• Title/Summary/Keyword: Restriction Factor

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Analytical Study on the Improvement of Concrete Placement in a Massive Wall-Structure (매스콘크리트 벽체구조물의 타설개선을 위한 해석적 연구)

  • 김진근;김상철;이두재;김국한
    • Proceedings of the Korea Concrete Institute Conference
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    • 1997.10a
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    • pp.539-545
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    • 1997
  • Since the length of massive wall-structure is generally longer and larger than its thickness and a lift height of concrete of placement, cracks induced by hydration heat are governed by outer structural restriction rather than inner one. However, the degree of restriction control is expected to be affected by the sizes of wall thickness, length and a lift height. Thus, this analytical study aims at the development of relationship among those to minimize thermal cracks. In addition, the effect of types of cement on the thermal heats and stresses is evaluated for anti-sulphate and 2blended Portland cements concrete. It was found from analytical study that a lift height of concrete placement is the most important factor controlling thermal cracks, and the increase of lift heights is not always detrimental to structural safety.

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Factors Related to Eating Breakfast of Middle and High School Students in Seoul (서울시 중.고등학생들의 아침식사 섭취 관련 요인)

  • Kim, Yang-Suk;Yoon, Ji-Hyun;Kim, Haeng-Ran;Kwon, Sung-Ok
    • Korean Journal of Community Nutrition
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    • v.15 no.5
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    • pp.582-592
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    • 2010
  • The purpose of this study was to determine the factors related to eating breakfast for middle and high school students in Seoul using the Theory of Planned Behavior. Out of 2,280 questionnaires distributed to 22 schools, 2,060 were returned (90.4% response rate) and 1,899 were analyzed (83.3% analysis rate). Gender, self-perceived household income level and mother's working status were examined as demographic factors. "Attitude", "Subjective norm", "Perceived difficulty in access to breakfast", "Perceived time restriction" and "Self restriction to breakfast" were extracted as psychosocial factors as the results of factor analysis and reliability test using 17 items. In case of middle school students, boys were more likely to skip breakfast than girls. The students perceiving their household income level "low or middle low" were more likely to skip breakfast than those who perceived their household income level "high or middle high". The students whose mother had a job tended to skip breakfast than those whose mother had no job. In case of high school students, the students perceiving their household income level "low or middle low" tended to skip breakfast than those perceiving their household income level "high or middle high". The results of analysis of variance, all the psychosocial factors examined in this study-"Attitude", "Subjective norm", "Perceived difficulty in access to breakfast", "Perceived time restriction" and "Self restriction to breakfast"- were related to the frequencies of eating breakfast during weekdays in both the middle and high school students.

Immune Evasion of G-CSF and GM-CSF in Lung Cancer

  • Yeonhee Park;Chaeuk Chung
    • Tuberculosis and Respiratory Diseases
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    • v.87 no.1
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    • pp.22-30
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    • 2024
  • Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.

Molecular Characteristics of R Plasmids in Shigella (Shigella R Plasmid의 분자적 특성)

