• Title/Summary/Keyword: Repair materials

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Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

  • Cao, Zhen;Dou, Ce;Li, Jianmei;Tang, Xiangyu;Xiang, Junyu;Zhao, Chunrong;Zhu, Lingyu;Bai, Yun;Xiang, Qiang;Dong, Shiwu
    • BMB Reports
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    • v.49 no.10
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    • pp.548-553
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    • 2016
  • Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage.

A Comparative Study on the Applicability of CNT-coated Glass Fiber for Wind Blades (풍력 블레이드를 위한 CNT 코팅 유리섬유의 적용성에 대한 비교 연구)

  • Jang, Hong-Kyu;Kim, Young-Chul
    • Composites Research
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    • v.29 no.6
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    • pp.336-341
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    • 2016
  • This paper conducted the study on the electromagnetic and mechanical applicability of CNT-coated glass fiber for wind blades. Large-size wind blade has the serious pending problems to meet the target, such as interfering radar signals, increasing weights, and increasing repair costs. In this paper, we are suggesting the CNT-coated glass fiber in order to overcome these problems. First, the CNTs were strongly coated on the surfaces of glass fiber by suggested coating process, and the CNT-coated glass fiber/epoxy composites were fabricated by Va-RTM process. We designed and fabricated a radar absorbing structure using the CNT-coated glass fiber, which showed over 90% radar absorbing performance between 8.3 and 12.1 GHz frequency. In addition, we confirmed the improvement of mechanical properties on the strength and modulus of tensile, compressive, and in-plane shear.

Manufacturing and Properties of Al-Al2O3 Composite Coating Layer Using Warm Spray Process (Warm spray를 이용한 알루미늄-알루미나 복합 코팅층의 제조 및 특성)

  • Kwon, Eui-Pyo;Lee, Jong-Kweon
    • Korean Journal of Materials Research
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    • v.27 no.7
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    • pp.374-380
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    • 2017
  • Properties of coatings produced by warm spray were investigated in order to utilize this technique as a repair method for Al tire molds. $Al-(0-10%)Al_2O_3$ composite powder was sprayed on Al substrate by warm spraying, and the microstructure and mechanical properties of the composite coating layer were investigated. For comparative study, the properties of the coating produced by plasma spray, which is a relatively high-temperature spraying process, were also investigated. The composite coating layers produced by the two spray techniques exhibited significantly different morphology, perhaps due to their different process temperatures and velocities of particles. Whereas the $Al_2O_3$ particles in the warm sprayed coating layer maintained their initial shape before the spray, flattened and irregular shape $Al_2O_3$ particles were distributed in the plasma sprayed coating layer. The coating layer produced by warm spray showed significantly higher adhesive strength compared to that produced by plasma spray. Hardness was also higher in the warm sprayed coating layer compared to the plasma sprayed one. Moreover, with increasing the fraction of $Al_2O_3$, hardness gradually increased in both spray coating processes. In conclusion, an $Al-Al_2O_3$ composite coating layer with good mechanical properties was successfully produced by warm spray.

Perceived risks in purchase decision of paper fashion products - Focusing on bags and wallets made with Jumchi-Hanji papers - (종이소재 패션제품 구매결정에서의 지각된 위험 - 줌치한지 종이소재 가방과 지갑 제품을 중심으로 -)

  • Hong, Heesook;Kim, Heyseong
    • The Research Journal of the Costume Culture
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    • v.26 no.3
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    • pp.450-470
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    • 2018
  • This study examined the risk components and risk types perceived in the context of purchasing decisions of paper fashion products. This study also identified the levels of perceived risk by consumers and the differences between age groups in risk perception. First, qualitative data were collected through a focus group interview with 7 Korean females in their 20s to 50s. The interviewees were presented with two types of paper materials (undyed and dyed Jumchi-Hanji) and products (bags and wallets) made with the papers. The interviewees mentioned 11 risk components which were classified into five types of risks: performance (easily torn/lack of durableness, lint/pilling/wear-out, lack of water-resistant, no washability, and deformation and discoloration over time), social-psychological (old and traditional image), aesthetic (lack of design diversity, unsatisfactory appearance due to repair), financial (expensive price, lack of usability in daily life) and time/convenience (difficulty in handling) risks. Based on the results of the interview, a measurement for evaluating the risk perception of paper fashion products was developed. Second, quantitative data were collected from 64 Korean women in their 20s to 50s using the measurement. Respondents who were presented with the paper materials and the products perceived the performance risk more strongly than the social-psychological risk and aesthetic risk. In addition, differences between age groups were found: younger respondents perceived performance risk and social-psychological risk more strongly than older respondents, but older respondents perceived financial risk more than younger respondents. Based on this study, strategies for the risk reduction of paper fashion products were proposed.

