• 한방안이비인후피부과학회지
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• 제30권2호
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• pp.1-18
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• 2017

Objectives : This review aims to evaluate a risk of bias by risk of bias tool and RoBANS(Risk of Bias Assessment tool for Non-randomized Study) tool for clinical trial papers proving treatment effect of Korean medicines to alopecia and provides the newest reason of effectiveness of herbs to alopecia. Methods : Data were collected through electronic database including NDSL, KISS, KMBASE, Koreantk, OASIS, KoreaMed, KISTI, Pubmed, Cochrane CENTRAL and CINAHL. Two experts in Oriental Medicine assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool and non-randomized controlled trials by RoBANS tool after searching, reviewing and selecting papers. Results : Total number of selected trials is 20 including 4 randomized controlled trial, 13 non-randomized controlled trials and 3 case reports. This study evaluate the risk of bias of 17 papers including 4 randomized controlled trials and 13 non-randomized controlled trials except 3 case reports by risk of bias tool and RoBANS tool. All papers of randomized controlled trials are evaluated unclear for random sequence generation and allocation concealment as there are no word on them. And all papers of non-randomized controlled trials are evaluated unclear for blinding of outcome assessments and relatively low for others. Conclusions : Korean medicine intervention can be an effective for treatment in alopecia. It was evaluated by hair density, thickness and expert panel assessment of photographs and all results are statistically significant. But enhancing levels of evidence, we must try to reduce bias in researches and report a safety, protocol and IRB.

• 혜화의학회지
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• 제24권1호
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• pp.25-36
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• 2015

Objective : This study aims to evaluate a risk of bias by Risk of Bias tool and RoBANS(Risk of Bias Assessment tool for Non-randomized Study) tool for clinical trial papers proving treatment effect of herbs to alopecia and provides the newest reason of effectiveness of herbs to alopecia. Methos : Data were collected through electronic database including NDSL, KISS, KMBASE, Koreantk, OASIS, KoreaMed, KISTI, Pubmd, Cochrane CENTRAL and CINAHL. Two experts in Oriental Medince assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool and non-randomized controlled trials by RoBANS tool after searching, reviewing and selecting papers. Results : Total number of selected trials is 20 including 4 randomized controlled trials, 13 non-randomized controlled trials and 3 case reports. This study evaluates the risk of bias of 17 papers including 4 randomized controlled trials and 13 non-randomized controlled trials except 3 case reports by risk of bias tool and RoBANS tool. All papers of randomized controlled trials are evaluated unclear for random sequence generation and allocation concealment as there are no word on them. And all papers of non-randomized controlled trials are evaluated unclear for blinding of outcome assessments and relatively low for others. Conclusion : We must try to specify concretely methods of allocation concealment after planning and practicing it for reducing a selection bias in randomized controlled trials. Also report a reason of missing value and blinding outcome assessments. And we have to agonize and mention methods of blinding of researchers for reducing a detection bias in non-randomized controlled trials.

• 한방안이비인후피부과학회지
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• 제30권3호
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• pp.166-181
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• 2017

Objectives : The study was done to verify the relation between early-onset androgenetic alopecia(AGA) and metabolic syndrome(MetS). Methods : Data were collected through electronic database including KoreaMed, National Assembly Library, KMBASE, NDSL, KCI, KERIS, Google Scholar, Pubmed, Cochrane CENTRAL and EBSCO MEDLINE. A total of 13 case-control studies related to the MetS of early-onset alopecia patients were used for the systematic review and meta-analysis. Risk of bias of included studies were assessed by RoBANS tool. RevMan5.3, CMA3 were used for the meta-analysis. Results : In 13 evaluated articles, most frequent bias was the participant selection bias that was found in 10 articles. Significant association between early-onset AGA and MetS was found in 10(76.9%) out of 13 articles in the systematic review. In meta-analysis, early-onset male AGA was associated with increased risk of metabolic syndrome(OR: 3.73, 95% CI:2.49 -5.61). Conclusions : AGA, particularly early -onset male AGA, is significantly associated with MetS. Therefore all patients with early onset male AGA should be suggested to take preventive treatment to reduce the risk of MetS and various problems associated with it.

