• Macromolecular Research
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• v.17 no.3
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• pp.203-206
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• 2009

• Progress in Superconductivity
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• v.5 no.1
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• pp.38-44
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• 2003

The aim of this study is to confirm clinical usefulness of magnetocardiogram (MCG) by analyzing MCG data of health subjects and patients with Wolff-Parkinson-White (WPW) syndrome and dilated cardiomyopathy (DCM). Measurement of MCG signals was done with a home-made 40-channel SQUID system. MCG signals of 30 healthy subjects were measured as the reference of MCG signals. Among the DCM patients, 7 patients showed abnormal the direction of T wave vector. For a WPW syndrome patient, we measured the MCG signals before and after the surgery. and compared the difference. From the measured magnetic field distribution, current vector map was obtained to show the myocardium current activity. By comparing the MCG signals and current maps, we showed the differences in the analysis results between the healthy subjects and patients with heart diseases.

• Nuclear Engineering and Technology
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• v.54 no.4
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• pp.1449-1455
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• 2022

A radiotracer investigation was carried out in a Thermal Stratification Test Facility (TSTF) with objectives of investigating the dispersion and diffusion of radionuclide and effectiveness of the thermocline to minimize the radionuclide content in the hot water layer. Technetium-99m (^99mTc) as sodium pertechnetate was used as a radiotracer in the investigation. Qualitative analysis showed that a thermocline is formed within the TSTF and is effective in preventing the transport of radionuclide from bottom section to the top section of the facility. It was found that the radiotracer injected at the bottom of the pool took about 17.4 h to disperse from bottom to the top of the facility. The results of the investigation helped in understanding the effectiveness of hot water layer and thus to minimize the pool top radiation levels.

• Journal of Electrochemical Science and Technology
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• v.13 no.3
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• pp.323-338
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• 2022

Heat generation and temperature of a battery is usually presented by an equation of current. This means that we need to adopt time domain calculation to obtain thermal characteristics of the battery. To avoid the complicated calculations using time domain, 'state of charge (SOC)' can be used as an independent variable. A SOC based calculation method is elucidated through the comparison between the calculated results and experimental results together. Experiments are carried for rapid resistive discharge of a large-capacitive lithium secondary battery to evaluate variations of cell potential, current and temperature. Calculations are performed based on open-circuit cell potential (SOC,T), internal resistance (SOC,T) and entropy (SOC) with specific heat capacity.

• BMB Reports
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• v.55 no.3
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• pp.142-147
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• 2022

Human pluripotent stem cells (PSCs) have been utilized as a promising source in regenerative medicine. However, the risk of teratoma formation that comes with residual undifferentiated PSCs in differentiated cell populations is most concerning in the clinical use of PSC derivatives. Here, we report that a monoclonal antibody (mAb) targeting PSCs could distinguish undifferentiated PSCs, with potential teratoma-forming activity, from differentiated PSC progeny. A panel of hybridomas generated from mouse immunization with H9 human embryonic stem cells (hESCs) was screened for ESC-specific binding using flow cytometry. A novel mAb, K312, was selected considering its high stem cell-binding activity, and this mAb could bind to several human induced pluripotent stem cells and PSC lines. Cell-binding activity of K312 was markedly decreased as hESCs were differentiated into embryoid bodies or by retinoic acid treatment. In addition, a cell population negatively isolated from undifferentiated or differentiated H9 hESCs via K312 targeting showed a significantly reduced expression of pluripotency markers, including Oct4 and Nanog. Furthermore, K312-based depletion of pluripotent cells from differentiated PSC progeny completely prevented teratoma formation. Therefore, our findings suggest that K312 is utilizable in improving stem cell transplantation safety by specifically distinguishing residual undifferentiated PSCs.

• Annals of Clinical Neurophysiology
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• v.11 no.2
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• pp.64-66
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• 2009

Acute longitudinal myelitis is a group of disorder characterized by multifocal, long-segmented inflammation of the spinal cord, rapidly evolving paraparesis, a sensory level on the trunk, and bilateral Babinski signs. We report a case of 30-year-old man with longitudinal myelitis extending to long segment of spinal cord. After 15 days of aggressive treatment with intravenous pulsed methylprednisolone for 5 days, motor and sensory functions of the lower extremities were almost recovered.

