• Title/Summary/Keyword: Risk reduction method

Search Result 333, Processing Time 0.026 seconds

Exploration of the Gene-Gene Interactions Using the Relative Risks in Distinct Genotypes (유전자형별 상대 위험도를 이용한 유전자-유전자간 상호작용 탐색)

  • Jung, Ji-Won;Yee, Jae-Yong;Lee, Suk-Hoon;Pa, Mi-Ra
    • The Korean Journal of Applied Statistics
    • /
    • v.24 no.5
    • /
    • pp.861-869
    • /
    • 2011
  • One of the main objects of recent genetic studies is to understand genetic factors that induce complex diseases. If there are interactions between loci, it is difficult to find such associations through a single-locus analysis strategy. Thus we need to consider the gene-gene interactions and/or gene-environment interactions. The MDR(multifactor dimensionality reduction) method is being used frequently; however, it is not appropriate to detect interactions caused by a small fraction of the possible genotype pairs. In this study, we propose a relative risk interaction explorer that detects interactions through the calculation of the relative risks between the control and disease groups from each genetic combinations. For illustration, we apply this method to MDR open source data. We also compare the MDR and the proposed method using the simulated data eight genetic models.

Finger reduction of nasal bone fracture under local anesthesia: outcomes and patient reported satisfaction

  • Lee, Young-Jae;Lee, Kyeong-Tae;Pyon, Jai-Kyong
    • Archives of Craniofacial Surgery
    • /
    • v.20 no.1
    • /
    • pp.24-30
    • /
    • 2019
  • Background: Closed reduction of the fracture under general or local anesthesia with elevators or forceps is widely used to treat nasal bone fractures. However, operating under general anesthesia increases the risk of morbidity and raises the cost of management. Furthermore, using forceps or elevators may cause undercorrection, new fractures, mucosal damage, and nasal hemorrhage. We therefore performed manual reduction under local anesthesia, using the little finger, to minimize the demerits of treatment under general anesthesia with forceps or elevators and aimed to assess functional and aesthetic outcomes, and patient satisfaction. Methods: Patients who visited the plastic and reconstructive surgery department between November 2016 and November 2017 with nasal bone fractures and treated by a single surgeon were prospectively followed up. Patients with simple unilateral or bilateral nasal bone fractures were treated with bedside finger reduction under local anesthesia and patients with comminuted nasal bone or septal fractures were scheduled for closed reduction under general anesthesia. Results: Of 84 patients, 28 met the inclusion criterion and underwent bedside finger reduction under local anesthesia. Twenty-seven patients (96.4%) were successfully contacted via telephone for survey. Twenty-three (85.2%) showed good and three (11.1%) showed fair results. All 27 patients (100%) were satisfied with their postoperative function and 25 (92.6%) were satisfied with their postoperative aesthetic result. Twenty-five patients (92.6%) preferred the finger reduction method under local anesthesia over closed reduction under general anesthesia. Conclusion: Finger reduction under local anesthesia in patients with mild unilateral or bilateral nasal bone fractures is an easy and efficient procedure with high patient satisfaction and favorable postoperative functional and aesthetic outcomes.

Eating Habits, Trend of disordered Eating, Weight Reduction Practice and Body Size Evaluation of College Students in Seoul (서울지역 일부 대학생의 식습관, 섭식장애 발생경향, 체중조절행태 및 비만도)

  • Sohng, Kyeong-Yae;Park, Chai-Soon
    • Women's Health Nursing
    • /
    • v.9 no.4
    • /
    • pp.457-466
    • /
    • 2003
  • Purpose: To provide the epidemiological information for developing preventive programs encourage appropriate eating and weight control behaviors. Method: 349 college students in Seoul were administered self-report question- naires to examine eating habits, trend of disordered eating, weight reduction practice and body size evaluation from September to October 2002. Data were analyzed by SAS program for frequency, t-test, ANOVA with Scheff test. Result: The mean eating score was moderate and it differed by subjects' characteristics. The mean score of EAT-26 was relatively lowered, and 3.4% of the subjects score showed disordered eating behavior. It differed significantly by subjects' general characteristics. 30.4% of total sample were currently trying to lose weight and had interested in trying to lose weight. EAT-26 was significantly different by weight reduction practices and interest. Perceived body size differed by the score of eating habit and EAT-26. Conclusion: It can be suggested weight preoccupation have a relation to eating habits, weight control practice and disordered eating. Further study is recommended educational interventions targeting at-risk subjects.