  • Lee, Yoo-Chul;Seol, Sung-Yong;Cho, Dong-Taek;Chun, Do-Ki
    • The Journal of the Korean Society for Microbiology
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    • v.22 no.1
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    • pp.35-53
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    • 1987
  • Multiply resistant Shigella strains isolated in Taegu area were subjected for the characterization of R plasmids. All strains isolated in 1984 and 1985 were susceptible to gentamicin, amikacin, and cephalothin, and most strains were susceptible to kanamycin (Km) and rifampin by agar dilution antimicrobial susceptibility test. The resistance frequency of S. flexneri against ampicillin (Ap) was higher than that of S. sonnei. The strains resistant to sulfisomidine (Su) and trimethoprim (Tp) were found at higher frequency in S. sonnei than in S. flexneri. The most prevalent resistance pattern of S. flexneri was chloramphenicol (Cm) tetracycline (Tc) streptomycin (Sm) Ap, followed by the pattern of CmTcSmSuApTp, CmTcSmSuApTp nalidixic acid, and CmTcSmSuAp in the decreasing order. The antibiogram of CmTcSmSuTp was found to be the most frequent pattern in S. sonnei. The ratio of conjugal transfer of S. flexneri was 47% and 75% of S. sonnei. The average number of plasmid harboring in Shigella was 4 and the size of plasmid ranged 1.3 to 134 megadalton (Mdal). Most S. flexneri carried plasmids of 2 to 3 Mdal and S. sonnei carried those of 3 to 4 Mdal size. The sizes of conjugative plasmids ranged 40-90 Mdal. The incompatibility group (Inc) F II plasmids (54-59 Mdal) were most frequent and rare Inc B plasmids (60 Mdal) of isolates in 1979 and 1980 and Inc FI (87 Mdal) of 1983 isolates were able to be classified by the colony test with standard reference plasmids. The R plasmids of known Inc group were tested for the restriction endonuclease analysis. The pattern of plasmids digested by EcoRl were apparently different by the Inc group but there was no significant difference between species or by the resistance patterns. Nonconjugative plasmids and their phenotypes were identified by transformation test. The transformants were resistant to less than two drugs. Colicin producing transformants carried the Col plasmid of 3.7 or 3.9 Mdal size. $Ap^r$ plasmids derived from S. sonnei were found to be mobilized by transfer factor RT641 to E. coli #CS100. $Ap^r$ plasm ids of same size shared by S. flexneri, S. sonnei, and E. coli were digested with Pstl. All of them showed two restriction fragments of 2.8 kilobase(kb) and 0.7kb. Other plasmids ($Sm^r\;Su^r$) derived from S. flexneri, S. boydii, and S. sonnei were digested with Pstl and they showed same restriction fragment patterns of 3.1kb and 2.9kb. The plasmid profiles of three strains of S. sonnei producing colicin and showing same resistance pattern of CmTcSmSuApTpKm appeared to be similar. Restriction patterns by EcoRl and the behavior of plasmids in conjugation or transformation process were also similar between those plasmids. The restriction patterns were significantly different between the plasmids of Inc FI group and those of unclassified Inc group.

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Effects of work ability on the employment status of people with disabilities: Comparing degrees of disability, ICF activity limitations & participation restriction, levels of assistance needed for daily activities, and self-assessed health status (근로능력평가지표의 취업에 대한 영향 비교: 장애등급, ICF 활동참여수준, 일상생활 도움필요정도 및 자기평가건강상태를 중심으로)

  • Lee, Sunwoo
    • Korean Journal of Social Welfare Studies
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    • v.42 no.2
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    • pp.323-350
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    • 2011
  • Work ability is a fundamental factor to determine who are the recipients of disability benefits or employment services. Disability Grade based on medical impairments is used as a work ability assessment in Korea, but it has been heavily criticized that it does not assess disabled person's work ability adequately. This study tried to find out an index which explains employment status of disabled persons the best among four work ability assessment indexes of disability grade, level of ICF activity limitations and participation restriction, level of help needed with daily activities, and self-assessed health status. As a result, the level of ICF activity limitations and participation restriction explained the employment status the best, and help needed for daily activities is the second, disability grade is the third, and self-assessed health status is the last. In conclusion, level of ICF activity limitations and participation restriction is the best work ability assessment in Disabled People Pension and Employment Policy for Disabled People. Therefore, it is the basic premise to develop a new work ability assessment index which consists of items in ICF activity limitations and participation restriction.

