• Journal of the Korean Statistical Society
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• v.34 no.2
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• pp.153-160
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• 2005

In this paper, modified second order slope rotatable designs are introduced and modified slope rotatable central composite designs (SRCCD) are constructed for $2 {\le} v {\le} 17$ (v: the number of factors). Further, it can be shown for certain values of 'v', the modified SRCCD can be viewed as SRCCD constructed as with the technique of augmentation of second order rotatable design (SORD) using central composite design to SRCCD. These designs are useful in parts to estimate responses and slopes with spherical variance functions.

• Journal of the Korean Statistical Society
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• v.35 no.2
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• pp.179-192
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• 2006

In this paper, a new method of modified second order slope rotatable designs (SOSRD) using balanced incomplete block designs (BIBD) for $4{\le}v{\le}16$ is presented. In this method the number of design points required is in some cases less than the number required in Victorbabu (2305) modified slope rotatable central composite designs. Further, a new method of construction of three level modified SOSRD using BIBD is presented. The modified SOSRD can be viewed as SOSRD constructed with the technique of augmentation of second order rotatable design (SORD) using BIBD to SOSRD. These designs are useful in parts to estimate responses and slopes with spherical variance functions.

• Journal of the Korean Statistical Society
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• v.31 no.2
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• pp.153-161
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• 2002

A new method of construction of second order slope rotatable designs (SOSRD) using symmetrical unequal block arrangements (SUBA) with two unequal block sizes is suggested. The proposed method may sometimes lead to designs with less number of design points than those available in the literature. Further, bounds for the parameters of SOSRD are also obtained.

• Communications for Statistical Applications and Methods
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• v.11 no.1
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• pp.121-137
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• 2004

Kim(2002) proposed a second type of central composite design (CCD2), in which the positions of the axial points are indicated by two numbers. In this paper, we study properties of CCD2 when we are interested in estimating the slope of a response surface. Conditions are obtained for CCD2 to be slope-rotatable over axial directions, and some CCD2's are presented that have slope rotatability over axial directions. Also values of a measure of slope rotatability over axial directions are tabulated for various CCD2's. Finally, it is shown that CCD2 is always slope-rotatable over all directions.

• Food Science and Biotechnology
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• v.16 no.1
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• pp.159-162
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• 2007

Optimization of the fermentation medium for phenylethyl alcohol (PEA) production by Pichia anomala SKM-T was performed. The carbon source (glucose), nitrogen source (L-phenylalanine), and initial pH value were independent variables of the optimized medium. The central composite rotatable design was used for the experimental design and the analysis of the results. The optimum medium composition for the maximal production (621.27 mg/L) of PEA was found to be an initial pH of 5.03, and concentrations of L-phenylalanine at 6.53 and glucose at 6.11 g/L (w/v). This experimental finding is in close agreement with the model prediction (702.79 mg/L; desirability 0.884) with an 11.6% difference.

• Communications for Statistical Applications and Methods
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• v.9 no.3
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• pp.595-605
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• 2002

The central composite design is widely used for estimating second order response surfaces. This type of design is composed of $2^k$ factorial points, axial points and center points. In this paper, we suggest a version of central composite design where the positions of the axial points are indicated by two numbers, and study properties of this design. We obtain the variances and covariances of the estimators of the regression coefficients. Conditions are obtained for this design to be orthogonal and rotatable. This design is compared with other designs on the basis of efficiency.

• Journal of the Korean Statistical Society
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• v.36 no.3
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• pp.373-386
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• 2007

In this paper, a review on second order slope rotatable designs (SOSRD) is studied. Further, different methods of constructions of SOSRD like slope rotatable central composite designs (SRCCD), SOSRD using balanced incomplete block designs (BIBD), SOSRD using pairwise balanced designs (PBD), SOSRD using partially balanced incomplete block type designs (PBIBD) and SOSRD using symmetrical unequal block arrangements (SUBA) with two unequal block sizes are examined in detail. A table is provided where for a range of different values of v (v stands for number of factors) the design points needed by different methods are compared. The optimum SOSRD with minimum number of design points for each factor is suggested for $2{\leq}v{\leq}16$.