User Acceptance of a Light-Emitting Diode Vest for Police Officer

  • Han, Hyunjeong;Park, Huiju;Jeon, Eunkyung
    • Fashion & Textile Research Journal
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    • v.15 no.5
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    • pp.834-840
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    • 2013
  • This study aims to suggest practical considerations for designing protective clothing with increased visibility that will have higher user acceptance by law enforcement officers. Light-emitting diode(LED) patrol vests were visually and structurally assessed, and 125 police officers' responses from surveys about user acceptance of the vest were analyzed. The current LED patrol vest was designed for enhanced safety of police officers by increasing visibility in the dark. However, the user acceptance rate of the LED patrol vest indicates low use of and low satisfaction with the vest despite its enhanced safety features. In particular, differences in materials, design, functionality of the pockets and size of the vest depending on the hours worked, were statistically significant. The police officers' responses suggest areas of improvement in design, materials, ease of movement, size and functionality. Key issues include 'tactile discomfort'; 'impeded vision from the glare of the LED'; 'frequent malfunctions of the LED'; 'impossible repair of the broken LED units'; 'no user feedback'; 'inconvenient to replace batteries'; 'brittle materials' and 'unpleasing look'. To increase user acceptance, designer should incorporate context-awareness, a convenient user interface, a modular design approach, first responders' self-image as public servants in relation to their aesthetic perspectives of their uniforms, and scientific evaluation of the effectiveness of the intended functions of the clothing. Suggested implications for designing the LED patrol vest can be applied to designing other functional/protective clothing for intended end users with special needs.

Tensile Bond Characteristics between Underwater Coating Materials and Concrete Substrate (수중코팅제와 콘크리트 모재 간의 인장 부착 특성)

  • Kim, Min Ook;Jeong, Yeonung;Kang, Sung-Hoon;Moon, Juhyuk;Yi, Jin-Hak
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.30 no.6
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    • pp.298-305
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    • 2018
  • In this study, we investigated the tensile bond characteristics of underwater coating materials, in order to obtain useful information in support of repair work for marine and coastal concrete structures. Test variables included type of underwater coating, surface conditions of the concrete substrate, and environmental conditions. Pull-off tensile bond strength was measured at 24 h after applying underwater coatings to concrete substrates, in compliance with the procedures specified in ASTM C1583. Failure modes (coating, interface, and parent concrete) for each coating were identified through visual inspection, and comparisons were made based on measured bond strength. The tensile bond strength decreased underwater compared to that under dry conditions, while no significant effect of surface roughness on the measured bond strength was observed in underwater tests. Key aspects that need to be considered regarding selection and use of underwater coating materials for marine and coastal concrete structures were discussed.

Conservation Treatment and Structural Characteristics of Armor and Helmets Housed in the National Museum of Korea - Armor and Helmets from the Mid- and late Joseon Dynasty (국립중앙박물관 소장 갑주(甲冑)의 보존처리와 구조적 특징 - 조선시대 중·후기 갑주를 중심으로-)

  • Park, Jinho;Park, Jihye;Hwang, Jinyoung
    • Conservation Science in Museum
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    • v.26
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    • pp.35-66
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    • 2021
  • This study conducted scientific analysis and conservation treatment on four suits of armor and two helmets from the collection of the National Museum of Korea. Based on the findings, it identified structural characteristics of armor from the middle and late Joseon Dynasty. Since a suit of armor is made of composite materials consisting of both organic and inorganic elements, conservation treatment was conducted to the extent that the stable condition of each material remained unaffected by the other materials. The process took place in the sequence of investigation and analysis, removal of contamination, stabilization and reinforcement, repair of damaged parts, and storage. The armor and helmets had suffered severe damage, but were safely repaired and partially restored through the conservation treatment. The findings from the conservation treatment revealed the materials used and structural characteristics of the armored skirt from a two-piece set of armor from the middle Joseon period and for the two suits of overcoat-style armor, suit of vest-style armor, and helmets from the late Joseon era. It also allowed the investigation of the production methods of the armor and helmets.

