurance. Significant differences were found on HLOC (F= 2.504, p=.033) and Wellbeing (F=2.451, p=.036). The results also showed significant differences on HPLP (total HPLP, F=4.655, p=.001; physical activity, F=2.967, p=.014; nutrition, F=4.250, p=.001; spiritual growth, F=4.398, p=.001; interpersonal relations, F=2.648, p=.025; and stress management, F=5.201, p<.001) using ANCOVA. However, there were no significant differences on depression, or health responsibility in HPLP between the groups. Conclusion: Understanding middle aged women's health adjustments based on their culture will enhance the ability of health professionals to provide culturally congruent care and enable middle aged women to develop healthy lifestyles.

격리된 입지환경에서 형성된 한라산 흑오미자 자생군락의 유전변이 (Genetic Variation of Natural Populations of Schisandra nigra in Mt. Halla)

  • 이갑연;이석우;김세현;김판기;정동준;한상섭
    • 한국농림기상학회지
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    • 제3권1호
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    • pp.30-36
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    • 2001
  • 우리나라에 자생하고 있는 흑오미자 유전자원을 보존하고 육성하기 위하여, 제주도 한라산이라는 격리된 지역에 천연분포하고 있는 3개 집단을 대상으로 동위 효소분석에 의한 유전변이를 조사하였다. 1. 흑오미자 자생지 3개 집단의 4개의 동위효소에 대한 대립유전자 빈도와 분포는 6개의 유전자좌 가운데 Mdh-l과 Pgi-l을 제외한 모든 유전자좌에서 2개 이상의 대립유전자가 관측되어 Idh, Mdh-2, Mnr, Pgi-2에서 다형성을 보였다. Pgi-2를 제외한 Idh, Mdh-2, Pgi-l, Mdh-1, Mnr 유전자좌에서 동일한 대립유전자가 빈도가 가장 높은 주대립유전자로 나타났다. 2. 유전자좌당 대립유전자수(A/L)는 평균 1.7개의 값을 보였으며, 95%( $P_{95}$ ) 및 99%( $P_{99}$) 수준에서의 다형적 유전자좌의 비율은 38.9%와 50%, 평균 이형접합도의 관측치( $H_{0}$$^{./}$)와 기대치( $H_{e}$ )는 각각 0.141과 0.147로 나타났다. 흑오미자와 같이 분포구역이 매우 제한적이거나 멸종위기에 처한 식물종들은 유전변이량이 매우 적게 나타나는데 비해 흑오미자는 다소 많은 유전변이량을 보유하고 있는 것으로 나타났다. 3. 유전변이의 대부분이 집단 간 차이보다 집단내 개체간의 차이(92.6%)로 나타났으며, Wright의 F분석결과, $F_{IS}$$F_{IT}$ 값 모두 0에 가까운 값을 나타내어 흑오미자 집단이 Hardy-Weinberg 평형 상태에 근접해 있는 것으로 나타났다.다.

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Control of Age-Dependent Population Systems

  • Mimura, A.;Kubo, S.;Kunimatsu, N.
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2004년도 ICCAS
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    • pp.433-438
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    • 2004
  • In this paper, we at first describe the linear age-dependent population system. In addition, we introduce the nonlinear population system. Using these age-dependent population systems, we evaluate the stability of these age-dependent population systems and determine the optimal birth rates that realize a target distribution which relaxes an aging population. In this paper, we focus on Japan's population and we use the amount of demographic statistics of Japan in year 2000.

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