• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.2066-2072
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• 2008

The time reversal was investigated for direct root between PZT and PZT, but in case of a circular PZT, lamb wave moves not only along the direct root but also another roots. The center frequency of lamb wave is kept when the lamb waves are reflected from damage. This paper presents experimental and theoretical results for the new structural health monitoring method by above features of lamb wave, and we can increase accuracy of the new structural health monitoring method by using STFT(Short Time Fourier Transform).

• 생약학회지
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• 제42권2호
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• pp.175-181
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• 2011

Oxidative stress or accumulation of reactive oxygen species (ROS) leads neuronal cellular death and dysfunction, and it contributes to neuronal degenerative disease such as Alzheimer's disease, Parkinson's disease and stroke. Glutamate is one of the major excitatory neurotransmitter in the central nervous system (CNS). Glutamate contributes to fast synaptic transmission, neuronal plasticity, outgrowth and survival, behavior, learning and memory. In spite of these physiological functions, high concentration of glutamate causes neuronal cell damage, acute insults and chronic neuronal neurodegenerative diseases. Heme oxygenase-1 (HO-1) enzyme plays an important role of cellular antioxidant system against oxidant injury. NNMBS020, the water-insoluble fraction of the 70% EtOH extract of root barks of Dictamnus dasycarpus, showed dominant neuroprotective effects on glutamate-induced neurotoxicity in mouse hippocampal HT22 cells by induced the expression of HO-1 and increased HO activity. In mouse hippocampal HT22 cells, NNMBS020 makes the nuclear accumulation of Nrf2 and stimulates extracellular signal-regulated kinase (ERK) pathway. The ERK MAPK pathway inhibitor significantly reduced NNMBS020-induced HO-1 expression, whereas the JNK and p38 inhibitors did not. In conclusion, the water-insoluble fraction of the 70% EtOH extract of root barks of D. dasycarpus (NNMBS020) significantly protect glutamate-induced oxidative damage by induction of HO-1 via Nrf2 and ERK pathway in mouse hippocampal HT22 cells.

• 한국자원식물학회지
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• 제32권6호
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• pp.714-722
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• 2019

Oxidative DNA damage negatively affects humans and the research is currently ongoing to find ways to reduce oxidative stress. Oxidative stress has been identified as a key factor in triggering various diseases. Thus, its alleviation is important for human health. Broussonetia kazinoki (B. kazinoki) has been used in traditional Korean medicine as a dermatological therapy to treat burns, pruritus, and acne. B. kazinoki is generally segregated into peeled root (PR), root bark (RB), peeled stem (PS), and stem bark (SB). To assess these components for their antioxidant activity and protection against DNA damage, their ethyl acetate fractions were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay. As a result of confirming the expression of factors involved in attenuating DNA damage, the protective effect of SB on oxidative stress suppressed the expression of p-p53 and γ-H2AX. Additionally, the levels of p53 and H2AX mRNA were significantly downregulated. In conclusion, these results indicated that the SB component of B. kazinoki had the potential to be used as an effective natural antioxidant compared to the other parts of the plant.

• 대한본초학회지
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• 제27권6호
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• pp.7-13
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• 2012

Objectives : Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods : Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and $Fe^{2+}$ chelating assay. Anti-oxidative effect of PL was evaluated by ${\varphi}X$-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results : PL had a dose-dependent hydroxyl radical scavenging and $Fe^{2+}$ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system. Conclusion : Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.

• Molecules and Cells
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• 제44권11호
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• pp.830-842
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• 2021

When perceiving microbe-associated molecular patterns (MAMPs) or plant-derived damage-associated molecular patterns (DAMPs), plants alter their root growth and development by displaying a reduction in the root length and the formation of root hairs and lateral roots. The exogenous application of a MAMP peptide, flg22, was shown to affect root growth by suppressing meristem activity. In addition to MAMPs, the DAMP peptide PEP1 suppresses root growth while also promoting root hair formation. However, the question of whether and how these elicitor peptides affect the development of the vascular system in the root has not been explored. The cellular receptors of PEP1, PEPR1 and PEPR2 are highly expressed in the root vascular system, while the receptors of flg22 (FLS2) and elf18 (EFR) are not. Consistent with the expression patterns of PEP1 receptors, we found that exogenously applied PEP1 has a strong impact on the division of stele cells, leading to a reduction of these cells. We also observed the alteration in the number and organization of cells that differentiate into xylem vessels. These PEP1-mediated developmental changes appear to be linked to the blockage of symplastic connections triggered by PEP1. PEP1 dramatically disrupts the symplastic movement of free green fluorescence protein (GFP) from phloem sieve elements to neighboring cells in the root meristem, leading to the deposition of a high level of callose between cells. Taken together, our first survey of PEP1-mediated vascular tissue development provides new insights into the PEP1 function as a regulator of cellular reprogramming in the Arabidopsis root vascular system.