Parental Childrearing, Behavior, Children's Sibling Relationships and Children's Self-Esteem (양육행동 및 형제관계와 아동의 자존감과의 관계 연구 : - 자존감에 대한 양육행동 및 형제관계의 독립적 기여와 상호작용 효과 -)

  • Park, Young Yae;Chung, Ock Boon
    • Korean Journal of Child Studies
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    • v.17 no.1
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    • pp.189-212
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    • 1996
  • The purpose of this study was to investigate how parental childrearing behavior and children's sibling relationships are related to children's self-esteem. 440 middle class families consisting of two children and their parents were the subjects of this study. The research instruments included a childrearing behavior questionnaire, the Sibling Relationships Questionnaire (Furman & Buhrmester, 1985), and the Self-Perception Profile for Children (Harter, 1985). Analyses of the data included correlation analysis, canonical correlation, regression, stepwise multiple regression, and MANOVA with stepwise discriminant analysis as the follow-up test. The most powerful predictors of children's self-esteem were the Warmth-Acceptance of childrearing behavior and the Warmth-Closeness of sibling relationships. The self-esteem dimension was best predicted by parental childrearing behavior and by children's sibling relationships was Global Self-Worth. Behavioral Conduct was best predicted by the Rejection-Restriction factor of childrearing, and by Conflict (for boys) and Rivalry (for girls) factors of sibling relationships. Children's self-esteem was related more strongly to the Warmth-Acceptance and the Rejection-Restriction of opposite-sex parents. The effects of Permissiveness-Nonintervention were stronger in same-sex parent-child dyads. Parental childrearing behaviors accounted for boy's self-esteem better than girl's with the exception of Behavioral Conduct. Sibling relationships accounted for girl's self-esteem better than boy's. The $2{\times}2$ MANOVA revealed interaction effects of parental childrearing behaviors and sibling relationships on children's self-esteem. Two factors of Rivalry and Conflict in sibling relationships and all three factors of childrearing behaviors showed significant interaction effects, The childrearing factor of Permissiveness-Nonintervention and the sibling factor of Rivalry, which were relatively weak predictors of self-esteem when acting alone, gained power in explaining children's self-esteem within the interactional context.

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Association of Polymorphisms in Epidermal Growth Factor, Prostaglandin-endoperoxide Synthase 2 and Prolactin Receptor Genes with Semen Quality in Duroc Boars

  • Huang, S.Y.;Song, H.L.;Lin, E.-C.;Lee, W.C.;Chiang, J.C.;Tsou, H.L.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.6
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    • pp.793-798
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    • 2006
  • The quality characteristics of semen are important indicators of the fertility of a boar. Development of genetic markers for the semen quality in boars will be beneficial to the improvement of porcine fertility. We investigated the relationship between the polymorphisms of epidermal growth factor (EGF), prostaglandin-endoperoxide synthase 2 (PTGS2) and prolactin receptor (PRLR) genes, and semen quality traits in boars. The genomic DNA of 233 boars (157 Duroc and 86 Landrace) from a central testing station was subjected to genotyping for surveying gene frequency. The EGF, PTGS2 and PRLR genotypes were determined using the restriction fragment length polymorphism method. Thirty-seven normal, mature Duroc boars from an AI center were also genotyped and their semen quality traits were collected. The effect of genotype on semen quality traits was analyzed by the least-squares means method using data corrected for season. The frequencies of the AA genotype of EGF, PTGS2 and PRLR in Duroc boars were 0.14, 0.01 and 0.66, respectively. In Landrace, the frequencies of the AA genotype were 0.03, 0.09 and 0.62, respectively. Boars with the BB genotype in EGF, with the AB genotype in PTGS2 and with the AA genotype in PRLR had significantly better semen quality with a higher percentage of normal sperm and a lower percentage of immature sperm than those with other genotypes. These findings imply that polymorphisms of EGF, PTGS2 and PRLR genes might be used as markers for improving the semen quality of boars.

