• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.4
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• pp.749-752
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• 2006

The house dust mites are well known to the most important causative allergens of major allergic diseases like pediatric asthma, allergic rhinitis or atopic dermatitis. This study was done for assessment of naphthalene effect against breeding suppression of the house dust mites. Twenty live adult house dust mites(Dermatophaogoides pteronyssinus) were each inoculated on mixed culture media containing 0 mg (control), 1mg, 2 mg, 3 mg, 5 mg, and 10 mg naphthalene and incubated at $25^{\circ}C$ with a relative humidity of 75%. After 4 weeks mean number of live house dust mites were 191.5, 24.3, 1.3, 1.3, 0, and 0, respectively. Above results showing that the naphthalene can suppress of breeding the house dust mites in vitro.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.1
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• pp.86-95
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• 2011

Objectives : Ulmus davidiana (UD) has been widely used in Korean herbal medicines used for treatment of acute and chronic inflammatory diseases, such as rhinitis, asthma, and abscess. In this study, To investigated the protective effect of UD on type 1 allergic response, we determined whether UD inhibits early and late allergic response. Methods : The effect of UD was analyzed by ELISA and RT-PCR in RBL-2H3 cells. Levels of ${\beta}$ -hexosaminidase, interleukin (IL)-4 and TNF-${\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISAs). mRNA levels of COX-2 and T-helper type 2(Th2) cytokines were analyzed with RT-PCR. Results : We found that UD suppressed ${\beta}$-hexosaminidase release in RBL-2H3 not only by the PMA plus A23187 stimulation, but also by the IgE-DNP-HSA stimulation at the antigen-antibody binding stage and antibody-receptor binding stage. UD also significantly inhibited COX2 level, along with reduced Th2 cytokine levels, such as IL-3, IL-4, IL-5, IL-13, GM-CSF, and TNF-${\alpha}$ in RBL-2H3. Conclusions : Our results indicate that UD protects against type 1 allergic response and exerts an anti-inflammatory effect through the inhibition of degranulation and expression of COX2 and Th2 cytokines.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.163-175
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• 2009

Objective : The aim of this study was to take a census of elementary school children who have atopic dermatitis(AD) especially the residents of Je-Cheon. Method : We conducted a questionnaire survey of the elementary school children in Je-Cheon who have atopic dermatitis. 96 patients with AD were involved in the survey. The questionnaire was made up of their family history, past history, weaning food, breast-fed or not, dietary treatment and Children's Dermatology Life Quality Index(CDLQI), etc. The student's T-test was used for statistical analysis. Results : Parents and siblings brothers and sisters past history has an effect on patients with AD. With regard to past history of patients, allergic rhinitis was the most common ailment. Formula feeding was common in the group under 6 months of age and the mean age of the start of weaning was 7.25 months. Fruit juice and weaning food of powder type were the first weaning foods in this study. Many parents introduced a grain diet, live diet, bone - soup, egg, milk, cheese and bean curd to their children under 12 months of age. A restricted diet was the most common dietary treatment method in this study. The highest scoring question for CDLQI was itching; the lowest one was related to bullying. Conclusion : We analyzed the patients' family history, past history, weaning food, dietary treatment and Children's Dermatology Life Quality Index(CDLQI), etc. Through this survey, we better understand the actual conditions of elementary school children who had AD in Je-Cheon.

• Journal of the Korean Society of School Health
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• v.31 no.1
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• pp.10-17
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• 2018

