• Journal of Radiation Industry
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• v.18 no.1
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• pp.9-14
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• 2024

In order to thoroughly verify the denuclearization of the Korean Peninsula, it is urgent to develop technology capabilities to monitor, detect, collect, analyze, interpret, and evaluate nuclear activities using nuclear materials and secure nuclear transparency. The IAEA is actively using seal technology to maximize the efficiency of safety measures, and currently uses metal cap, paper, COBRA, and EOSS as seal devices. Unlike facilities that comply with safety measures requirements, such as domestic nuclear facilities, facilities subject to denuclearization are likely to have various risk environments that make it difficult to apply safety measures, and there is a high possibility that continuity of knowledge (COK) such as damage, malfunction, and power loss will not be maintained. This study aims to develop a real-time active seal device that can be applied in such special situations to enable immediate response in the event of a similar situation. To this end, the main functions of the real-time seal device were derived and applied, and a commercialized seal device and operation software. The real-time seal technology developed through this study can be applied to all nuclear facilities in South Korea, especially used as storage equipment for dry cask storage facilities of heavy water reactor's after fuel, and it is believed that unnecessary radiation exposure by inspectors can be minimized.

• IMMUNE NETWORK
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• v.3 no.4
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• pp.302-309
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• 2003

Background: CTLA4 (CD152), which is expressed on the surface of T cells following activation, has a much higher affinity for B7 molecules comparing to CD28, and is a negative regulator of T cell activation. In contrast to stimulating and agonistic capabilities of monoclonal antibodies specific to CTLA-4, CTLA4Ig fusion protein appears to act as CD28 antagonist and inhibits in vitro and in vivo T cell priming in variety of immunological conditions. We've set out to confirm whether inhibition of the CD28-B7 costimulatory response using a soluble form of human CTLA4Ig fusion protein would lead to persistent inhibition of alloreactive T cell activation. Methods: We have used CHO-$dhfr^-$ cell-line to produce CTLA4Ig fusion protein. After serum free culture of transfected cell line we purified this recombinant molecule by using protein A column. To confirm characterization of fusion protein, we carried out a series of Western blot, SDS-PAGE and silver staining analyses. We have also investigated the efficacy of CTLA4Ig in vitro such as mixed lymphocyte reaction (MLR) & cytotoxic T lymphocyte (CTL) response and in vivo such as experimental autoimmune encephalomyelitis (EAE), graft versus host disease (GVHD) and skin-graft whether this fusion protein could inhibit alloreactive T cell activation and lead to immunosuppression of activated T cell. Results: In vitro assay, CTLA4Ig fusion protein inhibited immune response in T cell-specific manner: 1) Human CTLA4Ig inhibited allogeneic stimulation in murine MLR; 2) CTLA4Ig prevented the specific killing activity of CTL. In vivo assay, human CTLA4Ig revealed the capacities to induce alloantigen-specific hyporesponsiveness in mouse model: 1) GVHD was efficiently blocked by dose-dependent manner; 2) Clinical score of EAE was significantly decreased compared to nomal control; 3) The time of skin-graft rejection was not different between CTLA4Ig treated and control group. Conclusion: Human CTLA4Ig suppress the T cell-mediated immune response and efficiently inhibit the EAE, GVHD in mouse model. The mechanism of T cell suppression by human CTLA4Ig fusion protein may be originated from the suppression of activity of cytotoxic T cell. Human CTLA4Ig could not suppress the rejection in mouse skin-graft, this finding suggests that other mechanism except the suppression of cytotoxic T cell may exist on the suppression of graft rejection.

• Journal of the Korean Chemical Society
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• v.55 no.1
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• pp.63-69
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• 2011

This work discusses the fabrication, development and potential response behaviors of $Ag^+$ ion-selective electrodes ($Ag^+$-ISE) based on N,N'-bis(2-hydroxybenzyl)-1,3-diaminopropane (L1) and N,N'-bis(2-hydroxybenzyl)-2,2-dimethyl-1,3-diaminopropane (L2) as carriers. The observations indicated that the resulting electrode based on L1 toward $Ag^+$ showed stable near-Nernst slope approaching 58.7 mV/dec and the optimum potential response characteristics in a linear range at least five orders of magnitude with a detection limit of $1.0{\times}10^{-6}M$. The proposed electrode displayed the preferential selectivity to $Ag^+$ against other tested cations. The excellent potential analytical characteristics could lead to the successful applications of silver assay in significant real samples, indicating that the proposed $Ag^+$-ISE showed a significant advancement of measurement capabilities. But for the electrode based on L2, the poor potential response characteristics were observed in total experiment process.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.4
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• pp.473-482
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• 2021

