Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Localization, activation and deactivation of $Ca^{2+}$ dependent $Cl^-$ channels in pancreatic acinar cells

  • Park, Myoung-Kyu (Department of Physiology, Sungkyunkwan University School of Medicine) ;
  • Richard Lomax (Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpoo) ;
  • Alexei V. Tepikin (Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpoo) ;
  • Ole H. Petersen (Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool)
  • Published : 2001.06.01
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Abstract

In exocrine acinar cells, $Ca^{2＋}$ -activated Cl$^{[-10]}$ channels in the apical membrane are essential for fluid secretion, but it is unclear whether such channels are important for Cl$^{[-10]}$ uptake at the base. Whole cell current recording, combined with local uncaging of caged $Ca^{2＋}$, was used to reveal the Cl$^{[-10]}$ channel distribution in mouse pancreatic acinar cells, where ~90％ of the current activated by $Ca^{2＋}$ in response toacetylcholine was carried by Cl$^{[-10]}$ .(omitted)

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