Association of single-nucleotide polymorphisms in dual specificity phosphatase 8 and insulin-like growth factor 2 genes with inosine-5'-monophosphate, inosine, and hypoxanthine contents in chickens

  • Jean Pierre Munyaneza;Minjun Kim;Eunjin Cho;Aera Jang;Hyo Jun Choo;Jun Heon Lee
    • Animal Bioscience
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    • v.36 no.9
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    • pp.1357-1366
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    • 2023
  • Objective: This study aimed to identify the single-nucleotide polymorphisms (SNPs) in the dual-specificity phosphatase 8 (DUSP8) and insulin-like growth factor 2 (IGF2) genes and to explore their effects on inosine-5'-monophosphate (IMP), inosine, and hypoxanthine contents in Korean native chicken -red-brown line (KNC-R Line). Methods: A total sample of 284 (males, n = 127; females n = 157) and 230 (males, n = 106; females, n = 124) aged of 10 weeks old KNC-R line was used for genotyping of DUSP8 and IGF2 genes, respectively. One SNP (rs313443014 C>T) in DUSP8 gene and two SNPs (rs315806609A/G and rs313810945T/C) in IGF2 gene were used for genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and KASP methods, respectively. The Two-way analysis of variance of the R program was used to associate DUSP8 and IGF2 genotypes with nucleotide contents in KNC-R chickens. Results: The DUSP8 (rs313443014 C>T) was polymorphic in KNC-R line and showed three genotypes: CC, CT, and TT. The IGF2 gene (rs315806609A/G and rs313810945T/C) was also polymorphic and had three genotypes per SNP, including GG, AG, and AA for the SNP rs315806609A/G and genotypes: CC, CT, and TT for the SNP rs313810945T/C. Association resulted into a strong significant association (p<0.01) with IMP, inosine, and hypoxanthine. Moreover, the significant effect of sex (p<0.05) on nucleotide content was also observed. Conclusion: The SNPs in the DUSP8 and IGF2 genes might be used as genetic markers in the selection and production of chickens with highly flavored meat.

Analysis of robust performance improvement using loop shaping and structured singular value (루프쉐이핑과 구조적 특이치를 이용한 견실성능 개선)

  • 방경호;오도창;박홍배
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.33B no.5
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    • pp.17-24
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    • 1996
  • In this paper, we present a robust performance improvement method for the NLCF(normalized left coprime factor) uncertain structure using loop shaping and the structure singular value. For this, we select weighting functions for a loop shaping considering condition numer, and transform the NLCF uncertain structure into the 4-block structure. However, we can't get a good performance on account of the restriction of weighting functions. To cope with this, we motivate the use of structured singular vlaue in the robust performance improvement procedure. After all, the robust performance improvement can be obtained by a factor W$_{a}$ and a scaling factor of D-K iteration.

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The Relationship of HOME to Preschool Children's Developmental Levels (가정환경 자극검사(HOME)와 학령전 아동의 발달 수준과의 관계)

  • Jang, Young Ae;Suh, Yong Sun
    • Korean Journal of Child Studies
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    • v.4
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    • pp.1-10
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    • 1983
  • This study examined the characteristics of the relationship of home environment variables and preschool children's intelligence, learning readiness and socio-emotional developments. The subjects of this study were 63 children at age five and their mothers. Instruments included the children's intelligence test, preschool inventory for learning readiness, the socio-emtional rating scale and the inventory of HOME. The data of the present study were analyzed by the statistical methods of Pearson's product-moment correlation coefficient and step-wise multiple regression analysis. The kinds of HOME variables that significantly predict children's intelligence were "need gratification and avoidance of restriction" "quality of language environment" "play materials" "aspects of physical environment" "organization of stable and predictable environment". The variables that significantly predict children's socio-emotional developments were "breath of experience" "fostering maturity and independence" "developmental stimulation". All of the HOME variables were not significantly predict children's learning readiness. The kinds of HOME factors that significantly predict children's intelligence were factor II and factor III. Factor I predicted children's socio-emotional developments significantly. All of the HOME factors were not significantly predicted children's learning readiness.

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