• Childhood Kidney Diseases
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• v.15 no.1
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• pp.38-48
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• 2011

Purpose: Focal segmental glomerulosclerosis (FSGS) is the most common glomerulopathy causing pediatric renal failure. Since specific treatment targeting the etiology and pathophysiology of primary FSGS is yet elusive, the authors explored the pathophysiology of FSGS by transcriptome analysis of the disease using an animal model. Methods: FGS/kist strain, a mouse model of primary FSGS, and RFM/kist strain, as control and the parent strain of FGS/kist, were used. Kidney tissues were harvested and isolated renal cortex was used to extract mRNA, which was run on AB 1700 mouse microarray chip after reverse transcription to get the transcriptome profile. Results: Sixty two genes were differentially expressed in FGS/kist kidney tissue compared to the control. Those genes were related to cell cycle/cell death, immune reaction, and lipid metabolism/vasculopathy, and the key molecules of their networks were TNF, IL-6/4, IFN${\gamma}$, TP53, and PPAR${\gamma}$. Conclusion: This study confirmed that renal cell death, immune system activation with subsequent fibrosis, and lipid metabolism-related early vasculopathy were involved in the pathophysiology of FSGS. In addition, the relevance of methodology used in this study, namely transcriptome profiling, and Korean animal model of FGS/kist was validated. Further study would reveal novel pathophysiology of FSGS for new therapeutic targets.

• Journal of Korean Society of Transportation
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• v.23 no.7 s.85
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• pp.99-110
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• 2005

Total travel cost of route which connects origin with destination (O-D) is consist of the total sum of link travel cost and route perception cost. If the link perception cost is different according to the origin and destination, optimal route search has limitation to reflect the actual condition by route enumeration problem. The purpose of this study is to propose optimal route searching formulation and algorithm which is enable to reflect different link perception cost by each route, not only avoid the enumeration problem between origin and destination. This method defines minimum unit of route as a link and finally compares routes using link unit costs. The proposed method considers the perception travel cost at both origin and destination in optimal route searching process, while conventional models refect the perception cost only at origin. However this two-way searching algorithm is still not able to guarantee optimum solution. To overcome this problem, this study proposed an orign based optimal route searching method which was developed based on destination based optimal perception route tree. This study investigates whether proposed numerical formulas and algorithms are able to reflect route perception behavior reflected the feature of origin and destination in a real traffic network by the example research including the diversity of route information for the surrounding area and the perception cost for the road hierarchy.

• Journal of Korean Society of Transportation
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• v.22 no.2 s.73
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• pp.121-130
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• 2004

In these days, multiple-path generation method is highly demanded in practice and research areas, which can represents realistically travelers behavior in choosing possible alternative paths. The multiple-path generation algorithm is one of the key components for policy analysis related to ATIS, DRGS and ATMS in ITS. This study suggested a method to generate multiple Possible paths from an origin to a destination. The approach of the suggested method is different from an other existing methods(K-shortest path algorithm) such as link elimination approach, link penalty approach and simulation approach. The result of the multi-label vine-building shortest path algorithm(MVA) by Kim (1998) and Kim(2001) was used to generate multiple reasonable possible paths with the concept of the rational upper boundary. Because the MVA algorithm records the cost, back-node and back-back node of the minimum path from the origin to the concerned node(intersection) for each direction to the node, many potential possible paths can be generated by tracing back. Among such large number of the potential possible paths, the algorithm distinguishes reasonable alternative paths from the unrealistic potential possible paths by using the concept of the rational upper boundary. The study also shows the very simple network examples to help the concept of the suggested path generation algorithm.

• Information Systems Review
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• v.10 no.2
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• pp.137-158
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• 2008

Rapid development of various information technologies creates new opportunities in online and offline markets. In this changing market environment, customers have various demands on new products and services. Therefore, their power and influence on the markets grow stronger each year. Companies have paid great attention to customer relationship management. Especially, personalized product recommendation systems, which recommend products and services based on customer's private information or purchasing behaviors in stores, is an important asset to most companies. CRM is one of the important business processes where reliable information is mined from customer database. Data mining techniques such as artificial intelligence are popular tools used to extract useful information and knowledge from these customer databases. In this research, we propose a recommendation system that predicts customer's purchase intention. Then, customer's purchasing intention of specific product is predicted by using data mining techniques using receipt data set. The performance of this suggested method is compared with that of other data mining technologies.

• Journal of the Korean association of regional geographers
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• v.12 no.5
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• pp.540-556
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• 2006

The purpose of this paper is to analyze a process of formation of an ethnic community in the global era, taking an example of foreign workers in Igok-Dong, Dalseo-gu, Taegu. Previous studies suggest that playing a role as a hub of culture, resources and ethnic networks an ethnic community becomes an imagined space where its members can feel "us". Through this imagined space, ethnic people communicate and exchange information with each other and establish transnational linkages between their origin and destination countries or the third countries. In my research in Igok-Dong it was observed that ethnic shops had become the centers of the community of foreign workers and helped them connect with their own ethnic people from wider areas than their residence. Partly because of such networks exclusively focused on their own ethnics, there was little connection developed between foreign workers and locals. A social distance between the two parties may turn into antagonism as the ethnic community grows in number. Since it is foreseen that demands for foreign workers will continue to rise in Igok-Dong it is necessary to seek ways to achieve a more inclusive and harmonious multi-ethnic society for both foreign workers and locals.