Purpose: The purpose of this study was to examine the health behaviors and health status of adolescents in multicultural families according to gender. Methods: The study used raw data of the Korean Youth Risk Behavior Web-Based Survey performed in 2016. The 12th survey was conducted on 67,983 adolescents in 400 middle schools and 400 high schools. Among them, 759 adolescents were included in this study. Their data were analyzed using descriptive statistics, $x^2$-test, and Pearson's correlation. Results: There were significant differences in economic status, smoking experience, age of drinking onset, vigorous physical activity, soft drink consumption, toothbrushing after lunch, handwashing with soap before eating at school and eating at home and after coming home, BMI, subjective health status, stress, depression, and allergic rhinitis according to gender in multicultural adolescents. For boys, significant positive correlations were found between age and the age of drinking onset, between academic achievement and economic status, and between the age of smoking initiation and the age of drinking onset. However, there were significant negative correlations between economic status and stress and between subjective health status and stress. For girls, age had positive correlations with academic achievement, the age of drinking onset, BMI, and stress and economic status had positive correlations with academic achievement, the age of smoking initiation, and subjective health status. Also, the age of smoking initiation had positive correlations with the age of drinking onset and BMI. Lastly, there were negative correlations between age and economic status, between age and subjective health status, academic achievement and the age of smoking initiation, economic status and stress, and subjective health status and stress. Conclusion: The results of this study are expected to be useful as basic data for planning health interventions for boys and girls in multicultural families.

• Journal of Acupuncture Research
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• v.20 no.4
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• pp.53-65
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• 2003

Although the effect of Bee Venom has been reported, its mechanism has not been fully elucidated. Nitric Oxide(NO) is one of the free radicals and mediates in inflammation diseases. Chemokines contribute to the pathogenesis of several disorders such as allergic rhinitis and rheumatoid arthritis and so on. The objective of this study was to investigate the scavenging effect of Bee Venom on NO and on expression of chemokine genes. There was no significant NO scavenging effect in Crude Bee Venom, Apamin, Melittin, and MCD-peptide. The expression of chemokines was examined by RT-PCR using the human mast cell line(HMC-1), which is known to secrete and express chemokines. In order to investigate the protective effect of Bee Venom, HMC-1 cells were incubated with pretreatment of Bee Venom for 24 hrs and stimulated with 1 uM calcium ionophore A23178 for 2 hrs. RT-PCR analyses of chemokine genes showed that expressions of RANTES and MCP-1 were increased compared to the calcium ionophore-only treated group. But IL-8 and MCP-3 did not express increasing effect compared to control group. This study may provide important basic data on the possibility of the clinical treatment of Bee Venom in inflammation diseases.

• Journal of Korean Biological Nursing Science
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• v.13 no.3
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• pp.220-228
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• 2011

Purpose: This study was performed to investigate prevalence related characteristics and management status in children with atopic dermatitis(AD) for developing health promotion strategies led by community. Methods: Data were collected from 6,562 children with AD in preschool and elementary schools in a district of Ulsan city. Results: The majority of children(44.4%) were onset in less than 2 years after the birth. Seventy six point seven percent of subjects had skin rash and the pathologic lesion of them were flexion of upper extremities and extension of lower extremities. The prevalence rate of the respondents was 30.3%. In bathing, the children in AD group had used soap more frequently than children in normal group. The most preference type of complementary therapy in frequency order were aloe, aroma oil and Pasture. Conclusion: More effective management strategy for alleviating symptom and preventing advanced disease such as asthma and allergic rhinitis should be developed. And also scientific evidence for using complementary therapy is necessary to be provided.

• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.249-260
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• 1998

Ulmi radicis cortex is a herb medicine which has been used for the treatment of such allergic disease as urticaria, allergic rhinitis and athma. To assess the contribution of an aqueous extract of Ulmi radicis cortex(URC) in systemic anaphylaxis, we used compound 48/80 as a fatal anaphylaxis inducer in rats. URC inhibited anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW) 1 hr before injection of compound 48/80. URC significantly inhibited serum histamine levels induced by compound 48/80. URC (1.0 mg/g BW) also inhibited to 79.1% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. URC dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. Moreover, URC had a significant inhibitory effect on anti-DNP IgE-induced histamine release or tumor necrosis $factor-{\alpha}$ production from RPMC. The level of cAMP in RPMC, when URC was added, significantly increased compared with that of normal control. These results indicate that URC may possess strong antianaphylactic effect.

