• 문화기술의 융합
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• 제6권2호
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• pp.55-70
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• 2020

이 연구는 소규모 건설현장 구조물 공사 참여 근로자들을 대상으로 위험유발요인과 안전점검이 재해 저감 대책에 미치는 영향을 밝히고자 하였으며, 연구결과는 다음과 같다. 첫째, 위험유발요인이 인적요인에 미치는 영향에서 작업준비와 거푸집 해체, 그리고 조치 여부, 기록유지가 통계적으로 유의미한 영향을 미쳤다. 이는 안전점검은 위험유발요인이 인적요인에 미치는 영향에서 부분 매개 효과가 있음을 알 수 있었다. 둘째, 위험유발요인이 설비적요인에 미치는 영향에서 작업준비와 조치 여부가 유의미한 영향을 미쳤다. 따라서 안전점검은 위험유발요인이 설비적요인에 미치는 영향에서 부분 매개 효과가 있음을 알 수 있었다. 셋째, 위험유발요인이 관리적 요인에 미치는 영향에서 동바리설치와 위험성 평가가 유의미한 영향을 미쳤다. 따라서 안전점검은 위험유발요인이 관리적 요인에 미치는 영향에서 부분 매개 효과가 있음을 알 수 있었다. 넷째, 위험유발요인이 작업적요인에 미치는 영향에서 동바리설치에서만 유의미한 영향을 미쳤다. 따라서 안전점검은 위험유발요인이 작업적요인에 미치는 영향에서 완전매개 효과가 있음을 알 수 있었다. 마지막으로, 위험유발요인이 재해 저감 대책에 미치는 영향에서 작업준비와 동바리설치 그리고 조치 여부가 유의수준에서 유의미한 정(+)의 영향을 미쳤다. 마지막으로 기록유지는 유의수준에서 유의미한 부(-)의 영향을 미치는 것으로 나타났다. 결론적으로 안전점검은 위험유발요인이 관리적 요인에 미치는 영향에서 부분 매개 효과가 있음을 알 수 있다.

• 한국군사과학기술학회지
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• 제15권2호
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• pp.186-192
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• 2012

Noise is a major cause of hearing loss in the air base. There are lots of risk factors of hearing loss including noise, and hearing loss can be accelerated by combined effects of these risk factors. Here in, we reviewed risk factors of hearing loss, and analysed key risk factors inducing hearing loss in the air base. Risk factors exacerbating hearing loss with noise were mainly investigated in this research because noise could not be an avoidable risk factor in the air base. Analysed data will contribute to make green environment minimizing hearing loss of pilots and supporting personnels in the air base.

• 대한한의학회지
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• 제28권4호
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• pp.42-51
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• 2007

Background and Purpose : To prevent ischemic cerebral infarction, it is very important to reduce risk factors which might cause stroke. However, the relationship of coffee consumption with ischemic cerebral infarction still remains unclear. The purpose of this study was to investigate the effects of coffee consumption on the risk of ischemic cerebral infarction in Koreans. Methods : A case-control study was conducted from April 1, 2001 to July 31, 2004. Cases (n=435) of first incident ischemic cerebral infarction were enrolled and were mostly matched by age to stroke-free hospital controls (n=407). All subjects were interviewed, examined and had anthropometric measurements by using an organized questionnaire. The coffee consumption was classified by the average frequency of intake, being none, 1 cup/day, 2-4 cups/day, more than 5 cups/day. Odds ratios (ORs) of ischemic cerebral infarction were proved multivariate analysis after adjustment for demographic factors, diet factors, and vascular risk factors. Results : When adjusted for sex, age, and other factors, coffee consumption and stroke do not have a significant association. (${\leq}$ cup/day OR=1.035, 95% CI=0.880-2.756; 2-4cups/day OR=1.452, 95% CI=0.864-2.440; ${\geq}$ 5 cups/day OR=1.557, 95% CI=0.705-3.435) Conclusions : In this study, we conclude that coffee consumption is not an important risk factor of ischemic cerebral infarction in Koreans. Prospective and cohort study on the relation between coffee consumption and the possibility of inducing ischemic cerebral infarctions in Koreans will be required in the future.

• 한국조사연구학회지:조사연구
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• 제11권2호
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• pp.123-140
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• 2010

The purpose of this study is to determine the unidimensionality of Grasmick's operationalization of Gottfredson and Hirschi's criminality inducing the concept of low self-control. By applying confirmatory factor analysis procedures that incorporate advances in the application, the proposed six factor model and two alternative models were examined suggesting that Grasmick's low self-control scale actually contains 6 distinguishable factors, not a single factor. The factors identified to be consistent with the six-factor model were impulsivity, simple tasks, risk seeking, physical activities, self-centered, and temper.