The introduction of automated flight systems has greatly improved aviation safety, but aircraft pilots continue to face new challenges. The pilot's stress from an aeronautical perspective can be distinguished by the 'Startle and Surprise' responses. 'Startle' is a short, strong physiological response to sudden or threatening stimuli such as unexpected gunfire. 'Surprise' is a cognitive-emotional response to an event that goes beyond one's expectations. In Martin et al.'s (2012) Startle Effect Experiment, the pilot identified physiological responses in the 'Startle' state, including delayed response and increased heart rate. In the Rahim (2020) Startle/Surprise experiment, the pilot's breathing rate and pulse rate did not change due to pre-planned emergency training. On the other hand, it was confirmed that the pilot's respiratory and heart rate were greatly increased due to the complicated aircraft and unplanned emergencies. Based on the results of these experiments, domestic pilots need to be trained to handle non-technical and various unexpected emergencies that could arise in an aircraft, rather than be just put through courses for enhancing technical capabilities or simple repetitive training as required by aviation law.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.4
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• pp.429-435
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• 2020

North Korea declared itself complete with nuclear force after its sixth nuclear test in 2017. Despite efforts at home and abroad to denuclearize the Korean Peninsula, the prospects for the denuclearization are not bright. Along with political and diplomatic efforts to deter NK's WMD threats, the government is required to strengthen its consequence management capabilities against 'catastrophic situations' expected in case of emergency. Accordingly, this study was conducted to present measures to strengthen follow-up management against CBRN threats. The research model was partially supplemented and utilized by the THIRA process adopted and utilized by the U.S. Department of Homeland Security among national-level disaster management plan development models. Korea's consequence management (CM) system encompasses risk and crisis management on disaster condition. The system has been carried out in the form of a civil, government and military integrated defense operations for the purpose of curbing the spread or use of CBRNs, responding to threats, and minimizing expected damages. The preventive stage call for the incorporation of CBRN concept and CM procedures into the national management system, supplementing the integrated alarm systems, preparation of evacuation facilities, and establishment of the integrated training systems. In the preparation phase, readjustment of relevant laws and manuals, maintenance of government organizations, developing performance procedures, establishing the on-site support systems, and regular training are essential. In the response phase, normal operations of the medical support system for first aid and relief, installation and operation of facilities for decontamination, and development of regional damage assessment and control guidelines are important. In the recovery phase, development of stabilization evaluation criteria and procedures, securing and operation of resources needed for damage recovery, and strengthening of regional damage recovery capabilities linked to local defense forces, reserve forces and civil defense committees are required.

• Journal of Korea Technology Innovation Society
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• v.12 no.3
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• pp.471-498
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• 2009

The ability to judge a country's scientific standing is vital for the governments and businesses that must decide scientific priorities and funding. In this paper, we analyze the output and outcomes from research investment over the recent years, to measure the quality of scientific research on national scales and to set it in an international context. There are many ways to evaluate the quality of scientific research, but few have proved satisfactory. To measure the quantity and quality of science in different nations, we analyzed the numbers of published research papers and their citations. The number of citations per paper is a useful measure of the impact of a nation's research output. Essential at a were acquired from SCI database by Thomson Scientific, which indexes more than 8,000 journals, representing most significant materials in science and engineering. The purpose of this paper is to evaluate and compare the output and outcomes among nations in a variety of viewpoints and criteria. One of the implications in response to the result of analysis is that sustainable economic development in highly competitive world markets requires a direct engagement in the generation of knowledge. Even modest improvement in healthcare, clean water, sanitation, food, and transport need capabilities in engineering, technology, and medicine beyond many countries' reach. Nations exporting natural resources such as gold and oil can import technology and expertise, but only until these resources are exhausted. For them, sustainability should imply investment in alternative agricultural and technological capabilities through improvements in their skills base. A strong science base does not necessarily leat to wealth generation. However, strength in science has additional benefits for individual nations, and for the world as a whole.

• Journal of Internet of Things and Convergence
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• v.7 no.4
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• pp.69-75
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• 2021

This study investigated the status of disaster response, focusing on modern architecture. The modern architecture is drawing more attention and being more used in the local community among the architectural heritage in downtown collective. The railway employee residence area in Soje-dong, Daejeon is a collective building group, and the efforts to evaluate and preserve its historical, cultural, and architectural values have been underway. However, the area is now an undesignated cultural property that does not receive institutional protection. It carries significance in preserving it as a collective building group. Yet, since the main structure is made of wood, the risk of being destroyed by fire or disaster is high, and disaster prevention measures are insufficient. Therefore, this study examined the structural and non-structural conditions such as the arrangement and architectural characteristics of official residence buildings, and looked into measures of the construction of a disaster prevention system and residents' participation. To preserve the urban historical environment created as a collective architectural heritage, it is necessary that the area reinforces its own disaster prevention capabilities, such as establishing an effective disaster prevention system considering village characteristics, strengthening disaster prevention capabilities based on residents' participation, and forging formal and informal governance in the local community.

