• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5091-5096
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• 2012

Background: There is a large amount of evidence that the ABO blood group system may play a role in disease etiology. A relationship between ABO and Rhesus blood groups and cancer risk has been demonstrated in a number of studies. However, in relation to gynecological malignancies, these findings are inconsistent and contradictory. Aim: To perform a case-control study for analysis of the distribution of ABO and Rh blood antigens among women from South-East Siberia who suffered from ovarian, endometrial and cervical cancer, and to assess the potential role of these antigens in carcinogenesis. Design, Subjects and Methods: A total of 1,163 cases with ovarian cancer (n=551), endometrial cancer (n=440) and cervical cancer (n=172) were involved in the study. The control group was formed from 22,581 female blood donors. Blood groups were determined through patients medical records and blood donor records. Odds ratios (OR) with 95% confidence intervals (CI) were calculated. The blood group O was defined as the referent group, as it has the greatest frequency in the populations of Southern Siberia. P values less than 0.05 were regarded as statistically significant. Results: We found that carriage of non-O blood types increased the risk of ovarian cancer by 40-60%, and the magnitude of this relationship was strongest in women with the AB (IV) blood group. Carriage of the A (II) blood group strongly correlated with an increased risk of ovarian cancer in premenopausal, but not in postmenopausal women. No statistically significant correlations were obtained for endometrial cancer and cervical cancer. Additionally, we did not observe a relationship between Rhesus factor and cancer risk. Conclusion: We suggest that carriage of non-O blood groups may elevate risk of ovarian cancer and can play a role in its development.

• The Korean Journal of Applied Statistics
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• v.26 no.1
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• pp.23-36
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• 2013

In this study, we investigate how churn customers (who play a central connector or broker role) affect other customers' churn in their call networks with ego-network analysis using call data of a mobile telecom company in Korea. As a result of investigating Reciprocal Network, we found a relationship of attrition among churn customers. Churn provokers who influence other customers' attrition exist in customer churn networks. The characteristics of churn provokers is that they play a central connector and broker role in their groups. The proportion of churn provokers increases and the churn provoker's influence increases because the network is a reciprocal one.

• Parasites, Hosts and Diseases
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• v.52 no.4
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• pp.355-365
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• 2014

The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce caspase-3-dependent or -independent host cell death. Phosphorylinositol 3-kinase (PI3K) and protein kinase C (PKC) in E. histolytica play an important function in the adhesion, killing, or phagocytosis of target cells. In this study, we examined the role of amoebic PI3K and PKC in amoeba-induced apoptotic cell death in Jurkat T cells. When Jurkat T cells were incubated with E. histolytica trophozoites, phosphatidylserine (PS) externalization and DNA fragmentation in Jurkat cells were markedly increased compared to those of cells incubated with medium alone. However, when amoebae were pretreated with a PI3K inhibitor, wortmannin before being incubated with E. histolytica, E. histolytica-induced PS externalization and DNA fragmentation in Jurkat cells were significantly reduced compared to results for amoebae pretreated with DMSO. In addition, pretreatment of amoebae with a PKC inhibitor, staurosporine strongly inhibited Jurkat T cell death. However, E. histolytica-induced cleavage of caspase-3, -6, and -7 were not inhibited by pretreatment of amoebae with wortmannin or staurosporin. In addition, we found that amoebic PI3K and PKC have an important role on amoeba adhesion to host compartment. These results suggest that amebic PI3K and PKC activation may play an important role in caspase-independent cell death in Entamoeba-induced apoptosis.