• International Journal of Oral Biology
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• v.41 no.4
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• pp.253-262
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• 2016

Streptococcus mutans (S. mutans) is one of the most important bacteria in the formation of dental plaque and dental caries. S. mutans adheres to an acquired pellicle formed on the tooth surface, and aggregates with many oral bacteria. It initiates plaque formation by synthesizing glucan from sucrose, which is catalyzed by glucosyltransferases. Propolis is a resinous mixture produced by honeybees, by mixing saliva and beeswax with secretions gathered from wood sap and flower pollen. Bees prevent pathogenic invasions by coating the propolis to the outer and inner surface of the honeycomb. Propolis has traditionally been used for the treatment of allergic rhinitis, asthma and dermatitis. We investigated the inhibitory effects of propolis ethanol extract on biofilm formation and gene expression of S. mutans. The biofilm formation of S. mutans was determined by scanning electron microscopy (SEM) and safranin staining. We observed that the extract of propolis had an inhibitory effect on the formation of S. mutans biofilms at concentrations higher than 0.2 mg/ml. Real-time PCR analysis showed that the gene expression of biofilm formation, such as gbpB, spaP, brpA, relA and vicR of S. mutans, was significantly decreased in a dose dependent manner. The ethanol extract of propolis showed concentration dependent growth inhibition of S. mutans, and significant inhibition of acid production at concentrations of 0.025, 0.05, 0.1 and 0.2 mg/ml, compared to the control group. These results suggest that the ethanol extract of propolis inhibits gene expression related to biofilm formation in S. mutans.

• Child Health Nursing Research
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• v.22 no.4
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• pp.237-246
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• 2016

Purpose: The aim of the study was to assess the prevalence of preschooler obesity/overweight and to identify associated factors. Methods: This study was a cross-sectional study. Data for 591 preschoolers, 432 fathers and 538 mothers from the Korea National Health and Nutrition Examination Survey 2013-2014 were included. Obesity/overweight was defined by 2007 Korean National Growth Charts. T-test, Rao-Scott ${\chi}^2$, multivariate logistic regression was used for the analysis. Results: Prevalence rates for preschooler obesity/overweight were 14.9% (obesity, 5.4%; overweight, 9.5%). The preschoolers with atopic dermatitis or allergic rhinitis or asthma (OR=2.78, 95% CI [1.27-6.09], p=.011) and eating more thiamine per day (OR=1.01, 95% CI [1.00-1.02], p=.001) showed higher obesity/overweight development. The only parental factor affecting preschooler obesity/overweight was parental body mass index (father, OR=1.18, 95% CI [1.09-1.28], p<.001; mother, OR=1.09, 95% CI [1.04-1.15], p<.001). Conclusion: Interventions on preventing preschooler obesity should be introduced much earlier for children with risk factors. Results from this study can be used as preliminary data to develop effective strategies to prevent obesity in Korean preschoolers.

• Journal of Environmental Health Sciences
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• v.39 no.4
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• pp.383-390
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• 2013

Objectives: We evaluated the effects of an allergy control program on children with atopic dermatitis (AD) in five schools located within Gyeonggi-do. Methods: Based on the results of the 12-month prevalence of AD symptoms from an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire of all students (n=2109; 1040 boys, 1069 girls) at five randomly selected schools, 227 students with AD symptoms were screened. Finally, 188 students with greater than 1 on SCORAD (SCORing Atopic Dermatitis) determined by a physician were selected. The allergy control program includes education related to allergic diseases, skin prick tests, and SCORAD evaluation, as well as keeping a daily journal to check the usage of moisturizer at least once a day. To determine the effectiveness of the allergy control program, SCORAD evaluation was performed again six weeks later. Results: The most common symptom for 12-month prevalence was rhinorrhea (33.9%), followed by atopic skin lesions (14.8%) and wheezing (4.0%). The 12-month prevalences of the three allergic diseases were higher for boys than for girls, and a significant difference was found for allergic rhinitis (P<0.001). The mean SCORAD index decreased significantly from 26.1 to 17.5 after the completion of the six-week control program (P<0.01). In particular, these differences were more pronounced for the group which used the daily journal (P<0.001). Conclusions: Our findings indicate that the allergy control program including usage of a daily journal as well as regular monitoring could be a promising tool for preventing and alleviating the symptoms of allergic diseases.