• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2011년도 정기 학술대회
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• pp.680-683
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• 2011

This study deals with damage detection in beam structure by using modal strain energy-based technique with three different sensor types: accelerometer, lead zirconate titanate (PZT) piezoelectric sensor and electrical strain gage. First, the use of direct piezoelectric effect of PZT sensor for dynamic strain response are presented. Next, a modal strain energy-based damage detection method is outlined. For validation, forced vibration tests are carried out on lab-scale aluminum cantilever beam. The dynamic responses are measured for several damage scenarios. Based on damage localization results, the performance of three different sensor types is evaluated.

• Journal of Microbiology and Biotechnology
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• 제23권3호
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• pp.279-288
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• 2013

Phosphorylation and dephosphorylation of proteins trigger many critical events involved in cellular response, such as regulation of enzymatic activity, protein conformational change, protein-protein interaction, and cellular localization. Any malfunction of protein phosphorylation leads to a diseased state such as diabetes, cancer, and even neurodegenerative diseases. In order to comprehend the molecular view of the complex biological processes of these diseases in depth, very sensitive and detailed analytical methods are necessary for identification of the phosphorylated residues in a protein. As part of these efforts, phosphoproteomics has been developed and applied for the elucidation of neurodegenerative diseases. In this review, we present a brief summary of phosphoproteomics approaches that are now routinely used in biomedical research, and describe the biomedical application of phosphoproteomics especially in Alzheimer's and other neurodegenerative diseases.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.27-27
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• 2001

In exocrine acinar cells, $Ca^{2＋}$ -activated Cl$^{[-10]}$ channels in the apical membrane are essential for fluid secretion, but it is unclear whether such channels are important for Cl$^{[-10]}$ uptake at the base. Whole cell current recording, combined with local uncaging of caged $Ca^{2＋}$, was used to reveal the Cl$^{[-10]}$ channel distribution in mouse pancreatic acinar cells, where ~90％ of the current activated by $Ca^{2＋}$ in response toacetylcholine was carried by Cl$^{[-10]}$ .(omitted)

• 소성∙가공
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• 제24권3호
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• pp.194-198
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• 2015

Microstructure based FE simulations were conducted to investigate the micro-mechanical properties of ferrite-martensite dual-phase steels. The FE model was built based on real microstructure images which were characterized by optical microscopy through the thickness direction. Serial sectioned 2D images were converted into semi-2D representative volume elements (RVEs) model. Each RVE model was subjected to a non-proportional loading condition and the mechanical response was analyzed on both the macroscopic and microscopic levels. Macroscopically, stress-strain curves were described under tension-compression and tension-orthogonal tension conditions and the Bauschinger effect was well captured for both loading paths. In addition, micromechanical properties were investigated in the view of stress-strain partitioning and strain localization during monotonic tension.

• International Journal of Industrial Entomology and Biomaterials
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• 제37권2호
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• pp.49-54
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• 2018

To artificially enhance antimicrobial peptide expression in Bombyx mori, we constructed genetically engineered silkworms overexpressing Rel family transcription factor. The truncated BmRelish1 (BmRelish1t) gene contained a Rel homolog domain (RHD), nuclear localization signal (NLS), acidic and hydrophobic amino acid (AHAA)-rich region, and death domain (DD), but no ankyrin-repeat (ANK) domain. The BmRelish1t gene was controlled by B. mori cytoplasmic actin 3 promoter in the PiggyBac transposon vector. Chromosome analysis of G1 generations of a transgenic silkworm with EGFP expression confirmed stable insertion of BmRelish1t. BmRelish1t gene overexpression in transgenic silkworms resulted in higher mRNA expression levels of B. mori antimicrobial peptides such as lebocin(~20.5-fold), moricin(~8.7-fold), and nuecin(~17.4-fold) than those in normal silkworms.

• Smart Structures and Systems
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• 제23권2호
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• pp.123-139
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• 2019

Impact forces induced by external object collisions can cause serious damages to civil engineering structures. While accurate and prompt identification of such impact forces is a critical task in structural health monitoring, it is not readily feasible for civil structures because the force measurement is extremely challenging and the force location is unpredictable for full-scale field structures. This study proposes a novel approach for identification of impact force including its location and time history using a small number of multi-metric observations. The method combines an augmented Kalman filter (AKF) and Genetic algorithm for accurate identification of impact force. The location of impact force is statistically determined in the way to minimize the AKF response estimate error at measured locations and then time history of the impact force is accurately constructed by optimizing the error co-variances of AKF using Genetic algorithm. The efficacy of proposed approach is numerically demonstrated using a truss and a plate model considering the presence of modelling error and measurement noises.