• 대한통합의학회지
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• 제10권4호
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• pp.71-81
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• 2022

Purpose : This study aimed to present evidence by analyzing the characteristics and effectiveness of group art therapy interventions through an examination of domestic studies on group art therapy for older people with dementia. Methods : The database used DBpia, Riss, and Google Scholar, and the research period was from 2016 to November 2021. For the selected studies, the level of evidence was analyzed, bias evaluation was performed, and patient, intervention, comparison, and outcome were analyzed. For the evaluation of bias, the risk of bias assessment tool for non-randomized study (RoBANS) and Cochrane's risk of bias (RoB) were used. Results : As for the level of evidence of the included studies, level I consisted of five studies, and levels II and III each had one article. As a result of the bias evaluation of five studies through RoB, a "low risk of bias" was found for incomplete result data, selective result reporting, and others, except for four unclear evaluation areas. The "low risk of bias" ratio was 0~25 % in the evaluation of bias in two studies through RoBANS. For the evaluation tool, cognitive evaluation tool was used the most while mini-mental state examination-Korea was used the most frequently. For the intervention method, the most frequently used was group art therapy that employed recall in three studies, while collage, Korean painting, use of paper media, and procedural memory were used in each of the other studies. Each intervention was found to be significantly effective overall. Conclusion : This study provided clinical evidence by systematically reporting research on group art therapy for older people with dementia. In the future, it is necessary to check the effect of group art therapy on various areas other than cognition for older people with dementia. Moreover, the study should be conducted with the risk of bias sufficiently taken into consideration.

• Journal of Acupuncture Research
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• 제37권1호
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• pp.1-12
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• 2020

A total of 1,235 studies were retrieved on June 23, 2019, from 3 databases. Selected 59 studies were evaluated by year of publication, study type, subject condition/disease, acupoint, standards for reporting interventions in clinical trials of moxibustion (STRICTOM), Cochrane risk of bias (RoB), and risk of bias assessment tool for non-randomized study (RoBANS). Most studies were conducted in 2011, after which the number of studies decreased. The most common study type was 25 case reports (CR), 16 uncontrolled clinical trials (UCT), 11 randomized controlled trials (RCT), and 7 controlled clinical trials (CCT). Moxibustion treatment was mainly used for musculoskeletal and circulatory diseases/conditions. A total of 83 acupoints were used, A-shi points being the most used. As for STRICTOM, an average of 7.4 items were satisfactory for UCT and CR without a control group, and an average of 9.4 items were satisfactory for RCT and CCT. RCT was assessed using the RoB, and many items were rated as uncertain. In this study, the need for RCT of moxibustion treatment in Korea was identified. The detailed description of study methods and results will provide evidence for the efficacy of moxibustion treatment in preventive and therapeutic aspects of Korean traditional medicine.

• 한국산학기술학회논문지
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• 제21권6호
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• pp.116-126
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• 2020

본 연구의 목적은 이압요법이 60세 이상 노인의 수면장애 개선에 미치는 효과를 분석하기 위함이다. 자료수집은 국내외 컴퓨터 데이터베이스를 기반으로 하였다. 검색어는 'auricular', 'sleep', 'insomnia' 등을 조합하였다. 선정한 문헌의 비뚤림 위험평가는 RoB와 RoBANS도구를 사용하였고, 메타분석은 Cochrane Library의 RevMan 5.3 Program을 이용하였다. 총 386개의 문헌 중 7개 문헌이 선정되었다. 이압요법 중재 평균 횟수는 4.1회, 총 적용 기간은 평균 2.8주, 이압요법 1회 적용 시 유지 기간은 평균 4일이었다. 수면 장애 개선을 위해 자주 사용한 부위는 신문, 뒷머리, 심장으로 4편의 문헌에서 모두 사용되었다. 수면 정도는 총 중재 기간이 4주 미만인 문헌에서 WMD 25.66 (95% CI 20.18 to 31.14)로 대조군보다 유의하게 높았으며, 4주 이상인 문헌에서는 WMD 8.59 (95% CI 6.26 to 10.92)로 대조군보다 유의하게 높았다. 수면 만족도는 이압요법 1회 적용 시, 유지 기간이 3일 이하인 문헌에서 SMD 13.37 (95% CI 5.29 to 21.45)로 대조군보다 유의하게 높았으며, 4일 이상인 문헌에서 SMD 2.27 (95% CI 1.82 to 2.72) 대조군보다 유의하게 높았다. 이압요법은 수면 정도와 수면 만족도에 효과가 있어 노인의 수면 장애 개선에 효과가 있었다. 그럼에도 불구하고, 본 연구의 메타분석에 이용된 문헌은 모두 비 무작위 대조군 연구이며, 대조군에 아무런 조치도 취하지 않았으며, 주관적 도구만 사용하였다. 또한, 총 중재 기간, 1회 적용 시, 유지 기간에 따라 효과 크기가 다른 것으로 나타났으나, 문헌의 수가 적어 해석에 제한점이 있다.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.429-439
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• 2020

