The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of Ulmi radicis Cortex Extract on Systemic and Local Anaphaylaxis in Rats

유근피(楡根皮)가 전신적(全身的) 및 국소적(局所的) 아나필락시스에 미치는 효과(效果)

  • Oh, Myung-Jin (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Eon-Jeong (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Song, Bong-Keun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hyeong-Kyun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Dong-Hyuk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Seong-Jae (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 오명진 (원광대학교 한의학과 신계내과학교실) ;
  • 이언정 (원광대학교 한의학과 신계내과학교실) ;
  • 송봉근 (원광대학교 한의학과 신계내과학교실) ;
  • 김형균 (원광대학교 한의학과 신계내과학교실) ;
  • 김동혁 (원광대학교 한의학과 신계내과학교실) ;
  • 김성재 (원광대학교 한의학과 신계내과학교실)
  • Published : 1998.12.01
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Abstract

Ulmi radicis cortex is a herb medicine which has been used for the treatment of such allergic disease as urticaria, allergic rhinitis and athma. To assess the contribution of an aqueous extract of Ulmi radicis cortex(URC) in systemic anaphylaxis, we used compound 48/80 as a fatal anaphylaxis inducer in rats. URC inhibited anaphylactic shock 100% with a dose of 1.0 mg/g body weight (BW) 1 hr before injection of compound 48/80. URC significantly inhibited serum histamine levels induced by compound 48/80. URC (1.0 mg/g BW) also inhibited to 79.1% passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. URC dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. Moreover, URC had a significant inhibitory effect on anti-DNP IgE-induced histamine release or tumor necrosis $factor-{\alpha}$ production from RPMC. The level of cAMP in RPMC, when URC was added, significantly increased compared with that of normal control. These results indicate that URC may possess strong antianaphylactic effect.

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