• 농약과학회지
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• 제19권3호
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• pp.301-311
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• 2015

Bacillus thuringiensis (비티)의 약효를 증가시키기 위한 일환으로 Cry 독소단백질의 혼합효과를 검정하였다. 서로 다른 네 가지 비티 균주에서 분리된 Cry 독소단백질 추출물들은 각각 좁은 적용해충범위를 나타냈다. 이들 Cry 독소단백질을 혼합한 결과 적용범위가 현격하게 증가했다. Xenorhabdus nematophila (Xn) 세균 배양액은 조사된 모든 곤충의 세포성 면역을 억제하고 Cry 독소단백질의 살충력을 증가시켰다. 이 Xn 세균배양액을 혼합 Cry 독소단백질에 추가한 결과 적용해충범위와 살충력을 모두 증가시켰다.

• Journal of Korean Biological Nursing Science
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• 제16권3호
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• pp.164-172
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• 2014

Purpose: The purpose of this study was to identify the effects of an extreme heat Adaptation Program on the blood pressure, stress response, self-efficacy, and knowledge of management of hypertension and extreme heat of patients who suffered from hypertension. Methods: A quasi-experimental study with a non-equivalent control group pretest-posttest design was used. The data collection period was between July 2 and August 20, 2012. Thirty-seven patients participated in the study (18 in the experimental group and 19 in the control group). Data were analyzed using $X^2$-test, t-test, and Cronbach's alpha coefficients with SPSS/WIN 19.0. Results: Patients who participated in the program showed statistically significant improvements in systolic blood pressure (SBP), self-efficacy, and knowledge of management of hypertension and extreme heat. Conclusion: The results indicate that this extreme heat adaptation program can be utilized for patients suffering from hypertension in order to reduce their SBP and to increase self-efficacy and knowledge of management of hypertension and extreme heat. Therefore, it is recommended that this program be used for elderly patients suffering from chronic disease.

• 한국임상약학회지
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• 제29권4호
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• pp.247-253
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• 2019

Background: Glutamate is implicated in the pathophysiology of migraine, a common neurological disorder. Therefore, glutamate receptor antagonists (GluRAs) have been suggested as a novel migraine treatment that are able to overcome the limitations of triptans. Objective: The aim of this study was to perform a meta-analysis to assess the efficacy of GluRAs for patients with migraine. Method: The PubMed, Cochrane Library, CINAHL, and Clinical Trial.gov databases were searched for randomized placebo-controlled trials of the efficacy of GluRAs for patients with migraine conducted up to August 2019. Two independent reviewers screened the literature according to inclusion and exclusion criteria and performed quality assessment and data extraction. Review Manager 5.3 software was used for the meta-analysis. Results: Three studies involving a total of 206 patients were included in the final analysis. Compared with placebo, GluRAs significantly improved the pain-free response at 2 hours (odds ratio [OR]=3.85, 95% confidence intervals [CIs]=1.63-9.09) and the 24-hour sustained pain freedom (OR=7.40; 95% CIs=2.36-23.20). The use of rescue medications with GluRAs was lower compared to that with placebo, but the difference was not significant (OR=0.39, 95% CI=0.10-1.47). Conclusion: Our meta-analysis showed that GluRAs were more effective than placebo for patients with migraine.

• 제어로봇시스템학회논문지
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• 제16권12호
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• pp.1189-1196
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• 2010

This paper provides an identification method for three-parameter models i.e. first order with dead time models and second order with dead time models. The proposed identification method is based on step response and can be easily implemented using digital microprocessors. The proposed method first identifies the order of the plant i.e. first order or second order from the behavior of the plant with constant input. After the order of the plant is determined, a test step input is applied to the system and the three parameters of the plant are obtained from the corresponding response of the plant. The output of the plant need not to be zero when the test signal is applied. The efficacy of proposed algorithms is verified through simulation and experiment.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4567-4570
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• 2014

Background: This systemic analysis was conducted to evaluate the efficacy and safety of pemetrexed based chemotherapy in treating patients with metastatic breast cancer as first or second line chemotherapy. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with breast cancer were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: In first line pemetrexed based regimens, 10 clinical studies which including 513 patients with advanced breast cancer were considered eligible for inclusion. For second line pemetrexed based chemotherapy, 5 clinical studies which including 281 patients with advanced breast cancer were considered eligible. Systemic analysis suggested that, in all patients, pooled RR was 32.6% (167/513) in pemetrexed based first line regimens, and 13.9 % (39/281) in pemetrexed based second line regimens. Major adverse effects were neutropenia, leukopenia, fatigue, and anemia in pemetrexed based first line treatment; and lymphopenia, neutropenia, leukopenia, as well as anemia in second line chemotherapy. One treatment related death occurred with pemetrexed based second line treatment. Conclusion: This systemic analysis suggests that pemetrexed based first line regimens are associated with a reasonable response rate and acceptable toxicity, however with low response rate for treating patients with metastatic breast cancer when is used in the second line.