• Structural Monitoring and Maintenance
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• 제2권2호
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• pp.165-180
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• 2015

In this paper lead zirconate titanate transducers (PZT) are employed for damage detection of four reinforced concrete (RC) column specimens retrofitted with carbon fiber reinforced polymer (CFRP) jackets. A major disadvantage of FRP jacketing in RC members is the inability to inspect visually if the concrete substrate is damaged and in such case to estimate the extent of damage. The parameter measured during uniaxial compression tests at random times for known strain values is the real part of the complex number of the Electromechanical Admittance (Conductance) of the sensors, obtained by a PXI platform. The transducers are placed in specific positions along the height of the columns for detecting the damage in different positions and carrying out conclusions for the variation of the Conductance in relation to the position the failure occurred. The quantification of the damage at the concrete substrate is achieved with the use of the root-mean-square-deviation (RMSD) index, which is evaluated for the corresponding strain values. The experimental results provide evidence that PZT transducers are sensitive to damage detection from an early stage of the experiment and that the use of PZT sensors for monitoring and detecting the damage of FRP-retrofitted reinforced concrete members, by using the Electromechanical Admittance (EMA) approach, can be a highly promising method.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2004년도 봄 학술발표회 논문집
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• pp.373-380
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• 2004

This paper presents the feasibility of an impedance-based damage detection technique using piezoelectric (PZT) transducers for civil infrastructures such as steel bridges. The impedance-based damage detection method is based on monitoring the changes in the electrical impedance. Those changes in the electrical impedance are due to the electro-mechanical coupling property of the piezoelectric material and structure. An effective integrated structural health monitoring system must include a statistical process of damage detection that is automated and real time assessment of damage in the structure. Once measured, damage sensitive features from this impedance change can be statistically quantified for various damage cases. The results of the experimental study on three kinds of structural members show that cracks or loosened bolts/nuts near the PZT sensors may be effectively detected by monitoring the shifts of the resonant frequencies. The root mean square (RMS) deviations of impedance functions between before and after damages were also considered as a damage indicator. The subsequent statistical methods using the impedance signature of the PZT sensors were investigated.

• Smart Structures and Systems
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• 제31권6호
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• pp.561-571
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• 2023

Ensuring the safety of a structure necessitates that repairs are carried out based on accurate inspections and records of damage information. Traditional methods of recording damage rely on individual paper-based documents, making it challenging for inspectors to accurately record damage locations and track chronological changes. Recent research has suggested the adoption of building information modeling (BIM) to record detailed damage information; however, localizing damages on a BIM model can be time-consuming. To overcome this limitation, this study proposes a method to automatically localize damages on a BIM model in real-time, utilizing consecutive images and measurements from an inertial measurement unit in close proximity to damages. The proposed method employs a visual-inertial odometry algorithm to estimate the camera pose, detect damages, and compute the damage location in the coordinate of a prebuilt BIM model. The feasibility and effectiveness of the proposed method were validated through an experiment conducted on a campus building. Results revealed that the proposed method successfully localized damages on the BIM model in real-time, with a root mean square error of 6.6 cm.

• 대한치과교정학회지
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• 제48권3호
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• pp.189-199
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• 2018

For patients with bimaxillary protrusion, significant retraction and intrusion of the anterior teeth are sometimes essential to improve the facial profile. However, severe root resorption of the maxillary incisors occasionally occurs after treatment because of various factors. For instance, it has been reported that approximation or invasion of the incisive canal by the anterior tooth roots during retraction may cause apical root damage. Thus, determination of the position of the maxillary incisors is key for orthodontic diagnosis and treatment planning in such cases. Cone-beam computed tomography (CBCT) may be useful for simulating the post-treatment position of the maxillary incisors and surrounding structures in order to ensure safe teeth movement. Here, we present a case of Class II malocclusion with bimaxillary protrusion, wherein apical root damage due to treatment was minimized by pretreatment evaluation of the anatomical structures and simulation of the maxillary central incisor movement using CBCT. Considerable retraction and intrusion of the maxillary incisors, which resulted in a significant improvement in the facial profile and smile, were achieved without severe root resorption. Our findings suggest that CBCT-based diagnosis and treatment simulation may facilitate safe and dynamic orthodontic tooth movement, particularly in patients requiring maximum anterior tooth retraction.

• Toxicological Research
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• 제30권1호
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• pp.45-48
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• 2014

Helicobacter pylori (H. pylori) is the most important factor of gastric disease in clinical practice. Moreover, smoking, stress and a poor diet may be additive factors for gastric damage. With these factors, increasing infection of H. pylori triggers gastritis, gastric ulcers and gastric cancer. To develop a new protective agent, we are concerned with plant-derived extract. The extract of Coptis chinensis (C. chinensis) and its constituents were investigated to assess their protective activities against gastric damage. The C. chinensis extract showed a scavenging effect against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals, inhibition of H. pylori colonization and antiulcerogenic activities in rat. In particular, palmatine derived from C. chinensis was found to be the novel protective agent. It is better than the C. chinensis extract, berberine, a well-known constituent of C. chinensis. We suggest that palmatine from the root cortex of C. chinensis may be a good candidate for the development of new pharmaceuticals to prevent gastric disease.