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http://dx.doi.org/10.5487/TR.2014.30.1.045

Inhibitory Activities of Palmatine from Coptis chinensis Against Helicobactor pylori and Gastric Damage  

Jung, Joohee (College of Pharmacy, Duksung Women's University)
Choi, Jae Sue (Division of Food Science and Biotechnology, Pukyoung National University)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Toxicological Research / v.30, no.1, 2014 , pp. 45-48 More about this Journal
Abstract
Helicobacter pylori (H. pylori) is the most important factor of gastric disease in clinical practice. Moreover, smoking, stress and a poor diet may be additive factors for gastric damage. With these factors, increasing infection of H. pylori triggers gastritis, gastric ulcers and gastric cancer. To develop a new protective agent, we are concerned with plant-derived extract. The extract of Coptis chinensis (C. chinensis) and its constituents were investigated to assess their protective activities against gastric damage. The C. chinensis extract showed a scavenging effect against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals, inhibition of H. pylori colonization and antiulcerogenic activities in rat. In particular, palmatine derived from C. chinensis was found to be the novel protective agent. It is better than the C. chinensis extract, berberine, a well-known constituent of C. chinensis. We suggest that palmatine from the root cortex of C. chinensis may be a good candidate for the development of new pharmaceuticals to prevent gastric disease.
Keywords
Coptis Chinensis; Helicobactor pylori; Gastric damage; Palmatine;
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1 Yokozawa, T., Ishida, A., Kashiwada, Y., Cho, E.J., Kim, H.Y. and Ikeshiro, Y. (2004) Coptidis Rhizoma: protective effect against peroxynitrite-induced oxidative damage and elucidation of its active components. J. Pharm. Pharmacol., 56, 547-556.   DOI
2 Zhang, Q., Piao, X.L., Piao, X.S., Lu, T., Wang, D. and Kim, S.W. (2011) Protective effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem. Toxicol., 49, 61-69.   DOI   ScienceOn
3 Bae, E.A., Han, M.J., Kim, N.J. and Kim, D.H. (1998) Anti-Helicobacter pylori activity of herbal medicines. Biol. Pharm. Bull., 21, 990-992.   DOI   ScienceOn
4 Li, B., Liu, H.R., Pan, Y.Q., Jiang, Q.S., Shang, J.C., Wan, X.H., He, B.C., Yang, J.Q. and Zhou, Q.X. (2006) Protective effects of total alkaloids from rhizoma Coptis chinensis on alcohol-induced gastric lesion in rats. Zhongguo Zhong Yao Za Zhi, 31, 51-54.
5 Jung, J., Bae, K.H. and Jeong, C.S. (2013) Anti-helicobactoer pylori and antiulcerogenic activities of the root cortex of Paeonia suffruticosa. Biol. Pharm. Bull., 36, 1535-1539.   DOI
6 Jia, Y.T., Wei, W., Ma, B., Xu, Y., Liu, W.J., Wang, Y., Lv, K.Y., Tang, H.T., Wei, D. and Xia, Z.F. (2007) Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injury. J. Immunol., 179, 7808-7819.   DOI
7 Schinella, G.R., Tournier, H.A., Prieto, J.M., Mordujovich de Buschiazzo, P. and Rios, J.L. (2002) Antioxidant activity of anti-inflammatory plant extracts. Life Sci., 70, 1023-1033.   DOI   ScienceOn
8 Jung, H.A., Yoon, N.Y., Bae, H.J., Min, B.S. and Choi, J.S. (2008) Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch. Pharm. Res., 31, 1405-1412.   과학기술학회마을   DOI   ScienceOn
9 Jung, J., Lee, J.H., Bae, K.H. and Jeong, C.S. (2011) Anti-gastric actions of eugenol and cinnamic acid isolated from Cinnamomi Ramulus. Yakugaku Zasshi, 131, 1103-1110.   DOI   ScienceOn
10 Kong, W.J., Zhao, Y.L., Xiao, X.H., Wang, J.B., Li, H.B., Li, Z.L., Jin, C. and Liu, Y. (2009) Spectrum-effect relationshios between ultra performance liquid chromatography fingerprints and anti-bacterial activities of Rhizoma coptidis. Anal. Chim. Acta, 634, 279-285.   DOI   ScienceOn
11 Jung, H.A., Min, B.S., Yokozawa, T., Lee, J.H., Kim, Y.S. and Choi, J.S. (2009) Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol. Pharm. Bull., 32, 1433-1438.   DOI   ScienceOn
12 Liu, F. and Ng, T.B. (2000) Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci., 66, 725-735.   DOI   ScienceOn
13 Kim, J.M., Jung, H.A., Choi, J.S. and Lee, N.G. (2010) Identification of anti-inflammotory target genes of Rhizoma coptidis extract in lipopolysaccaharide-stimulated RAW264.7 murine macrophage-like cells. J. Ethnopharmacol., 130, 354-362.   DOI   ScienceOn
14 Choi, Y.Y., Kim, M.H., Cho, I.H., Kim, J.H., Hong, J., Lee, T.H. and Yang, W.M. (2013) Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia. J. Ethnopharmacol., 149, 506-512.   DOI   ScienceOn
15 Malfertheiner, P., Megraud, F., O'Morain, C.A., Atherton, J., Axon, A.T., Bazzoli, F., Gensini, G.F., Gisbert, J.P., Grahan, D.Y., Rokkas, T., El-Omar, E.M. and Kuipers, E.J. (2012) The European Helicobacter Study Group. Management of Helicobacter pylori infection-the maastricht IV/Florence consensus report. Gut, 61, 646-664.   DOI   ScienceOn
16 Nash, J., Lambert, L. and Deakin, M. (1994) Histamine H2-receptor antagonists in peptic ulcer disease. Evidence for a prophylactic use. Drugs, 47, 862-871.   DOI   ScienceOn
17 Blaser, M.J. (2006) Who are we? Indigenous microbes and the ecology of human disease. EMBO Rep., 7, 956-960.   DOI   ScienceOn