• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.680-683
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• 2011

This study deals with damage detection in beam structure by using modal strain energy-based technique with three different sensor types: accelerometer, lead zirconate titanate (PZT) piezoelectric sensor and electrical strain gage. First, the use of direct piezoelectric effect of PZT sensor for dynamic strain response are presented. Next, a modal strain energy-based damage detection method is outlined. For validation, forced vibration tests are carried out on lab-scale aluminum cantilever beam. The dynamic responses are measured for several damage scenarios. Based on damage localization results, the performance of three different sensor types is evaluated.

• Journal of Microbiology and Biotechnology
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• v.23 no.3
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• pp.279-288
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• 2013

Phosphorylation and dephosphorylation of proteins trigger many critical events involved in cellular response, such as regulation of enzymatic activity, protein conformational change, protein-protein interaction, and cellular localization. Any malfunction of protein phosphorylation leads to a diseased state such as diabetes, cancer, and even neurodegenerative diseases. In order to comprehend the molecular view of the complex biological processes of these diseases in depth, very sensitive and detailed analytical methods are necessary for identification of the phosphorylated residues in a protein. As part of these efforts, phosphoproteomics has been developed and applied for the elucidation of neurodegenerative diseases. In this review, we present a brief summary of phosphoproteomics approaches that are now routinely used in biomedical research, and describe the biomedical application of phosphoproteomics especially in Alzheimer's and other neurodegenerative diseases.

• Proceedings of the Korean Biophysical Society Conference
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• 2001.06a
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• pp.27-27
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• 2001

In exocrine acinar cells, $Ca^{2＋}$ -activated Cl$^{[-10]}$ channels in the apical membrane are essential for fluid secretion, but it is unclear whether such channels are important for Cl$^{[-10]}$ uptake at the base. Whole cell current recording, combined with local uncaging of caged $Ca^{2＋}$, was used to reveal the Cl$^{[-10]}$ channel distribution in mouse pancreatic acinar cells, where ~90％ of the current activated by $Ca^{2＋}$ in response toacetylcholine was carried by Cl$^{[-10]}$ .(omitted)

• Transactions of Materials Processing
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• v.24 no.3
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• pp.194-198
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• 2015

Microstructure based FE simulations were conducted to investigate the micro-mechanical properties of ferrite-martensite dual-phase steels. The FE model was built based on real microstructure images which were characterized by optical microscopy through the thickness direction. Serial sectioned 2D images were converted into semi-2D representative volume elements (RVEs) model. Each RVE model was subjected to a non-proportional loading condition and the mechanical response was analyzed on both the macroscopic and microscopic levels. Macroscopically, stress-strain curves were described under tension-compression and tension-orthogonal tension conditions and the Bauschinger effect was well captured for both loading paths. In addition, micromechanical properties were investigated in the view of stress-strain partitioning and strain localization during monotonic tension.

• International Journal of Industrial Entomology and Biomaterials
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• v.37 no.2
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• pp.49-54
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• 2018

To artificially enhance antimicrobial peptide expression in Bombyx mori, we constructed genetically engineered silkworms overexpressing Rel family transcription factor. The truncated BmRelish1 (BmRelish1t) gene contained a Rel homolog domain (RHD), nuclear localization signal (NLS), acidic and hydrophobic amino acid (AHAA)-rich region, and death domain (DD), but no ankyrin-repeat (ANK) domain. The BmRelish1t gene was controlled by B. mori cytoplasmic actin 3 promoter in the PiggyBac transposon vector. Chromosome analysis of G1 generations of a transgenic silkworm with EGFP expression confirmed stable insertion of BmRelish1t. BmRelish1t gene overexpression in transgenic silkworms resulted in higher mRNA expression levels of B. mori antimicrobial peptides such as lebocin(~20.5-fold), moricin(~8.7-fold), and nuecin(~17.4-fold) than those in normal silkworms.

• Smart Structures and Systems
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• v.23 no.2
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• pp.123-139
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• 2019

Impact forces induced by external object collisions can cause serious damages to civil engineering structures. While accurate and prompt identification of such impact forces is a critical task in structural health monitoring, it is not readily feasible for civil structures because the force measurement is extremely challenging and the force location is unpredictable for full-scale field structures. This study proposes a novel approach for identification of impact force including its location and time history using a small number of multi-metric observations. The method combines an augmented Kalman filter (AKF) and Genetic algorithm for accurate identification of impact force. The location of impact force is statistically determined in the way to minimize the AKF response estimate error at measured locations and then time history of the impact force is accurately constructed by optimizing the error co-variances of AKF using Genetic algorithm. The efficacy of proposed approach is numerically demonstrated using a truss and a plate model considering the presence of modelling error and measurement noises.

