• Title/Summary/Keyword: Response evaluation

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Response Evaluation of Chemotherapy for Lung Cancer

  • Hwang, Ki-Eun;Kim, Hak-Ryul
    • Tuberculosis and Respiratory Diseases
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    • v.80 no.2
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    • pp.136-142
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    • 2017
  • Assessing response to therapy allows for prospective end point evaluation in clinical trials and serves as a guide to clinicians for making decisions. Recent prospective and randomized trials suggest the development of imaging techniques and introduction of new anti-cancer drugs. However, the revision of methods, or proposal of new methods to evaluate chemotherapeutic response, is not enough. This paper discusses the characteristics of the Response Evaluation Criteria In Solid Tumor (RECIST) version 1.1 suggested in 2009 and used widely by experts. It also contains information about possible dilemmas arising from the application of response assessment by the latest version of the response evaluation method, or recently introduced chemotherapeutic agents. Further data reveals the problems and limitations caused by applying the existing RECIST criteria to anti-cancer immune therapy, and the application of a new technique, immune related response criteria, for the response assessment of immune therapy. Lastly, the paper includes a newly developing response evaluation method and suggests its developmental direction.

Evaluation of Velocity Response Spectrum of Seismic Base and Response Displacement for the Seismic Design of Buried Structures (지중구조물 내진설계를 위한 기반면의 속도 응답스펙트럼 및 응답변위 산정기법에 대한 연구)

  • 김동수;김동수;유제남
    • Proceedings of the Earthquake Engineering Society of Korea Conference
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    • 2003.03a
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    • pp.129-139
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    • 2003
  • The response displacement method is the most frequently used method for seismic design of buried structures. This method is pseudo-static method, and the evaluations of velocity response spectrum of seismic base and response displacement of surrounding soil are the most important steps. In this study, the evaluation of velocity response spectrum of seismic base according to the Korean seismic design guide and the simple method of calculating the response displacement were studied. It was found that velocity response spectrum of seismic base can be estimated by direct integrating the ground-surface acceleration response spectrum of soil type $S_{A}$, and the evaluation of the response displacement using double cosine method assuming two layers of soil profile shows the advantages in the seismic design.n.

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Serviceability evaluation methods for high-rise structures considering wind direction

  • Ryu, Hye-Jin;Shin, Dong-Hyeon;Ha, Young-Cheol
    • Wind and Structures
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    • v.30 no.3
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    • pp.275-288
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    • 2020
  • High-rise buildings are very slender and flexible. Their low stiffness values make them vulnerable to horizontal loads, such as those associated with wind or earthquakes. For high-rise buildings, the threat to serviceability caused by wind-induced vibration is an important problem. To estimate the serviceability under wind action, the response acceleration of a building at the roof height is used. The response acceleration is estimated by the same wind speed at all wind directions. In general, the effect of wind direction is not considered. Therefore, the response accelerations obtained are conservative. If buildings have typical plans and strong winds blow from relatively constant wind directions, it is necessary to account for the wind direction to estimate the response accelerations. This paper presents three methods of evaluating the response accelerations while considering the effects of wind direction. These three serviceability evaluation methods were estimated by combining the wind directional frequency data obtained from a weather station with the results of a response analysis using wind tunnel tests. Finally, the decrease in the efficiencies of the response acceleration for each serviceability evaluation method was investigated by comparing the response acceleration for the three methods accounting for wind direction with the response acceleration in which wind direction was not considered.

The Role of Imaging in Current Treatment Strategies for Pancreatic Adenocarcinoma

  • Hyungjin Rhee;Mi-Suk Park
    • Korean Journal of Radiology
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    • v.22 no.1
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    • pp.23-40
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    • 2021
  • In pancreatic cancer, imaging plays an essential role in surveillance, diagnosis, resectability evaluation, and treatment response evaluation. Pancreatic cancer surveillance in high-risk individuals has been attempted using endoscopic ultrasound (EUS) or magnetic resonance imaging (MRI). Imaging diagnosis and resectability evaluation are the most important factors influencing treatment decisions, where computed tomography (CT) is the preferred modality. EUS, MRI, and positron emission tomography play a complementary role to CT. Treatment response evaluation is of increasing clinical importance, especially in patients undergoing neoadjuvant therapy. This review aimed to comprehensively review the role of imaging in relation to the current treatment strategy for pancreatic cancer, including surveillance, diagnosis, evaluation of resectability and treatment response, and prediction of prognosis.