• Journal of Families and Better Life
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• v.31 no.2
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• pp.25-39
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• 2013

The main purpose of this study was to examine the relationship among co-parenting, maternal parenting stress, and preschoolers' anxiety and hyperactivity with a sample of 155 mothers with 3 to 4 year old children (83 boys and 72 girls) living in Seoul. They completed a questionnaire on co-parenting, maternal parenting stress, and preschoolers' anxiety and hyperactivity. The results were analyzed by means of correlations and regressions. Co-parenting was positively correlated with preschoolers' anxiety and hyperactivity but affectionate, integrated co-parenting was negatively correlated with preschoolers' anxiety and hyperactivity. Maternal stress of parental suffering, dysfunctional interaction, and difficult temperament were positively related to preschoolers' anxiety and hyperactivity. Conflicting co-parenting was positively correlated with maternal stress of parental suffering, but affectionate and integrated co-parenting was negatively correlated with maternal stress of parental suffering and difficult temperament. Furthermore, maternal parenting stress mediated the relationship between co-parenting and preschoolers' anxiety and hyperactivity. Especially, maternal stress of parental suffering tended to play a perfectly mediating role between conflicting and integrated co-parenting and preschoolers' anxiety, between conflicting co-parenting and preschoolers' hyperactivity. Maternal stress of difficult temperament tended to play a perfectly mediating role between integrated co-parenting and preschoolers' anxiety and between conflicting co-parenting and preschoolers' hyperactivity. These results clearly indicate that maternal parenting stress plays a crucial role in the levels of preschoolers' anxiety and hyperactivity.

• Korean Journal of Bronchoesophagology
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• v.5 no.1
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• pp.49-54
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• 1999

The etiology of inverted papilloma(IP) remains unknown, but several studies have reported that Human Papillomavirus(HPV) may play a role in the pathogensis of sinonasal inverted papilloma(IP). And recent reports demonstrate the possible etiologic role of Epstein-Barr virus (EBV) in sinonasal IP. The aim of this study is to detect HPV and EBV in sinonasal IP, to examine the relationship between HPV subtype and sinonasal IP, to investigate the relation between HPV and EBV. We reviewed 30 cases of sinonasal IP(simple IP 19 cases, IP with dysplasia 8 cases, IP with squamous cell carcinoma 3 cases). Paraffin embedded archival tissue was used in this study. Detection of HPV, EBV were examined by in situ hybridization(ISH) using HPV type 6/11, 16/18, 31/33/35 DNA probe and EBER probe. The HPV was detected in 6(20%) out of 30 cases. The HPV 6/11 was dectected in 4 out of 19 cases of simple IP, HPV 16/18 in 1, HPV 31/33/35 in 1 out of 8 cases of IP with dysplasia respectively. The EBV was not detected in 30 cases. HPV may play a role in the pathogensis of sinonasal inverted papilloma. But EBV is not a etiopathologic factor to be considered in the development of sinonasal IP.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.3
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• pp.275-281
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• 2015

Orthostatic hypotension is most common in elderly people, and its prevalence increases with age. Attenuation of the vestibulo-sympathetic reflex (VSR) is commonly associated with orthostatic hypotension. In this study, we investigated the role of glutamate on the vestibulo-solitary projection of the VSR pathway to clarify the pathophysiology of orthostatic hypotension. Blood pressure and expression of both pERK and c-Fos protein were evaluated in the nucleus tractus solitarius (NTS) after microinjection of glutamate into the medial vestibular nucleus (MVN) in conscious rats with sodium nitroprusside (SNP)-induced hypotension that received baroreceptor unloading via sinoaortic denervation (SAD). SNP-induced hypotension increased the expression of both pERK and c-Fos protein in the NTS, which was abolished by pretreatment with glutamate receptor antagonists (MK801 or CNQX) in the MVN. Microinjection of glutamate receptor agonists (NMDA or AMPA) into the MVN increased the expression of both pERK and c-Fos protein in the NTS without causing changes in blood pressure. These results indicate that both NMDA and AMPA receptors play a significant role in the vestibulo-solitary projection of the VSR pathway for maintaining blood pressure, and that glutamatergic transmission in this projection might play a key role in the pathophysiology of orthostatic hypotension.