• Journal of Internet Computing and Services
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• v.24 no.6
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• pp.119-125
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• 2023

Through the Ukraine-Russia war, the military importance of drones is being reassessed, and North Korea has completed actual verification through a drone provocation towards South Korea at 2022. Furthermore, North Korea is actively integrating artificial intelligence (AI) technology into drones, highlighting the increasing threat posed by drones. In response, the Republic of Korea military has established Drone Operations Command(DOC) and implemented various drone defense systems. However, there is a concern that the efforts to enhance capabilities are disproportionately focused on striking systems, making it challenging to effectively counter swarm drone attacks. Particularly, Air Force bases located adjacent to urban areas face significant limitations in the use of traditional air defense weapons due to concerns about civilian casualties. Therefore, this study proposes a new passive air defense method that aims at disrupting the object detection capabilities of AI models to enhance the survivability of friendly aircraft against the threat posed by AI based swarm drones. Using laser-based adversarial examples, the study seeks to degrade the recognition accuracy of object recognition AI installed on enemy drones. Experimental results using synthetic images and precision-reduced models confirmed that the proposed method decreased the recognition accuracy of object recognition AI, which was initially approximately 95%, to around 0-15% after the application of the proposed method, thereby validating the effectiveness of the proposed method.

• The Journal of the Acoustical Society of Korea
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• v.43 no.4
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• pp.414-421
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• 2024

In this paper, we design and verify a system that can detect piping leakage noise in an environment with significant reverberation and reflection using a multi-channel acoustic sensor module as a technology to prevent major plant accidents caused by leakage. Four-channel microphones arranged in a tetrahedron are designed as a single sensor module to measure three-dimensional sound intensity vectors. In an environment with large effects of reverberation and reflection, the measurement error of each sensor module increases on average, so after placing multiple sensor modules in the field, measurement results showing locations with large errors due to effects such as reflection are excluded. Using the intersection between three-dimensional vectors obtained from several pairs of sensor modules, the coordinates where the sound source is located are estimated, and outliers (e.g., positions estimated to be outside the site, positions estimated to be far from the average position) are detected and excluded among the points. For achieving aforementioned goal, an excluding algorithm by deciding the outliers among the estimated positions was proposed. By visualizing the estimated location coordinates of the leakage sound on the site drawing within 1 second, we construct and verify a system that can detect the location of the leakage sound in real time and enable immediate response. This study is expected to contribute to improving accident response capabilities and ensuring safety in large plants.

• Korean Journal of Labor Studies
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• v.24 no.2
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• pp.367-408
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• 2018

This study examines the features of globalization process in GM and Hyundai Motors, especially in the expansion into China auto market, through a joint venture(hereafter JV) research center. Due to the large scale market in China and the 50:50 JV, the two companies had to respond in some way to the Chinese government's request for localization of research and development functions, and their response affected the role of the JV research center. Even though the improvement in technological capability expected from the JV by the Chinese side did not appear well in the early stage in both JV, but relatively the Shanghai GM JV research center had a technological progress compared to the Beijing Hyundai JV research center. This paper explains the differences in the technical capabilities of the two JV research center, despite the same type of JV, as the difference between the status of the Chinese partner and the global strategy of the parent company. SAIC, a Chinese partner in Shanghai GM as a top-tier company, not only has been strongly demanding technology transfer from GM since the beginning of the JV, but has also made efforts to improve its own technical capabilities. Meanwhile, BAIC, a Chines partner in Beijing Hyundai as a mid-tier company, has not been strongly demanding technology transfer and lacked its own research base. Regarding the parent company's global strategy, although both companies controlled the core areas of research and development by their parent companies, GM actively considered using the Chinese RV to develop Chinese and emerging country vehicles. On the other hand, Hyundai Motors responded to the localization demand of the Chinese government while paying more attention to preventing technology leakage through its independent research center in China. The above discussion shows that the process of globalization of a company is a political process in which the global strategy of the parent company and the demands of the stakeholders surrounding the subsidiary are collided and compromised, rather than a process in which the harmony and cooperation between the parent company and its subsidiaries are smoothly achieved as the parent company's policies are unilaterally implemented.