Safety Evaluation of Individual Intersection Considering the Bio-Response (Electroencephalography) and the Cognitive Characteristics (생체반응(뇌파)과 인지평가 특성에 의한 개별 교차로 안전성 평가에 관한 연구)

  • Namgung, Moon;Lee, Byung Joo;Seo, Im Ki
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.30 no.3D
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    • pp.231-240
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    • 2010
  • As majority of the traffic accidents in intersections is caused by human factor, a close examination is required on its contributing factors through measuring the psychological and physiological response according to the driving characteristics of the drivers and the road conditions. In this study, for the safety evaluation of individual intersection considering human factors of the drivers, electroencephalography reaction was measured utilizing cutting-edge measuring equipment and survey on drivers' cognitive characteristics in ordinary times and while driving test was conducted. The relationship between the electroencephalography response when approaching the intersection and cognitive evaluation survey data in driving test was clarified, and individual intersection safety evaluation model was built considering cognitive evaluation factor and the reaction of a bio-response electroencephalography data. As a result, I could find out that cognitive evaluation was made through the reaction of a bio-response (Electroencephalography) process because electroencephalography reaction of a bio-response showed differently by the physical characteristics of the intersection and cognitive evaluation had a difference.

Limitations of Structural Behavior Response Performance Evaluation for Waterproofing Materials Under Non-Constrained Conditions and Suggestions for Future Improvement Measures (방수재료의 거동대응성능 시험시 비 구속조건에서의 구조물 거동 대응성능 평가의 한계와 향후 개선 방안 제안)

  • An, Ki-Won;Oh, Gyu-Hwan;Kim, Soo-Yeon;Oh, Sang-Keun
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2021.11a
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    • pp.212-213
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    • 2021
  • As structure and the waterproofing material are compressed through the backfilling process after the waterproofing material is installed on the underground structure at the actual site, there is a difference between the behavioral response force of the waterproofing material in the compressed state and the behavioral response force in the non-constrained state. In this regard, we will analyze the limitations of the current structural behavioral response evaluation and suggest an improvement plan so that the future test and evaluation environment can be evaluated under conditions similar to the field.

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The Interaction Roles of Ambient Pride Type and Advertisement Type on Product Evaluation (프라이드의 유형과 광고유형의 광고제품평가에 대한 상호작용효과)

  • Choi, Nak-Hwan
    • Journal of Distribution Science
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    • v.13 no.5
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    • pp.61-70
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    • 2015
  • Purpose - This study investigates whether the effectiveness of self trait-advertisement versus communion-focused advertisement on product evaluations depends on a type of pride felt as ambient emotion. It also explores whether the mediating roles of cognitive and affective response to the effect of the advertisement type on product evaluation are moderated by types of pride such as hubristic pride or authentic pride. Research Design, Data, and Methodology - This research uses a restaurant service as the experimental object and employs a 2 (pride type: hubristic pride vs. authentic pride) × 2 (advertisement type: self trait-focused advertisement versus communion-focused advertisement) between-subjects design, with cognitive response and affective response as within-subject. Each experimental group consisted of 40 undergraduate students assigned to participate in the experiment. One questionnaire from the authentic pride and self-trait focused advertisement group and two questionnaires from the hubristic pride and communion-focused advertisement group were removed due to answer errors, resulting in a participant number of 157. The author conducts a 2 (pride type: hubristic pride vs. authentic pride) × 2 (advertisement type: self trait-focused advertisement versus communion-focused advertisement) ANOVA on advertised product evaluations, and to better understand the interaction effects, also conducts separate analysis of the hubristic and the authentic pride groups. Additionally, the study conducts mediated moderation analysis to check the mediation role difference of the cognitive response and the affective response to each advertisement on the interaction effects on product evaluations between the hubristic and the authentic pride groups. Results - The findings indicate that participants in the hubristic pride group more positively evaluate the product in self-trait focused advertisement, whereas participants in the authentic pride group more positively evaluate the product in communion-focused advertisements. In addition, the mediating role of cognitive response on the positive interaction effect of advertisement type and pride type on product evaluation is partially moderated by the pride type. However, the mediating role of affective response on the positive interaction effect of advertisement type and pride type on the product evaluation is not moderated by the pride type. Conclusions - The results of this study contribute to advertisement theory development by exploring interaction effects of ambient pride type and advertisement type on product evaluation, as well as to the theory of consumer behavior by exploring how pride type moderates the mediating roles of cognitive response on the positive interaction effect of advertisement type and pride type on product evaluation. From the perspective of the current research, advertisers should research what kinds of events consumers have experienced to increase the effectiveness of their advertisements, and use self-trait advertisements when consumers are grouped under ambient hubristic pride, and use communion-focused advertisements when consumers are grouped under ambient authentic pride. However, future research is necessary to discover the reasons why the mediating role of affective response to advertisements in the interaction effects of pride type and advertisement type on product evaluation is not moderated by pride type.