• 대한두경부종양학회지
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• 제21권2호
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• pp.126-131
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• 2005

Objectives: To evaluate the efficacy and safety of induction chemotherapy with docetaxel and cisplatin in locally advanced head and neck cancer. Materials and Methods: Between June 1998 and December 2004, 30 patients were enrolled and among them, 20 patients were evaluable. Patients were treated with docetaxel $75mg/m^2$ and cisplatin $60mg/m^2$ on day 1 every 21 days. Results: The median age was 71(range 54-80) years old. All 20 patients were male. Nineteen patients had pathologically squamous cell carcinoma and 1 had undifferentiated carcinoma. Fourteen of 20 patients(70%) demonstrated an objective response with two(10%) achieving a complete clinical response and eleven(60%) a partial response. The median response duration was 5.3(1.6-32.1) months and the median time to progression was 5.6(1.4-33.8) months. The median overall survival of all patients was 14(range 2.2-34) months. The median overall survival of responders was 17.5(range 5-34) months and that of non-responders was 3.2(range 2.2-23) months, but it was not statistically significant(p=0.106). During a total of 92 cycles, granulocytopenia worse than CTC(Common toxicity criteria) grade 2 occurred in 6%, thrombocytopenia in 2%, and anemia in 3%, respectively. Non-hematologic toxicities were minor and easily controlled. Conclusion: The induction chemotherapy of docetaxel and cisplatin has moderate efficacy with acceptable toxicities in patients with locally advanced head and neck cancer.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권2호
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• pp.116-122
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• 2016

Purpose: We aimed to investigate the efficacy and safety of adalimumab in pediatric-onset Crohn's disease patients who had failed treatment with infliximab. Methods: In this retrospective study, patients included were those who had been diagnosed with Crohn's disease before 18 years old, and had received treatment with adalimumab after infliximab failure. The efficacy of adalimumab treatment was investigated at 1 month and 1 year, and adverse events that had occurred during treatment with adalimumab were explored. Results: Ten patients were included in this study. The median duration from diagnosis to adalimumab treatment was 5.5 years (range: 2.4-7.9 years). At 1 month after adalimumab initiation, 80% (8/10) of patients showed clinical response, and 40% (4/10) achieved clinical remission. At 1 year, 71% (5/7) of patients showed clinical response, and 43% (3/7) were under clinical remission. Among the total included patients, 5 patients (50%) showed clinical response at 1 year. Primary non-response to adalimumab was observed in 2 patients (20%), and secondary failure to adalimumab was observed in 3 patients (30%) during 1 year treatment with adalimumab. No serious adverse event had occurred during adalimumab treatment. Conclusion: Adalimumab was effective for 1 year without serious adverse events in half of pediatric-onset Crohn's disease patients who had failed treatment with infliximab.

• 한국안전학회지
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• 제39권2호
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• pp.28-37
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• 2024

The recent surge in the production and handling of hazardous materials in Korea necessitates developing and implementing robust emergency response plans. These plans are crucial in safeguarding the well-being of workers and residents in the event of an incident. The consequence analysis methodology outlined in the KOSHA guidelines provides a foundation for designing emergency response plans in the event of chemical accidents. However, the consequence analysis is evaluated based on assumed accident cases or worst-case scenarios. Consequently, the emergency response plan based on the consequence analysis may overestimate the damage area, complicating rescue efforts and unnecessarily increasing costs. More information and parameters become available after an accident, enabling more accurate consequence analysis. This implies that the results of consequence analysis based on this detailed information provide more realistic results than those based on assumed accidents. This study attempts to optimize the resource allocation and cost-effectiveness of emergency response plans for chemical accidents. Existing procedures and manuals are revised to elucidate the proposed model and conduct real-time consequence analysis. The existing emergency response plan is compared to verify the proposed model's efficacy. The obtained results indicate that the proposed model can exhibit better performance.

• 한국산학기술학회논문지
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• 제18권7호
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• pp.300-309
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• 2017

본 연구는 간호여대생의 지각된 부와의 의사소통, 부의 정서표현, 성정체성이 자기효능감에 미치는 영향을 파악하여 자기효능감 향상을 위한 기초자료를 제공하기 위하여 시도되었다. 연구대상자는 B시의 간호학과 여학생으로 자료수집은 2016년 5월 23일부터 5월 27일까지 였고, 최종 270부를 분석하였다. 수집된 자료는 SPSS/WIN 21.0 프로그램을 이용하여 실수, 백분율, 평균과 표준편차, 일원분산분석, 피어슨 상관계수, 다중회귀분석으로 분석하였다. 연구결과 연구대상자의 자기효능감은 $3.21{\pm}0.38$점으로 나타났고, 일반적 특성에 따른 자기효능감은 경제상태(F=5.13, p=.006), 부와의 관계(F=4.74, p=.001), 성적(F=5.22, p=.006), 성만족(F=4.00, p=.004)에서 유의한 차이를 나타냈다. 연구대상자의 부와의 의사소통, 부의 정서표현, 성정체성, 자기효능감과의 상관관계에서 자기효능감은 개방적 의사소통(r=.30, p<.001), 긍정적 정서표현(r=.37, p<.001), 성정체성(r=.26, p<.001)과는 정적 상관관계, 폐쇄적 의사소통(r=-22, p<.001), 부정적 정서표현(r=-.26, p<.001)과는 부적상관관계를 나타냈다. 연구대상자의 자기효능감에 영향을 미치는 요인은 부의 긍정적 정서표현, 부정적 정서표현과 성정체성으로 나타났고, 설명력은 18.2%로 나타났다. 본 연구 결과를 통하여 간호여대생의 자기효능감에 영향을 미치는 다양한 요인을 확인하기 위한 반복연구가 필요하고, 자기효능감의 영향 요인에 대한 중재가 필요하다.

• 한국양식학회:학술대회논문집
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• 한국양식학회 2005년도 춘계학술발표대회 논문요약집
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• pp.70-71
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• 2005