• Journal of Microbiology and Biotechnology
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• v.25 no.2
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• pp.255-267
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• 2015

Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic debilitating disease affecting ruminants worldwide. In the present study, we aimed to determine the major gene networks and pathways underlying the immune response to MAP infection using whole-blood cells, as well as provide the potential transcriptional markers for identifying the status of MAP infection. We analyzed the transcriptional profiles of whole-blood cells of cattle identified and grouped according to the presence of MAP-specific antibodies and the MAP shed by them. The grouping was based on the results obtained by ELISA and PCR analyses as follows: i) Test1 group: MAP-negative results obtained by ELISA and positive results obtained by PCR; ii) Test2 group: MAP-positive results obtained by ELISA and negative results obtained by PCR; iii) Test3 group: MAP-positive results obtained by ELISA and positive results obtained by PCR; iv) uninfected control: MAP-negative results obtained both by ELISA and PCR analysis. The results showed down-regulated production and metabolism of reactive oxygen species in the Test1 group, activation of pathways related to the host-defense response against MAP (LXR/RXR activation and complement system) in the Test2 and Test3 groups, and anti-inflammatory response (activation of IL-10 signaling pathway) only in the Test3 group. Our data indicate a balanced response that serves the immune-limiting mechanism while the host-defense responses are progressing.

• Journal of Oral Medicine and Pain
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• v.20 no.2
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• pp.407-420
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• 1995

This study was performed to evaluate and compare conservative treatment results by several parameters such as age, sex, symptom duration, type and timing of joint sound, parafunctional habits, splint type, and diagnostic classification. There have been too many articles reporting long term results of conservative treatment but articles related to comparison of treatment results by patients' self-evaluation have been rarely reported. For this study 258 patients with temporomandibular disorders(TMDs) were selected and examined by routine diagnostic procedure for TMDs. The subjects were classified into 5 TMDs subgroups ad treated with conservative treatments involving splints, physical modalities, jaw exercises, and counseling. Visual analogue scale(VAS) about pain, joint sound, and mouth opening limitation was recorded respectively during treatment period. From the VAS data and treatment duration, VAS treatment index(VAS Ti) was calculated. The obtained results were as follows : 1. Pain was the most frequent main symptom in subjects with temporomandibular disorders, and main symptom for mouth opening limitation was comparatively less than for pain or sound in disk displacement with reduction group or in degenerative joint disease group. 2. Degenerative joint disease group had the most poor treatment results and highest occlusal index of Helkim's index. 3. Good prognosis for conservative treatment was observed in acute group, under 6 months than chronic group, 6months over in symptom duration, and subjects with 40 years over in age showed the most poor prognosis. 4. Subjects treated with anterior repositioning splint had better treatment results than subjects treated with centric relation splint, but statistical significance in VAS Ti and treatment duration was not observed. 5. Treatment results according to affected side, types and point of joint sound did not show consistent statistical results. 6. The result for conservative treatment was observed poor in subjects with bruxism and clenching. 7. In studying coincidence between preferred chewing and affected side, frequency of preferred chewing side, in unilateral affection, was higher in ipsilateral than in contralateral side.

• Journal of the Korean Arthroscopy Society
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• v.1 no.1
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• pp.91-97
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• 1997

There has been a controversy about the effectiveness of the synovectomy of the knee in the rheumatoid arthritis. So we studied to determine if the arthroscopic synovectomy of the knee was of benefit in the rheumatoid arthritis. We ana lysed 25 knees of 15 patients who underwent the arthroscopic synovectomy of the knee joint for their rheumatoid arthritis from Jun. 1995 to Oct. 1996. The average follow-up period was 20.1 months($12\~28$ months). The results were as follows; 1. Satisfactory results were obtained in 20 knees $(80\%)$ for the pain and the effusion each, 23 $(92\%)$ for the range of motion and 19 $(76\%)$ for the functional capacity. 2. In the overall results for the pain. effusion. range of motion and the functional capacity. we obtained excellent results in 14 knees $(56\%)$ and satisfactory results in 9 knees $(32\%)$. 3. In the patient's self assessment, 11 patients $(44\%)$ were delighted and 10 patients $(40\%)$ were satisfactory. 4. In the overall results according to the articular cartilage damage, satisfactory results were obtained in 15 $(93\%)$ out of 16 knees in Grade I and II, and 6 $(75\%)$ out of 8 knees in Grade III and IV. In conclusion, arthroscopic synovectomy could be one of very useful treatments for the rheumatoid knee. But further study is needed to get the long-term results of the synovectomy because there's many reports saying gradual decrease of good results with increasing time. And continuous and proper medical treatment including DMARDs, is needed to effectively control the rheumatoid arthritis even after the synovectomy.