Interaction Effects of Arousal Level of Positive Ambient Emotion and Advertisement Type on Product Evaluation

  • Choi, Nak Hwan;Oyunbileg, Tamir
    • Asia Marketing Journal
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    • v.18 no.1
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    • pp.37-53
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    • 2016
  • The purpose of this study is to show that the effectiveness of utilitarian versus hedonic attributefocused advertisement on product evaluation depends on the arousal level of positive emotion, and to explore mediation effect of cognitive response to utilitarian attribute-focused advertisement and affective response to hedonic attribute-focused advertisement on the effectiveness of utilitarian versus hedonic attribute-focused advertisement. This research employs a 2 (arousal level: mild vs. elevated) × 2 (advertisement type: utilitarian vs. hedonic) between-subjects design, and 200 undergraduate students participate in the experiment, in which there are 50 students at each experimental group. The results of ANCOVA with positive emotion level as a covariate on advertised product evaluation show significant interaction effect of arousal level and advertisement type, and no effect of positive emotional level. Both of the mediation effects of the cognitive response and those of the affective response are significant. Participants under mild (elevated) arousal of positive emotion more positively evaluate the product in utilitarian (hedonic) attribute-focused advertisement. The positive effect of utilitarian (hedonic) attributefocused advertisement on product evaluation is partially mediated by cognitive (affective) response to the advertisement when consumers are under the mild (elevated) arousal of positive emotion. The results of this study show that advertisers should use utilitarian (hedonic) attribute-focused advertisement to consumers under the mild (elevated) arousal of ambient positive emotion, which should be searched by exploring what kind of event they have experienced.

A Shape of the Response Spectrum for Evaluation of the Ultimate Seismic Capacity of Structures and Equipment including High-frequency Earthquake Characteristics (구조물 및 기기의 한계성능 평가를 위한 고진동수 지진 특성을 반영한 응답스펙트럼 형상)

  • Eem, Seung-Hyun;Choi, In-Kil
    • Journal of the Earthquake Engineering Society of Korea
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    • v.24 no.1
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    • pp.1-8
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    • 2020
  • In 2016, an earthquake occurred at Gyeongju, Korea. At the Wolsong site, the observed peak ground acceleration was lower than the operating basis earthquake (OBE) level of Wolsong nuclear power plant. However, the measured spectral acceleration value exceeded the spectral acceleration of the operating-basis earthquake (OBE) level in some sections of the response spectrum, resulting in a manual shutdown of the nuclear power plant. Analysis of the response spectra shape of the Gyeongju earthquake motion showed that the high-frequency components are stronger than the response spectra shape used in nuclear power plant design. Therefore, the seismic performance evaluation of structures and equipment of nuclear power plants should be made to reflect the characteristics of site-specific earthquakes. In general, the floor response spectrum shape at the installation site or the generalized response spectrum shape is used for the seismic performance evaluation of structures and equipment. In this study, a generalized response spectrum shape is proposed for seismic performance evaluation of structures and equipment for nuclear power plants. The proposed response spectrum shape reflects the characteristics of earthquake motion in Korea through earthquake hazard analysis, and it can be applied to structures and equipment at various locations.

How Does the Presentation Mode of Product Information Affect Product Evaluation? : The Mediation of Construal Level and the Moderation of Response Time

  • Cho, Hyun Young
    • International Journal of Contents
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    • v.16 no.1
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    • pp.44-56
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    • 2020
  • The purpose of this study was to examine how the presentation mode (sequential- vs. simultaneous-mode) of information influences its evaluation. Three experiments revealed the interaction effect between the presentation mode and the valence of the product information. When respondents read about the positive aspects of the product, the evaluation was higher in the simultaneous presentation mode than in the sequential presentation mode. For negative product information, respondents' evaluation was higher in the sequential presentation mode than in the simultaneous presentation mode. The simultaneous presentation mode intensified the impact of the information valence on evaluation. This study proposed that the sequential and the simultaneous presentation modes prime high and low construal levels, respectively. The mediation analysis provides support for such a prediction. Finally, the mediating effect of construal levels in evaluation was shown to disappear when respondents focused on the product information for a longer duration, while the mediation effect remained when the response time was short.