• Proceedings of the Technology Innovation Conference
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• 2006.02a
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• pp.5-20
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• 2006

An efficient and productive R&D operation is a major source of competitive advantage in today's economy, and a lot of efforts are made to raise R&D productivity. A prerequisite for making R&D more efficient and productive is to be able to measure it. Hence, a number of studies have attempted to measure R&D productivity. R&D productivity, in the previous studies, was measured with patents at the firm or industry level. However, most previous studies considered only a quantitative aspect, not a quantitative aspect of patents. In this study, various dimensions of patent quality as well as patent quantity were considered for the measurement of R&D performance. The differences in R&D performance across sectors were examined, and it was found that electrical/electronic industry shows higher R&D performance than mechanic and chemical industries. Discriminant analysis based on inputs and outputs for R&D shows' that there exist a strong discriminatory power across industries. The results of this research can provide the directions 'for the firm's R&D policy.

• Communications of the Korean Mathematical Society
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• v.19 no.4
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• pp.601-618
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• 2004

Throughout this paper, we will consider that R is a near-ring and G an R-group. We initiate the study of monogenic, strongly monogenic R-groups, 3 types of nonzero R-groups and their basic properties. At first, we investigate some properties of D.G. (R, S)-groups, faithful R-groups, monogenic R-groups, simple and R-simple R-groups. Next, we introduce modular right ideals, t-modular right ideals and 3 types of primitive near-rings. The purpose of this paper is to investigate some properties of primitive types near-rings and their characterizations.

• Communications of the Korean Mathematical Society
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• v.38 no.1
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• pp.11-19
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• 2023

Let 𝓗₀ be the set of rings R such that Nil(R) = Z(R) is a divided prime ideal of R. The concept of maximal non φ-chained subrings is a generalization of maximal non valuation subrings from domains to rings in 𝓗₀. This generalization was introduced in [20] where the authors proved that if R ∈ 𝓗₀ is an integrally closed ring with finite Krull dimension, then R is a maximal non φ-chained subring of T(R) if and only if R is not local and |[R, T(R)]| = dim(R) + 3. This motivates us to investigate the other natural numbers n for which R is a maximal non φ-chained subring of some overring S. The existence of such an overring S of R is shown for 3 ≤ n ≤ 6, and no such overring exists for n = 7.

• Management & Information Systems Review
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• v.28 no.4
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• pp.109-129
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• 2009

This study aims at investigating the effectiveness of SME's R&D system empirically. Specifically, this study analyze the relationships among R&D inputs(R&D investment, R&D human resource management), process(R&D planning, external network, internal cooperation), and output(technological innovation). A questionnaire was developed to measure the above variables. To test these relations, data were collected from the small and medium-sized IT firms located in Daegu-Kyungbuk region. The survey data of 154 firms were integrated as the empirical base for testing the relations. Most respondents were from the managers. Structural equation modeling analyses were used to examine the relations. Major results are as follows: Firstly, R&D HRM was positively and significantly influenced on the R&D planning. Secondly, R&D planning was positively and significantly affected on the external network, internal cooperation, and technological innovation. Thirdly, the both relations between R&D investment and R&D planning, and external network and technological innovation were not significant statistically. These results suggest the following implications. First, R&D human resource management is very important for IT SMEs. Secondly, internal cooperation mediates R&D inputs and technological innovation by approaching the other department's unique resources and by sharing the cost of new resource development. Several future researches need to overcome the limitations of this research. First, this study's sample was based on the small and medium-sized IT firms just located in Daegu-Kyungbuk region. This limitation may imply that empirical results can not represent overall small and medium-sized firm's situations. Therefore, future research needs to include different samples. Secondly, this study depends on the latitudinal study.

• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.

• Clinical and Experimental Pediatrics
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• v.58 no.5
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• pp.165-171
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• 2015

Purpose: To analyze the correlation between serum alanine aminotransferase (ALT) and obesity indices including body mass index (BMI), body fat percentage (BFP), total fat mass (FM), truncal fat mass (TFM), waist circumference (WC), and waist-to-height ratio (WHtR) in Korean adolescents. Methods: This was a cross-sectional study based on data derived from the 2010-2011 Korean National Health and Nutrition Examination Surveys (KNHANES). Subjects were Korean adolescents aged 10-18 years (871 total; 475 boys and 396 girls) who participated in KNHANES. Results: In both sexes, BMI, FM, TFM, WC, and WHtR were higher when ALT levels were in the 4th quartile. In boys, there was a significant positive correlation between ALT level and BMI, BFP, FM, TFM, WC, and WHtR (r=0.55, P<0.0001 for BMI; r=0.52, P<0.0001 for BFP; r=0.58, P<0.0001 for FM; r=0.61, P<0.0001 for TFM; and r=0.56, P<0.0001 for WC; r=0.62, P<0.0001 for WHtR), and the correlation coefficient was higher than that in girls. Conclusion: Our results suggest a significant positive association between serum ALT level and obesity indices in male adolescents.

