• Quality Improvement in Health Care
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• v.6 no.1_2
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• pp.80-91
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• 1999

Background : With the CQI concepts, which emphasize doing the right things right the first time, we tried to enhance the timely completion of medical records by changing the review process from retrospective method to concurrent one. Methods : Against the current retrospective QA activity, Medical record administrator did the concurrent QA of the inpatient medical records with the deficiency sheets. One general surgery ward was chosen as a trial one. The deficiency rate of the medical records of the discharged patients was compared before and after the enforcement of the system. Job analysis of the medical record departments was done about four tertiary care hospitals located in Seoul to estimate the cost and the time consumed by current system. Results : There was a little improvement in the completion rate of the medical records after the trial. The new system was effective. And job analysis showed that much money and time were wasted by current retrospective feedback system. Conclusion : Though the result was not so satisfactory, it should be considered that this test was a voluntary one and the interns and residents were not forced to complete the medical records during this trial period. If there be any strong motivation to complete the medical record in time, this system is sure to be succeed. As the DRG system requires the concurrent review of the medical records to confirm severity of the patient's illness and to assure the timely discharge, it is desirable to enforce this method with the DRG system together. DRG coding and reducing deficiency rate of the medical records can be accomplished simultaneously.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.9
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• pp.5790-5795
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• 2014

Elliptic curve cryptography (ECC) is an extremely important part of information protection systems because it has outstanding safety among public key encryption algorithms. On the other hand, as ECC cannot obtain accurate values using a real number field because of the slow calculation and errors from rounding off, studies of ECC have focused on a finite field. If ECC can be extended to the real number field, more diverse keys can be selected compared to ECC only based on a finite field. Accordingly, in this paper, a method for constructing a cryptographic system with a high degree of safety is proposed through the diversification of keys selected by the user based on the operant extension method instead of extracting keys only using integer values.

• Structural Engineering and Mechanics
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• v.68 no.3
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• pp.335-344
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• 2018

The execution of an experiment is a complex affair. It includes the preparation of test specimens, the measurement process itself and also the evaluation of the experiment as such. Financial requirements can differ significantly. In contrast, the cost of numerical simulations can be negligible, but what is the credibility of a simulated experiment? Discussions frequently arise concerning the methodology used in simulations, and particularly over the geometric model used. Simplification, rounding or the complete omission of details are frequent reasons for differences that occur between simulation results and the results of executed experiments. However, the creation of a very complex geometry, perhaps all the way down to the resolution of the very structure of the material, can be complicated. The subject of the article is therefore a means of creating the material structure of concrete contained in a test specimen. Because a complex approach is taken right from the very start of the numerical simulation, maximum agreement with experimental results can be achieved. With regard to the automation of the process described, countless material structures can be generated and randomly produced samples simulated in this way. Subsequently, a certain degree of randomness can be observed in the results obtained, e.g., the shape of the failure - just as is the case with experiments. The first part of the article presents a description of a complex approach to the creation of a geometry representing real concrete test specimens. The second part presents a practical application in which the numerical simulation of the compressive testing of concrete is executed using the generated geometry.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.26-39
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• 2006

Objective : The effect of water extract of Chungjogupae-tang (CJGPT) was investigated on the growth of human lung carcinoma A549 cells. Methods : MTT assay and fluorescent microscope performed to compare and examine the efficacy of CJGPT treatment on the cytostaticity of lung cancer cells in proportion to time and doses, and DAPI staining and Western blot analysis were used to examine their effect on apoptosis. In addition the quantitative RT-PCR was used to examine to lung cancer cells growth and Progtaglandin E2 and Telomerase activity were measured Results : Exposure of A549 cells to CJGPT resulted in the growth inhibition and apoptosis in a dose-dependent manner as measured by MTT assay and fluorescent microscope. The antiuoliferative effect by CJGPT treatment in A549 cells was associated with morphological changes such as membrane shrinking and cell rounding up. CJGPT treatment resulted in an up-regulation of cyclin-dependent kinase inhibitor p21(WAF1/CIPl) in a p53-independent fashion. We found that CJGPT treatment decreased the levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthease (iNOS) expression without significant changes in the expression of COX-1, which was correlated with a decrease in protaglandin E2 (PGE2) synthesis. CJGPT treatment also inhibited the levels of human telomerase reverse transcriptase (hTERT) and telomerase-associated protein (TEP)-1 mRNA expression, however the activity of telomerase was slightly increased by CJGPT treatment. Conclusion : These findings suggested that CJGPT-induced inhibition of human lung carcinoma A549 cell growth was connected with the induction of apoptotic cell death and the results provided important new insights into the possible molecular mechanisms of the anti-cancer activity of CJGPT.

