• 제어로봇시스템학회:학술대회논문집
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• 1996.10a
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• pp.173-176
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• 1996

This paper deals with the problem of designing an adaptive regulator in order to improve transient performance in time-response when the linear state-space model of the plant contains unknown parameters which vary within prescribed bounds. The whole possible parameter space is divided into some subspaces and multiple models and controllers are established from the view point that each controller gives satisfactory transient behavior for systems corresponding to each parameter subspace. Based on time-response and an associated cost function, an appropriate controller is selected on-line out of multiple controllers.

• Proceedings of the KIEE Conference
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• 1991.11a
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• pp.370-373
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• 1991

This paper considers the linear multivariable model following servo system synthesis method in which linear optimal regulator problem is used to design controllers that make the response of the plant should be kept close to a specified ideal response of the model. The characteristics of this system is that the constructed system is robust in the presence of the constant disturbances or the parameter perturbations of the plant. Especially, the steady state offset is excluded for the ramp response of the model by direct feedforward compensator from the reference input.

• Toxicological Research
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• v.25 no.4
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• pp.159-173
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• 2009

Nuclear factor erythroid derived 2-related factor-2 (Nrf2) is a master transcription regulator of antioxidant and cytoprotective proteins that mediate cellular defense against oxidative and inflammatory stresses. Disruption of cellular stress response by Nrf2 deficiency causes enhanced susceptibility to infection and related inflammatory diseases as a consequence of exacerbated immune-mediated hypersensitivity and autoimmunity. The cellular defense capacity potentiated by Nrf2 activation appears to balance the population of $CD4^+$ and $CD8^+$ of lymph node cells for proper innate immune responses. Nrf2 can negatively regulate the activation of pro-inflammatory signaling molecules such as p38 MAPK, NF-${\kappa}B$, and AP-1. Nrf2 subsequently functions to inhibit the production of pro-inflammatory mediators including cytokines, chemokines, cell adhesion molecules, matrix metalloproteinases, COX-2 and iNOS. Although not clearly elucidated, the antioxidative function of genes targeted by Nrf2 may cooperatively regulate the innate immune response and also repress the expression of pro-inflammatory mediators.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.28B no.5
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• pp.421-430
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• 1991

This paper investigated the errect of the right-half-plane zero on stability in the buck-boost DC-DC converter which is one type of the switching regulator and the stability region for the variation of the output current is obtained by evaluating the feedback gain. And it is clarified that the damping ratio decreases gradually by increase of the feedback loop gain and the regulation system of the converter becomes unstable, and from the transient response analysis we obtainedthe stability region about this converter. From above result it is known that the stability decreases by the existence of the right-half-plane zero. For the improvement of stability, we carried out one pole compensation in feedback circuit and obtained the avaliable stability region in relation to the gain bandwidth product from the stability and transient response analysis. These results were established experiment.

• Animal cells and systems
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• v.12 no.3
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• pp.127-136
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• 2008

Caspase-11 has been known as a dual regulator of cytokine maturation and apoptosis. Although the role of caspase-11 under pathological conditions has been well documented, its physiological role has not been studied much. In the present study, we investigated a possible physiological function of caspase-11 during immune response. In the absence of caspase-11, immunized spleen displayed increased cellularity and abnormal germinal center structure with disrupted microarchitecture. The rate of cell proliferation and apoptosis in the immunized spleen was not changed in the caspase-11-deficient mice. Furthermore, the caspase-11-deficient peritoneal macrophages showed normal phagocytotic activity. However, caspase-11-/-splenocytes and macrophages showed defective migrating capacity. The dysregulation of cell migration did not seem to be mediated by caspase-3, interleukin-$1{\alpha}$ or interleukin-$1{\beta}$ which acts downstream of caspase-11. These results suggest that a direct regulation of immune cell migration by caspase-11 is critical for the formation of germinal center microarchitecture during immune response. However, humoral immunity in the caspase-11-deficient mice was normal, suggesting the formation of germinal center structure is not essential for the affinity maturation of the antibodies.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.1008-1009
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• 2005

In order to screen ionizing radiation induced early-response genes, we employed subtractive hybridization method and isolated a metabolism associated gene. The gene expression was very sensitive to ionizing radiation as revealed by a rapid induction of its messenger RNA. We characterized the function of this gene in radiation response. This gene activated p53 and enhanced cell killing effect of ionizing radiation. This effect was attributable to p53 phosphorylation and transcriptional activation.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.10 no.5
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• pp.78-84
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• 2001

The translation system is made up of springs, masses and a dashpot. This precise piece of equipment is controlled electro-mechanically by a motor and operating program. The control strategy of the system can be changed by spring stiffness, change of mass, and the damping coefficient of the dashpot. This system proves the necessity and effect of a closed loop control. In this paper, PD control experiments were implemented for the translation system. When the north falter was added on the PD controller, we compared the response characteristics of the two systems. The state feedback controller minimized scalar control gains and the resulting response characteristics of the system were studied using the LQR design. Finally, we improved the response characteristics of the translation system which are rising time, settling time, steady state error, and overshoot LQR was better as compared with PD control.

• Journal of Microbiology and Biotechnology
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• v.20 no.2
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• pp.301-310
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• 2010

Bacillus subtilis strains produce a broad spectrum of bioactive peptides. The lipopeptide surfactin belongs to one well-known class, which includes amphiphilic membrane-active biosurfactants and peptide antibiotics. Both the srfA promoter and the ComP-ComA signal transduction system are an important part of the factor that results in the production of surfactin. Bs-M49, obtained by means of low-energy ion implantation in wild-type Bs-916, produced significantly lower levels of surfactin, and had no obvious effects against R. solani. Occasionally, we found strain Bs-M49 decreased spore formation and the development of competence. Blast comparison of the sequences from Bs-916 and M49 indicate that there is no difference in the srfA operon promoter PsrfA, but there are differences in the coding sequence of the comA gene. These differences result in three missense mutations within the M49 ComA protein. RT-PCR analyses results showed that the expression levels of selected genes involved in competence and sporulation in both the wild-type Bs-916 and mutant M49 strains were significantly different. When we integrated the comA ORF into the chromosome of M49 at the amyE locus, M49 restored hemolytic activity and antifungal activity. Then, HPLC analyses results also showed the comA-complemented strain had a similar ability to produce surf actin with wild-type strain Bs-916. These data suggested that the mutation of three key amino acids in ComA greatly affected the biological activity of Bacillus subtilis. ComA protein 3D structure prediction and motif search prediction indicated that ComA has two obvious motifs common to response regulator proteins, which are the N-terminal response regulator receiver motif and the C-terminal helix-turn-helix motif. The three residues in the ComA N-terminal portion may be involved in phosphorylation activation mechanism. These structural prediction results implicate that three mutated residues in the ComA protein may play an important role in the formation of a salt-bridge to the phosphoryl group keeping active conformation to subsequent regulation of the expression of downstream genes.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.10a
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• pp.251-251
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• 2017

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.613-618
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• 1993

This paper presents the aircraft autopilot system with a pre-designed gain schedule. It is mainly consisted of the parameter estimation end the autopilot system design. For off-line parameter estimation, leastsquare methods are investigated. The design of a controller is done in frequenced domain using classical control method and it is designed to satisfy the predetermined requirement such as time constant and transient response. Finally, it is compared with a optimal regulator.