• Journal of Microbiology and Biotechnology
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• v.31 no.7
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• pp.921-932
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• 2021

LINC01272 is a long non-coding RNA (lncRNA) that has been considered as a biomarker for many diseases including lung squamous cell carcinoma. Here, we investigated the function and mechanism of LINC01272 on lung cancer (LC). The differential expression of LINC01272 in LC and normal samples was analyzed by GEPIA based on the data from TCGA-LUAD database, as survival prognosis was analyzed through Kaplan-Meier Plotter. LINC01272 overexpression plasmid and miR-7-5p mimic were transfected into A549 and PC-9 cells. LINC01272, miR-7-5p and cardiolipin synthase 1 (CRLS1) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction. Cell viability was detected through MTT assay. Cell multiplication was evaluated by cell formation assay. Cell apoptosis was assessed through flow cytometry assay. Through bioinformatics, the target miRNA of LINC01272 and downstream genes of miR-7-5p were predicted. The targeting relationship was tested by dual luciferase reporter analysis. CRLS1, B-cell lymphoma-2 (Bcl-2), BCL2-associated X (Bax) and cleaved caspase-3 protein levels were detected through western blot. LINC01272 was downregulated in LC and low LINC01272 expression had poor prognosis. In A549 and PC-9 cells, LINC01272 inhibited cell viability and multiplication and induced apoptosis. LINC01272 negatively regulated miR-7-5p and CRLS1 was a target of miR-7-5p. MiR-7-5p reversed the effect of LINC01272 on viability, multiplication, apoptosis and expression of miR-7-5p and CRLS1 as well as apoptosis-related factors (Bcl-2, Bax and cleaved caspase-3). LINC01272 suppressed cell multiplication and induced apoptosis via regulating the miR-7-5p/CRLS1 axis in LC.

• IE interfaces
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• v.24 no.4
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• pp.314-322
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• 2011

This study analyzes a relationship between Data Envelopment Analysis(DEA) efficiency scores and a normalization index in order to examine the validity of DEA models. A normalization index concerned in this study is 'sales per R&D project fund' which is regarded as a crucial R&D project performance evaluation index in practice. For this correlation analysis, three distinct DEA models are selected such as DEA basic model, DEA/AR-I revised model(i.e. DEA basic model with Acceptance Region Type I constraints) and Super-Efficiency(SE) model. Especially, SE model is adopted where efficient R&D projects(i.e. Decision Making Units, DMU's) with DEA efficiency score of unity from DEA basic model can be further differentiated in ranks. Considering the non-normality and outliers, two rank correlation coefficients such as Spearman's ${\rho}_s$ and Kendall's ${\tau}_B$ are investigated in addition to Pearson's ${\gamma}$. With an up-to-date empirical massive dataset of n = 482 R&D projects associated with R&D Loan Program of Korea Information Communication Promotion Fund in the year of 2011, statistically significant (+) correlations are verified between the normalization index and every model's DEA efficiency scores with all three correlation coefficients. Especially, the congruence verified in this empirical analysis can be a useful reference for enhancing the practitioner's acceptability onto DEA efficiency scores as a real-world R&D project performance evaluation index.

• International Area Studies Review
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• v.13 no.1
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• pp.309-340
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• 2009

Multinational Corporations (MNCs) are increasingly establishing globally-distributed R&D (Research and Development) centers in which sites around the world work collaboratively to develop new manufacturing and product technologies. Following new globalization strategies, these projects more often include sites in Emerging/Newly Industrializing Economies (E/NIEs). The success of these ventures promises to be increasingly important both for the bottom line of MNCs and for the development ambitions of E/NIEs. This study attempts to identify these trends and to compare R&D transfer between Korea and China. The study identifies specific factors on MNC's R&D transfer and compares those operating factors between the R&D centers in Korea and China, which attract many MNCs in the world. Among those eight dimensions relating to MNCs' operation, there are significant differences in site selection, market characteristics, government support, and R&D networking between Korea and China. The analysis show more positive factors on China than Korea regarding R&D operations. The result will be helpful for both MNC's managers and governments' decision makers with respect to R&D transfer.

• Journal of the Korean Mathematical Society
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• v.49 no.4
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• pp.687-701
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• 2012

Let $R$ be a ring and $nil(R)$ the set of all nilpotent elements of $R$. For a subset $X$ of a ring $R$, we define $N_R(X)=\{a{\in}R{\mid}xa{\in}nil(R)$ for all $x{\in}X$}, which is called a weak annihilator of $X$ in $R$. $A$ ring $R$ is called weak zip provided that for any subset $X$ of $R$, if $N_R(Y){\subseteq}nil(R)$, then there exists a finite subset $Y{\subseteq}X$ such that $N_R(Y){\subseteq}nil(R)$, and a ring $R$ is called weak symmetric if $abc{\in}nil(R){\Rightarrow}acb{\in}nil(R)$ for all a, b, $c{\in}R$. It is shown that a generalized power series ring $[[R^{S,{\leq}}]]$ is weak zip (resp. weak symmetric) if and only if $R$ is weak zip (resp. weak symmetric) under some additional conditions. Also we describe all weak associated primes of the generalized power series ring $[[R^{S,{\leq}}]]$ in terms of all weak associated primes of $R$ in a very straightforward way.