• Journal of Veterinary Clinics
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• v.20 no.2
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• pp.150-154
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• 2003

A disease with severe diarrhea occurred in a herd of one thousand, 1-week-old piglets in Chinju, Korea, and was diagnosed as porcine epidemic diarrhea by the detection of N gene of porcine epidemic diarrhea virus (PEDV) from small intestines. A PEDV, named as Chinju99, was also isolated from the intestines after two blind-passages in Vero cells supplemented with trypsin (10 ug/ml). and the biological and physicochemical properties of the isolate were characterized. The virion was roughly spherical in shape and had spike peplomers on its outer surface. The virus exhibited cytopathic effects such as rounding degeneration at initiation of infection and syncytia formation later in Vero cells. The virus was labile to 20% ether and 5% chloroform but stable in acid with pH 4-7 at $4^{\circ}C$. The infectivity of the virus was maintained at $50^{\circ}C$ for 180 min, and the buoyant density of the virus in sucrose was 1.180 g/ml. All biological and physicochemical properties of the virus were typical features of coronaviruses.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.6
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• pp.511-518
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• 2001

The effect of mycolactone, a recently reported apoptosis-inducing factor, was investigated in SCC15 oral squamous cell carcinoma(OSCC) cell line. Mycolactone rapidly induced cell death in OSCC cells in 2days, which was similar to that found in apoptotic cell such as detaching from culture plate and rounding-up of cells. Apoptotic cells were increased 4hrs after mycolactone treatment and more than half of cells showed apoptosis after 72hrs. Caspase 3 activation a biochemical evidence of apoptosis, was determined by Western blotting. Caspase 3 activation was started at 2hrs that lasted until 8hrs after mycolactone treatment. The expression of bcl-2 family genes was determined to explain the mechanism of apoptosis found in OSCC cells. The expressions of bad, bak, and bax (pro-apoptotic genes) and bcl-w and bcl-2 genes (anti-apoptotic genes) were not changed by mycolactone treatment. The expression of bcl-xi was decreased 8 hrs after mycolactone treatment. Mcl-1 expression was initially increased at 2 hrs which was decreased 8 hrs after mycolactone treatment. The down-regulation of these two anti-apoptotic genes might explain the mycolactone-induced apoptosis in OSCC cells. In this study, mycholactone was revealed to induce cell death in OSCC cells apoptosis and the apoptosis mechanism of OSCC cells was shown to be down-regulation of anti-apoptotic genes, bcl-xi and mcl-1. These results suggested the applicability of mycolactone for the development of an anti-cancer drug candidate by inducing apoptosis of OSCC cancer cell.

• Journal of the Korean Geotechnical Society
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• v.32 no.8
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• pp.47-59
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• 2016

Rocking behavior of shallow foundation reduces the superstructure load during earthquake. However, because of deficiency of understanding of rocking mechanism and soil permanent deformation, it has not been applied to real construction. In this study, slow cyclic tests were conducted for embedded shallow foundations with various slenderness ratio via centrifuge tests. From the variation of earth pressure 'soil rounding surface' phenomenon which makes maximum overturning moment equal to ultimate moment capacity was observed. Rocking and sliding behavior mechanism was evaluated. Also, nonlinear behavior and energy dissipation increase as rotation angle increases. And ultimate moment capacity of embedded foundation is larger than that of surface foundation. Finally, adequate ultimate moment capacity can be suggested for seismic design through this study.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.39 no.7
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• pp.66-73
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• 2002

As floating-point operations become widely used in various applications such as computer graphics and high-definition DSP, the needs for fast division become increased. However, conventional floating-point dividers occupy a large hardware area, and bring bottle-becks to the entire floating-point operations. In this paper, a high-performance and small-area floating-point divider, which is suitable for embedded processors, is designed using he series expansion algorithm. The algorithm is selected to utilize two MAC(Multiply-ACcumulate) units for quadratic convergence to the correct quotient. The two MAC units for SIMD-DSP features are shared and the additional area for the division only is very small. The proposed divider supports all rounding modes defined by IEEE 754 standard, and error estimations are performed for appropriate precision.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1177-1183
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• 2002

We investigated the effects of Sabaek-san (SBS) water extract on the cell proliferation of human lung carcinoma A549 cells. SBS treatment resulted in the inhibition of cell proliferation in a concentration-dependent manner. This anti-proliferative effect of A549 cells by SBS treatment was associated with morphological changes such as membrane shrinking and cell rounding up. DNA flow cytometric histograms showed that population of G1 phase of the cell cycle was increased by SBS treatment in a concentration-dependent manner. SBS treatment induced a marked accumulation of tumor suppressor p53 and a concomitant induction of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP, which appears to be transcriptionally upregulated and is p53 dependent. In addition, SBS treatment resulted in down-regulation of cyclooxygenase-2 (COX-2) as determined by RT-PCR analysis. The present results indicated that SBS-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1/S progression the induction of apoptosis.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.13 no.2
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• pp.64-72
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• 2014

In the past, prism patterns have been linear triangular shapeswith a $90^{\circ}$ angle; however, new micro prism patterns having acute angles or obtuse angles have recently been the subject of demandin the display, lighting and photovoltaic industries. Micro-cutting experiments for micro-prism patterns having $60^{\circ}$, $90^{\circ}$, and $120^{\circ}$ angles on an electroplated Ni mold were performed and it was found in this study that the specific cutting resistance increased with a decrease in the tool angles (prism pattern angles). The cause of this variation had been thought to be the increase of the ploughing force due to tip rounding and the friction force due to the edge effect. However, the depth of the cut was large enough that it was possible to neglect these effects. Therefore, this study introduced the concept of representative stress of indentation. The measured stress was varied according to the indentation depth eventhoughthetestedspecimenswereidentical ; the varied stress was termed the representative stress. According to indentation theory, the strain that the Ni mold experienced increased with a decrease in the tool angle. Based on the stress-strain relationship, higher strain means higher stress and higher specific cutting resistance. Therefore, the specific cutting resistance was higher at smaller tool angles that had higher strain and stress.