• Archives of design research
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• v.20 no.1 s.69
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• pp.65-78
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• 2007

The mobile phone and wireless network, location based technology and other newly introduced technologies and communication media gave birth to the new terminology "ubiquitous" and are changing our daily life. Influence of such technologies and communication media is not an exception in the arts. New media art pieces using these technologies are increasing, and taking on the characteristics of public art within a wider scope of a city as a backdrop, beyond the traditional boundaries of art galleries. Of such art, locative media art using locative media has a closer relationship with city space than any other form of an, and makes various attempts to allow the spectator to reinterpret and experience city space and induce communication. These characteristics of locative media art can be considered as a method that can solve quality problems of the city space, especially the loss of the sense of place and the absence of communication. is one such locative media project with a purpose of solving quality problems of city space, especially the recovery of commercial sites and inducing communication. This project uses the paths of the city as its canvas, movement of people as its brush, the color of the roads as its pallet, and by allowing the partakers to draw paths of their own and to share their paths with others. People are encouraged to share stories about their paths. The project proceeds using barcodes that are frequently used commercially. When users wish to create their own place, they can enter their place and colors of their choice using input devices installed in the city space. Paths that are created through such a process will be displayed in public areas throughout the city, shared with others, and can create and share a stories about the city using on/off-line media.

• Journal of Engineering Education Research
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• v.9 no.2
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• pp.34-51
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• 2006

In knowledge based society of 21c, engineers require not only their own speciality but also engineering basic competency such as creative thinking, the ability of working together, the ability of communication. Engineering colleges responsible for educating engineers consider developing curriculum including Engineering Basic Competency which is reflecting the needs of the times. By utilizing the accreditation programs of engineering education, UK-SPEC of UK Engineering Council, EA(Engineering Australia) standards/handbook of the Institute of Engineers Australia, O*NET of U.S. Occupational Network, this study generates core elements of engineering basic competency to prove the capability of engineering basic competency required to desired engineers. Core constituents derived from the study were categorized into 3 major areas of the basic engineering literacy in Humanities and Social Sciences(HSS), the ability of Creativity Engineering Design, Career development and each category and constituents were surveyed and checked by engineers in the field to deduce engineering basic competency that should be educated in the engineering college.

• Science of Emotion and Sensibility
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• v.16 no.2
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• pp.249-264
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• 2013

Using social network analysis, this study examined cognitive representations of ideal public figures as well as politicians and entertainers who are often regarded as public figures in Korea. Participants expected ideal public figures to possess only positive characteristics, such as high morality, integrity, competence. However, their assessment of politicians and entertainers reflected in their cognitive representations turned out to be fairly different from the image of ideal public figures. Personality traits and behavioral characteristics featured in cognitive representations of politicians were dominantly negative. Cognitive representations of entertainers incorporated both positive and negative characteristics highly interconnected to each other. This study also explored how people respond affectively toward ideal public figures, politicians and entertainers. Participants showed only positive feelings toward ideal public figures. However, their' affective responses toward politicians were entirely negative and toward entertainers, both positive and negative affects were shown. We discussed the disjunction between the representations of politicians and entertainers and of ideal public figures and suggested directions of future research.

• Journal of KIISE:Information Networking
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• v.36 no.4
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• pp.286-296
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• 2009

A major challenge in next generation optical Internet (NGOI) networks based on dense-wavelength division multiplexing (DWDM) is the provision of guaranteed quality-of-service (QoS) for a wide variety of multimedia applications. One of the critical issues in NGOI is the routing and wavelength assignment problem that is embossed as very important and plays a key role in improving the global efficiency for capacity utilization. But the previous researches had the delay problem, and the path routed by higher priority nodes may be congested and interfere with potential future multicast session requests. To overcome these problems, in this research we suggest a Priority-based Minimum Interference Path Multicast Routing (PMIPMR) algorithm, a new routing algorithm which finds alternative routes based on node priorities and Virtual Source (VS) nodes that has both splitting and wavelength conversion, and then chooses a path that does not interfere with potential future multicast session requests when congestions occur in the network. The PMIPMR algorithm reduces blocking rate significantly and increases the wavelength utilization by avoiding congestion in future multicast session requests.

• Journal of Korean Library and Information Science Society
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• v.45 no.4
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• pp.67-93
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• 2014

This study aims to present a direction for local libraries on how to collect folk culture content and provide services in cooperation with public libraries across the country, with a focus on public libraries, in implementing the government policy to collect, classify, store, research, and utilize folk culture content. Results of the study drawn from literature review, surveys, case-studies are as follows: First, based on the advantage of higher accessibility than other institutions in charge of folk culture content provision, libraries should take a role to collect, store, and utilize folk culture content for public purpose of improving knowledge and interests of residents and storing local history. Second, folk culture content collection, enhanced content-creating, and user-oriented services reflecting various demands should be expanded, seeking ways to improve management conditions of folk culture content based on collaboration network between libraries, along with drawing interests and support from the local government and the central government. Thirdly, libraries should provide expanded services of collection, creation, use of folk culture content with a focus on local culture through regular and systematic study and building of folk culture content.