• 보건행정학회지
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• 제16권1호
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• pp.1-16
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• 2006

Recently, there has been prevailing of the combined utilization (CU) with herbs and prescribed drugs in medical therapies in the world. But the information about frequency, efficacy and safety of this CU has not well known in Korea, yet. This study aimed to identify the status of CU by Koreans, and to inquire which side effects of CU represent to those people. A self-completed questionnaire survey was performed through each health examination center in twenty general hospitals and one oriental hospital. Of the initial 2,100 health examinees, 1,851 were participated in this survey, resulting in a response rate of 88.1%. The proportion of CD was 26.3%. The most commonly mentioned reason of CD was 'to promote general health and well-being' (17l persons, 35.5%). The main route of taking CD was self-purchase at drugstore or at herbs market, followed by the prescription of (oriental)physicians. 33.0% (151 persons) of those who took the CD rated it as effective. 93 respondents (19.8%) were experienced several adverse effects including nausea, fatigue, and dizziness. The growing simultaneous use of herbal products and pharmaceutical drugs by Korean consumers may be continuously increased the risk of herb-drug interactions. The medical professionals should be provided with comprehensive and up-to-date information about potential benefits and risks of herbs and prescribed drugs. In the future studies it may be recommended to deal common cold, health promotion, indigestion, headache, and hypertension for the effect and safety of the CD by well-organized prospective study design.

• 한국식생활문화학회지
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• 제15권5호
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• pp.398-412
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• 2000

The purposes of this study are : (a) to investigate the attitude to various coffee and tea of women, (b) to analyze the characteristics of each classified group according to eating frequency, and (c) to abstract the factors which can influence the consumption of coffee and tea. Questionnaires were hand delivered to 1,200 women residing in Seoul. A total of 1012 was usable: resulting in 84% response rate. Statistical data analysis was completed using SAS Package program for the one way-analysis of variance(ANOVA), Duncan's multiple comparison test, factor analysis and analysis of covariance (ANOCOVA). (a) Instant coffee was most consumed(22.1 times a month), green tea in tea bag(8.7), Donggulre tea(8.3), Coffee (72) in order of frequency. Among Korean traditional tea Donggulre tea(8.3) and Yuja tea (2.0) were most prefered but still a minute quantity of Korean traditional tea was enjoyed. (b) Coffee and Black tea was regarded unhealthful but habitual, delicious and familiar beverage. Green tea was regarded good for health but not so habitual, practical and familiar. The consumer awareness can be grouped into 3 clases : Healthy factor, Habitual Practical factor, Familiar factor. (c) The sociodemographic characteristics of women influenced the beverage consumption. Women in their 30s and 40s consumed much of instant coffee and coffee. 10s and 20s consumed much of canned coffee. Working women drank much of instant coffee and green tea in tea bag. Women in highest income group$({\geq}\;4,000,000\;won/month)$ consumed much of coffee. (d) The factors which influenced the eating frquency of those beverages were various. The eating frequency of instant coffee was influenced by the age, familiar factor and habitual practical factor. And coffee were influenced by income level, habitual practical factor. The frequency of green tea in tea bag was influenced by habitual practical factor and familiar factor, green tea was influenced by healthy factor and habitual practical factor, Donggulre tea was influenced by habitual practical factor.

• 한국어병학회지
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• 제1권2호
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• pp.77-85
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• 1988

1987년(年) 3(월)月 부산수산대학(釜山水産大學) 어병학(魚病學) 실험실(實驗室)에서 사육중(飼育中)이던 틸라피아 (Oreochromis niloticus)에 세균성(細菌性) 질병(疾病)이 발생(發生)하여 만성적(慢性的)으로 몇마리씩 폐사(斃死)하였다. 본(本) 연구(硏究)는 이러한 질병(疾病)의 원인(原因)을 밝히기 위하여 원인균(原因菌)을 분리(分離)하였으며, 형태적(型態的), 생화학적(生化學的) 성상(性狀)을 관찰(觀察)하고 병원성(病原性), 약제감수성(藥劑感受性) 실험(實驗)을 하였으며 시험항원(試驗抗原)을 제작(制作)하여 그 항원성(抗原性)을 조사하였는바, 그 결과(結果)를 요약(要約)하면 다음과 같다. 1. 병어(病魚)에서 분리(分離)된 원인균(原因菌)은 Edwardsiella tarda로 동정(同定)되었다. 2. 분리균(分離菌)을 틸라피아에 접종하여 재현성실험(再現性實驗)을 한 결과(結果) 전형적인 E. tarda의 감염증상을 나타내고 사망(死亡)했으며, 어류(魚類)로부터 동일균(同一菌)을 얻을 수 있었다. 3. 분리균(分離菌)은 oxytetracycline에서 감수성(感受性)이 높았고, MIC는 6.9로 나타났다. 4. 분리균(分離菌)은 병원성(病原性)이 강한 균(菌)이었으며, 48-LD50은 $10^{6.4}cell$/fish 이었다. 5. 시험항균(試驗抗原)으로, 포르말린사균항원, 초음파처리항원, 균여과액항원을 사용하였으며, 이 세가지를 사용한 항원성시험(抗原性試驗) 결과 포르말린사균항원의 시험구에서 높은 응집가와 방어력을 나타내었다.