• Journal of the Korean Arthroscopy Society
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• v.1 no.1
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• pp.116-122
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• 1997

We have studied the results of reconstruction by freeze-dried patellar allografts or patellar autografts in ACL-deficient patients prospectively. From January 1995 to December 1995, we performed ACL reconstruction using an arthroscopic-assisted technique with patellar autografts in 21 patients and patellar allografts in 13 patients. Minimum followup time was 1 year(average 26 months). All patients were evaluated by using KT-2000 arthrometer and MRI as well as by physical examination. Final results were rated as satisfactory or unsatisfactory by using a modified Feagin knee scoring scale. Good or excellent were considered to have satisfactory results and fair or poor were considered to have unsatisfactory results. As measured by the KT-2000, 19 cases$(90.5\%)$ had a 5-mm or Jess side-to-side differential, a satisfactory results in autograft group, 2 cases of unsatisfactory results had joint instability. In allograft group, 10 cases$(76.9\%)$ had a 5-mm or less side-to-side differential, a satisfactory results, 3 cases of unsatisfactory results had joint instability including postoperative infection(1 case). In conclusion, the results of ACL reconstruction with autografts were better than those with allografts. The problem of allograft reconstruction were rehydration, aseptic control and improper mechanical tensioning. So, we thought that success of allograft reconstruction was depended on careful implant preparation including pretensioning technique.

• Journal of the Korea Safety Management & Science
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• v.13 no.2
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• pp.83-90
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• 2011

It has been very important to have an exact evaluation for risk factors in order to prevent WMSDs(Work-related Musculoskeletal Disorders). However, most WMSDs evaluation methods have always been some problems of possibilities associated with subjective evaluation. Therefore, this study tried to conduct a sort of usability analysis on three major evaluation methods(OWAS, RULA, REBA). Specifically, major subjects in the study consisted of three parts as follows; comparison of the results between experienced and inexperienced observers, analysis for the consistency of the results in terms of different evaluation times, and analysis for the consistency of the results in terms of different job characteristics(based on the part of the automobile). The results of the study were summarized as follows; 1) There was statistically significant difference of the results by RULA and by REBA between experienced and inexperienced observers. This might be due to the fact that experienced observers have had better ability to detect the important working posture during evaluation. However, the results by OWAS did not give any significantly different results between experienced and inexperienced observers, 2) All three checklists applied by experienced subjects did not show any single result significantly different in terms of different evaluation times. This might have to do with high intra-observer reliability from some of previous studies, 3) The five parts of an automobile were selected as five major jobs with different job characteristics in the automobile industry. Specifically, they were door part, front part(hood, etc.), inside part(dash board, seats, etc.), rear part(trunk etc.), and bottom part. All three methods did not show any significant differences for the results from each observers. Further study on this subject would eventually provide a sophisticated evaluating guidelines for WMSDs regarding determination of observer-specific evaluation, identification of repetitive number of evaluations for stable results for each checklist, determination of job-specific evaluation methods, and so on.

• The Journal of Korea Robotics Society
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• v.17 no.3
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• pp.296-302
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• 2022

This paper proposes a center of plantar foot pressure (CoP) trajectory estimation method based on Gaussian process regression, with the aim to show robust results regardless of the regions and numbers of FSRs of the insole sensor. This method can bring an interpolation between the measurement points inside the wearable insole sensor, and two experiments are conducted for performance evaluation. For this purpose, the input data used in the experiment are generated in three types (13 FSRs, 8 FSRs, 5 FSRs) according to the regions and numbers of FSRs. First, the estimation results of the CoP trajectory are compared using Gaussian process regression and weighted mean. As a result of each method, the estimation results of the two methods were similar in the case of 13 FSRs data. On the other hand, in the case of the 8 and 5 FSRs data, the weighted mean varies depending on the regions and numbers of FSRs, but the estimation results of Gaussian process regression showed similar results in spite of reducing the regions and numbers. Second, the estimation results of the CoP trajectory based on Gaussian process regression during several gait cycles are analyzed. In five gait cycles, the previous cycle and the current estimation results are compared, and it was confirmed that similar trajectories appeared in all. In this way, the method of estimating the CoP trajectory based on Gaussian process regression showed robust results, and stability was confirmed by yielding similar results in several gait cycles.

• International Journal of Advanced Culture Technology
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• v.12 no.2
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• pp.236-248
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• 2024

This study aims to empirically analyze the effects of leadership level and toxic leadership on leadership performance results among male and female military leaders in the Army, and to verify whether the leader's gender has a moderating effect in this process. Additionally, by comparing and analyzing the leadership level, toxic leadership, and leadership performance results of female military leaders by position, this study seeks to examine the characteristics of female military leadership according to position. The research model was established with leadership level and toxic leadership as independent variables, leadership performance results as the dependent variable, and the leader's gender as a moderating variable. Data were collected through a survey of 216 male and female officers serving in the positions of platoon leader, company commander, and battalion commander in the Army. The collected data were analyzed using descriptive statistics, reliability analysis, correlation analysis, and hierarchical regression analysis. The results showed that leadership level had a significant positive effect on leadership performance results, while toxic leadership had a significant negative effect. The leader's gender moderated the relationship between leadership level and leadership performance results, with female leaders receiving lower evaluations than male leaders at the same level of leadership competency. Gender also moderated the relationship between toxic leadership and leadership performance results, with female leaders exhibiting the same level of toxic leadership receiving lower performance evaluations than male leaders. In the comparative analysis of female military leadership characteristics by position, the leadership level of the platoon leader and company commander groups was not significantly different from that of male soldiers, but the battalion commander group showed slightly lower leadership competency compared to male soldiers. Based on these results, this study suggests ways to improve the leadership level of female military leaders, reduce toxic leadership, and prepare support measures to strengthen the leadership competency of female military officers at the battalion commander level and above from policy, institutional, and educational perspectives.

