• Biomolecules & Therapeutics
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• v.21 no.1
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• pp.35-41
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• 2013

Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune system. Current immunotherapies focus on the potential of immunomodulatory strategies for the treatment of T2D. In this study, we examined the effects of metformin on the antigen-presenting function of antigen-presenting cells (APCs). Metformin decreased both MHC class I and class II-restricted presentation of OVA and suppressed the expression of both MHC molecules and co-stimulatory factors such as CD54, CD80, and CD86 in DCs, but did not affect the phagocytic activity toward exogenous OVA. The class II-restricted OVA presentation-regulating activity of metformin was also confirmed using mice that had been injected with metformin followed by soluble OVA. These results provide an understanding of the mechanisms of the T cell response-regulating activity of metformin through the inhibition of MHC-restricted antigen presentation in relation to its actions on APCs.

• Proceedings of the Korean Statistical Society Conference
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• 2000.11a
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• pp.159-164
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• 2000

In the study of the isotonic regression problem, several procedures for testing the homogeneity of a normal mean vector versus order restricted alternatives have been proposed since Barlow's trial(1972). In this paper, we consider the problem of testing the equality of two order restricted normal mean vectors based on the likelihood ratio principle.

• Proceedings of the Safety Management and Science Conference
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• 2009.04a
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• pp.185-192
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• 2009

The research contributes extending and reviewing of restricted (constrained) and unrestricted (unconstrained) models in GLM(Generalized Linear Models). The paper includes the methodology for finding EMS(Expected Mean Square) and $F_0$ ratio. The results can be applied to the gauge R&R(Reproducibility and Repeatability) in MSA(Measurement System Analysis).

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.6-11
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• 1994

For a safety supervision, watching a restricted area so that no one go there is very important. This has been mostly accomplished by people. They keep an eye on many monitors at onece for a long time. It, however, is too simple and boring to concentrate it for a long time. So it's worth while to construct a watching system by image processing. And the system we made is now actually working at a certain hydroelectric power plant and some other restricted areas in Japan.

• Proceedings of the Safety Management and Science Conference
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• 2009.11a
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• pp.657-665
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• 2009

The paper reviews gauge R&R studies by two-factor mixed models including random and fixed factors. The two-factor mixed models include restricted models and unrestricted models considering the interaction of two factors. This study also classifies the models according to the number of factors, and the combination of various factors such as random factor, fixed factor, block factor and repetition type.

• Honam Mathematical Journal
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• v.35 no.2
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• pp.251-302
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• 2013

We study convolution sums of certain restricted divisor functions in detail and present explicit evaluations in terms of usual divisor functions for some specific situations.

• Journal of applied mathematics & informatics
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• v.39 no.3_4
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• pp.359-380
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• 2021

The main purpose and motivation of this work is to investigate and provide some new results for coefficients derived from eta quotients related to 3. The result of this paper involve some restricted divisor numbers and their convolution sums. Also, our results give relation between the coefficients derived from infinite product, infinite sum and the convolution sum of restricted divisor functions.

• Bulletin of the Korean Mathematical Society
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• v.60 no.4
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• pp.1025-1034
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• 2023

Let U be the restricted quantized enveloping algebra Ũ_q(𝖘𝖑₂) over an algebraically closed field of characteristic zero, where q is a primitive 𝑙-th root of unity (with 𝑙 being odd and greater than 1). In this paper we show that any indecomposable submodule of U under the adjoint action is generated by finitely many special elements. Using this result we describe all ideals of U. Moreover, we classify annihilator ideals of simple modules of U by generators.

• International Journal of Industrial Entomology and Biomaterials
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• v.5 no.2
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• pp.213-216
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• 2002

Food consumption and conversion efficiency of new bivoltine hybrids (CSR2$\times$CSR4 and CSR2$\times$CSR5) were studied under restricted feeding levels (10, 20 and 30% less quantity of mulberry leaves). The data were compared with a control fed with standard quantum of feed as per the recommendation. The nutritional indices parameters i. e. ingests, digesta, approximate digestibility (%) and reference ratio were recorded higher in control batches compared to less feed batches while nutritional efficiency parameters i. e., ECI and ECD to cocoon and shell were recorded significantly higher in restricted feeding level batches. This increase is attributed due to the physiological adaptation under nutritional stress condition.

• IE interfaces
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• v.15 no.4
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• pp.338-348
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• 2002

In this paper, we present a restricted tabu search(RTS) algorithm that schedules jobs on identical parallel machines in order to minimize the maximum lateness of jobs. Jobs have release times and due dates. Also, sequence-dependent setup times exist between jobs. The RTS algorithm consists of two main parts. The first part is the MATCS(Modified Apparent Tardiness Cost with Setups) rule that provides an efficient initial schedule for the RTS. The second part is a search heuristic that employs a restricted neighborhood generation scheme with the elimination of non-efficient job moves in finding the best neighborhood schedule. The search heuristic reduces the tabu search effort greatly while obtaining the final schedules of good quality. The experimental results show that the proposed algorithm gives better solutions quickly than the existing heuristic algorithms such as the RHP(Rolling Horizon Procedure) heuristic, the basic tabu search, and simulated annealing.