  • PDF

Relevance of the Watson-Jones anterolateral approach in the management of Pipkin type II fracture-dislocation: a case report and literature review

  • Nazim Sifi;Ryad Bouguenna
    • Journal of Trauma and Injury
    • /
    • v.37 no.2
    • /
    • pp.161-165
    • /
    • 2024
  • Femoral head fractures with associated hip dislocations substantially impact the functional prognosis of the hip joint and present a surgical challenge. The surgeon must select a safe approach that enables osteosynthesis of the fracture while also preserving the vascularization of the femoral head. The optimal surgical approach for these injuries remains a topic of debate. A 44-year-old woman was involved in a road traffic accident, which resulted in a posterior iliac dislocation of the hip associated with a Pipkin type II fracture of the femoral head. Given the size of the detached fragment and the risk of incarceration preventing reduction, we opted against attempting external orthopedic reduction maneuvers. Instead, we chose to perform open reduction and internal fixation using the Watson-Jones anterolateral approach. This involved navigating between the retracted tensor fascia lata muscle, positioned medially, and the gluteus medius and minimus muscles, situated laterally. During radiological and clinical follow-up visits extending to postoperative month 15, the patient showed no signs of avascular necrosis of the femoral head, progression toward coxarthrosis, or heterotopic ossification. The Watson-Jones anterolateral approach is a straightforward intermuscular and internervous surgical procedure. This method provides excellent exposure of the femoral head, preserves its primary vascularization, allows for anterior dislocation, and facilitates the anatomical reduction and fixation of the fracture.

Wind-induced fragility assessment of urban trees with structural uncertainties

  • Peng, Yongbo;Wang, Zhiheng;Ai, Xiaoqiu
    • Wind and Structures
    • /
    • v.26 no.1
    • /
    • pp.45-56
    • /
    • 2018
  • Wind damage of urban trees arises to be a serious issue especially in the typhoon-prone areas. As a family of tree species widely-planted in Southeast China, the structural behaviors of Plane tree is investigated. In order to accommodate the complexities of tree morphology, a fractal theory based finite element modeling method is proposed. On-site measurement of Plane trees is performed for physical definition of structural parameters. It is revealed that modal frequencies of Plane trees distribute in a manner of grouped dense-frequencies; bending is the main mode of structural failure. In conjunction with the probability density evolution method, the fragility assessment of urban trees subjected to wind excitations is then proceeded. Numerical results indicate that small-size segments such as secondary branches feature a relatively higher failure risk in a low wind level, and a relatively lower failure risk in a high wind level owing to windward shrinks. Besides, the trunk of Plane tree is the segment most likely to be damaged than other segments in case of high winds. The failure position tends to occur at the connection between trunk and primary branches, where the logical protections and reinforcement measures can be implemented for mitigating the wind damage.

A Case Study of Risk Assessment of Ozone Impact on Forest Tree Species in Japan

  • Watanabe, Makoto;Yamaguchi, Masahiro;Matsumura, Hideyuki;Kohno, Yoshihisa;Koike, Takayoshi;Izuta, Takeshi
    • Asian Journal of Atmospheric Environment
    • /
    • v.5 no.4
    • /
    • pp.205-215
    • /
    • 2011
  • Ozone ($O_3$) is a main component of photochemical oxidants and a phytotoxic air pollutant. Although the current levels of tropospheric $O_3$ in East Asia could adversely affect productivity of forest tree species, risk assessments of $O_3$ impact were limited. In this paper, we summarize the methodology of risk assessment of $O_3$ on forest tree species based on our two previous studies, risk assessments of $O_3$ impact on the growth of Fagus crenata by Watanabe et al. (2012) and on the annual carbon absorption of three representative conifers, Cryptomeria japonica, Pinus densiflora and Larix kaempferi by Watanabe et al. (2010). $O_3$ sensitivity of each tree species obtained from an experimental study, $O_3$ exposure and atmospheric N deposition based on field monitoring and vegetation survey were integrated by geographic information system method. Based on the results, we conclude that the area with high risk of $O_3$ impact does not necessarily correspond to the area with high $O_3$ exposure. The varieties of tree habitat, tree sensitivity to $O_3$ and annual carbon absorption among the tree species, and N deposition-induced change in the $O_3$ sensitivity of F. crenata are raised as the factors of discordance between areas with high risk and those with high $O_3$ exposure. In the last part of this paper, we discuss the present uncertainty and perspectives of risk assessment for the future studies on the impact of $O_3$ on forest tree species in East Asia.

Quantitative Risk Assessment Method for Metals in Water Body using WASP (WASP 모의를 이용한 하천 수계 중금속 위해성평가 방법)

  • Shin, Yu-Ri;Yoon, Chun-Gyeong;Jeon, Na-Jeong;Rhee, Han-Pil
    • Journal of Korean Society on Water Environment
    • /
    • v.26 no.4
    • /
    • pp.629-636
    • /
    • 2010
  • According to the spatial movements of the Nak-dong river watershed, the changes in heavy metal concentrations were simulated by WASP7.3. The risk assessment was performed using the predicted data of WASP7.3. The target heavy metal was manganese (Mn). In the simulated manganese data of WASP7.3, the average concentration by regions was from 0.03 mg/L to 0.07 mg/L. It is lower than drinking water standard in korea. The risk assessment was presented that it was high at the junction of Nak-dong river and Kumho river. It was influenced by the discharge of industrial complexes and large cities which were located in the junction. In comparison of drinking water standard and predicted data of WASP7.3 risk assessment, whole watershed was also low level at predicted data. However, to keep the similar risk value ($10^{-7}$) in adults and children anywhere, it requires the additional treatment of the point source discharges. It was also reflected by regions. Through this study, it was possible to evaluate heavy metal influence in unattainable monitoring regions and to estimate heavy metal addition and reduction by locations. Therefore, the outcomes of WASP7.3 can connect with the risk assessment and it can evaluate the safety of human by regions.