• The Journal of the Acoustical Society of Korea
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• v.36 no.5
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• pp.345-352
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• 2017

We propose a methods which is reducing direction estimation error of sound source in the reverberant and noisy environments. The proposed algorithm divides speech signal into voice and unvoice using VAD. We estimate the direction of source when current frame is voiced. TDOA (Time-Difference of Arrival) between microphone array using the GCC-PHAT (Generalized Cross Correlation with Phase Transform) method will be estimated in that frame. Then, we compare the peak value of cross-correlation of two signals applied to estimated time-delay with other time-delay in time-table in order to improve the accuracy of source location. If the angle of current frame is far different from before and after frame in successive voiced frame, the angle of current frame is replaced with mean value of the estimated angle in before and after frames.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8339-8343
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• 2016

Background: To determine the outcome and cost saving by placing ultrasound guided surgical clips for tumor localization in patients undergoing neo-adjuvant chemotherapy for breast cancer. Materials and Methods: This retrospective cross sectional analytical study was conducted at the Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan from January to December 2014. A sample of 25 women fulfilling our selection criteria was taken. All patients came to our department for ultrasound guided core biopsy of suspicious breast lesions and clip placement in the index lesion prior to neo-adjuvant chemotherapy. All the selected patients had biopsy proven breast cancer. Results: The mean age was $45{\pm}11.6years$. There were no complications seen after clip placement in terms of clip migration or hemorrhage. The cost of commercially available markers was approximately PKR 9,000 (US$ 90) and that of the surgical clip was PKR 900 (US$ 9). The cost of surgical clips in 25 patients was PKR 22,500 (US$ 225), when compared to the commercially available markers which may have incurred a cost of PKR 225,000 (US$ 2,250). The total cost saving for 25 patients was PKR 202,500 (US$ 2, 025), making it PKR 8100 (US$ 81) per patient. Conclusions: The results of our study show that ultrasound guided surgical clip placement in index lesions prior to neo-adjuvant therapy is a safe and cost effective method to identify tumor bed and response to treatment for further management.

• Journal of Digital Convergence
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• v.18 no.5
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• pp.99-104
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• 2020

It is needed to advance into the global market at the present time, which has the best educational contents along with the Korean Wave. In this study, an analysis was conducted to emphasize the necessity of entering educational contents into the global market, and in the necessity of disseminating educational contents and branding educational contents were approached. The strategies to enter the global market for educational contents are as follows; First, the government established a strategy for disseminating and using educational contents to expand overall cultural exchange with developing countries. Second, localization strategy for continuous growth of educational contents. Third, localization of contents and formation of partnership for local resistance, which is a response to unilateral propagation. Through the advancement of educational contents to the global market, it will be possible to sustain not only the positive effect on the national image, but also the economic effect that Korean Wave originally has.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.90-90
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• 2017

Regulation of seed dormancy is important in many grains to prevent pre-harvest sprouting. To identify and understand the gene related to seed dormancy regulation, we have screened for viviparous phenotypes of rice mutant lines generated by insertion of Ds transposon in a Korean Japonica cultivar (Dongjin) background. One of the mutants, which represented viviparous phenotype, was selected for further seed dormancy regulation studies and designated dor1. The dor1 mutant has single Ds insertion in the second exon of OsDor1 gene encoding glycine-rich protein. The seeds of dor1 mutant showed a higher germination potential and reduced abscisic acid (ABA) sensitivity compared to wild type Dongjin. Over-expression of Dor1 complements the viviparous phenotype of dor1 mutant, indicating that Dor1 function in seed dormancy regulation. Subcellular localization assay of Dor1-GFP fusion protein revealed that the OsDor1 protein mainly localized to membrane and the localization of OsDOR1 was influenced by presence of a giberelin (GA) receptor OsGID1. Further bimolecular fluorescence complementation (BiFC) analysis indicated that OsDOR1 interact with OsGID1. The combined results suggested that OsDOR1 regulates seed dormancy by interacting with OsGID1 in GA response. Additionally, expression of OsDOR1 partially complemented the cold sensitivity of Escherichia coli BX04 mutant lacking four cold shock proteins, indicating that OsDOR1 possessed RNA chaperone activity.