• Applied Chemistry for Engineering
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• v.26 no.6
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• pp.730-736
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• 2015

Cyclotrimethylene trinitramine (RDX) is a high explosive commonly used for military applications. Submicronization of RDX particles has been a critical issue in order to alleviate the unintended and accidental stimuli toward safer and more powerful performances. The purpose of this study is to optimize experimental variables for drowning-out crystallization applied to produce submicron RDX particles. Effects of RDX concentration, anti-solvent temperature and anti-solvent mass were analyzed by the central composite rotatable design. The adjusted determination coefficient of regression model was calculated to be 0.9984 having the p-value less than 0.01. Response surface plots based on the central composite rotatable design determined the optimum conditions such as RDX concentration of 3 wt%, anti-solvent temperature of $0.2^{\circ}C$ and anti-solvent mass of 266 g. The optimum and experimental diameters of RDX particles were measured to be $0.53{\mu}m$ and $0.53{\mu}m$, respectively. The regression model satisfactorily predicts the average diameter of RDX particles prepared by drowning-out crystallization. Structure of RDX crystals was found to be ${\alpha}$-form by X-ray diffraction analysis and FT-IR spectroscopy.

• Journal of Korean Society for Quality Management
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• v.47 no.3
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• pp.523-535
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• 2019

Purpose: We research on the efficient response surface methodology(RSM) design to develop a design space in Quality by Design(QbD). We propose practical designs for the successful construction of the design space in QbD by allowing different number of replicates at the box points, star points, and the center point in the rotatable central composite design(CCD). Methods: The fraction of design space(FDS) plot is used to compare designs efficiency. The FDS plot shows the fraction of the design space over which the relative standard error of predicted mean response lies below a given value. We search for practical designs whose minimal half-width of the tolerance interval per a standard deviation is less than 4.5 at 0.8 fraction of the design space. Results: The practical designs for the number of factors between two and five are listed. One of the designs in the list could be chosen depending on the experimental budget restriction. Conclusion: The designs with box points replications are more efficient than those with the star points replication. The sequential method to establish a design space is illustrated with the simulated data based on the two examples in RSM.

• Preventive Nutrition and Food Science
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• v.14 no.4
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• pp.323-328
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• 2009

Cryotin F could be used for hydrolyzing shrimp byproducts into bioactive ingredients, which could be used as value-added products. The objective of this study was to investigate the optimum condition for antioxidative activities of the enzymatic hydrolysate produced with Cryotin F using response surface methodology with central composite rotatable design. Shrimp byproducts (shells and heads) were hydrolyzed with Cryotin F. The experimental ranges of the independent variables for 20 experimental runs were 28.2-61.8${^{\circ}C}$ reaction temperature, pH 6-10 and 0.5-5.5% enzyme concentration. The degree of hydrolysis for the reaction products was measured. Their antioxidative activities were measured using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity and Fe-chelating activity. The experimental method with central composite rotatable design was well designed to investigate the optimum condition for biofunctional ingredients with antioxidative activities using Cryotin F because of their high R2 values of 0.97 and 0.95 for DPPH-scavenging activity and Fe-chelating activity, respectively. Change in enzyme concentration did not significantly affect their antioxidative activities (p<0.05). Both DPPH scavenging activity and chelating activity against Fe for the enzyme hydrolysates were more affected by the pH of enzyme hydrolysis than by their action temperature. DPPH-scavenging activity was higher at acidic pH than alkali pH, while chelating activity against Few was inversely affected. Hydrolysate of shrimp byproducts showed high antioxidative activities depending on the treatment condition, so the optimum treatment of enzymatic hydrolysate with Cryotin F and other proteases can be applied to shrimp byproducts (shells) and other protein sources for biofunctional ingredients.