The effect of the cariview test and professional brushing training on the reduction of PHP index of dental hygiene students (Cariview test와 전문가 칫솔질 교육이 치위생(학)과 신입생의 PHP index 감소에 미치는 효과)

  • Kim, Youn-Hwa;Kim, Yu-Geun;Yoo, Jin-Ah;Park, Jung-Eun
    • Journal of Korean society of Dental Hygiene
    • /
    • v.17 no.6
    • /
    • pp.993-1001
    • /
    • 2017
  • Objectives: This study was conducted to examine the effectiveness in oral health promotion through oral health education for freshmen students of the dental hygiene department. Methods: To verify its effectiveness, research was conducted on 74 freshmen of the dental hygiene department by the evaluation of DMFT index, PHP index, and Cariview test (2015-2016). Results: The analysis of the test results using Cariview equipment shows a categorization of low risk group consisting of 10 students (13.5%), middle risk group consisting of 47 students (63.5%), and a high risk group consisting of 17 students (22.9%). DT index according to the number of daily tooth brushing by <2 is DT index average score higher and in such a case, statistics are considered meaningful (p<0.01). Oral health state at DMFT index of low risk group according to Cariview risk group for an analysis is lower than both the middle risk group and the high risk group (p<0.001). Conclusions: A review of the effect of the promotion of oral health through oral health education on the behavior change rather than of Cariview test and value of dental plaque through tooth brushing method was conducted.

A Measuring Model of Risk Impact on The App Development Project in The Social App Manufacturing Environment (Social App Manufacturing 환경의 앱 개발 프로젝트에서 위험영향도 측정 모델)

  • Baek, Jung Hee;Lim, Young Hwan
    • KIPS Transactions on Software and Data Engineering
    • /
    • v.3 no.9
    • /
    • pp.335-340
    • /
    • 2014
  • Crowd Sourcing-based Social App Manufacturing environment, a small app development project by a team of anonymous virtual performed without the constraints of time and space, and manage it for the app development process need to be automated method. Virtual teams with anonymity is a feature of the Social App Manufacturing, is an important factor that increases the uncertainty of whether the completion of the project or reduction in visibility of the progress of the project. In this study, as one of how to manage the project of Social App Manufacturing environment, the impact of risk that can be used to quantitatively measure the impact of the risk of delay in development has on the project also proposes a measurement model. Effects of risk and type of the impact of risks associated with delays in the work schedule also define the characteristic function, measurement model that has been proposed, suggest the degree of influence measurement equation of risk of the project in accordance with the progressive. The advantage of this model, the project manager is able to ensure the visibility of the progress of the project. In addition, identify the project risk of work delays, and to take precautions.

Treatment of Atrial Fibrillation in Elderly Patients with the Cox Maze Procedure Concurrently with Other Cardiac Operations

  • Kuh, Ja Hong;Song, Joon Young;Kim, Tae Youn;Kim, Jong Hun;Choi, Jong Bum
    • Journal of Chest Surgery
    • /
    • v.50 no.3
    • /
    • pp.171-176
    • /
    • 2017
  • Background: In elderly patients who have atrial fibrillation (AF), surgical ablation of the arrhythmia during cardiac surgery may be challenging. Despite the reported advantages of ablating AF with the Cox maze procedure (CMP), the addition of the CMP may complicate other cardiac operations. We evaluated the effect of the CMP in elderly patients concurrent with other cardiac operations. Methods: From October 2007 to December 2015, we enrolled 27 patients aged >70 years who had AF and who underwent the CMP concurrently with other cardiac operations. The mean preoperative additive European System for Cardiac Operative Risk Evaluation score was $8{\pm}11$ (high risk). Results: Only 1 hospital death occurred (4%). The Kaplan-Meier method showed a high 5-year cumulative survival rate (92%). At mean follow‐up of 51 months, 23 patients (89%) had sinus rhythm conversion. The postoperative left atrial dimensions did not significantly differ between the 8 patients who had reduction plasty for giant left atrium ($53.4{\pm}7.5cm$) and the 19 patients who did not have reduction plasty ($48.7{\pm}5.7cm$). Conclusion: In patients aged >70 years, concurrent CMP may be associated with a high rate of sinus rhythm conversion without increased surgical risk, despite the added complexity of the main cardiac procedure.