• 한국음향학회지
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• 제36권5호
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• pp.345-352
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• 2017

본 논문에서는 잔향과 잡음이 존재하는 실제 환경을 모델링하여 두 개의 마이크로폰을 이용한 음원 위치추정의 정확성을 향상시키는 방법을 제안하였다. 입력신호에 VAD(Voice Activity Detection)를 적용하여 묵음 구간을 제외한 음성 구간만을 사용하였고, 샘플링 주파수의 제한으로 인한 측정 범위를 벗어나는 프레임은 업샘플링(up-sampling)을 통해 지연시간을 다시 추정하였다. 여기서 계산된 도착 지연 시간은 Time-table을 참조해 주변 후보위치의 지연 값들과의 비교로 최대 파워 값을 갖는 지연 시간을 선택하여 음원 위치의 정확도를 높였다. 또한 프레임간의 상관성을 이용하여 연속된 음성 프레임의 경우 큰 추정 차가 발생하는 곳을 찾아 주변 프레임의 평균값으로 대체함으로써 음원의 위치 추정 성능을 향상시켰다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8339-8343
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• 2016

Background: To determine the outcome and cost saving by placing ultrasound guided surgical clips for tumor localization in patients undergoing neo-adjuvant chemotherapy for breast cancer. Materials and Methods: This retrospective cross sectional analytical study was conducted at the Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan from January to December 2014. A sample of 25 women fulfilling our selection criteria was taken. All patients came to our department for ultrasound guided core biopsy of suspicious breast lesions and clip placement in the index lesion prior to neo-adjuvant chemotherapy. All the selected patients had biopsy proven breast cancer. Results: The mean age was $45{\pm}11.6years$. There were no complications seen after clip placement in terms of clip migration or hemorrhage. The cost of commercially available markers was approximately PKR 9,000 (US$ 90) and that of the surgical clip was PKR 900 (US$ 9). The cost of surgical clips in 25 patients was PKR 22,500 (US$ 225), when compared to the commercially available markers which may have incurred a cost of PKR 225,000 (US$ 2,250). The total cost saving for 25 patients was PKR 202,500 (US$ 2, 025), making it PKR 8100 (US$ 81) per patient. Conclusions: The results of our study show that ultrasound guided surgical clip placement in index lesions prior to neo-adjuvant therapy is a safe and cost effective method to identify tumor bed and response to treatment for further management.

• 디지털융복합연구
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• 제18권5호
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• pp.99-104
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• 2020

한류열풍과 함께 우수한 교육컨텐츠를 보유하는 현시점에 세계시장으로 이를 알리고 진출하는 것이 필요하다. 본 연구는 한국의 교육컨텐츠의 세계시장 진출의 필요성을 강조하기 위해 교육컨텐츠 보급의 필요성과 브랜드화에 관한 분석을 하였으며, 이를 진행하기 위한 전력방법을 제시하여 한류와 더불어 한국교육컨텐츠의 세계시장 진출방안을 모색하고자 한다. 전략방법으로는 첫째 교육컨텐츠 보급과 활용을 통한 문화교류 확대, 둘째 교육컨텐츠의 지속적인 성장을 위한 현지화 방안, 셋째 일방적 전파로 비추어질 수 있는 상황에 대처를 위한 컨텐츠 현지화 및 현지 파트너쉽 형성이 있다. 교육컨텐츠의 세계시장 진출은 국가이미지에 긍정적인 영향은 뿐만아니라 한류가 본래 가지고 있었던 경제적 효과도 지속시키는데 도움을 줄 수 있을 것이다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.90-90
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• 2017

Regulation of seed dormancy is important in many grains to prevent pre-harvest sprouting. To identify and understand the gene related to seed dormancy regulation, we have screened for viviparous phenotypes of rice mutant lines generated by insertion of Ds transposon in a Korean Japonica cultivar (Dongjin) background. One of the mutants, which represented viviparous phenotype, was selected for further seed dormancy regulation studies and designated dor1. The dor1 mutant has single Ds insertion in the second exon of OsDor1 gene encoding glycine-rich protein. The seeds of dor1 mutant showed a higher germination potential and reduced abscisic acid (ABA) sensitivity compared to wild type Dongjin. Over-expression of Dor1 complements the viviparous phenotype of dor1 mutant, indicating that Dor1 function in seed dormancy regulation. Subcellular localization assay of Dor1-GFP fusion protein revealed that the OsDor1 protein mainly localized to membrane and the localization of OsDOR1 was influenced by presence of a giberelin (GA) receptor OsGID1. Further bimolecular fluorescence complementation (BiFC) analysis indicated that OsDOR1 interact with OsGID1. The combined results suggested that OsDOR1 regulates seed dormancy by interacting with OsGID1 in GA response. Additionally, expression of OsDOR1 partially complemented the cold sensitivity of Escherichia coli BX04 mutant lacking four cold shock proteins, indicating that OsDOR1 possessed RNA chaperone activity.