• Korean Journal of Radiology
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• v.20 no.1
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• pp.158-165
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• 2019

Objective: Recent studies demonstrated that core needle biopsy (CNB) can effectively reduce the possibility of inconclusive results and prevent unnecessary diagnostic surgery. However, the effectiveness of CNB in patients with suspicious thyroid nodules has not been fully evaluated. This prospective study aimed to determine the potential of CNB to assess thyroid nodules with suspicious ultrasound (US) features. Materials and Methods: Patients undergoing CNB for thyroid nodules with suspicious features on US were enrolled between May and August 2016. Diagnostic performance and the incidence of non-diagnostic results, inconclusive results, conclusive results, malignancy, unnecessary surgery, and complications were analyzed. Subgroup analysis according to nodule size was performed. The risk factors associated with inconclusive results were evaluated using multivariate logistic regression analysis. Results: A total of 93 patients (102 thyroid nodules) were evaluated. All samples obtained from CNB were adequate for diagnosis. Inconclusive results were seen in 12.7% of cases. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for diagnosis of malignancy were 93.8%, 100%, 100%, 78.9%, and 95%, respectively. None of the patients underwent unnecessary surgery. The diagnostic performance was not significantly different according to nodule size. On multivariate logistic regression analysis, larger nodule size and shorter needle length were independent risk factors associated with inconclusive results. Conclusion: Samples obtained by CNB were sufficient for diagnosis in all cases and resulted in high diagnostic values and conclusive results in the evaluation of suspicious thyroid nodules. These findings indicated that CNB is a promising diagnostic tool for suspicious thyroid nodules.

• Herbal Formula Science
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• v.20 no.1
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• pp.133-147
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• 2012

Objectives : This study was intended to understand characteristics of symptoms, oriental medicine prescription and laboratory test results according to elapsed time of stroke. Methods : Through the medical records of 205 stroke inpatients in the oriental medical hospital in the year 2010, we investigated manifested symptoms, administered oriental medicine prescription and clinical pathological examination results. Collected items were classified to depend on stroke types, cerebral infarction and hemorrhage. We analyzed association between manifested symptoms, the oriental medicine prescription, and laboratory test results of stroke patients and elapsed time. Chi-square tests were performed to determine the significance level of association. Results : All symptoms, prescriptions and laboratory test results in cerebral infarction patients were associated with elapsed time. Especially, symptoms, prescriptions and pathological examination results showed very high statistical significance with elapsed time (a symptom; chi-square(df)=164.3(22), p<0.001, prescription; chi-square(df)=93.5(22), p<0.001, and pathological examination results; chi-square(df)=164.3(22), p<0.0004). But in the case of cerebral hemorrhage, there was not statistical significance. Conclusions : The elapsed time of stroke may be an essential requisite in catching symptoms and prescribing for stroke patients in oriental medical treatment.

• Clinics in Shoulder and Elbow
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• v.18 no.4
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• pp.229-236
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• 2015

Background: Twenty-six patients (12 male and 14 female) with symptomatic scapular winging caused by serratus anterior dysfunction were managed by split pectoralis major tendon transfer (sternal head) with autogenous hamstring tendon augmentation from 1998 to 2006. Methods: Twenty-five patients showed positive results upon long thoracic nerve palsy on electromyography. The mean duration of symptoms until surgery was 48 months (range, 12-120 months). Four patients had non-traumatic etiologies and 22 patients had traumatic etiologies. On follow-up assessment for functional improvement, a Constant-Murley score was used. Twenty-one patients were completely evaluated, while five patients who had less than 12 months of follow-up were excluded. Results: Pain relief was achieved in 19 of the 21 patients, with 20 patients showing functional improvement. The pain scores improved from 6.0 preoperatively to 1.8 postoperatively. The mean active forward elevation improved from $108^{\circ}$ (range, $20^{\circ}-165^{\circ}$) preoperatively to $151^{\circ}$ (range, $125^{\circ}-170^{\circ}$) postoperatively. The mean Constant-Murley score improved from 57.7 (range, 21-86) preoperatively to 86.9 (range, 42-98) postoperatively. A recurrence developed in one patient. Of the 21 patients, ten had excellent results, six had good results, four had fair results, and one had poor results. Conclusions: Most patients with severe symptomatic scapular winging showed functional improvement and pain relief with resolution of scapular winging.