• The Journal of the Petrological Society of Korea
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• v.18 no.3
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• pp.181-194
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• 2009

The Cheongryangsan Formation was reported to stratigraphically overlie the Gasongdong Formation and underlie the Dogyedong Formation in the northern part of the Yeongyang subbasin, and be divided into the lower Cheongryangsan Member and the Osipbong Member. But the members have more widely called as the Cheongryangsan Conglomerate and the Osipbong Basalt, because the latter have initially meant that thin basalt flows several times intercalate sedimentary rocks in the northern part but later must consider that they have a very dominant volume in the eastern one. Both formations are based on classifying the stratigraphy and play a role of an excellent key bed for stratigraphic correlation between local spaces in the subbasin dominant absolutely for reddish beds. Both formations play a role of excellent key bed in the northern and northwestern areas of the subbasin; the Osipbong Basalt, the midwestern, eastern and southern ones; the Cheongryangsan Conglomerate, the southeastern one.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.14 no.4
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• pp.11-23
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• 2011

Mountain streams, which are major components of an entire river network, play an important role as the source of water, sediment, coarse and fine organic matter, and nutrients for lowland rivers. Therefore, dynamics and downstream linkages of each compartment of the mountain stream can be essential for watershed management in catchment scale. The dynamics and downstream linkages are understood as a development of step-pool sequences along a river course. Recently, stream restoration after flooding event often employ the development of step-pool sequences in the world. In this paper, we 1) examined the geomorphic characteristics and the role of step-pool sequences in steep mountain streams by reviewing the results of past studies, and 2) introduced the case studies of stream restoration using step-pool sequences, and finally 3) addressed design methods considering geometry and stability of artificial step-pool sequences for stream restoration. Step-pool sequences play an important role not only as roughness with energy dissipation but also as heterogeneity of stream feature for aquatic habitat. Step-pool sequences, even if they are constructed artificially along a stream, may be effective for small stream restoration considering eco-friendly torrent controls. So far the artificial step-pool sequences were employed for mountainous streams, but those would be applied to urban stream.

• Journal of Korean language education
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• v.29 no.2
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• pp.73-100
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• 2018

The purpose of this study is to investigate learner-learner dialogue during speaking tasks. In the Korean language classroom, conversation between learners is an important activity as speaking practice. However, learner dialogue is also a tool to enable learners to collaboratively conduct various cognitive activities in the classroom. In previous research, it was unfolded that through learner-learner dialogue, learners can solve second-language related problems and set a goal to carry out tasks. Therefore, this study analyzed learner-learner dialogue to investigate what kinds of cognitive activities are activated during the role-play task. As a result, the learners collaboratively generated and monitored language and content for role play. Also, in order to accomplish tasks more successfully, learners shared the same understanding about the goal of the task, and tried to manage the task procedure. Through learner-learner dialogue, learners can participate in cognitive activities such as content, language construction, and task management voluntarily without the help from teachers. This means that learner-learner dialogue can be an activity to support language learning tasks. Also, it can make learners actively involved in learning and by sharing resources with each other. It is also important that learners can experience language use that participates in real-world communication activities, such as learning in the classroom and collaborating with peer learners. This study is an exploratory study for a basic understanding of learner's conversation as a cognitive activity, and the scope of the study is limited to clarifying contents of learner-learner dialogue as a cognitive activity in speaking tasks. Based on the findings of this study, future research should be conducted on the function of learner-learner dialogue as a cognitive activity in Korean language learning and its role in the classroom of Korean language education.

• International Area Studies Review
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• v.20 no.2
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• pp.235-256
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• 2016

The local governments have utilized overseas offices of businesses within their jurisdiction as a forward operating base to discover and expand the overseas market. In addition, overseas offices of businesses are expected to play a big role in economic, cultural, and personal exchange, and collection of information regarding overseas market trends. Recently, inviting foreign capital, promoting cities, and attracting foreign tourists are being done through them. Since foreign capital invitation has an effect on creating jobs, the population influx, increasing local government revenues, there is a high degree of competition for it among local governments. Also, while local governments have set out to actively attract foreign tourists through city promotion marketing and developing products in connection with their region, overseas offices of businesses are playing a major role in doing the job. However, due to low performance satisfaction against the budget invested, there have been criticisms that they need to improve efficiency. As a result, each local government is faced with a task to seek efficient operational plans since overseas offices of businesses in each local government are expected to play a bigger role in trade support and international exchanges.