• Proceedings of the KIEE Conference
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• 2005.07a
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• pp.217-219
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• 2005

배전계통의 소극적인 원격감시제어 만이 가능한 소규모 배전자동화 시스템이 1998년 처음 설치된 이후로 지금에 이르기까지 한국의 배전자동화 시스템은 종합 배전자동화로 이름만 변모 한 것이 아니라 기술수준과 표현능력에 있어서 비약적인 발전을 거듭하고 있다. 선로운영자의 계통상황 인식을 수월하게 하기위한 실지도상의 선로 표현창과 함께 기술검토를 위한 단선도 창이 추가되었고, 이를 통해 배전망 최적운영을 위한 다수의 기술검토용 운영프로그램들이 포함되어지고 있다. 본 논문에서는 고장발생시 그 위치를 추정하는 알고리즘을 연구하고 이를 배전자동화 시스템에 시험 적용한 사례를 소개한다.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.337-341
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• 2005

Blood pulsation has been reported to have an advantageous effect on extracorporeal blood circulation. However, the study of pulsatile blood flow in renal replacement therapy is very limited. The in-vitro experimental results of pulsatile blood flow on ultrafiltration, when compared with the conventional roller pump, are described in this paper. Methods: Blood flow rate (QB) and transmembrane pressure (TMP) were considered as regulating factors that have an influence on ultrafiltration. Experiments were performed under the condition of equal TMP and OB in both pulsatile and roller pump groups, Several kinds of hollow fiber dialyzers were tested using distilled water containing chemicals as a blood substitute. Mean TMP (mTMP) varied from 10 to 90mmHg while the QB was 200ml/min. Results: Ultrafiltration rate (QUF) was found to be linearly proportional to TMP, whereas QB had little influence on QUF. In addition, QUF was higher in the pulsatile group than the roller pump group at the identical TMP. Conclusion: In the controlled test, QUF increased solely as a consequence of blood pulsation, which implies that the pulse frequency represents an additional and important clinical variable during renal replacement therapy.

• Molecules and Cells
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• v.25 no.4
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• pp.559-565
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• 2008

Members of the TGA family of basic domain/leucine zipper transcription factors regulate defense genes through physical interaction with NON-EXPRESSOR OF PR1 (NPR1). Of the seven TGA family members, TGA4/octopine synthase (ocs)-element-binding factor 4 (OBF4) is the least understood. Here we present evidence for a novel function of OBF4 as a regulator of flowering. We identified CONSTANS (CO), a positive regulator of floral induction, as an OBF4-interacting protein, in a yeast two-hybrid library screen. OBF4 interacts with the B-box region of CO. The abundance of OBF4 mRNA cycles with a 24 h rhythm under both long-day (LD) and short-day (SD) conditions, with significantly higher levels during the night than during the day. Electrophoretic mobility shift assays revealed that OBF4 binds to the promoter of the FLOWERING LOCUS T (FT) gene, a direct target of CO. We also found that, like CO and FT, an OBF4:GUS construct was prominently expressed in the vascular tissues of leaf, indicating that OBF4 can regulate FT expression through the formation of a protein complex with CO. Taken together, our results suggest that OBF4 may act as a link between defense responses and flowering.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2877-2881
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• 2016

Background: Lung cancer is one of the most common causes of death that is rising in many countries including Iran. This study aimed to determine the impact of factors on survival of lung cancer patients at a referral center of lung diseases in Tehran, Iran. Materials and Methods: A retrospective study was conducted on adult lung cancer cases admitted to a referral center for lung diseases from 2011 to 2015. Multivariate analysis was performed to determine the risk factors for all-cause mortality. Results: Of a total 933 patients with lung cancer, 53.4% died, 49.3% of them at the hospital. Overall median follow-up time was 7 months. The most common histological type of cancer was adenocarcinoma with a 13 month median survival time. Age ${\geq}55$ and smoking remained significant for all-cause mortality on Cox analysis, whereas gender was not. Conclusions: The survival of lung cancer patients is poor and the patients with history of smoking and age${\geq}55$ are at increased risk of death. Having a large hospital-based registry provides a good measurement of prognostic statistics for lung cancer. Further investigations are necessary to establish reasons for mortality.