• 한국화재소방학회논문지
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• 제32권5호
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• pp.46-51
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• 2018

본 연구는 재난 재해 상황에서 피난을 할 때 재해정보지도에 나타나는 피난경로의 정보만으로 피실험자가 대피 장소까지 빠르고 정확하게 대피하는 것을 목적으로 하고 있다. 이를 위하여 본 연구에서는 국내 외 재해정보지도의 현황 및 관련 법규를 조사하고 실험을 실시하여 교차경로에 있어 효과적인 유형을 도출하고자 한다. 이를 위하여 1차 예비 실험 및 설문조사를 통해 얻게 된 재해정보지도의 문제점을 도출하였고 도출된 문제점을 바탕으로 하여 재해정보지도의 효율적 표시정보를 제공하기 위하여 유형별 실험을 실시하였다. 또한 교차경로의 수에 따른 보행특성을 알아보기 위하여 직전속력과 통과속력을 비교하여 교차경로에서의 감소율을 유형별로 도출하였다. 이를 바탕으로 하여 대피경로 탐색과정에서 교차경로의 판단을 할 때 빠르고 정확하게 경로를 판단할 수 있도록 재해정보지도에 제안 할 수 있을 것이다. 결과적으로 본 논문의 실험을 통해 재난상황의 대응에 있어 재해정보지도만으로도 조속하고 정확한 대피를 이루고, 재난의 대응체계에 대한 가이드라인을 시민들에게 제시하여 인명피해를 줄일 수 있도록 기여하고자 한다.

• 한국식품과학회지
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• 제35권5호
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• pp.764-768
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• 2003

본 연구는 생물학적, 비생물학적인 스트레스에 대한 방어물질중의 한가지인 trans-resveratrol를 포도와 포도가공품(포도주, 포도쥬스)으로부터 분석하는 방법을 확립하였다. trans-Resveratrol 기기분석 조건은 다음과 같다. 분석 column은 Nucleosil 100-5 C18을 사용하였으며 이동상은 acetonitrile: water(40:60, v/v)로서 UV검출기(306 nm)를 이용하여 0.3 mL/min의 유속으로 측정하였다. 분석한 결과, 재현성과 반복성의 CV%는 10%이하였으며, 회수율은 $90{\sim}110%$이었다. 또한, 포도, 포도주 그리고 포도쥬스의 최소검출한계는 14.5 ng/g, 3.62 ng/mL 그리고 4.02 ng/mL이고, 최소정량한계는 14.8 ng/g, 3.69 ng/mL 그리고 4.10 ng/mL이었다. 표준물질인 trans-resveratrol 농도가 $0.048{\sim}2.4\;{\mu}g/mL$일때 $R^2$ 값은 0.999이었다. 32품종의 포도, 9종류의 포도주 그리고 9종류의 포도쥬스 내의 trans-resveratrol 함량은 각각 $0.76{\sim}207.14\;{\mu}g/100\;g$, $5.41{\sim}275.66\;{\mu}g/L$ 그리고 $63.25{\sim}751.55\;{\mu}g/L$로 분석되었다.

• 보건교육건강증진학회지
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• 제14권2호
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• pp.43-57
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• 1997

Educational goals of SPH were two-fold : One was to train a health professions who should take charge of a leading roles, another were to educate the researchers of public health. There were strong demands to evaluate whether these goals had been effectively achieved through the master's course of SPH or not. According to the educational goals of SPH, public health is an applied science to be applicable to health-related fields. The curriculum of SPH has to be built under this principle and be evaluated by someone regularly. Who evaluates that? The most pertinent appraiser is the graduates of public health currently working at health-related jobs. It was the purpose of the study to let the graduates evaluate their education and the curriculum that they had undertaken during master's course at SNU. If the results of the evaluation by the graduates were not satisfactory, we should find the actual causes of low scored apraisal and reform the curriculum of SPH as the process of problem solving. During September and October 1996, a postal survey was undertaken of the 293 SNU graduates of public health who had been engaged in the health related jobs. As 198 graduates answered out of 293, the response rate was 67.6%. The questionnaire was designed to ascertain how well the SNU master's course of public health had helped their practice. The SAS package was used for statistical analysis and $x^2$-test as a test of statistical significance. Major findings of the study were summarized as follows: $\cdot$ The health related abilities consisted of three categories, which were health administration abilities composed of 14 items, health education abilities composed of 5 items, health research abilities composed of 10 items. $\cdot$ The respondents had acquired 'Worldwide trends of health policy', 'evaluation concepts of health projects', 'interpersonal relationships in professional life', and 'communication through writings' moe than other detailed items in the category of health administration abilities. $\cdot$ 'Establishment of educational and learning golas' was the most acquired item of 5 detailed items of health education abilities. $\cdot$ Respondents indicated that they had acquired ability 'to search reference', ' to understand health problems', 'to establish study plannings', and 'to collect health related data' more than other detailed items in the category of health research abilities.