Comparison of the sealing ability of various bioceramic materials for endodontic surgery

  • Benjamin Rencher ;Ana M. Chang ;Hanson Fong;James D. Johnson;Avina Paranjpe
    • Restorative Dentistry and Endodontics
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    • v.46 no.3
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    • pp.35.1-35.11
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    • 2021
  • Objectives: Endosequence Bioceramic Root Repair Material (BC-RRM) is used in endodontic microsurgery. It is available as a paste and a putty. However, no studies to date have examined the sealing ability of these forms alone or in combination as root-end filling materials. Hence, this study aimed to compare the sealing properties of these 2 forms of BC-RRM. Materials and Methods: Forty-two extracted upper anterior teeth were divided into 3 experimental groups, a positive and negative control. After the root canal treatment, the root ends were resected, retroprepared and retrofilled with either putty, paste + putty or mineral trioxide aggregate (MTA). The teeth were mounted in tubes so the apical 3 mm was submerged in Brain Heart Infusion (BHI) broth. The coronal portions of the canals were inoculated with Enterococcus faecalis and BHI broth and incubated for 30 days. The broth in the tubes was analyzed for colony forming units to check for leakage of bacteria from the canal. The teeth from the groups were sectioned and analyzed using scanning electron microscopy (SEM). The Kruskal-Wallis test and analysis of variance were used to analyze the data with a significance level p < 0.05. Results: The BC-RRM and MTA groups showed similar sealing ability. The positive control showed leakage in all samples. The SEM imaging showed the presence of bacteria in all experimental groups at the material-tooth interface. Conclusions: No significant differences were noted in the experimental groups, providing sufficient evidence that any combination could be effectively used during endodontic microsurgery.

Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue

  • Ranjdar Mahmood Talabani;Balkees Taha Garib;Reza Masaeli;Kavosh Zandsalimi;Farinaz Ketabat
    • Restorative Dentistry and Endodontics
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    • v.46 no.1
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    • pp.1.1-1.13
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    • 2021
  • Objectives: The aim of this study was to evaluate the dystrophic mineralization deposits from 3 calcium silicate-based cements (Micro-Mega mineral trioxide aggregate [MM-MTA], Biodentine [BD], and EndoSequence Root Repair Material [ESRRM] putty) over time after subcutaneous implantation into rats. Materials and Methods: Forty-five silicon tubes containing the tested materials and 15 empty tubes (serving as a control group) were subcutaneously implanted into the backs of 15 Wistar rats. At 1, 4, and 8 weeks after implantation, the animals were euthanized (n = 5 animals/group), and the silicon tubes were removed with the surrounding tissues. Histopathological tissue sections were stained with von Kossa stain to assess mineralization. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM/EDX) were also used to assess the chemical components of the surface precipitates deposited on the implant and the pattern of calcium and phosphorus distribution at the material-tissue interface. The calcium-to-phosphorus ratios were compared using the non-parametric Kruskal-Wallis test at a significance level of 5%. Results: The von Kossa staining showed that both BD and ESRRM putty induced mineralization starting at week 1; this mineralization increased further until the end of the study. In contrast, MM-MTA induced dystrophic calcification later, from 4 weeks onward. SEM/EDX showed no statistically significant differences in the calcium- and phosphorus-rich areas among the 3 materials at any time point (p > 0.05). Conclusions: After subcutaneous implantation, biomineralization of the 3-calcium silicate-based cements started early and increased over time, and all 3 tested cements generated calcium- and phosphorus-containing surface precipitates.

A Study on the Change of Landscape in Bulguksa Temple through a Iconographic Materials in the Period of Japanese Occupation (일제강점기 도상자료를 통한 불국사의 경관변화에 관한 연구)

  • Kim, Kyu-Won;Ahn, Gye-Bog;Sim, Woo-Kyung
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.33 no.1
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    • pp.21-30
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    • 2015
  • Bulguksa Temple, a typical temple of Silla was lost during Japanese Invasion of Korea and there are records of reconstructing in its record, Bulguksa Sajeok. There is no record after that. And reconstructing was stopped due to lack of money and repair works were conducted for two times in Japanese colonial era. First repair work was from 1989 to 1919 and second repair work was conducted from 1922 to 1925. After Liberation, Bulguksa Temple Restoration Committee was established in 1969 and the construction has started since 1970 after excavation investigation to complete in 1973. The shape of south arcade without walls in the main temple of Bulguksa was found in a blue print of Bulguksa in Japanese colonial era in National Archives of Korea now and a picture of Bulguksa in 1902 taken by Sekino Tadashi. It verified the correlation between Gupumyeonji which was discovered in restoration work in 1970s and a legend of Muyoungtap. And a stair from the hall of Paradise to the main temple was introduced as a stair including Pure Land Buddhism doctrine in many literature materials, but a blue print of Bulguksa in Japanese colonial era and reports of excavation investigation in 1970s verified that it was a temporary stair built by Japan and its meaning was given later. This research checked the scenery of Bulguksa Temple before Japanese colonial era and it is intended for basic data to conduct restoration or reconstruction project in the future.