본 연구의 목적은 메타분석을 통해 가상현실 프로그램이 뇌졸중 환자의 상지기능에 미치는 효과크기를 알아보고자 한다. 데이터베이스는 한국교육학술정보원(RISS), 한국학술정보(KISS), 국립중앙도서관, 한국학술지인용색인(KCI), 국가과학기술정보센터(NDSL)를 활용하였다. 2010년 1월부터 2019년 6월까지 가상현실 프로그램을 실시한 선행연구들을 조사하였다. 본 연구는 PICO(Patient, Intervention, Comparison, Outcome, PICO)기준에 의거하여 최종 14편을 선정하여 메타분석을 실시하였다. 질 평가도구로 RCT(Randomized Control Trials) 연구는 RoB(Risk of Bias) 도구, NRCT(Non-Randomized Control Trials) 연구는 RoBANS(Risk of Bias Assessment tool for Non-randomised Study) 도구를 사용하였다. 선정된 각 연구들의 효과크기를 산출하기 위해 CMA 3.0프로그램을 사용하였다. 추가적으로 하위집단분석과 메타회귀분석 및 출판편의 분석을 실시하였다. 가상현실 프로그램이 상지기능에 대한 전체 효과크기는 Hedges's=0.390 (95 % CI: 0.192~0.587)으로 확인되었다(p<.05). 가상현실 프로그램은 뇌졸중 환자의 상지기능에 긍정적인 영향을 미친다. 따라서, 4차 산업에 발맞추어 뇌졸중 환자를 위한 다양한 가상현실 프로그램과 산학 협력 기술 개발이 요구된다. 향후 가상현실 프로그램에 대한 RCT연구들과 세부적인 상지기능에 대한 연구가 질적 및 양적으로 확보되어야 할 것이다.

• 동의신경정신과학회지
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• 제28권3호
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• pp.165-182
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• 2017

Objectives: The purpose of this systematic review was to understand clinical usefulness of Emotional Freedom Techniques (EFT) on students' mental health. Methods: Ten databases were included to extract clinical studies on effects of EFT intervention with students. Characteristics of selected studies were described, and biases were assessed with Risk of Bias (RoB) or Risk of Bias Assessment for Non-Randomized Studies (RoBANS). Results: A total of 14 clinical trials were extracted for analysis. There were 8 randomized-controlled trials (RCTs), 2 non-randomized-controlled trials (nRCTs), and 4 before-after studies. EFT have significant clinical usefulness in public speaking anxiety, test anxiety, stress, depression, learning related emotions, adolescent anxiety, and eating issues. The risk of selection bias in most studies was high or uncertain. Conclusions: EFT is an effective clinical technique for managing students' mental health issues. However, the included studies have been conducted with relatively poor quality and small sample size. Clinical trials with high quality study design and well-designed EFT education programs are needed to generalize clinical usefulness.

• 혜화의학회지
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• 제24권1호
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• pp.15-24
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• 2015

Objectives : This study was carried out to assess the risk of bias of clinical trials on acne treatment with herbal medicine that have been published in Korea. Methods : 7 electronic databases in Korea were searched for clinical trials on acne treatment. Two independent reviewers selected clinical trials on herbal medicine treatment for acne. Selected studies are categorized according to DAMI(Study Design Algorithm for Medical literature of Intervention). RCTs are assessed according to Cochrane RoB(Risk of Bias), non-randomized studies(Before-after studies) are assessed according to RoBANS(Risk of Bias Assessment tool for Non-randomized Study). Results : After selection process, 25 articles are left. Among 25 articles, 3 RCTs and 4 before-after studies are finally included. In RCTs, the proportion of 'unclear' is high in criteria of 'random sequence generation', 'allocation concealment', and 'blinding'. In before-after studies, 'high' is high in criteria of 'blinding for outcome assessment' and 'incomplete outcome data'. Conclusions : Considering the above results of the assessment, it is necessary to conduct more well designed clinical trials on acne treatment with herbal medicine.

• 인간식물환경학회지
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• 제23권2호
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• pp.125-138
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• 2020

The aim of this study was to review previous literature to determine the effects of nature-based program for workers. This systematic review was conducted in accordance with National Evidence-based Healthcare Collaborating Agency's guidance for undertaking systematic reviews for intervention. Literature search was performed using National Assembly Digital Library, Korean Studies Information Service System, and Korea Education & Research Information Service for literature published until March 2019. The participants were full-time workers, and intervention of nature-based programs was conducted in the outdoor, indoor, and indirect nature contact exposures, with comparators in the control group who did not receive the treatment. The results showed that the programs were effective in physical, psychological, and social health. The methodological quality of randomized controlled trials (RCT) was assessed using the Cochrane Risk of Bias(RoB) tool, while non-randomized controlled trials (N-RCT) were assessed using the Cochrane Risk of bias assessment tool for non-randomized studuies (RoBANS). A total of 16 studies were selected for assessment: two RCTs, 10 N-RCTs, and four one-group pretest-posttest designs. Most interventions were provided at the workplace and in the community. There were many kinds of nature-based interventions, and forest therapy and horticultural therapy programs were most common. Various interventions for workers effectively improved job stress, depression, serum cortisol and stress-response. However, the included studies lacked methodological rigor. Future research is needed to evaluate the long-term effectiveness of nature-based programs for workers using rigorous research designs.