• 한국병원경영학회지
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• 제20권3호
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• pp.45-55
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• 2015

While the influence of healthcare accreditation system to the quality improvement of hospitals has more increased, regarding the preparation costs for healthcare accreditation, it has never been empirically studied about the costs that are actually invested by hospitals. This study is going to determine the difficulties in the preparation process of accreditation and details of accreditation preparation costs for hospitals that participated in the healthcare accreditation system and acquired accreditation. The survey was performed in a self-reported form from February 28 to March 21 2014 for 189 acute hospitals accredited as a hospital from 2011 to February 2014. Of all questionaries of survey participants, 98 were recovered; the response rate was 51.9%. A total of 40 questionnaires were used except for 58 containing insincere answers. Main findings are followings: Firstly, findings showed that advanced general hospitals spent the most statistically significantly highest in terms of equipments and total costs among cost items for accreditation preparation. When accreditation preparation costs items were classified according to classification of hospitals, advanced general hospitals spent the most statistically significantly highest in the equipments and total costs. Also in terms of regional, Gyeonggi, Incheon regions were found to spend statistically significantly higher costs in the equipments costs. Secondly, as a result of the survey in the distribution of the total accreditation preparation costs, advanced general hospitals have disbursed the most out of all. However, the result in hospitals does not show significant difference to the expense of advanced general hospitals and that especially other regional hospitals spent higher costs. As such, all hospitals are under a heavy burden of higher costs on accreditation preparation, especially hospitals. The build-up of infrastructures by hospitals through an accreditation system consequently led to a higher initial investment; if the accreditation system is effective in improving the quality of health care and patient safety, appropriate responses are needed. In other words, financial support for investment costs needs to be given to allow hospitals to actively participate in the accreditation system.

• 한국건설관리학회논문집
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• 제14권4호
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• pp.97-107
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• 2013

건설업 '산업안전보건관리'라 함은 발주자로 하여금 공사종류 및 규모에 따라 일정금액을 도급금액에 별도로 책정토록 하여 건설공사 중 발생할 수 있는 각종 재해를 미연에 예방코자 사용되는 금액을 의미한다. 이러한 안전관리비는 1988년 2월 고용노동부고시로 제정되었고 이를 근거로 기획재정부"계약예규"'예정가격 작성기준'이 마련되어 건설공사공사 원가계산 제비율 적용기준의 산업안전보건관리비로서 공사종류별 및 대상 금액별 요율이 차등 책정되어 활용되고 있다. 그러나 건설업에 대한 관리기술의 발전 및 건설현장 여건변화, 비용에 대한 감가삼각, 안전보건관리기술 발전 및 관련 정책변화 등 건설업이 대내 외적으로 다양한 환경변화가 이루어져왔음에도 불구하고 안전관리비 요율 책정은 1988년 고용노동부 고시로 제정된 이래 현재까지 변경 없이 그대로 적용되고 있다. 따라서 이 연구의 목적은 고용노동부 고시에서 제시하고 있는 건설업 산업안전보건관리비 사용 실태에 대한 현황 조사 및 설문분석을 통해 현(現) 건설현장 안전관리 실태에 부합되는 산업안전관리비 적정 요율을 공사종류 및 대상액별로 제안하는 것이다. 건설공사를 수행함에 있어 적정 산업안전관리비의 산정 및 사용은 건설 안전관리 분야의 업무 효율성 제고는 물론 궁극적으로는 건설공사의 안전사고 비율 저감에 긍정적인 영향을 미칠 것으로 기대된다.

• Genomics & Informatics
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• 제16권3호
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• pp.52-58
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• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• 한국지반신소재학회논문집
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• 제9권3호
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• pp.77-85
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• 2010

저수지의 수위변화는 저수지 주변 강기슭 사면파괴의 주요 요인이다. 중국의 삼협댐 저수위는 홍수량 조절을 위해 145m와 175m사이에서 변화한다. 삼협댐 저수위의 정상적 운영상태에서 저수위 변동속도는 0.67m~3.0m의 범위에 있다. 마지아고 사면은 자시강의 2.1km 상류 좌측기슭에 위치한다. 자시강은 삼협지역내에 있는 양츠강의 지류이다. 2003년 저수위가 95m에서 135m로 상승한 직후, 마지아고 사면의 후면부에서 길이 20m, 폭 3~10의 균열이 발생하였다. 지금은 균열 보수 후 특별한 징후는 보이지 않고는 있으나, 이 큰 균열은 마지아고 사면의 산사태 가능성을 암시하고 있었다. 이 연구에서는 저수위 변화와 관련하여 사면내에서 간극수압의 변화를 모의하기 위해 불포화 및 포화 침투해석이 수행되었다. 얻어진 간극수압은 저수위에 따른 안전율 변화를 평가하기 위해 사용되었다. 연구결과 침윤선은 저수위 변화보다 상당히 지연된 반응을 보였고, 저수위의 상승-하강과정에서 침윤선은 각각 요면과 철면의 형상을 나타내었다. 또한 저수위의 변동은 사면의 전면부에만 영향을 미치고 있었고 후면부에는 영향을 미치지 않았다.