• 대한한의학회지
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• 제24권4호
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• pp.19-24
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• 2003

Background and Purposes : Smoking is a well-known risk factor for ischemic stroke. It may contribute to s1Toke by inducing the aggregation of platelets and formation of atheroma, reducing cerebral blood flow, and increasing fibrinogen. However, the relative risk varies according to different ethnicity and area. Therefore, we performed this study to assess the risk of smoking for ischemic s1Toke in Korea. Methods : Cigarette smoking habit was studied in 308 patients with ischemic s1Toke and in 348 age- and sex-matched control subjects who had no history of stroke using case control methods. In multiple logistic regression analysis, smoking had a significant value of odds ratio adjusted for hypertension, diabetes mellitus, and hyperlipidemia. Results : The adjusted odds ratio (AOR) and 95％ confidence interval (CI) was significant in the medium smokers (AOR, 1.92; 95％ CI, 1.11 to 3.33: p< 0.05) and heavy smokers (AOR, 2.80; 95％ CI, 1.64 to 4.78: p< 0.05). Furthermore, the OR was higher in hypertensive subjects than in normotensive subjects compared to non-smokers (AOR, 1.98; 95％ CI, 1.01 to 3.85: p< 0.05). Conclusions : Our findings suggest that smoking is an independent risk factor for ischemic stroke in Korea.

• Journal of Microbiology and Biotechnology
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• 제27권5호
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• pp.1032-1037
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• 2017

The poly-${\gamma}$-$\small{D}$-glutamic acid (PGA) capsule, a major virulence factor of Bacillus anthracis, provides protection of the bacterium from phagocytosis and allows its unimpeded growth in the host. We investigated crosstalk between murine natural killer (NK) cells and macrophages stimulated with the PGA capsule of Bacillus licheniformis, a surrogate of the B. anthracis capsule. PGA induced interferon-gamma production from NK cells cultured with macrophages. This effect was dependent on macrophage-derived IL-12 and cell-cell contact interaction with macrophages through NK cell receptor NKG2D and its ligand RAE-1. The results showed that PGA could enhance NK cell activation by inducing IL-12 production in macrophages and a contact-dependent crosstalk with macrophages.

• Journal of Veterinary Science
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• 제24권1호
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• pp.2.1-2.14
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• 2023

Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4℃) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.

• Molecules and Cells
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• 제27권2호
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• pp.211-215
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• 2009

Toll-like receptors (TLRs) play a critical role in sensing microbial components and inducing innate immune and inflammatory responses by recognizing invading microbial pathogens. Lipopolysaccharide-induced dimerization of TLR4 is required for the activation of downstream signaling pathways including nuclear factor-kappa B ($NF-{\kappa}B$). Therefore, TLR4 dimerization may be an early regulatory event in activating ligand-induced signaling pathways and induction of subsequent immune responses. Here, we report biochemical evidence that 6-shogaol, the most bioactive component of ginger, inhibits lipopolysaccharide-induced dimerization of TLR4 resulting in the inhibition of $NF-{\kappa}B$ activation and the expression of cyclooxygenase-2. Furthermore, we demonstrate that 6-shogaol can directly inhibit TLR-mediated signaling pathways at the receptor level. These results suggest that 6-shogaol can modulate TLR-mediated inflammatory responses, which may influence the risk of chronic inflammatory diseases.

• IMMUNE NETWORK
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• 제21권1호
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• pp.10.1-10.13
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• 2021

The coronavirus disease 2019 (COVID-19) pandemic (severe acute respiratory syndrome coronavirus 2) is a global infectious disease with rapid spread. Some patients have severe symptoms and clinical signs caused by an excessive inflammatory response, which increases the risk of mortality. In this study, we reanalyzed scRNA-seq data of cells from bronchoalveolar lavage fluids of patients with COVID-19 with mild and severe symptoms, focusing on Ab-producing cells. In patients with severe disease, B cells seemed to be more activated and expressed more immunoglobulin genes compared with cells from patients with mild disease, and macrophages expressed higher levels of the TNF superfamily member B-cell activating factor but not of APRIL (a proliferation-inducing ligand). In addition, macrophages from patients with severe disease had increased pro-inflammatory features and pathways associated with Fc receptor-mediated signaling, compared with patients with mild disease. CCR2-positive plasma cells accumulated in patients with severe disease, probably because of increased CCL2 expression on macrophages from patients with severe disease. Together, these results support the hypothesis that different characteristics of B cells might be associated with the severity of COVID-19 infection.

• 한국방재안전학회논문집
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• 제5권2호
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• pp.61-70
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• 2012

특정관리 대상 시설의 범위는 건축물 분야와 토목 시설물 분야로 구분되며 이들 시설 중 본 연구에서는 건축물 분야의 주거와 비주거시설에 대한 최근 5년간 발생한 화재발생을 중심으로 위험도 분석을 수행하였다. 주거시설 및 비 주거시설에서 발생한 화재사건은 전기적 원인에 의한 화재발생이 가장 많았으며 이로 인한 인명 피해 또한 매우 높은 것으로 분석되었다. 따라서 본 연구에서는 화재가 발생하게 된 원인적인 내용을 규명하고 이를 근거로 각 시설물 별 화재에 얼마나 위험한 수준인지를 위험도 평가지수 개발을 통해 분석하였다. 본 분석은 향후 이들 시설의 안전 관리를 위한 기준으로 활용될 수 있으며 이를 바탕으로 좀 더 전문적이고 집중적인 안전관리를 유도할 수 있을 것으로 판단된다.